Full
Outline
Gegen Qinlian Decoction（葛根芩连汤，GQD），a classical formula recorded in the Treatise on Febrile Diseases，possesses the efficacy of relieving the exterior and clearing the interior，ascending the clear and stopping dysentery. Traditionally，it has been primarily used to treat diarrhea or dysentery caused by damp-heat. Given the similarities in pathological mechanisms and primary symptoms between traditional indications of GQD and modern gastrointestinal inflammatory diseases，particularly ulcerative colitis（UC），GQD has been widely used in modern clinical practice to treat such diseases. The research has shown that the mechanism of GQD treating UCinvolves multiple pathways and targets，including regulating immune response，protecting intestinal mucosal barrier，antioxidant stress and inhibiting inflammatory response. The realization of these mechanisms is intricately linked to the sophisticated regulatory network among cytokines. Moreover，the significance of cytokines in the pathogenesis of UChas become increasingly prominent. The imbalance between pro-inflammatory and anti-inflammatory cytokines leading to immune dysregulation is considered a critical factor influencing the progression and prognosis of UCand has become a focal point of current research. Based on this，this study systematically reviewed the mechanism of Gegen Qinlian Decoction in the treatment of UCfrom the perspective of cytokines，and explored it in depth from pro-inflammatory cytokines and anti-inflammatory cytokines，aiming to provide further theoretical support and reference for the rational clinical application of GQD.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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