To study the optimal fermentation conditions of Enterobacter albieri and Cordyceps pupae for Shenling Baizhu Powder（参苓白术散），and evaluate the safety and efficacy of the fermentation solution on alcoholic gastric injury at cell level.

In this experiment，the contents of functional components in fermentation broth of the modified formula of Shenling Baizhu Powder after fermentation under different conditions were measured and comprehensively evaluated. The alcoholic gastric injury model of GES-1 cells was established after 24 h of alcohol intervention. The intervention effects of water extract（0.938 mg/g）and fermentation broth of the modified formula of Shenling Baizhu Powder at low，medium and high doses（0.469 mg/g，0.938 mg/g，1.876 mg/g）on basic apoptosis of GES-1 cells were investigated.

The optimal fermentation process of Enterobacter asburiae for Shenling Baizhu Powder was pH value 5，inoculation amount 1% and fermentation time1 day. The optimal fermentation process of Shenling Baizhu Powder was pH 6，inoculation amount 3% and fermentation time 3 days. The best inoculation sequence for multistrain fermentation was to vaccinate Enterobacter asburiae first. The contents of ginsenoside Re，hesperidin，total flavonoids and total polysaccharides were significantly increased under the optimal fermentation process. The fermentation solution of Shenling Baizhu Powder improved GES-1 cells at 48 h，and the fermentation solution of medium and high dose groups could reduce the total apoptosis rate of GES-1 cells.

After fermentation，the composition of the modified formula of Shenling Baizhu Powder had a great influence，the content changed obviously and the fermentation process was feasible. It had a proliferation effect on GES-1 cells，and at the same time it could reduce the overall apoptosis rate of GES-1 cells.

To evaluate the clinical efficacy of Simo Decoction Oral Liquid（四磨汤口服液）in the treatment of functional bloating（FB）.

Sixty cases of FB patients included in four hospitals from March 2022 to May 2023 were randomly divided into two groups，30 cases in the treatment group were given oral administration of Simo Decoction Oral Liquid，and the other 30 cases in the control group were treated with Simo Decoction Oral Liquid simulant for a period of 8 weeks. The response rate of visual analogue scale（VAS），gastrointestinal symptoms rating scales（GSRS），each individual symptom score，overall disease effectiveness rate，hospital anxiety and depression scale（HAD）score and adverse reactions were observed in the two groups.

The bloat VASresponse rate［Full Analysis Set（FAS）：80.00%；Per Protocol Set（PPS）：82.10%］and GSRSeffective rate（FAS：96.67%；PPS：96.40%）in the treatment group were higher than those of the control group［the bloat VASresponse rate（FAS：23.33%；PPS：24.1%）and GSRSeffective rate（FAS：86.67%；PPS：86.20%），and the difference was statistically significant（P<0.05）. The change value of abdominal distension VASscore in the treatment group（FAS：-4.37±2.08；PPS：-4.27±2.07）was greater than that in the control group（FAS：-1.34±1.32；PPS：-1.34±1.32），and the difference was statistically significant（P<0.05）. The GSRSscores and change values of the treatment group before and after treatment，the scores and change values of each single symptom of FB（severity and frequency of episodes of bowel sounds，bowel irregularity，bloating，nausea，and flatulences），the effective rate of overall evaluation of the disease，as well as the change values of the anxiety of the HAD scores（FAS and PPS）were better than those of the control group，and the differences were statistically significant（P<0.05）. No adverse reactions related to the study drug occurred in either group.

Simo Decoction Oral Liquid can improve the symptoms of abdominal distension and other symptoms of FB patients，the efficacy is exact，and the medication is safe. At the same time，to a certain extent，it can relieve the patient's anxiety and depression，and improve the patient's quality of life.

To establish the TCM syndrome differentiation model of cancer pain based on artificial intelligence，so as to provide basis for the development of TCM syndrome differentiation of cancer pain.

The TCM medical record data of cancer pain was collected from CNKI，VIPChinese Science and Technology periodical Database，Wanfang database，China Biology Medicine disc，and Ancient and Modern Medical Record Cloud Platform from the embellishment time up to September 2023. Machine learning algorithms，such as linear support vector classification（LSVC），nearest centroid（NC），multinomial Na？ve Bayes（MNB），random forest（RF），stochastic gradient descent（SGD）and multilayer perceptron（MLP）were used to quantitatively analyze the data set，and the syndrome differentiation model of cancer pain was established. The model was evaluated by 5-fold cross validation. The evaluation indexes included Accuracy，Precision，Recall，F1 score and AUC value.

There were 72 input variables and 6 output variables for TCM syndromes of cancer pain. The Accuracy，Precision，Recall and F1 score of the six models were all above 0.89，and the AUCvalue was above 0.94. Among them，the Accuracy，Precision and Recall of the nearest centroid model were the highest. The Accuracy，precision，recall and F1 score were 0.978，0.980，0.978 and 0.977，respectively，and the AUCvalue was 0.986，which was higher than other algorithm models. The TCM interpretation of the parameters basically accorded with the principle of TCM diagnosis.

The TCM syndrome differentiation model of cancer pain based on the nearest centroid algorithm model has high diagnosis and prediction ability，which can provide reference for clinical workers to carry out TCM intelligent syndrome differentiation of cancer pain.

Information extraction is an important means of natural language processing. Based on the natural language processing ability of ChatGPT，this paper extracted the symptom information from traditional Chinese medicine electronic medical records in rheumatism department through ChatGPT.

Through the small sample learning based on ChatGPT large model，the information extraction and standardization of chief complaint and present medical history，specialist examination and tongue and pulse data in rheumatic electronic medical records were realized. At the same time，a large model ChatGLM was selected for the same small sample learning as ChatGPT，the same information extraction task was completed and the accuracy of the extraction results of the two large models was compared.

Aiming at the problem of medical named entity recognition，the accuracy of ChatGPT after small sample learning reached 98.7% in chief complaint symptom extraction task，92% in specialist examination and extraction task，and 98% in tongue and pulse image extraction and standardization task. The correct rates of ChatGLM on the same three tasks were 85.7%，91% and 98% respectively. From the extraction results，the two large models had different defects in the extraction task，but on the whole，ChatGPT performed better.

This paper realized the TCM symptom information preprocessing based on ChatGPT small sample learning，which was more convenient and efficient than the traditional model，and performed better than ChatGLM as a whole，which provided a new idea for TCM clinical text information extraction research.

To carry out the rapid and nondestructive identification of Dihuang（Rehmannia glutinosa）of different origins.

The infrared absorption spectrum of a total of 166 batches of Dihuang（Rehmannia glutinosa）in 16 counties and districts in four provinces was collected for differential analysis，and the results of the analysis were verified by high performance liquid chromatography.

The infrared spectra of the 166 samples were basically similar in peak shape，with the same absorption at 2928，1643，1419，1353，1238，1145，1053，925，799，700～543 cm^-1. The differences between samples from the three sites in Henan Province were mainly at 1519～1494 cm^-1. The differences between samples from different sites in Hebei Province were mainly at 1571 and 1020 cm^-1. The differences between samples from different sites in Shanxi Province were mainly at 1790～1642，1440，1030 cm^-1. Then among the differences between provinces，Shandong Province was significantly different from other provinces mainly at 1796，1718，1640，1606～1567，1492，1453，1277，1024 cm^-1. Among of them，the main characteristic component in the band of 1640～1439 cm^-1 was catalpol，and the strong absorption peak at 1052 cm^-1 was C-O bond stretching vibration absorption in the structure of pistil side.

Infrared spectroscopy combined with HPLCcan provide ideas for the rapid and non-destructive identification of different origins of Dihuang（Rehmannia glutinosa）.

To explore the characteristics of tongue in patients with coronary heart disease（CHD）and phlegmblood stasis syndrome，and to analyze the changes in the tongue image.

A total of 210 patients with stable angina pectoris（also known as effort angina）in the Cardiology Department of Liaoning Provincial Hospital of Traditional Chinese Medicine from November 2020 to November 2021 were included in this study. The patients were divided into phlegm-blood stasis syndrome group and non-phlegm-blood stasis syndrome group. According to the WHO（World Health Organization）age classification standard，the phlegm-blood stasis syndrome group was divided into middle age group（27 cases），young elderly group（40 cases）and old elderly group（17 cases）. The tongue features such as HSV（Hue，Saturation，Value）and RGB（Red，Green，Blue）parameters were analyzed in patients with phlegm-blood stasis syndrome in different age groups to explore the age-related changes in the tongue image.

