To analyze the incidence trend of viral hepatitis C (HCV) in China from 2006 to 2020, and to explore the influence of age, period and birth cohort on the incidence of HCV.

The data of hepatitis C cases and demographic data were collected in China from 2006 to 2020. The Joinpoint regression model was applied to analyze the trend of the incidence of hepatitis C in the whole population and by age group. The age-period-cohort model was applied to explore the effects of age, period and birth cohort on the incidence.

The incidence of hepatitis C increased from 2006 to 2020, and the average incidence was 12.82 per 100 000. Unlike other age groups, the incidence of hepatitis C in people age group 60 and above still showed an upward trend from 2010 to 2018 (APC=3.40). The time of onset effect of hepatitis C increased from 0.63 (95%CI: 0.77-0.70) during 2006-2010 to 0.92 (95%CI: 0.84-1.00) during 2016 to 2020. The birth cohort effect was lowest in the 1926-1930 cohort and peaked in the 1991-1995 cohort (RR=1.41, 95%CI: 1.01-1.97).

The incidence of hepatitis C increased during the study period, and the disease burden increased with age. High-risk groups should be regularly screened and monitored.

To analyze the epidemiological characteristics, spatial clustering, and influencing factors of tuberculosis recurrence in Kashgar within three years after successful treatment to provide a scientific basis for tuberculosis recurrence management.

Taking the tuberculosis patients successfully treated in Kashgar from 2013 to 2020 as the research object, we observed the recurrence epidemic characteristics, conducted spatial analysis to understand the recurrence clustering, and used the Cox regression model to explore the influencing factors.

Among the 104 899 objects,14 180 experienced recurrences within three years, with a cumulative recurrence rate of 13.52%. Spatial analysis showed a positive spatial correlation of tuberculosis recurrence, with recurrence hotspots mainly concentrated in Shache, Yingjisha, and Bachu counties. The Cox model showed that male (aHR=1.155, 95%CI: 1.118-1.195), Uyghur (aHR=2.186, 95%CI: 1.786-2.681), 45-<60 age groups (aHR=1.631, 95%CI: 1.061-2.507) and ≥60 age groups (aHR=1.782, 95%CI: 1.160-2.738), farmers and herdsmen (aHR=1.104, 95%CI: 1.039-1.173), re-treatment (aHR=1.086, 95%CI: 1.036-1.138), positive aetiology result (aHR=1.377, 95%CI: 1.324-1.432), positive sputum smear after two months of treatment (aHR=1.699, 95%CI: 1.501-1.924), total delay ≥30 days (aHR=1.129, 95%CI: 1.088-1.171) and living in hotspots (aHR=1.470, 95%CI: 1.413-1.530) were independent risk factors for recurrence after successful treatment.

Priority should be given to improving the monitoring and management of patients in hotspot regions and those at high risk of relapse after treatment to ensure early detection of TB relapse and standardized care.

To investigate the correlation between UHR and CKD in middle-aged and elderly population.

The data of this study was obtained from 2015 China Health and Retirement Longitudinal Survey(CHARLS).A total of 9 204 people≥45 years old were included.Multivariate Logistics regression analysis was used to analyze the correlation between UHR and CKD.The receiver operating characteristic(ROC)curves was used to analyze the predictive value of UHR for the risk of CKD.

The subjects who we included have the mean age of 60.78±9.32 years with the prevalence of CKD of 3.97%.The odd rations for the highest quartile group (Q₄ group)of UHR was increased for CKD(OR=12.01, 95%CI:7.50-20.00).ROC curve analysis showed that the area under the ROC Curve(AUC) for UHR predicting CKD for middle-aged and elderly population was 0.76(95%CI:0.73-0.78),the AUC for UHR predicting CKD for male group was 0.74(95%CI:0.70-0.77)and the AUC for UHR predicting CKD for female group was 0.77(95%CI:0.73-0.81).

There was a positive correlation between the increased UHR level and risk of CKD among the middle-aged and elderly population in China.UHR might serve as a risk factor and demonstrated good predictive value for CKD in the middle-aged and elderly population in China.

To explore the impact of perceived HIV-related discrimination on antiretroviral therapy (ART) adherence among middle-aged and elderly individuals living with HIV/AIDS and the modifying effect of social support, so as to provide guidance for improving ART treatment success rates.

By using cluster random sampling method, a questionnaire survey was conducted among middle-aged and elderly HIV/AIDS patients in the city of Mianyang. The survey assessed their sociodemographic characteristics, social support, perceived discrimination, and treatment adherence. Logistic regression models were used to analyze the relationship between these factors and ART adherence.

The study included 401 middle-aged and elderly HIV/AIDS patients receiving ART. Good adherence was observed in 69.82% of participants, while 30.18% had poor adherence. Univariate analysis revealed that patients with effective viral suppression (viral load ≤20) demonstrated better adherence compared to treatment failure patients (viral load >20). Adherence was also higher among those following single or dual antiretroviral drug regimens. Logistic regression results indicated that fear of disclosure (OR=1.116, 95% CI: 1.023–1.217), public discrimination (OR=1.105, 95% CI: 1.008–1.211), and internal shame (OR=1.119, 95% CI: 1.022–1.225) significantly influenced treatment adherence. Stratified analysis further revealed that fear of disclosure (OR=1.159, 95% CI: 1.034–1.299), public discrimination (OR=1.128, 95% CI: 1.004–1.267), and internal shame (OR=1.150, 95% CI: 1.021–1.297) were associated with adherence.

Enhancing social support, particularly at the individual and family levels, is crucial to mitigate the impact of fear of disclosure, public discrimination, internal shame, and treatment regimens on HIV/AIDS treatment adherence. Public education and support programs should aim to reduce discrimination, strengthen viral load monitoring, and adjust personalized treatment plans promptly.

