To explore the association between blood lipid, lipid ratios and glucose metabolism disorders, and to explore the dose-response relationship between lipid ratios and glucose metabolism disorders.

During July 2022 to March 2023, a total of 7 527 residents aged 35 and above in Changzhou were selected. basic information, blood pressure, fasting plasma glucose and blood lipid of the subjectswere collected. Binary logistic regression was used to explore the correlation between prediabetes, diabetes and blood lipid, lipid ratios, respectively. The dose–response relationship was evaluated by restricted cubic spline analysis. ResultsOur results showed that TC, LDL-C, TC/HDL-C, TG/HDL-C, LDL-C/HDL-C and non-HDL-C/HDL-C were risk factors for both prediabetes and diabetes (P<0.05), and HDL-C was a protective factor for both prediabetes and diabetes (P<0.05). The dose-response relationships between TC/HDL-C, TG/HDL-C, LDL-C/HDL-C, non‐HDL-C/HDL-C and glucose metabolism disorders were statistically significant, and the cutoff values were 3.78, 1.07, 2.10 and 2.77, respectively.

TC/HDL-C, TG/HDL-C, LDL-C/HDL-C and non‐HDL-C /HDL-C increase the risk of prediabetes and diabetes, which may be useful indicators to identify future glucose metabolism disorders.