There were significant differences in the distribution of tongue color，texture and shape between the phlegm-blood stasis syndrome group and non-phlegm-blood stasis syndrome group. In terms of tongue color，the middle age group had more red tongues，while the young elderly group had more light purple tongues，and the old elderly group had more dark red and purple tongues（P<0.05）. In terms of texture features，the middle age group had a smaller H value in the tip of the tongue compared to the young elderly group and old elderly group（P<0.05），while the middle age group had a higher V value in the tip of the tongue compared to the other two groups（P<0.05）. The old elderly group had a higher Svalue in the left，right and middle parts of the tongue compared to the middle age group and young elderly group（P<0.05），while the old elderly group had a lower V value in the left，right and middle parts of the tongue compared to the middle age group and young elderly group（P<0.05）. The old elderly group had a higher R+B/R+G+B value in the left，right and middle parts of the tongue compared to the other two groups. In terms of shape features，the middle age group had more plump and tooth imprint tongues，while the old elderly group had more thin tongues with cracks，old tongues and tender tongues（P<0.05）. In terms of fur features，the middle age group had more white furry fur like tofu covered on their tongues，while the old elderly group had more light yellow sticky fur like egg yolk covered on their tongues，with a gradually decreasing proportion of greasy fur，with the lowest proportion of greasy fur in the old elderly group（P<0.05）. The middle age group had a higher V value in the left，right and middle parts of their tongues compared to the young elderly group and old elderly group（P<0.05），while the old elderly group had a higher Svalue in the left，right and middle parts of their tongues compared to the middle age group and young elderly group（P<0.05），with lower V values at the root of their tongues compared to the other two groups（P<0.05）. The old elderly group had a higher R+G/R+G+B value in the middle and root parts of their tongues compared to the other two groups.

1. The middle age group is prone to phlegm-heat transformation.2. With aging，blood stasis gradually increases.3. The old elderly group is prone to phlegm-blood stasis syndrome causing damage to Yin fluids.4. The old elderly group is prone to deficiencyexcess coexistence.

In the actual test，it is found that the leaching rate of 31 batches of Dangshen（Codonopsis pilosula）from different origins is different，with the lowest and highest differences of 20.869%. Therefore，even genuine Chinese medicine will have different effects depending on the place of origin. The appearance of these 31 batches of Dangshen（Codonopsis pilosula）is very similar，and it is impossible to distinguish them by trait identification. Because the 31 batches of Dangshen（Codonopsis pilosula）are all genuine and their main components are the same，they cannot be distinguished by microscopic identification and thin layer identification. In the past，the methods of judging the origin of traditional Chinese medicines，such as liquid chromatography，gas chromatography and polymerase chain reaction，were accurate but required professionals to test for hours or even days. Therefore，this paper took Dangshen（Codonopsis pilosula）as an example to study a method to quickly identify the origin of traditional Chinese medicine based on fourier transform infrared spectroscopy technology（FT-IR）.

Ten batches of Dangshen（Codonopsis pilosula）from different origins were randomly selected and infrared spectrum data was collected separately. Firstly，the similarity of the infrared spectra of Dangshen（Codonopsis pilosula）of different origins was calculated，and the similarity heat map was drawn for preliminary analysis. Five different methods were used to preprocess the original infrared spectrum. The partial least squares（PLS1）model was established and the optimal processing method was selected and the cluster analysis was carried on the selected optimal group. The continuous projection algorithm was used to select the optimal wavelength for the optimal processing method group，establishing a multispectral model and calculating the regression equation for identifying the production location. Finally，the discriminant performance of the regression equation was verified by using the confusion matrix.

The optimal processing method for the full-spectrum model was normalization（NOR）. The spectral data of 10 batches of Dangshen（Codonopsis pilosula）from different origins after NOR treatment can be completely clustered into10 categories by cluster analysis，and samples from the same origin were all clustered in the same category. The value of R2 p of the full spectrum model group was0.980 0，the corresponding RMSEPwas 0.406 7%，and the value of R2 p of the multispectral model established by the 13 optimal wavelengths selected by SPA was 0.990 6 and RMSEPwas0.280 4%. The prediction performance of the multispectral model was better than that of the full-spectrum model，and the variables that needed to be input were greatly reduced，saving time and effort，and the accuracy was high. The regression equation of origin discrimination calculated based on the multispectral model was verified by the confusion matrix，and its sensitivity and specificity were more than 97%，so it is believed that the regression equation can quickly and accurately determine the origin of Dangshen（Codonopsis pilosula）.

The FTIR method of determining the origin of traditional Chinese medicines studied by taking Dangshen（Codonopsis pilosula）as an example is fast and effective，which provides ideas for the research on the origin of other traditional Chinese medicines and provides a theoretical basis for the development of rapid inspection equipment for traditional Chinese medicines in the future.

To study the antibacterial effect of eight kinds of Chinese drugs in vitro，screen the best compound ratio for external use to treat acne and prepare compound microemulsion gel for in vivo pharmacodynamic study of acne model in mice.

Propionibacterium acnes and Staphylococcus aureus were selected as target bacteria，and the diameter of inhibition zone and minimum inhibitory concentration（MIC）of eight Chinese drugs were determined by filter paper method. Orthogonal test was used to optimize the compound ratio. The physical and chemical properties of microemulsion and microemulsion gel were comprehensively evaluated by preparing microemulsion with pseudo ternary phase diagram as evaluation index. A mouse acne model was established by injecting Propionibacterium acnes into the back，and the blank group，model group，positive drug group，microemulsion gel group and compound microemulsion gel group were set up. Histopathological changes were observed by HE and Masson staining，and the levels of inflammatory factors［interleukin-1β（IL-1β），interleukin-10（IL-10）and tumor necrosis factor-（TNF-α）］in serum were detected by enzyme-linked immunosorbent assay（ELISA）.

The results showed that all the eight Chinese drugs had different antibacterial effects，among which Huanglian（Coptidis Rhizoma）had the best antibacterial effect on Propionibacterium acnes and Gancao（Glycyrrhizae Radix et Rhizoma）had the best antibacterial effect on Staphylococcus aureus，with MIC of 31.25 mg mL^-1. The orthogonal test results showed that the sterilization rate of Dahuang（Rhei Radix et Rhizoma）（250 mg mL^-1），Huanglian（Coptidis Rhizoma）（250 mg mL^-1），Huangqin（Scutellariae Radix）（125 mg mL^-1）and Gancao（Glycyrrhizae Radix et Rhizoma）（62.5 mg mL^-1）was the best when the ratio was 4∶4∶2∶1. According to the pseudo-ternary phase diagram，the final microemulsion formula was Tween-80（3 g），PEG 400（6 g），isopropyl myristate（1 g）and distilled water（12 g），and 1% carbomer 940 was added according to the mass ratio，and the microemulsion gel was obtained after full swelling，and the compound microemulsion gel was obtained by replacing the water phase with the compound extract of the Chinese medicine compound. The pharmacodynamic experiment showed that compared with those of the blank group，the skin tissue of the model group showed obvious pathological changes，and the contents of IL-1β，IL-10 and TNF-αin serum increased significantly（P<0.01）. Compared with those in the model group，the pathological changes in the drug group were relieved to varying degrees，and the contents of serum inflammatory factors were decreased，especially those in the compound microemulsion gel group（P<0.01）.

The compound of Dahuang（Rhei Radix et Rhizoma），Huanglian（Coptidis Rhizoma），Huangqin（Scutellariae Radix）and Gancao（Glycyrrhizae Radix et Rhizoma）has obvious bacteriostatic effect. The preparation of the compound microemulsion gel has a good therapeutic effect on acne model in mice，and can effectively alleviate acne inflammation caused by Propionibacterium acnes.

By studying the anti-aging effect of Cistanche deserticola polysaccharides（CDPS）in vivo，it aimed to explore the possible mechanisms underlying this anti-aging effect.

Seventy-five Kunming species（KM）mice aged 12 months were randomly divided into a blank control group（WT），a low-dose group of Cistanche deserticola polysaccharides（CDPS. L），a medium dose group of Cistanche deserticola polysaccharides（CDPS. M），a high-dose group of Cistanche deserticola polysaccharides（CDPS. H），and a positive drug group（P）. The mice were given corresponding drugs or the same volume of distilled water by gavage until obvious signs of death appeared. The other mice that did not show obvious signs of death were uniformly sampled 180 days after administration. The levels of glutathione peroxidase（GSH-Px），total superoxide dismutase（TSOD）and malondialdehyde（MDA）in serum were detected to observe the antioxidant effect of Cistanche deserticola polysaccharides.16SrRNA sequencing was used to analyze the structure of gut microbiota. The effects on cognitive ability and intestinal function of mice were observed through HE staining of pathological sections of the hippocampus and intestines.