To understand the utilization of mental health education services and its influencing factors among the elderly floating population in China, and to provide reference for the effective development of mental health education for the elderly.

The data of 5 589 elderly migrants in the 2018 National Floating Population Health and Family Planning Dynamic Monitoring Questionnaire were analyzed, and the Anderson model was used as the theoretical framework, and the main analysis methods included statistical description, χ² test and binary logistic regression analysis.

The utilization rate of mental health education services for the elderly floating population in China was 16.84%, and the methods which wereused were mainly publicity materials, publicity columns, knowledge lectures and public health consultation activities, and the logistic regression results showed that the education level was college degree or above (OR=1.229, 95%CI: 0.901-1.676), the flow range was inter-city in the province (OR=1.219, 95%CI: 1.047-1.593), and the inflow area was Northeast China (OR=1.419, 95%CI: 1.159-1.737), central region (OR=1.980, 95%CI: 1.582-2.478) were the protective factors for the use of mental health education services in the elderly floating population, the migration duration was 10-20 years (OR=0.689, 95%CI: 0.521-0.913), the health records were not established and unknown (OR=0.473, 95%CI: 0.333-0.672), Unclear health record establishment (OR=0.683, 95%CI: 0.473-0.986), uncontracted and uninformed family contracted doctors (OR=0.537, 95%CI: 0.37-0.767), and unclear family doctor contract (OR=0.597, 95%CI: 0.423-0.844) were risk factors for the utilization of mental health education services in the elderly migrant population.

The utilization rate of mental health education services for the elderly floating population needs to be improved, the awareness of mental health of the elderly floating population should be strengthened, the mental health publicity of the elderly floating population should be increased, and the elderly floating population should be guided to actively receive mental health education.

To analyze the epidemiological characteristics of severe acute respiratory syndrome corona virus 2 (referred to as SARS-CoV-2) and influenza viruses in Inner Mongolia Autonomous Region in 2023, and to provide a scientific basis for the prevention and control of acute respiratory infectious diseases in the region.

Collect the ILI surveillance data and nucleic acid detection data of influenza virus and SARS-CoV-2 from the first to 52nd week of 2023 in the whole district and describe and statistically analyze the percentage of ILI among outpatient cases and the epidemiological data of influenza virus and SARS-CoV-2, statistical methods used were χ² test.

A total of 166 307 cases of ILI were reported in sentinel hospitals from weeks 1 to 52 in 2023, and the total number of cases attended was 6 143 210, and the percentage of ILI in the number of cases attending outpatient emergency departments (ILI%) was 2.71%. ILI% was statistically different in different weeks (χ²=35 246.742, P<0.05) and different regions (χ²=71 475.341, P<0.05)were statistically different. A total of 25 680 ILI specimens were collected in the sentinel hospitals, and the nucleic acid positivity rate of SARS-CoV-2 was 11.75%, and the positivity rate was statistically different in different weeks (χ²=2 272.239, P<0.05), different age groups (χ²=1 012.19, P<0.05), different regions (χ²=114.624, P<0.05), and different genders (χ²=26.464, P<0.05) were statistically different. Influenza virus nucleic acid positivity rate was 12.77%, and the positivity rate was statistically different in different weeks (χ²=9 606.493, P<0.05), different age groups (χ²=717.307, P<0.05), and different regions (χ²=41.406, P<0.05).

COVID-19 infection and influenza are alternately prevalent in Inner Mongolia Autonomous Region from week 1 to 52 in 2023, and continuous monitoring of SARS-CoV-2 and influenza virus is needed to obtain more monitoring data to provide scientific data support for effective prevention and control of acute respiratory infectious diseases.

To investigate the causal relationship between immune cell mediated liposomes and non-small cell lung cancer (NSCLC) using two-sample Mendelian randomization and two-step analysis.

Summary data of GWAS for plasma liposomes were obtained from the GWAS Catalog as exposure data. Summary data of GWAS for 731 types of immune cells were selected as potential mediators, and NSCLC data from the ninth release of the FinnGen database were used as outcome data. Inverse-variance weighted (IVW) was used for two-step. Two-sample Mendelian randomization analysis was used to investigate the causal relationship between liposomes and NSCLC and the mediating role of immune cells in the lipid-NSCLC association. Weighted median and MR-Egger methods were used as supplements, along with pleiotropy and heterogeneity tests to ensure result stability.

The IVW method identified 36 liposomes associated with NSCLC, with no evidence of reverse causation. A total of 47 immune cell types were strongly associated with NSCLC. Notably, triglyceride (TG) (58:8) had a causal effect on NSCLC (OR=1.183, 95%CI: 1.061-1.319). The mediation effect mediated by Effector Memory CD8+ T cell %CD8+ T cell was 0.003 (95%CI: -0.007-0.013), accounting for 1.94% of the total effect, while the mediation effect mediated by CD8+ and CD8dim T cell %leukocyte was 0.012 (95%CI: -0.004-0.028), accounting for 7.24% of the total effect.

This study suggests a causal relationship between liposomes and NSCLC, identifying TG as a risk factor for NSCLC progression. Effector Memory CD8+ T cell %CD8+ T cell and CD8+ CD8dim T cell %leukocyte play a mediating role in this process.

To analyze the quality of life (QOL) and its related factors among residents, and to explore the contribution of each factors to QOL by Shapley method, so as to provide references for health policy making.

Questionnaire survey was conducted in 5 cities of Hubei Province from July to August 2021 by stratified random sampling to measure the QOL of 1 387 residents according to SF-12 scale, multivariate regression model and Shapley decomposition method were applied to analyze the influencing factors and its contribution to QOL.

