Full
Outline
To explore the effect of Compound Danshen Dropping Pills（复方丹参滴丸）on the changes of threedimensional echocardiography and leukocyte derived inflammation indicators in patients with coronary heart disease of Qi deficiency and blood stasis type.
A total of 122 patients with coronary heart disease and angina pectoris in the hospital from January 2021 to January 2023 divided into a control group（61 cases）and a observation group（61 cases）. The control group was treated with atorvastatin calcium tablets and trimetazidine tablets，while the observation group was treated with Compound Danshen Dropping Pills on the basis of control group. The treatment period was 12 weeks. The therapeutic effects，changes in main symptom scores，duration and frequency of angina pectoris，electrocardiogram parameters，three-dimensional echocardiographic indicators and leukocyte derived inflammation indicators before and after treatment and adverse reactions of the two groups were compared.
The effective rate of the observation group was higher than that of the control group（P<0.05）. After treatment，the scores of chest tightness and chest pain of two groups were lower than those before treatment（P<0.05）. The scores of chest tightness and chest pain of the observation group were lower than those of the control group（P<0.05）. After treatment，the duration and frequency of angina pectoris of two groups were lower than those before treatment（P<0.05）. The duration and frequency of angina pectoris of the observation group were lower than those of the control group（P<0.05）. After treatment，QTc interval and QRStime limit values of two groups were lower than those before treatment（P<0.05）. QTc interval and QRStime limit values of the observation group were lower than those of the control group（P<0.05）. After treatment，the values of left ventricular ejection fraction（LVEF）and cardiac output（CO）of two groups were higher than those before treatment，while the values of left ventricular end diastolic diameter（LVEDD）and left ventricular end systolic diameter（LVESD）were lower than those before treatment（P<0.05）. The values of LVEF and COin the observation group were higher than those of the control group，while the values of LVEDD and LVESD were lower than those of the control group（P<0.05）. After treatment，the serum levels of interleukin-6（IL-6）and interleukin-18（IL-18）of two groups were lower than those before treatment，while the levels of interleukin-33（IL-33）were higher than those before treatment（P<0.05）. The serum levels of IL-6 and IL-18 in the observation group were lower than those of the control group，while the levels of IL-33 was higher in the control group（P<0.05）. The adverse reactions of two groups had no significant difference（P>0.05）.
Compound Danshen Dropping Pills have a significant therapeutic effect on patients with coronary heart disease of Qi deficiency and blood stasis type，which can significantly improve their cardiac function and alleviate inflammatory reactions.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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