Compared with that o the WT group，the survival rate of the mice treated with CDPSwas improved，and the effect of CDPS. M and CDPS. H groups was better than that of Pgroup，but it was not significant. Compared with those of the WT group mice，the GSH-Px activity and T-SOD activity of the CDPSgroups were significantly increased，and the MDA levels in each treatment group were significantly reduced compared to that in the WT group，and the GSH-Px activity of CDPS. H group was significantly improved compared to that in Pgroup. CDPScan improve the intestinal microbiota homeostasis in mice，increase the levels of Akkermansia muciniphila，Alloprevotella and Prevotellaceae probiotics，and improve intestinal function. Compared with those of the other groups，the intestinal villus length and wall thickness of mice were longer. CDPSalso can reduce hippocampal neuronal death caused by aging.

CDPShas anti-aging effects，which may be due to its antioxidant properties and its ability to improve intestinal function，thereby affecting the homeostasis of gut microbiota，resulting in an increase in the levels of Akkermansia muciniphila，Alloprevotella and Prevotellaceae probiotics. Additionally，the effect of CDPSon reducing hippocampal neuronal death in mice may also be one of the anti-aging mechanisms of CDPS.

To study the effect of Buzhong Yiqi Decoction（补中益气汤）on the neural development of the offsprings of subclinical hypothyroidism（SCH）rats and explore its possible mechanism of action. At the same time，to compare the therapeutic effects of different doses of traditional Chinese medicine and Western medicine.

Adult female SD rats were used to establish an SCH model using total thyroidectomy and postoperative subcutaneous injection of L-T4，and the rats were randomly divided into the following 6 groups：sham surgery group，model group，low-dose group of Buzhong Yiqi Decoction［4.1 g/（kg·d）］，medium dose group of Buzhong Yiqi Decoction［8.19 g/（kg·d）］，high-dose group of Buzhong Yiqi Decoction［16.38 g/（kg·d）］，euthyrox group［4.5μɡ/（kg·d）］. After completing the SCH model，the model rats mated with normal male rats in a cage，and started administration 2 weeks before mating until sample collection. The samples were taken out from placental tissue at day 13 of pregnancy（E13）and brain tissue from offsprings at day 7 after birth（P7）. Water maze experiments were performed on offsprings at day 21. Radioimmunoassay（RIA）method was used to detect total thyroxine（T4）in serum. Enzyme linked immunosorbent assay（ELISA）was used to detect thyroid stimulating hormone（TSH）in serum. The mitochondrial morphology of brain tissue was observed through electron microscopy. Intracellular reactive oxygen species（ROS）was detected by DCFH-DA probe method. Mitochondrial DNA copy number was detected by using RT-PCR. DNA methyltransferase（DNMT）1，DNMT3a，DNMT3b，ten-eleven-translocation protein（TET）1 and TET2 were detected by the Western blotting（Wb）method.

Compared with those of the sham surgery group，the serum TSH levels of the model group were significantly increased，the Morris water maze scores of the 21-day offspring rats were significantly decreased，and the morphology of neuronal mitochondria was damaged under electron microscopy. On day 13，the levels of ROSincreased and the activities of mitochondrial respiratory chain complexes I and Ⅱ decreased in placental tissue and brain tissue of 7-day offspring rats. On day 7，the grayscale values of DNMT1，DNMT3a and DNMT3b proteins promoted methylation in brain tissue decreased，and the levels of TET1 and TET2 proteins regulated by reverse methylation increased. Compared with those of the model group，the medium dose and high dose groups of Buzhong Yiqi Decoction as well as the Western medicine group can reduce the elevated TSH levels in SCH rats，improve Morris water maze performance in 21-day offspring rats，reduce ROS levels and mitochondrial respiratory chain complex I and Ⅱ activity in brain tissue，improve the morphology of neuronal mitochondria in offspring rats，increase the grayscale values of methylated DNMT1，DNMT3a and DNMT3b proteins，and reduce the levels of TET1 and TET2 proteins regulated by reverse methylation.

Buzhong Yiqi Decoction can improve the learning and memory abilities of offsprings of maternal SCH rats，and its mechanism may be related to regulating methylation to improve mitochondrial energy metabolism and restore mitochondrial function.

To investigate the effects of electroacupuncture（EA）preconditioning on myocardial ischemia-reperfusion injury（MIRI）and its regulation of the inflammatory response through the mTOR/NLRP3 signaling pathway.

Seventy SD rats were randomly divided into five groups：sham operation group，model group，EA group，EA+saline group and EA+mTOR agonists（EA+MHY1485）group，with 14 rats in each group. After the intervention，it evaluated cardiac function by measuring the left ventricular ejection fraction（LVEF）and left ventricular fraction shortening（LVFS）. Additionally，it performed hematoxylin-eosin（HE）staining to observe histopathological changes in the myocardium. The levels of tumor necrosis factor-α（TNF-α）in myocardial tissue were measured using an enzyme-linked immunosorbent assay（ELISA）. Furthermore，it assessed the gene expression levels of apoptosis-associated speck-like protein containing a CARD（ASC），cysteinyl aspartate specific proteinase-1（Caspase-1），interleukin-1β（IL-1β）and interleukin-18（IL-18）in cardiac tissue using quantitative polymerase chain reaction（RT-qPCR）. Finally，it analyzed the protein expression levels of mammalian target of rapamycin（mTOR），NOD-like receptor thermal protein domain associated protein 3（NLRP3）and nuclear factor kappa-B（NF-κB）by Western blotting.

Compared to the sham operation group，the rats in the model group showed decreased values of LVFS and LVEF（P<0.05）. Myocardial tissue exhibited muscle fiber rupture，blurred structure and a significant infiltration of inflammatory cells. Additionally，the TNF-αlevel in the myocardial tissue increased（P<0.05）. The relative gene expression levels of Caspase-1，ASC，IL-1βand IL-18 were significantly increased（P<0.05），along with increased protein expression levels of mTOR，NLRP3 and NF-κB. In contrast，the rats in the EA group showed increased FSand EF values（P<0.05）. The myocardial tissue structure improved，inflammatory cell infiltration decreased and the expression of TNF-αin the myocardial tissue decreased（P<0.05）. The relative expression levels of Caspase-1，ASC，IL-1βand IL-18 genes also decreased（P<0.05），as well as the protein expressions of mTOR，NLRP3 and NF-κB（P<0.05）. However，compared to the EA+saline group，the EA+MHY1485 group showed worsened rats myocardial tissue，increased TNF-αlevel in the myocardial tissue（P<0.05），increased relative expression levels of Caspase-1，ASC，IL-1βand IL-18 genes（P<0.05），and increased protein expression levels of mTOR，NLRP3 and NF-κB（P<0.05）.

The mTOR agonist MHY1485 can weaken the protective effect of electricity against myocardial tissue damage in MIRI rats，and EA pretreatment can reduce the inflammatory response of MIRI rat myocardial cells，thereby improving myocardial tissue damage caused by ischemia-reperfusion. Therefore，it is inferred that the mechanism of EA pretreatment to improve MIRI injury in rats may be related to the mTOR/NLRP3 signaling pathway.

To observe the clinical effect of Shenqi Guben Pobi Decoction（参芪固本破壁饮）combined with moxibustion at Du meridian on liver cancer fatigue.

A total of 120 patients with fatigue due to liver cancer admitted to the hospital from October 2020 to May 2023 were divided into traditional Chinese medicine（TCM）group and conventional group by means of random number table，with 60 patients in each group. The conventional group received routine treatment such as sleep management，nutritional guidance，exercise therapy and psychological counseling. On the basis of conventional treatment，the patients in the TCM group were given Shenqi Guben Pobi Decoction combined with moxibustion at Du meridian treatment. In the course of treatment，3 cases fell off in the conventional group and 5 cases in the TCM group. There were 57 cases remained in the conventional group and 55 cases in the TCM group. The clinical data observation of patients in each group included the clinical efficacy，the changes of TCM symptom scores（fatigue，shortness of breath，spontaneous sweating，lazy speech，insomnia palpitation，dizziness，etc.）and Piper's Fatigue Scale（PFS）scores before and after treatment. Hamilton Anxiety Scale-14（HAMA-14）and Hamilton Depression Scale-17（HAMD-17）were used to assess the negative emotions of the patients in each group. The Pittsburgh sleep quality index（PSQI）was used to evaluate the sleep quality of the patients before and after treatment，and the Spitzer Quality of life index（SQLI）was used to evaluate the changes of patients'quality of life before and after treatment，and voluntary treatment satisfaction questionnaire was adopted to investigate the satisfaction rate of patients in each group.