The scores of residents’ physical component summary (PCS) and mental component summary (MCS) were 71.04±17.43 and 75.70±12.51 respectively. Age≥60 (β=-6.073), employment status (retirement (β=-12.752), unemployed (β=-7.292)), annual income (50 000-100 000 Yuan (β=3.516), >100 000 Yuan (β=6.169)), no chronic disease history (β=9.202), and no physical exercise (β=-3.182) had significant effects on PCS (P<0.05), whereas married (β=2.106), employment status (retirement (β=-6.788),unemployed (β=-5.174)), personal annual income >100 000 Yuan (β=3.842), without medical insurance (β=-4.455), no chronic disease history (β=3.450) and no physical exercise (β=-2.056) had significant effects on MCS (P<0.05). Shapley decomposition results showed that employment, chronic medical history and income were the main influencing factors of residents’ quality of life. The variables contributing to PCS were chronic disease history (32%), age (25%), employment status (24%)，income (12%) and weekly exercise (7%). The factors mainly contributing to MCS were employment status (35%), chronic disease history (21%), income (18%), weekly exercise (12%).

The overall quality of life of residents in survey areas of Hubei is good. Employment status, chronic disease history, income and weekly exercise are main influencing factors of residents’ quality of life. Increasing income levels, strengthening chronic disease management, and improving health behaviors may improve residents’ quality of life.

To analyze the pneumoconiosis mortality change trend, influencing factors and differences between Chinese residents from 2002 to 2021.

Using the Joinpoint model of crude pneumoconiosis mortalityrate and standardized mortalityrate, the annual percentage change (APC) and mean annual percentage change (AAPC) were calculated. The effect of three effects on pneumoconiosis mortality changes was analyzed by the age-period-cohort model.

The urban standardized mortality rate showed an overall downward trend (APC=-0.2%, P>0.05) and increased in rural areas from 2004 to 2021 (APC=7.9%, P<0.001). The age effect showed that both urban and rural pneumoconiosis mortality rate increased with increasing age. The period effect increased with time, and it was different between urban and rural areas, with the risk of urban death decreasing, and the risk of rural death increasing. The cohort effect showed that the risk of death decreased with later birth, and the rural resident birth cohort showed a fluctuating trend.

The increasing effect of age, period and cohort will affect rural pneumoconiosis mortality more than in urban areas.

To explore the epidemiological characteristics of foodborne disease events in a rural banquet in Sichuan Province from 2004 to 2023, and to provide a scientific basis for the prevention and control of foodborne disease in the rural banquet.

The data of foodborne disease events in a rural banquet in Sichuan Province from 2004 to 2023 were collected from the National Foodborne Disease Outbreaks Surveillance System and National Management Information System of Public Health Emergencies and analyzed by descriptive statistics.

From 2004 to 2023, a total of 189 foodborne disease events in rural banquet were reported in Sichuan Province with 5 971 cases and 22 deaths, and the case fatality rate was 0.37%. The third quarterly was the high incidence period, accounting for 43.39% of the total events. The top three regions with the highest number of reported events were Chengdu (25 events), Luzhou (19 events) and Yibin (18 events). Microbial pathogens were the main pathogenic factors, accounting for 66.67% of the total events. Chemicals were the main causes of death, with 15 and 5 deaths caused by methanol and nitrite, respectively. Meat and meat products were the main causes of foodborne diseases. Improper processing and storage were the main inducing factors.

The targeted health education, supervision, monitoring, and emergency handling should be carried out to effectively prevent and control foodborne disease events in rural banquets.

To explore the level and influencing factors of dietary recommendation knowledge among residents aged 18-64 years in Hunan Province in 2021, and to provide a reference for targeted dietary nutrition education.

In 2021, a total of 4351 adult residents from 13 districts (counties) survey sites of Hunan Province were surveyed using the Nutrition and Health Knowledge Questionnaire. The total score of the questionnaire was 100. The knowledge dimension of dietary recommendation included 19 knowledge points, with a total score of 30, the total score of this dimension ≥ 22.5 was considered to be aware of dietary recommendation related knowledge. Binary logistic regression was used to analyze the influencing factors of adult residents’ knowledge level of dietary recommendation.

A total of 4 010 adults were included in the survey, with an average age of (38.6±12.0) years. The average score of dietary recommendation knowledge dimension was (17.7±4.4) points, and the awareness rate of knowledge about dietary recommendations was 13.6%. The results showed that there were significant differences in the scores and awareness rates of dietary recommendation related knowledge among residents with different genders, age groups, education levels, work units and specific situation of chronic diseases (P<0.05). Logistic regression analysis showed that compared with the corresponding reference group, the awareness rate of dietary recommendation related knowledge was relatively higher in female residents (OR=1.267, 95%CI=1.051 - 1.526) and residents with education level of junior high school and above [junior high school (OR=1.528, 95%CI=1.042-2.242), seniorhigh school (OR=2.123, 95%CI=1.421 - 3.172), college/professional college (OR=3.653, 95%CI=2.386-5.593),bachelor’s degree and above (OR=3.385, 95%CI=2.120 - 5.405)]. Compared with those working in medical and health institutions, those working in education-related institutions had a lower awareness rate of dietary recommendation knowledge (OR=0.547, 95%CI: 0.322-0.930). Compared with those without chronic diseases, the awareness rate of dietary recommendation was lower in adults who did not know their specific situation of chronicdiseases (OR=0.613, 95%CI=0.487-0.772).

There is significant room for improvement in the knowledge level of diet recommendation among adult residents in Hunan Province. In the future, more attention should be paid to the dietary nutrition education of adult males, middle-aged and elderly people, patients with chronic diseases, and residents who do not work in medical and health institutions.

To analyze the association between family functioning and primary school students’ emotion regulation strategies, and to provide a theoretical basis for promoting the development of primary school students’ psychological health.

A random cluster sampling method was used to select 9 868 students from six primary schools in a region of Xinjiang for the study, and questionnaires were administered using the Basic Information Questionnaire, the Family Functioning Scale (FAD), and the Emotion Regulation Questionnaire for Children and Adolescents (ERQ-CA).

The total family functioning score of primary school students was (138.99±17.54), and multiple linear regression analyses showed that total family functioning (β=-1.03), problem-solving (β=-0.10), affective involvement (β=-0.09), communication (β=0.05), affective response (β=0.05), and age (β=0.50) had a predictive role in primary school students’ cognitive reassessment strategy effect (R²=0.101, all P<0.01). Total family functioning (β=0.22), problem-solving scores (β=0.18), emotional involvement scores (β=0.09), roles (β=0.04), and communication (β=-0.03) were predictive of primary schools’ children’s expressive inhibition strategies (R²=0.120, all P<0.05).

Elementary school students’ family functioning is at a moderately low level, and upper primary schools’ students are more inclined to use the emotion regulation strategy of expression inhibition, which can be improved by increasing the level of family functioning in each dimension.

To explore the relationship between online sexual harassment experiences and the sexual values of primary and secondary school students, and to provide scientific reference for comprehensive sex education for primary and secondary school students.

The study used a multi-stage stratified cluster sampling method to select 4 051 primary and secondary school students from 9 schools in Fushun County, collecting information on the social demographics, online sexual harassment experiences, sexual values, psychological resilience, and social capital of primary and secondary school students. The study analyzed the impact of online sexual harassment experiences on the sexual values of primary and secondary school students using a multiple linear regression model. The mediating effect of psychological resilience was tested using the Bootstrap method (repeated sampling 5 000 times).

It showed that out of 4 051 primary and secondary school students surveyed, 754 students (18.61%) reported experiencing online sexual harassment. In the regression model, online sexual harassment experiences were negatively associated with scores on sexual violence and safety perceptions (β=-0.50, P<0.05), gender power and social gender perceptions (β=-0.25, P<0.05), and positively associated with scores on sexual and reproductive health perceptions (β=0.31, P<0.05). Psychological resilience played a partial mediating role (β=-0.38, P<0.05), accounting for 46.34% of the mediating effect between online sexual harassment experiences and the sexual values of primary and secondary school students.

Online sexual harassment experiences are negatively associated with the sexual violence and safety perceptions, gender power and social gender perceptions of primary and secondary school students while being positively associated with the sexual and reproductive health perceptions of primary and secondary school students. Improving psychological resilience may help promote the formation of scientific and normative sexual values among primary and secondary school students.

To analyze the influencing factors of bullying and suicide-related behaviors among primary and secondary middle school students in Hubei Province, and to summarize the high-risk groups of bullying and suicide-related behaviors (thoughts/plans/attempts).

A stratified random sampling method was used to select primary, middle, and high school/vocational high school students from 4 counties in Hubei Province for questionnaire survey. Multivariate logistic regression model was used to analyze the influencing factors of bullying and suicide-related behaviors. The interaction between bullying and related variables was by adding interaction terms.

A total of 1618 students were included in the survey. In the past 12 months, 33.9% of them had been bullied, 17.9%, 12.2%, and 7.8% of them had suicidal ideas, plans, and behavior. The RR values of suicide thoughts, plans, and attempts among bullies were 3.03(95%CI：2.24-4.12), 2.21(95%CI：1.57-3.12), and 2.28(95%CI：1.51-3.45). Middle school students, those with poor relationships with their parents, those who are not confident in their appearance, and those whose friends do not care about them are more likely to be bullied. Students who have been bullied, female students, ethnic minorities, and students who have heard of their classmates’ suicide-related behaviors are more likely to engage in suicide-related behaviors.

The main influencing factors of bullying and suicide-related behaviors among primary and middle school students in Hubei Province were summarized, which could provide a reference for future health interventions.

To understand the obesity, overweight and malnutrition status of primary and secondary school students in Karamay from 2014 to 2021, and to provide basis for targeted interventions on nutritional status of primary and secondary school students.

70 792 autumn physical health monitoring data of primary and secondary school students in Karamay from 2014 to 2021 were collected, and SPSS 22.0 software was used. Chi square tests were used for gender comparisons, and trend chi square tests were used for statistical analysis of age groups and years.

The malnutrition rate of primary and secondary school students in Karamay City decreased from 11.4% in 2014 to 5.7% in 2021 (χ²=1 329.791, P<0.01), and the overweight and obesity rates increased from 14.1% and 8.4% to 17.2% and 14.0% respectively (χ²=687.21 and 725.13, respectively, with P<0.01). From 2014 to 2021, the detection rates of malnutrition (except 2018), overweight and obesity (except 2014) in boys were higher than those in girls (P<0.01).

The malnutrition status of primary and secondary school students in Karamay City has been improved yearly, but the overweight and obesity rates have shown an increasing trend year by year. The bipolar problem of male students’ nutritional status is more prominent than that of female students. Schools and health management departments should carry out targeted interventions and countermeasures.

To investigate the demand for home medical service among cancer patients in Pudong New Area and analyze the main influencing factors.

A convenience sampling method was used, and a self-designed questionnaire was administered to 1 161 cancer patients in Pudong New Area. Single-factor analysis, non-parametric rank sum test, and multiple linear regression model were used to analyze the influencing factors.