The total effective rate of the TCM group（96.36%）was higher than that of the conventional group（84.21%）（P<0.05）. Before treatment，TCM syndrome scores（fatigue，shortness of breath，spontaneous sweating，lazy speech，insomnia palpitation，dizziness，etc.），PFSscore，HAMA-14 score，HAMD-17 score，PSQI score and SQLI score were not significant between two groups（P>0.05）. After treatment，TCM syndrome scores（fatigue，shortness of breath，spontaneous sweating，lazy speech，insomnia palpitation，dizziness，etc.），PFSscores，HAM-14 scores，HAMD-17 scores，PSQI scores and SQLI scores were significantly improved in both groups. After treatment，TCM syndrome scores（fatigue，shortness of breath，spontaneous sweating，lazy speech，insomnia palpitation，dizziness，etc.），PFSscores，HAMA-14 scores，HAMD-17，PSQI scores，SQLI scores and other indicators in the TCM group were better than those in the conventional group（P<0.05）. The treatment satisfaction rate of the TCM group（93.36%）was higher than that of the conventional group（84.21%）（P<0.05）.

Shenqi Guben Pobi Decoction combined with moxibustion at Du meridian in the treatment of liver cancer fatigue has better clinical effect. After treatment，the symptoms，negative emotions，sleep quality and quality of life of the patients all improved and the patients were satisfied and recognized. It is worthy of applying.

To observe the effect of Buyang Huanwu Decoction（补阳还五汤）on vascular revascularization rate and other indexes in patients with acute cerebral infarction after mechanical thrombectomy.

A total of 60 patients with acute cerebral infarction admitted to the Department of Neurology and Emergency Department of the hospital from June 2022 to June 2023 were selected as the research objects. According to the random number table method，the patients were evenly divided into control group and observation group，with 30 cases in each group. The patients in the control group received instrument thrombectomy treatment，and those in the observation group were treated with Buyang Huanwu Decoction on the basis of the control group. The clinical effect，coagulation index，prognosis，nerve function，vascular recanalization and adverse events of the two groups were observed.

The effective rate of the control group was 66.67%，and that of the observation group was 90.00%，which was significantly higher than that of the control group（P<0.05）. The vascular recirculation rate（m-TICIlevel 2b or 3）of the control group was 66.67%，and that of the observation group was 73.33%，with no significant statistical significance between the two groups（P>0.05）. Before treatment，there was no significant difference in National Institute of Health stroke scale（NIHSS）score between the two groups（P>0.05）. Compared with those before treatment，NIHSSscores in both groups were significantly lower at 24 hours and 3 months after treatment（P<0.01）. Compared with those in the control group，the NIHSSscores in the observation group were significantly lower at 24 hours and 3 months after treatment（P<0.01）. Before treatment，there were no significant differences in coagulation indexes such as platelet count（PLT），D-dimer（D-D），activated partial thromboplastin time（APTT），prothrombin time（PT），thrombin time（TT）or international normalized ratio（INR）between two groups（P>0.05）. After the intervention，the levels of PLT，D-D，APTT and PT in the observation group were significantly reduced compared with those in the control group，and the differences were statistically significant（P<0.01，P<0.05）. The good prognosis rate of mRSin the control group and the observation group at 3 months was 43.33% and 70.00%，respectively. Compared with that in the control group，the good prognosis rate in the observation group was significantly increased（P<0.05）. During treatment，the main adverse events of the two groups were oral，cutaneous mucous and digestive tract hemorrhage and liver and kidney damage. The total incidence of adverse events in the control group and the observation group was 13.33% and 20.00% respectively，with no statistical significance（P>0.05）.

Buyang Huanwu Decoction combined with mechanical thrombectomy can better improve the nerve function，coagulation index and prognosis of patients with acute cerebral infarction，which is suitable for popularization.

To explore the clinical effect of Sanyin Zhitong Prescription（三因止痛方）combined with traditional Chinese acupuncture on migraine by external factors.

A total of 90 migraine patients by external factors admitted to the Department of Neurology from June 2022 to June 2023 were divided into two groups（observation group，45 cases）and control group，45 cases）by random number table method. All patients in the control group were treated with flunarizine. The observation group combined with Sanyin Zhitong Prescription and traditional Chinese acupuncture on the basis of drug treatment treatment. The clinical data of patients in each group was observed，including clinical efficacy after treatment，changes in scores of TCM symptoms（headache，distension and pain，insomnia and dreaminess，irritability，dizziness，sighing，etc.）before and after treatment，changes in visual analogue pain scale（VAS）score，changes in monthly headache frequency and duration of each headache before and after treatment，changes in patients'quality of life score［Medical Outcomes Study 36-Item Short-Form Health Survey（SF-36）］and adverse reactions.

The total effective rate of the observation group（95.56%）was significantly higher than that of control group（80.00%）（P<0.05）. Before treatment，the scores of TCM symptoms（headache，hypochondrial distending pain，insomnia and dreaminess，irritability，dizziness，sighing，etc.），VAS score，monthly frequency of headache occurrence，duration of each headache，SF-36 score and other indicators were significant between two groups（P>0.05）. After treatment，the scores of TCM symptoms（headache，distension and pain，insomnia and dreaminess，irritability，dizziness，sighing，etc.），VASscores，monthly headache frequency，duration of each headache，SF-36 scores and other indicators were significantly improved in each group. After treatment，the scores of TCM symptoms（headache，hypochondrial pain，insomnia and dreaminess，irritability，dizziness，sighing，etc.），VASscores，monthly frequency of headache and duration of each headache and SF-36 scores in the observation group were significantly better than those in the control group（P<0.05）. The adverse reaction rates of observation group and control group were 2.22% and 4.44%，respectively（P>0.05）.

Sanyin Zhitong Prescription combined with traditional Chinese acupuncture and moxibustion has good clinical effect in the treatment of migraine，with pain relief，symptoms improvement，quality of life increase，less adverse reaction and safe and reliable treatment，worthy of application.

To optimize the processing technology of Huanglian（Coptidis Rhizoma）-processed Wuzhuyu（Euodiae Fructus）and establish quality standards for the decoction pieces of Wuzhuyu（Euodiae Fructus）.

Limonin，evodiamine，rutecarpine and ethanol soluble extractives were used as the evaluation indicators，and soaking time，frying temperature and frying time were the influencing factors. Orthogonal experiments were used to optimize the optimal process parameters for preparing Huanglian（Coptidis Rhizoma）-processed Wuzhuyu（Euodiae Fructus）. And through thin layer identification，determination of moisture，ash content，alcohol extract，active ingredient content and characteristic maps of 10 batches of samples，a quality standard for Huanglian（Coptidis Rhizoma）-processed Wuzhuyu（Euodiae Fructus）was established.

The best processing technology was decocting for 40 min and roasting at 140℃for 11 min. The experimental results show that the processing technology is stable and feasible. It is recommended to stipulate that the water content of the decoction pieces should not exceed 10%，the total ash content should not exceed 10%，and the alcohol soluble extract should not be less than 30%. The mass fractions of limonin，evodiamine and rutecarpine should not be less than 1.0%，0.1% and 0.1%，respectively.

The optimized processing technology for Huanglian（Coptidis Rhizoma）-processed Wuzhuyu（Euodiae Fructus）is stable and feasible，with strong controllability of quality standard.

By studying the effect of Buzhong Yiqi Decoction（补中益气汤）on the endoplasmic reticulum stress of A549 cells and A549/DDP cells through Nrf2/ROSpathway，the molecular mechanism of Buzhong Yiqi Decoction improving cisplatin resistance in non-small cell lung cancer was investigated.

The serum containing Buzhong Yiqi Decoction was prepared and A549 cells and A549/DDP cells were cultured. They were randomly divided into group A（A549 cells），Group B（A549 cells+20μg/mL cisplatin），group C（A549 cells+20μg/mL cisplatin+10% Buzhong Yiqi Decoction-containing serum），group D（A549/DDP cells），group E（A549/DDP cells+20μg/mL cisplatin）and group F（A549/DDP cells+20μg/mL cisplatin+10% Buzhong Yiqi Decoction-containing serum）. Half inhibitory concentration of cisplatin（IC₅₀）was detected by CCK-8 method，and reactive oxygen species（ROS）were detected by DCFH-DA fluorescent probe method. The protein expression levels of Nrf2，P-Nrf2，PERK，P-PERK，eIF2α，P-eIF2α，IRE1 and XBP1 were detected by Western blot.

In both A549 cells and A549/DDP cells，Buzhong Yiqi Decoction significantly decreased the IC₅₀ value of cisplatin（P<0.05）. In both cells，cisplatin could up-regulate the protein expressions of Nrf2 and P-Nrf2，and after the intervention of Buzhong Yiqi Decoction，the expression levels of both were down-regulated（P<0.05）in A549/DDPcells compared with those in A549 cells（P<0.05）. Compared with the blank group，cisplatin could up-regulate the ROSexpression of the two cells（P<0.05），the ROS expression was further up-regulated after combined with Buzhong Yiqi Decoction（P<0.05），and the ROSexpression level of A549 cells was significantly higher than that of A549/DDP cells（P<0.05）. There were no significant differences in the expressions of PERK and eIF2αamong all groups（P>0.05）. Cisplatin significantly up-regulated the protein expressions of PPERK，P-eIF2α，IRE1 and XBP1 in the two cell lines，and the expression was up-regulated again after the intervention of Buzhong Yiqi Decoction（P<0.05），and the expression of ER stress protein in A549 cells was higher than that in A549/DDP cells（P<0.05）.

Buzhong Yiqi Decoction may improve cisplatin resistance of A549 cells and A549/DDP cells by regulating ERSthrough Nrf2/ROSsignal pathway.

To analyze the correlation of the distribution of TCM syndromes in patients with sepsis-induced lung injury and lung injury-related indicators and sequential organ failure assessment（SOFA），acute physiology and chronic health evaluation Ⅱ（APACHE Ⅱ）score.

Eighty patients with sepsis-induced lung injury admitted to the hospital from January 2022 to January 2023 were selected. The general data，lung injury-related indicators｛arterial oxygenation index（PaO₂/FiO₂），alveolar arterial oxygen partial pressure difference［P（A-a）O₂］｝and SOFA and APACHE Ⅱ scores of the patients were collected. The patients with sepsis-induced lung injury were classified according to the classification criteria of traditional Chinese medicine. The above observation indexes of patients with sepsis-induced lung injury of different types were compared and the correlation was analyzed.

Among the patients with sepsis-induced lung injury，the lung heat obstruction type accounted for the highest proportion［35.00%（28/80）］，followed by the blood stasis type［27.50%（22/80）］，the lung obstruction type［23.75%（19/80）］，and the water retention type［13.75%（11/80）］. There was no significant difference in gender or age among patients with different syndromes（P>0.05）. There were statistically significant differences in PaO₂/FiO₂ and P（A-a）O₂ among patients with different syndromes（P<0.05）. There were significant differences in SOFA and APACHE Ⅱ scores among patients with different syndromes（P<0.05）. There was a significant negative correlation of PaO₂/FiO₂ and lung heat obstruction，blood stasis obstructing lung，lung congestion and Fu-organ excess，water retention and lung depression（P<0.05），and a significant positive correlation with P（A-a）O₂，SOFA score and APACHE Ⅱ score（P<0.05）.

The TCM syndromes of patients with sepsis-induced lung injury are mainly lung heat obstruction，blood stasis obstructing lung，lung congestion and Fu-organ excess，water retention obstructing lung，which are closely related to lung injury-related indicators and SOFA and APACHE Ⅱ scores. Mastering the characteristics of syndrome differentiation of sepsis-induced lung injury and observing the changes of lung injury-related indicators and SOFA and APACHE Ⅱ scores have high value for disease diagnosis，treatment and prognosis evaluation.

To investigate the clinical prognostic effect of Wenyang Sanjie Decoction（温阳散结汤）combined with immunotherapy on patients of epidermal growth factor receptor（EGFR）mutated advanced non-small cell lung cancer（NSCLC）.

Ninety-three NSCLCpatients with EGFR mutation admitted to the hospital from January 2019 to January 2023 were selected as study subjects，and all patients received the same chemotherapy regimen. Forty patients treated with immune checkpoint inhibitors（ICIs）were selected as the control group，and the other 53 patients treated with Wenyang Sanjie Decoction combined with ICIs were selected as the observation group. Tumor response，tumor markers and quality of life before and after treatment were compared between the two groups. The occurrence of toxic and side effects was compared.

The disease control rate（DCR）and objective response rate（ORR）of the observation group were 98.11% and 66.04%，respectively，and those of the control group were 95.00% and 65.00%，respectively. There was no significant difference in short-term efficacy between the groups（P>0.05）. After treatment，the levels of carbohydrate antigen 125（CA125）and carcinoembryonic antigen（CEA）in both groups were significantly lower than those before treatment（P<0.05），but there was no statistical significance between two groups（P>0.05）. After treatment，the total score of the observation group was significantly lower than that of the control group（P<0.05），and there was no significant difference between the two groups（P>0.05）. The total incidence of toxic and side effects was 32.08% in observation group and 47.50% in control group（P>0.05）.

Wenyang Sanjie Decoction combined with immunotherapy for advanced NSCLCwith EGFR mutation is effective in improving the symptoms of traditional Chinese medicine and has a high safety，suitable for promotion.

To explore the therapeutic effect of Bufei Xichuan Decoction（补肺息喘汤）on stable stage chronic obstructive pulmonary disease（SCOPD）patients and its impact on the levels of inflammatory factors，Toll like receptor 4（TLR4）and chemokine CXC ligand 13（CXCL13）in patients.

A total of 160 SCOPD patients from April 2022 to April 2024 in the hospital were divided into observation group and control group，each with 80 cases. The patients of the control group inhaled indatelopram bromide，while those of the observation group took Bufei Xichuan Decoction on the basis of the control group. The treatment period for both groups was 8 weeks. The therapeutic effects of two groups was compared. The changes in lung function，6-minute walking distance（6MWT），COPD assessment test（CAT）questionnaire scores，inflammatory factors，TLR4 and CXCL13 before and after treatment were compared.

The effective rate of the observation group was higher than that of the control group（P<0.05）. After 8 weeks of treatment，the values of FEV1/FVC，PEF，FEV1 and 6MWT of the two groups were higher than those before treatment，while the CAT score，the levels of tumor necrosis factor-α（TNF-α），interleukin-6（IL-6），interleukin-8（IL-8），TLR4 and CXCL13 were lower than those before treatment（P<0.05）. The values of FEV1/FVC，PEF，FEV1 and 6MWT of the observation group were higher than those of the control group，while the CAT score，the levels of TNF-α，IL-6，IL-8，TLR4 and CXCL13 were lower than those of the control group after treatment（P<0.05）.

-Bufei Xichuan Decoction has a significant therapeutic effect on SCOPD patients，reducing cellular inflammatory response and lowering the levels of TLR4 and CXCL13，which is worthy of clinical reference.

To investigate the effect of Buzhong Yiqi Decoction（补中益气汤）on immune function and prognosis of elderly patients undergoing laparoscopic inguinal hernia repair.

Ninety-six elderly patients with inguinal hernia admitted to the hospital were selected and randomly divided into two groups，48 cases in each group. Both groups received laparoscopic inguinal hernia repair. The control group received anti-infection treatment on the basis of this and the observation group was combined with Buzhong Yiqi Decoction on the basis of the control group for 7 days. The clinical therapeutic effect，immune function，visual analogue score（VAS）score，exhaust time，time of getting out of bed，length of hospital stay and postoperative complications of the two groups were compared.

The total effective rate of the control group（87.50%）was significantly lower than that of the observation group（97.92%），with statistical significance（P<0.05）. After 3 days of treatment，VASscores in both groups were significantly lower than those before treatment（P<0.05）. There was no statistical difference between the groups. After 7 days of treatment，VASscores of both groups were significantly lower than those before treatment and 3 days after treatment，and the score of the observation group was significantly lower than that of the control group（P<0.05）. The levels of immunoglobulin G（IgG），immunoglobulin A（IgA）and immunoglobulin M（IgM）in both groups were significantly increased after treatment compared with those before treatment（P<0.05），and the improvement in the observation group was significantly better than that in the control group（P<0.05）. Anal exhaust，postoperative getting out of bed and postoperative hospitalization time in the observation group were better than those in the control group（P<0.05）. The complication rate was 14.59% in the control group and 2.08% in the observation group. The complication rate in the observation group was significantly lower than that in the control group（P<0.05）.

Buzhong Yiqi Decoction has a good therapeutic effect on the elderly patients undergoing laparoscopic inguinal hernia repair. It can improve the immune function，promote the rehabilitation，reduce the complications，and has high safety. It is worthy of clinical application.

To investigate the mechanism of Yixiao Ointment（一效膏）in promoting the healing of skin ulcers in diabetic rats by inhibiting pyroptosis.