18.2% of cancer patients had home medical service demands, with demands across all four dimensions. Among which the demand for health education, social support and rehabilitation guidance was more. Cancer patients’ needs are influenced by factors such as age, education level, economic status, and more (P<0.05). The driving factors include the number of comorbidities (β=0.111, t=3.643, P<0.001), being bedridden (β=0.121, t=4.299, P<0.001), and having a college degree or higher (β=0.071, t=2.416, P=0.016). The inhibiting factors include economic status (β=-0.072, t=-2.057, P=0.04) and daily condition (β=-0.192, t=-5.219, P<0.001).

Home medical services have significant demands among cancer patients. Relevant institutions should combine the characteristics of patient needs, improve service project evaluation, cost payment models, and relevant laws and policies, and strengthen supervision to promote the standardized and sustainable development of home medical services.

To explore the association between social isolation, loneliness, and smoking behavior among Chinese older adults.

In this study, data from the 2020 China Health and Retirement Longitudinal Study (CHARLS) were selected and statistically analyzed using Stata 17.0. Binary logistic regression was used to analyze the associations between social isolation, loneliness, and smoking behavior. Multiple interpolation with chained equations was used to fill in missing values and perform sensitivity analyses.

A total of 9 234 older adults aged 60 years and above were included, and the prevalence of social isolation and loneliness was 30.88% and 31.48%, respectively. Multi-model adjustment showed that socially isolated (OR=1.39, 95%CI: 1.23-1.57) older adults were at greater risk of smoking. Subgroup analyses of age and gender showed a greater risk in 65-<75 years (OR=1.25, 95%CI: 1.04-1.50), and men (OR=1.24, 95%CI: 1.07-1.44). No association between loneliness (OR=1.09, 95%CI: 0.95-1.25) and smoking behavior was observed, and the results of sensitivity analyses remained consistent.

In China, the older adults who are socially isolated are more likely to smoke. Therefore a tripartite effort by society, community and family is needed to pay attention to the social contact as well as social participation of older adults, particularly the high-risk groups of social isolation and smoking behaviors, in order to improve the healthy behavior among the older.

To systematically analyze randomized controlled trials (RCT) on improving the coordination of care in emergency medical services (EMS), and to mainly focus on sequential intervention that aimed to achieve seamless care between difference service settings, as well as to provide evidence-based suggestion for improving the integration of emergency medical system.

Using keyword and Mesh-term search, Embase, PubMed, CNKI, Wanfang Database and other eight databases were searched to identify related studies, and then the interventions were confirmed by study screening and quality evaluation. Effectiveness of the interventions were assessed according to treatment time, patient outcomes and satisfaction.

In total, 19 articles were included. Sequential intervention maximumly could shorten pre-hospital time and in-hospital time by 68.7 minutes and 79.8 minutes, respectively. The incidence of adverse events could be reduced by from 3.8% to 16.7%. There were significant reductions in the rates of readmission (20%), mortality (17%) and complication (28.9%). The functional status and satisfaction of the patients in the intervention group were better than that in the control group.

Interventions aiming to improve coordination of care in EMS play a positive role in shortening treatment time and improving patient outcome. Given the quality of the included studies, study locations and study sample, future studies should pay more attention to the rigorousness of their study design and the completeness of their outcome report.

To analyze the spatial compatibility between maternal and child health beds and the needs of women and children in Jiangsu at the county scale.

Spatial autocorrelation was used to analyze the spatial distribution of bed resources and maternal and child population in maternal and child health institutions in Jiangsu Province, and the adaptability of bed resources to the supply and demand of maternal and child population was analyzed by clustering degree.

The population of women and children of childbearing age showed obvious spatial aggregation in all districts and counties of Jiangsu Province, mainly concentrated in Suzhou and Xuzhou.There were 122 maternal and child health care institutions in Jiangsu, including 12 tertiary institutions and 29 secondary institutions, with a total of 11 878 beds. It was worth noting that there were 41 districts and counties with 0 beds, of which Suzhou City accounts for 7 districts and counties. The number of beds per 1 000 women and children in Zhonglou District of Changzhou City was the highest, 2.7 per 1 000 women and children. From the perspective of concentration degree, the bed resources of 17 districts (17.89%) were adequate geographically, while those of 76 districts (80%) were scarce geographically.After considering the demand population, it was found that the supply was greater than the demand in 21 districts (22.11%) and that the supply was less than the demand in 74 districts (77.89%).

There are regional differences in the supply and demand adaptation of maternal and child health care resources in Jiangsu Province, so it is necessary to adjust the service scope of the region where the supply exceeds the demand, and increase the service capacity building.

To explore the impact of cultural activities (CA) and physical exercise (PE) on residents’ subjective well-being (SWB)and its mechanism.

Using the 2021 China Comprehensive Social Surveydata, the ordered logistic model and mediating effect model were used for empirical analysis.

CA and PE could significantly enhance residents’ SWB, and the effect of CA on enhancing SWB was greater than that of PE. CA had a relatively greater impact on SWB of women, elderly, and rural residents. PE had a relatively greater impact on SWB of young and urban residents. Health status, social networks, social trust and sense of fairness all played a mediating role in the relationship between CA and SWB. Social trust had the greatest mediating effect, followed by health status, social networks and sense of fairness. Health status, social networks, social trust and sense of fairness all played a mediating role in the relationship between PE and SWB. Health status had the greatest mediating effect, followed by social trust, social networks and sense of fairness.

The government should strengthen efforts to promote the development of culture and sports industry, so that the people can get better spiritual and cultural nourishment and physical and mental health improvement, and have bigger SWB.

To explore the mediating effect of quality of sleep and cognitive reserve in the association of depression and cognitive function among the community-dwelling older adults.

A total of 492 community-dwelling elderly in the Pudong New Area of Shanghai were selected by convenience sampling method and investigated with the general information questionnaire, 15-item Geriatric Depression Scale (GDS-15), Pittsburgh Sleep Quality Index(PSQI), Cognitive Reserve Index Questionnaire(CRIq), and Beijing version of the Montreal Cognitive Assessment(MoCA). SPSS 25.0 software was used to explore the mediating role of sleep quality and cognitive reserve.