Seventy-two male SD rats of SPF grade were randomly divided into blank group and model group，and the diabetes model was induced by high-fat and high-sugar chow combined with small-dose streptozotocin（STZ）intraperitoneal injection in the model group. One month later，the rats in each group were cut into the skin to create open wounds to construct the diabetic rat ulcer model. After successful modeling，the model group was divided into a model control group（physiological sodium chloride injection），a Yixiao Ointment group（Yixiao Ointment）and an epidermal growth factor group（human epidermal growth factor gel）with 18 rats in each group. After intervention for 14 consecutive days，the healing of skin ulcerations was observed. Enzyme-linked immunosorbent assay（ELISA）was used for detecting the expression levels of interleukin-1（IL-1），interleukin-18（IL-18）and tumor necrosis factor-α（TNF-α）in serum，and the protein levels and mRNA expression levels of NOD-like receptor thermoprotein structural domain-associated protein 3（NLRP3），cysteine protease-1（Caspase-1），nuclear factorκB（NF-κB），apoptosis-associated speck-like protein（ASC）were detected by Western blot and reverse transcription-polymerase chain reaction（RT-PCR）.

Visual observation of the ulcer surface showed that the ulcerated skin of rats in the Yixiao Ointment group healed significantly. Compared with those of the model control group，the levels of IL-1，IL-18 and TNF-αwere significantly decreased in the Yixiao Ointment group，and the protein expressions of NLRP3，Caspase-1，NF-κB and ASCwere decreased in the Yixiao Ointment group.

Yixiao Ointment can promote the healing of diabetic ulcerated skin，and its mechanism of action may be related to its ability to reduce the inflammatory response and inhibit cellular death.

To analyze the chemical composition and contents of Zhishi（Aurantii Immaturus Fructus）-Baizhu（Atractylodis Macrocephalae Rhizoma）essential oil（ZBEO）and explore the acute toxicity of different doses of chemical constituents of ZBEOin mice.

GC-MSwas used to analyze and identify the chemical composition. After oral administration of jojoba oil and ZBEO，the activity，diet，water intake，body weight，mortality and other conditions of the mice were observed. The values of median lethal dose（LD₅₀）and 95% confidence interval were calculated by using the weighted regression method（Bliss）.

Through GC-MS analysis，a total of 10 chemical components were identified in ZBEO，accounting for 46.41% of the total oil content. The main components were curzerenone，D-limonene，β-pinene，γ-elemene，atractylenolide Ⅱ，β-elinene and trans-caryophyllene. The toxicity experiment of ZBEO on mice showed no significant effects on the diet，water intake or body weight of the surviving mice. The value of LD₅₀ of ZBEO was calculated to be 1.681 mL/kg by using the Bliss method，indicating a certain level of toxicity. The 95% confidence interval for LD₅₀ was 3.367～7.417 mL/kg. The regression equation was Y（Probit）＝-1.228+7.612 lgD.

Curzerenone and D-limonene are the main components of ZBEO. The essential oil exhibits a certain level of toxicity，mainly affecting the blood vessels as indicated by organ index and pathological observations. The main affected organs are liver，spleen and kidney. The toxicity is dose-dependent，and within a certain dosage range，it can be safely used.

To observe the clinical efficacy of Modified Erchen Decoction（二陈汤加减）in the treatment of nonalcoholic fatty liver disease，and analyze the impact of this treatment on liver function，blood lipids and other indicators in patients.

The clinical data of 80 patients with non-alcoholic fatty liver disease admitted to Dongguan Hospital of Guangzhou University of Chinese Medicine from January 2022 to June 2023 were collected. They were randomly divided into a control group and an observation group，with 40 patients in each group. The patients of the control group were treated with Atorvastatin Calcium Tablets. Those of the observation group were treated with Modified Erchen Decoction on the basis of the control group. The clinical efficacy，liver function，blood lipid levels and changes in inflammatory markers were observed and compared between the two groups.

The effective rate of the control group was 75.00%（30/40），while that of the observation group was 92.50%（37/40）. Compared with that of the control group，the effective rate of the observation group significantly increased，with a statistically significant difference（P<0.05）. After treatment，the levels of aspartate aminotransferase（AST），alanine aminotransferase（ALT）and total bilirubin in serum（TBIL）in the observation group significantly decreased compared to those in the control group（P<0.01）. There was no significant difference in values of controlled attenuation parameter（cap）or body mass index（BMI）between the two groups before administration（P>0.05）. After the intervention，the values of CAPand BMI of the observation group significantly decreased compared to those of the control group（P<0.01）. There was no significant difference in blood lipid levels between the two groups before administration（P>0.05）. After intervention，compared to those of the control group，the levels of triglycerides（TG），low density lipoprotein cholesterol（LDL-C）and total cholesterol（TC）of the observation group patients were significantly reduced，while the high density lipoprotein cholesterol（HDL-C）levels were significantly upregulated，with statistically significant differences（P<0.05，P<0.01）. There was no significant difference in the levels of inflammatory indicators between the two groups before administration（P>0.05）. After intervention，compared to those of the control group，the levels of IL-6，tumor necrosis factor-α（TNF-α）and hypersensitive C-reactive protein（hs-CRP）in the observation group were significantly decreased than those in the control group（P<0.05）. There were 4 cases of adverse reactions in the control group，with an incidence rate of 10.00%（4/40），and 3 cases in the observation group，with an incidence rate of 7.50%（3/40）. There was no significant difference in the incidence of adverse reactions between the two groups（P>0.05）.

The combination of Modified Erchen Decoction and conventional Western medicine treatment can not only improve the clinical efficacy of NAFLD，improve liver function，reduce blood lipid levels，but also delay the process of liver fibrosis，inhibit the level of inflammation in the body，and improve the patients'condition without increasing adverse reactions.

To evaluate the clinical efficacy and mechanism of Anchang Lishi Xiehao Prescription（安肠利湿泄浊方）combined with Compound Glutamine Enteric-Coated Capsule in the treatment of active ulcerative colitis.

A total of 100 patients with active ulcerative colitis admitted to the hospital from March 2020 to March 2023 were selected as the research objects. According to the randomized control method，the patients were divided into observation group and reference group，with 50 cases in each group. The reference group was treated with mesalazine combined with Compound Glutamine Enteric-Coated Capsules. In the observation group，the basis of treatment in the reference group was oral treatment with Anchang Lishi Xiehao Prescription. The treatment cycle was 7 days，and there was a total of 4 cycles of treatment. The diarrhea，pus and blood stool before and after treatment were compared between the two groups. The changes of TCM syndrome scores such as abdominal pain，nausea and abdominal distension were compared between the two groups. The serum levels of diamine oxidase（DAO），D-lactic acid（D-LA），hypoxic-induced-factor-1α（HIF-1α），interleukin-6（IL-6），C-reactive protein（CRP）and tumor necrosis factor-α（TNF-α）were compared between the two groups before and after treatment.

The therapeutic effect of the observation group was 94%（47/50），which was better than that（80%，40/50）of the reference group（P<0.05）. Diarrhea，pus and blood stool were relieved in both groups. The scores of TCM syndromes such as abdominal pain，nausea and abdominal distension were significantly lower than those before treatment，and the reduction of the observation group was better than that of the reference group（P<0.05）. The antidiarrheal time，febrile time and disappearance time of symptoms and signs in the observation group were better than those in the reference group（P<0.05）. The indexes related to intestinal mucosal barrier function（DAO，D-LA and HIF-1α）were significantly decreased after treatment in both groups compared with those before treatment，and the decreases in the observation group were better than those in the reference group（P<0.05）. After treatment，the levels of inflammatory factors（IL-6，CRP and TNF-α）in two groups were lower than those before treatment，and the reduction range in the observation group was better than that in the control group（P<0.05）.

It is more feasible and effective to treat ulcerative colitis with Anchang Lishi Xiehao Prescription combined with Compound Glutamine Enteric-Coated Capsule，which can significantly improve the clinical symptoms of patients，shorten the time of diarrhea prevention，fever reduction and disappearance of symptoms and signs，and improve the therapeutic effect. The mechanism of action is speculated to be related to reducing the levels of inflammatory factors in the body and promoting the repair of intestinal mucosa.

To explore the effect of Compound Danshen Dropping Pills（复方丹参滴丸）on the changes of threedimensional echocardiography and leukocyte derived inflammation indicators in patients with coronary heart disease of Qi deficiency and blood stasis type.

A total of 122 patients with coronary heart disease and angina pectoris in the hospital from January 2021 to January 2023 divided into a control group（61 cases）and a observation group（61 cases）. The control group was treated with atorvastatin calcium tablets and trimetazidine tablets，while the observation group was treated with Compound Danshen Dropping Pills on the basis of control group. The treatment period was 12 weeks. The therapeutic effects，changes in main symptom scores，duration and frequency of angina pectoris，electrocardiogram parameters，three-dimensional echocardiographic indicators and leukocyte derived inflammation indicators before and after treatment and adverse reactions of the two groups were compared.