Pearson’s partial correlation analysis showed the cognitive function of elderly was significantly positively correlated with the cognitive reserve scores (r=0.189,P<0.001), and negatively correlated with the depression scores and sleep quality scores (r=0.179 and -0.362, both P<0.001); depression scores were significantly negatively correlated with cognitive reserve scores (r=-0.152, P<0.01), and significantly positively correlated with sleep quality scores (r=0.185, P<0.001), after adjusting for significant covariates including age, marital status, economic income and BMI, the mediating analysis showed depression had a significantly negative directly effect oncognitive function (β=-0.297, P<0.001); depression also had an indirectly negative effect on cognitive function through the pathways: reducing sleep quality and diminishing cognitive reserve, with medication effect values (β=-0.019, P<0.001) both accounted for 5.69%.

Community-dwelling elderly with depression, sleep disorders, and lower cognitive reserve have poorer cognitive function. Depression may directly affect cognitive function, and may also have indirect effects on cognitive function in elderly by decreasing sleep quality and cognitive reserve.

To explore the effects of intervention based on planned behavior theory on disease cognition, exercise self-efficacy, and daily living ability in elderly patients with sarcopenia.

Using convenience sampling method, 124 elderly patients with sarcopenia were selected from Lishuiwan Community and Shuxiangyuan Community in Shijiazhuang City as the research subjects. Using the coin toss method, 62 elderly people from Lishuiwan community were included in the intervention group on a residential community basis, while 62 elderly people from Shuxiangyuan community were included in the control group. The intervention group implemented interventions based on the Theory of Planned Behavior, which included five aspects: behavioral attitude, support from important others, perceived behavioral control, behavioral intention, and behavior. The control group maintained their original lifestyle and the intervention duration was 12 weeks. Two groups of patients were evaluated using the Simplified Disease Cognitive Questionnaire, Exercise Self Efficacy Scale, and Daily Living Ability Scale before and 12 weeks after intervention.

Before intervention, there was no statistically significant difference in disease cognition, exercise self-efficacy, and daily living ability scores between the two groups of patients (P>0.05). After intervention, the elderly patients in the intervention group showed improvements in disease cognition, exercise self-efficacy, and daily living ability compared to the control group, with statistically significant differences (P<0.05).

Interventions based on planned behavior theory can improve the disease cognition level, exercise self-efficacy, and daily living ability of elderly patients with sarcopenia.

To identify the influencing factors of stroke in elderly patients with hypertension based on community health survey, and establish a nomogram prediction model according to the influencing factors.

In 2022, the multi-stage sampling method was used to select the residents of Zhengzhou City, Henan province who lived for more than half a year for community health survey, and univariate and multivariate analysis was used to screen the influential factors of elderly hypertension patients complicated with stroke, and a nomogram prediction model was constructed. ROC curve, calibration curve and DCA decision curve are used to verify the accuracy and stability of the nomogram model.

A total of 15 995 elderly patients with hypertension were included in this study. The original data set was randomly divided into a training set and a validation set at 7:3. Model construction: The results of binary logistics analysis of the training set showed that age, gender, waist circumference, blood pressure control, overweight or obesity, exercise, smoking, drinking, balanced diet, dyslipidemia and heart disease were independent influencing factors for stroke. A nomogram model was constructed according to the results of multi-factor analysis. Model validation: the area under the ROC curve of the training set and the verification set is 0.748\0.779 respectively, and the calibration curve is well fitted, indicating that the model has good predictive value.

In this study, we established a nomogram prediction model for elderly hypertensive patients with stroke, including demographic characteristics, health status and lifestyle. The model is accurate and stable, which can help to screen high-risk individuals, provide clinical decision-making and prevention recommendations.

To explore the association between blood lipid, lipid ratios and glucose metabolism disorders, and to explore the dose-response relationship between lipid ratios and glucose metabolism disorders.

During July 2022 to March 2023, a total of 7 527 residents aged 35 and above in Changzhou were selected. basic information, blood pressure, fasting plasma glucose and blood lipid of the subjectswere collected. Binary logistic regression was used to explore the correlation between prediabetes, diabetes and blood lipid, lipid ratios, respectively. The dose–response relationship was evaluated by restricted cubic spline analysis. ResultsOur results showed that TC, LDL-C, TC/HDL-C, TG/HDL-C, LDL-C/HDL-C and non-HDL-C/HDL-C were risk factors for both prediabetes and diabetes (P<0.05), and HDL-C was a protective factor for both prediabetes and diabetes (P<0.05). The dose-response relationships between TC/HDL-C, TG/HDL-C, LDL-C/HDL-C, non‐HDL-C/HDL-C and glucose metabolism disorders were statistically significant, and the cutoff values were 3.78, 1.07, 2.10 and 2.77, respectively.

TC/HDL-C, TG/HDL-C, LDL-C/HDL-C and non‐HDL-C /HDL-C increase the risk of prediabetes and diabetes, which may be useful indicators to identify future glucose metabolism disorders.

To explore the association between HIV testing frequency and pre - / post-exposure prophylaxis (PrEP/PEP) use among individuals at risk of HIV.

Utilizing a follow-up cohort of men who have sex with men (MSM) conducted in five cities (Nanning, Liuzhou, Guilin, Yulin, and Beihai) in Guangxi Province, China, we employed a group-based trajectory model (GBTM) to analyze the developmental trajectories of HIV testing frequency among MSM. Furthermore, we conducted logistic regression analysis to examine the factors associated with different trajectory groups of HIV testing frequency and their relationship with the utilization of PrEP/PEP before and after HIV exposure.

The analysis included a total of 327 MSM participants, with an average age of 27.722±8.137 years. Based on evaluation criteria such as the Bayesian information criterion, GBTM identified three trajectory groups of HIV testing frequency: low-frequency group (73.87%), medium-frequency group (19.75%), and high-frequency group (6.37%). Comparing to the low-frequency group, MSM in the high-frequency group exhibited higher utilization rates of PrEP (9.49% vs. 55.56%) (χ²=32.02, P<0.001) and PEP (17.39% vs. 44.44%) (χ²=8.19, P<0.017). After controlling for relevant confounding factors, the low-frequency group and medium-frequency group showed of the used PrEP by OR=0.153 (95%CI:0.047-0.501, P=0.002) and OR=0.251 (95%CI:0.070-0.907, P=0.035), respectively, compared to the high-frequency group. Furthermore, regarding the frequency of HIV self-testing in the past year, as HIV testing frequency decreased, there was an increase in the frequency of HIV self-testing in the past year (low-frequency group OR=5.664, 95%CI:1.313-24.428, P=0.020) (medium-frequency group OR=5.087. 95%CI:1.082-23.926, P=0.039).

MSM who engage in higher-risk sexual behaviors are more likely to undergo regular and frequent HIV testing, and they are more proactive in using PrEP/PEP for HIV prevention. Compared with MSM with higher frequency of regular HIV testing, MSM with lower frequency of HIV testing showed higher rates of self-testing.

To understand the trends and factors associated with newly reported HIV and syphilis infections among men who have sex with men (MSM) in Nanning city, and provide a reference for developing targeted prevention strategies for the MSM population.

A questionnaire survey was conducted among MSM people in Nanning, Guangxi from 2019 to 2023, and venous blood samples were collected to detect HIV, HCV and syphilis. The trend chi-square test was used to analyze the trends of newly reported HIV,syphilis, and self-reported sexually transmitted infections prevalence. Logistic regression was employed to identify factors associated with newly reported HIV and syphilis infection.

A total of 1,954 MSM participated in the survey. The prevalence of newly reported HIV and syphilis were 3.8% and 4.6%. Respectively, there was a significant decline in newly reported HIV prevalence, from 6.8% in 2019 to 2.5% in 2023 (，trend P<0.05), while newly reported syphilis prevalence increased from 1.8% to 11.1% during the same period (, trend P<0.05). The study identified several factors associated with newly reported HIV infection, including lower education levels (aOR=1.70,95%CI:1.04-2.77) and inconsistent condoms use during anal intercourse (aOR=10.11, 95%CI: 5.94-16.89). Lower education levels (aOR=2.74, 95%CI: 1.71-4.38), a history of drug use (aOR=6.96, 95%CI: 1.42-34.19), and a history of self-reported sexually transmitted diseases (aOR=10.37, 95%CI:5.79-19.89) were found to be associated with newly reported syphilis infection. aged ≥30 (aOR=0.50, 95%CI:0.31-0.81)was identified as a protective factor against syphilis infection.

The prevalence of newly reported HIV was a downward trend, but the trend of newly reported syphilis prevalence showed an upward trend among MSM in Nanning, 2019-2023. The study suggests that relevant health departments need to take targeted intervention measures for the MSM population in conjunction with the internet, improve the usage rate of condoms, and strengthen the regulation of drugs and pharmaceuticals.

To conduct a comparative analysis of the research topics on home and international chronic disease management from 2013 to 2023, aiming to provide valuable insights for future studies.

The Chinese databases selected for this study were CNKI, Wanfang Database, and Sinomed, while the English database chosen was Web of Science core dataset. EndNote 20 software was utilized to gather literature on "chronic disease management", and visual analysis was conducted using VOSviewer and CiteSpace software.

A total of 6 621 Chinese articles and 4 096 English articles met the inclusion criteria. Over the course of the decade, there was a consistent upward trend in the number of articles pertaining to home-based chronic disease management both domestically and internationally. According to the co-occurrence cluster analysis, six clusters were identified in China for the management of chronic diseases, including community-based comprehensive disease management, common chronic disease management, self-management of chronic diseases, pharmaceutical care for chronic disease management, health education for chronic disease management, and traditional Chinese medicine-based prevention and treatment of chronic diseases. Abroad, there were also 6 cluster themes identified: Health-care of chronic diseases, Regional trends and management of chronic diseases, The impact of emergencies, Major chronic diseases, Quality of life for patients with chronic diseases, Multiple chronic diseases.

Foreign research is more sensitive to current affairs and frontier hotspots. Domestic research is based on domestic specific forms, which is more in line with the national conditions and has localized characteristics. Chronic disease management in China should continue to deepen the research on basic chronic disease management and chronic diseases in the elderly and other topics that fit the reality, and further develop the prevention and treatment of traditional Chinese medicine to form unique local advantages. At the same time, it keeps up with international research hotspots and supplements scientific research on digital health, mental health, multiple chronic diseases, etc.

To investigate the pollution status of lead, cadmium, total mercury, total arsenic, total chromium, manganese, nickel, aluminum, copper on sale vegetables in Taizhou City, and to assess the health risks to people.

According to the requirements of relevant national standards, detect the contents of metals and metalloids in four types of commercial vegetable samples collected from 2019 to 2023. The pollution status evaluated by single factor pollution index (P_i) and Nemerow composite pollution index (P_M) method, the health risks were evaluated by both target hazard quotient (THQ)and total target hazard quotient (TTHQ).