The effective rate of the observation group was higher than that of the control group（P<0.05）. After treatment，the scores of chest tightness and chest pain of two groups were lower than those before treatment（P<0.05）. The scores of chest tightness and chest pain of the observation group were lower than those of the control group（P<0.05）. After treatment，the duration and frequency of angina pectoris of two groups were lower than those before treatment（P<0.05）. The duration and frequency of angina pectoris of the observation group were lower than those of the control group（P<0.05）. After treatment，QTc interval and QRStime limit values of two groups were lower than those before treatment（P<0.05）. QTc interval and QRStime limit values of the observation group were lower than those of the control group（P<0.05）. After treatment，the values of left ventricular ejection fraction（LVEF）and cardiac output（CO）of two groups were higher than those before treatment，while the values of left ventricular end diastolic diameter（LVEDD）and left ventricular end systolic diameter（LVESD）were lower than those before treatment（P<0.05）. The values of LVEF and COin the observation group were higher than those of the control group，while the values of LVEDD and LVESD were lower than those of the control group（P<0.05）. After treatment，the serum levels of interleukin-6（IL-6）and interleukin-18（IL-18）of two groups were lower than those before treatment，while the levels of interleukin-33（IL-33）were higher than those before treatment（P<0.05）. The serum levels of IL-6 and IL-18 in the observation group were lower than those of the control group，while the levels of IL-33 was higher in the control group（P<0.05）. The adverse reactions of two groups had no significant difference（P>0.05）.

Compound Danshen Dropping Pills have a significant therapeutic effect on patients with coronary heart disease of Qi deficiency and blood stasis type，which can significantly improve their cardiac function and alleviate inflammatory reactions.

To exploring the enhancing effect of salt processing on the nourishing Yin and clearing heat effects of Dihuang（Rehmanniae Radix）.

Based on the ancient records of salt preparation method and modern evolution，the saltprocessed products of Dihuang（Rehmanniae Radix）were prepared. On this basis，a mouse model of Yin deficiency and internal heat induced by oral administration of levothyroxine sodium（160 mg· kg^-1），which was relatively recognized and widely used，was studied by observing the gross signs，water intake，anal temperature，thermotropism as well as serum triiodothyronine（T3），thyroxine（T4），cyclic adenosine monophosphate（cAMP），cyclic guanosine monophosphate（cGMP），Na⁺-K⁺-ATP（Sodium Potas）and other factors to comprehensively evaluate the synergistic effect of salt processing on the main efficacy of nourishing Yin and clearing heat in Dihuang（Rehmanniae Radix）.

The model caused a significant increase in water intake，anal temperature，serum levels of T3，T4，cAMP，cAMP/cGMP，Na⁺-K⁺-ATPase and Ca²⁺-Mg²⁺-ATPase in mice（P<0.01），and the thermalization of the hot and cold board was significantly reduced（P<0.01）. Raw Dihuang（Rehmanniae Radix）and its various salt-processed products can significantly improve the abnormalities in the above indicators caused by the model（P<0.05 or P<0.01），among which the improvement effect of Dihuang（Rehmanniae Radix）salt-products was better than that of their raw products，and the effect of Dihuang（Rehmanniae Radix）salt-products processed by salt sealing freeze-drying method was particularly good.

The processing with salt can enhance the main effect of Dihuang（Rehmanniae Radix）in nourishing Yin and clearing heat. In particular，the enhancing effect of salt sealing freeze-drying processing method on the main effects of Dihuang（Rehmanniae Radix）is the best.

To explore the therapeutic effect of Wuling Capsules（乌灵胶囊）combined with Shenqi Wuweizi Tablets（参芪五味子片）on elderly patients with stable angina pectoris and anxiety and depression.

A total of 126 elderly patients with stable angina pectoris combined with anxiety and depression admitted to the cardiology department of the hospital from February 2022 to February 2023 were selected and randomly divided into experimental group and control group，with 63 cases in each group. The control group patients received Western medicine treatment，including Bisoprolol Fumarate Tablets，Xinkang Sustained-Release Tablets and Aspirin Enteric Coated Tablets. On the basis of the control group，the experimental group received Wuling Capsules combined with Shenqi Wuweizi Tablets. The efficacy of stable angina pectoris，electrocardiogram efficacy，traditional Chinese medicine syndrome efficacy，the scores of anxiety and depression，the sleep quality score，the levels of plasma atrial natriuretic peptide（ANP），endothelin（ET），cholesterol（TC），triacylglycerol（TG），norepinephrine（NE），5-hydroxytryptamine（5-HT）and dopamine（DA）and the occurrence of adverse reactions of two groups were compared.

Compared with that of the control group，the treatment effect of stable angina pectoris in the experimental group was better（P<0.05）. Compared with those before treatment，the self-rating anxiety scale（SAS），self-rating depression scale（SDS）and Pittsburgh sleep quality index（PSQI）scores of the two groups decreased after treatment. Compared with the control group，the SAS，SDSand PSQI scores of the experimental group were lower after treatment（P<0.05）. After treatment，compared with those before treatment，the levels of ANP，ET，TCand TG in the two groups decreased. After treatment，compared with the control group，the experimental group had lower levels of ANP，ET，TCand TG，with statistically significant differences（P<0.05）. Compared with those before treatment，the levels of NE，5-HT and DA in the two groups increased after treatment. Compared with the control group，the experimental group had higher levels of NE，5-HT and DA after treatment（P<0.05）. There was no difference in the occurrence of adverse reactions between the two groups（P>0.05）.

Wuling Capsules combined with Shenqi Wuweizi Tablets can improve the symptoms of angina pectoris in elderly patients with stable angina pectoris and anxiety，alleviate negative emotions such as anxiety and depression and down-regulate the levels of ANP，ET，TC，TG and monoamine neurotransmitters，making it suitable for clinical application.

To investigate the effect of ultrasound interventional radiofrequency ablation combined with Lianqi Decoction（莲芪煎剂）on the short-term clinical efficacy，tumor marker levels and immune function indexes of patients with primary liver cancer.

A total of 90 patients with primary liver cancer who were treated in the hospital from June 2018 to June 2020 were retrospectively selected as the research subjects. According to the different treatment plans of the patients，they were divided into a routine group and an observation group with 55 cases in each group. The routine group was treated with radiofrequency ablation，and the observation group was treated with Lianqi Decoction on the basis of the routine group. The short-term efficacy，expression levels of serum T lymphocyte subsets，expression levels of serum seed bulb markers，liver function，liver hardness and safety of the two groups were observed and compared.

The short-term clinical total effective rate of the observation group was significantly higher than that of the conventional group（P<0.05）. After treatment，the levels of alpha fetoprotein（AFP），carcinoembryonic antigen（CEA）and carbohydrate antigen 199（CA199）in the observation group were significantly lower than those in the conventional group（P<0.05）. After treatment，the levels of CD₃⁺ and CD₄⁺ in the observation group were higher than those in the conventional group，and CD₈⁺ was lower than those in the conventional group（P<0.05）. After treatment，the levels of alanine transaminase（ALT），aspartate transaminase（AST）and total bilirubin（TBIL）in the observation group were lower than those in the conventional group（P<0.05）. The incidence of total adverse reactions in the observation group was significantly lower than that in the conventional group（P<0.05）. After treatment，the liver stiffness measurernents（LSM）value of the observation group was better than that of the conventional group（P<0.05）. The patients in the observation group were better than those in the conventional group at 2 years follow-up（P<0.05）.

Ultrasound interventional radiofrequency ablation combined with Lianqi Decoction has better short-term clinical treatment effect on patients with primary liver cancer，which can significantly improve the expression levels of tumor markers，liver elasticity and liver function，and has a good clinical effect. application prospects.

To study the effect of Bailing Capsule（百令胶囊）combined with angiotensin Ⅱ receptor blocking agent resistance（ARB）class antihypertensive drugs in the treatment of diabetes nephropathy（DN）on serum levels of transforming growth factor-β（TGF-β）/Smad，p38 mitogen activated protein kinase（p38MAPK）.

A total of 78 patients with DN admitted to the hospital from January 2020 to January 2022 were selected and divided into the control group（39 cases）and the observation group（39 cases）by random number method. The control group was given Candesartan Cilexetil Tablets and insulin. The observation group was added Belling Capsule on the basis of the control group，all of which were treated for 16 weeks. Before and after treatment，the levels of fasting plasma glucose（FPG），glycosylated hemoglobin（HbA1c），serum creatinine（SCr），urea nitrogen（BUN）and serum TGF-β，Smad1，Smad2，Smad3，p38MAPK，P-P38MAPK protein of two groups were compared. In addition，the adverse reaction incidence of the two groups were compared after treatment.

The total effective rate was 87.74% in the observation group，significantly higher than that（69.23%）in the control group（P<0.05）. The levels of FPG，HbA1c，SCr and BUN in the observation group were significantly lower than those before treatment and those in the control group after treatment（P<0.05）. The protein levels of TGF-β，Smad1，Smad2 and Smad3 after treatment in the observation group were significantly lower than those before treatment and those in the control group after treatment（P<0.05）. The serum levels of p38MAPK，p-p38MAPK and p-p38MAPK/p38MAPK in the observation group after treatment were significantly lower than those before treatment and those in the control group after treatment（P<0.05）. There was no significant difference in the total incidence of adverse reactions between the two groups（41.03% vs 33.33%，P>0.05）.

Belling Capsule combined with ARB class antihypertensive drugs in the treatment of DN can play a significant role in lowering blood glucose and improving renal function，and also can regulate the protein levels of TGF-β/Smad and p38MAPK，without significantly increasing the adverse reactions of drug treatment，which is worthy of clinical promotion and use.

To observe the effect of “supplementing Yang and dredging collateral” electroacupuncture combined with hand rehabilitation robot on hemiplegia patients with ischemic stroke.

In this study，60 patients with ischemic stroke hemiplegia（admitted from January 2020 to December 2022）were divided into two groups by random number table method，namely control group and treatment group，with 30 cases in each group. The patients in the control group were given routine treatment of ischemic stroke hemiplegia and rehabilitation intervention by hand rehabilitation robot. Those in the treatment group were combined with “supplementing Yang and dredging collateral” electroacupuncture on the basis of the control group，and the treatment data of patients in each group was compared，including the efficacy，the changes of total TCM symptom scores before and after treatment，National Institute of Health Stroke Scale（NIHSS）score，Fugl-Meyer assessment（FMA）and simple test for evaluating hand function（STEF）score，the changes of hand function indicators such as maximum flexion angle，maximum extension angle and active range of digital active finger movement（AROM），the changes of Berg balance scale（BBS）scores and modified Barthel index（MBI），the flow velocity changes of middle cerebral artery（MCA），posterior cerebral artery（PCA）and anterior cerebral artery（ACA）in brain circulation indicators.

The curative effect of the treatment group was better than that of the control group（P<0.05）. The total TCM symptom score，NIHSS score，FMA score and STEF score，hand function indexes（maximum flexion angle，maximum extension angle，AROM），BBS score and MBI score，brain circulation indexes（MCA，PCA，ACA）were not significant in both groups before treatment（P>0.05）. After treatment，the total TCM symptom score，NIHSS score，FMA score and STEF score，hand function indexes（maximum flexion angle，maximum extension angle，AROM），BBS score and MBI score，brain circulation indexes（MCA，PCA，ACA）of all patients in each group were improved. After treatment，the total TCM symptom score，NIHSSscore，FMA score and STEF score，hand function indexes（maximum flexion angle，maximum extension angle，AROM），BBSscore and MBI score，brain circulation indexes（MCA，PCA，ACA）in the treatment group were all better than those in the control group（P<0.05）.

“Supplementing Yang and dredging collateral” electroacupuncture combined with hand rehabilitation robot can promote the rehabilitation of patients with hemiplegia after ischemic stroke. The treatment effect of patients is improved，the symptoms are relieved，and the limb function of patients is recovered well. It is worthy of application.

To explore the effect of scalp acupuncture combined with betahistine on clinical symptoms，sleep quality and recurrence in patients with peripheral vertigo.

The patients with peripheral vertigo of liver-Yang hyperactivity type from May 2022 to June 2023 were divided into observation group and control group with 47 cases in each group according to simple randomization method. The control group received betahistine treatment，and the observation group was treated with scalp acupuncture combined with betahistine，and both groups were continuously treated for 4 weeks. Before treatment and after 4 weeks of treatment，the vertigo degree［Dizziness Handicap Inventory（DHI）score，TCM syndrome score］，vestibular function indicators［total length of barycentric movement（PL），total area of barycentric movement（CA），canal paresis value］，hemodynamic indicators［whole blood viscosity（HBV），hemocrit（Hct），vertebral artery flow velocity，basilar artery flow velocity］and sleep quality［Pittsburgh Sleep Quality Index（PSQI）］were compared between the two groups. The incidence of adverse reactions during treatment and recurrence within 3 months after treatment were recorded in both groups.

After 4 weeks of treatment，the DHI value，TCM syndrome score，PL，CA，canal paresis value，HBV，Hct and sleep quality score in both groups were significantly decreased compared with those before treatment，and the above indicators in the observation group were lower than those in the control group（all P<0.05）. The blood flow velocities of vertebral artery and basilar artery in the two groups were significantly enhanced than those before treatment，and the two velocities in the observation group were faster than those in the control group（all P<0.05）. There was no significant difference in the incidence of adverse reactions between the two groups（P>0.05），and the recurrence in the observation group within 3 months after treatment was significantly lower than that in the control group（P<0.05）.

Scalp acupuncture combined with betahistine can significantly improve the symptoms，effectively enhance the sleep quality and reduce the risk of recurrence in patients with peripheral vertigo.

To explore the effect of Tongli Huayu Xingnao Decoction（通里化瘀醒脑汤）combined with lower extremity acupoint acupuncture on quality of life of stroke patients.

The study included 113 stroke patients，all of whom were admitted to the hospital from January 2021 to December 2022，and were divided into observation group and control group by random number table method. The patients in the control group（56 cases）received routine clinical treatment，and those in the observation group（57 cases）received combined treatment with Tongli Huayu Xingnao Decoction and lower limb acupoint acupuncture on the basis of treatment in the control group. The effects，complications，changes of TCM syndrome scores（dizziness and delirium，skew of mouth，hemiplegia，palpitation and shortness of breath，pale complexion，etc.）and neurological impairment scores were compared between the two groups. The changes in National Institute of Health stroke scale（NIHSS），Brunel Balance Assessment（BBA）score，Fugl-Meyer motor function assessment（FMA），quality of life score（Barthel index）and patient satisfaction with treatment of the two groups were compared.

Compared with that of the control group（71.43%），the effective rate of the observation group（87.72%）was higher（P<0.05）. The complication rate of the observation group and the control group was significant（1.75% vs 12.50%）（P<0.05）. The TCM syndrome scores（dizziness and delirium，skew of mouth，hemiplegia，palpitation and shortness of breath，pale complexion，etc.），NIHSSscore，BBA score，FMA score and Barthel index score before treatment in the observation group and the control group were similar（P>0.05）. After treatment，TCM syndrome scores（dizziness and delirium，skew of mouth，hemiplegia，palpitation and shortness of breath，pale complexion，etc.），NIHSS score，BBA score，FMA score and Barthel index were all improved in each group. And the indexes above in the observation group were better than those in the control group（P<0.05）. The treatment satisfaction rate of the observation group（96.49%）was higher than that of the control group（82.14%）（P<0.05）.

Tongli Huayu Xingnao Decoction combined with lower extremity acupoint acupuncture can significantly improve the clinical efficacy，quality of life and motor function of stroke patients，and reduce the complication rate，with good recovery and high satisfaction rate.

To analyze the effect of Tongmai Huayu Decoction（通脉化瘀方）combined with directional drug penetration technology in the application of stroke in upper limb hemiplegia.

A total of 80 stroke patients with upper limb hemiplegia admitted to the Rehabilitation Department of The First Affiliated Hospital of Nanyang Medical College from August 2021 to December 2022 were randomly selected to be included in the study，and were divided into control group（40 cases）and experimental group（40 cases）according to random number table method. The control group was treated with routine western medicine，and the experimental group was treated with Tongmai Huayu Decoction combined with directional drug penetration. The therapeutic effect of the two groups was evaluated after 1 month of treatment，and the changes of TCM symptom scores，upper limb function［Wolf Motor Function Test（WMFT）］and blood flow index of the two groups were compared before and after treatment.

The total effective rate of the experimental group was higher than that of the control group（P<0.05）. After treatment，the WMFT scores of the two groups were higher than that before treatment（P<0.05），and the investigator WMFT score was higher than that of the control group（P<0.05）. After treatment，the TCM symptom scores and blood flow index levels of the two groups were lower than those before treatment（P<0.05），and the TCM symptom score and blood flow index level of the experimental group were lower than those of the control group（P<0.05）.

Tongmai Huayu Decoction combined with directional drug penetration can effectively improve that treatment effect of stroke patients with upper limb hemiplegia，relieve the TCM syndrome，and improve the upper limb function and blood supply of the patients.