A total of 419 samples of four types of vegetables were collected, manganese and copper had the highest detection rate with both of 100.0%, the others from high to low were nickel (89.17%)>aluminum (87.26%)>cadmium (85.20%)>total arsenic (52.03%)>lead (35.32%)>total chromium (30.55%)>total mercury (2.39%). The overall cadmium exceeding rate was 2.63% and all concentrated in root vegetables, the other elements did not exceed the limit. The P_i and P_M of lead, cadmium, total mercury, total arsenic, total chromium in different types of vegetables were all did not exceed 0.7. The TTHQ of four types of vegetables for adults were all less than 1.0, but the TTHQ were more than 1.0 while children consumed root and leafy vegetables.

The overall pollution levels of nine metals and metalloids in four categories of vegetables in Taizhou city were low, and the health risk level of these metals and metalloids in residents was acceptable. However, intake of root and leafy vegetables may have negative effects on human health in children.

To explore the application of integrated clustering methods in identifying low-grade glioma subtypes and prognostic prediction.

A comprehensive clustering algorithm (MOVICS), which pools ten clustering algorithms, was used to integrate the multi-omics data of LGG patients downloaded from TCGA to obtain cluster subtypes; prognostic factors of LGG were analyzed by multifactorial Cox regression. A random forest classification prediction model was constructed using mRNA data to evaluate the classification performance and externally validated with the CGGA dataset.

LGG patients were clustered into two subtypes, and the difference in survival between the two groups was statistically significant (χ²=54.410, P<0.001). The results of multifactorial Cox regression analysis showed that age (HR=1.053，95%CI: 1.037-1.069), cancer grade (HR=2.733，95%CI: 1.836-4.069) and cluster typing (HR=3.210，95%CI: 2.216-4.650) were all prognostic factors for LGG, and the results of Nomogram plots, calibration curves and ROC curves indicated good predictive performance of the model. The average prediction accuracy of the ten-fold cross-validated RF model was 87.81%, and the C-indexes of the training set, the internal validation set, and the two external validation sets were 0.717, 0.721, 0.574, and 0.572, and the Brier scores were 0.044, 0.066, 0.179, and 0.128, and the differences in the survival of the two external validation datasets were all statistically significance (P<0.05).

The comprehensive clustering method can effectively identify LGG subtypes, which are prognostic factors for LGG patients, and has been validated in an external dataset, CGGA, which can provide an important theoretical basis for clinical personalized treatment of LGG.

To understand the Prevalence of abnormal glucose metabolism and its influencing factors in Kunming, and to provide scientific basis for the prevention and treatment of diabetes.

From August to November 2020, 6332 eligible residents from 32 administrative villages/neighborhood committees in 4 counties (districts) of Kunming City were selected as survey subjects, physical examinations, and laboratory tests. Multivariate logistic regression was used to analyze the influencing factors of abnormal glucose metabolism.

The prevalence of abnormal glucose metabolism in adults in Kunming was 26.93% (PDM 12.86%, diabetes 14.07%). Multivariate logistic regression analysis showed that ≥60 years old (OR=2.408, 95%CI:1.468-3.951), overweight (OR=1.348, 95%CI:1.063-1.709), central obesity (OR=1.740, 95%CI:1.374-2.203), hypertension (OR=1.301, 95%CI:1.020-1.660) and dyslipidemia (OR=1.407, 95%CI:1.160-1.706) were associated with the risk of PDM. 40-49 years old (OR=3.230，95%CI:1.942-5.373), 50 - 59 years old (OR=5.229，95%CI：3.229-8.467),≥60 years old (OR=8.924，95%CI:5.515-14.438), low body weight (OR=1.065，95%CI：1.032-2.498), obesity (OR=1.540，95%CI:1.180-2.009), central obesity (OR=1.565, 95%CI:1.288-1.901), hypertension (OR=1.482, 95%CI:1.264-1.737) and dyslipidemia (OR=1.677, 95%CI:1.437-1.958). Family history of diabetes (OR=3.926, 95%CI:3.179-4.850) and insufficient physical activity (OR=1.473, 95%CI:1.259-1.725) were associated with the risk of diabetes. Physical labor (OR=0.581, 95%CI:0.387-0.873) was associated with a lower risk of diabetes mellitus. There were statistically significant.

The prevalence of abnormal glucose metabolism in adult residents of Kunming City is high. Age, overweight and obesity, history of hypertension and dyslipidemia, family history of diabetes, and lack of physical activity are risk factors for abnormal glucose metabolism. Prevention and control should be focused on these factors.

To assess the disease burden of migraine in China from 1990 to 2019 and predict the changing trends in disease burden from 2020 to 2030, which may provide reliable data support for public health decision-making.

The study utilized data from the Global Burden of Disease 2019 (GBD2019) database and analyzed the age-standardized incidence rate (ASIR) and age-standardized DALY rate of migraine in China from 1990 to 2019. Estimation of annual percentage change (EAPC) models and Bayesian age-period-cohort (BAPC) analysis methods were employed to reveal changes and trends.

From 1990 to 2019, both the ASIR and age-standardized DALY rate of migraine in China showed an upward trend, with EAPCs of 0.24% (95%CI: 0.20%-0.29%) and 0.27% (95%CI: 0.22%-0.32%), respectively. The highest ASIR for migraine was observed in the age group of 10-15 years, followed by a fluctuating decline, and then an increase in ASIR in the 25-30 age group. The age-standardized DALY rate peaked in the 40-45 age group. Disease burden indicators for females exceeded those for males during the same period. According to the BAPC model predictions, the ASIR for migraine in the entire population of China was expected to increase from 2020 to 2030, with an annual growth rate of 0.88%. The annual growth rates of ASIR for males and females were projected to be 1.21% and 0.64%, respectively.

The burden of migraine in China remains quite severe, and there should be a focus on adolescents and young to middle-aged populations. Customized prevention and intervention strategies are crucial for high-risk populations of different ages and genders.