To explore the clinical effect of Sanyin Zhitong Prescription（三因止痛方）combined with traditional Chinese acupuncture on migraine by external factors.

A total of 90 migraine patients by external factors admitted to the Department of Neurology from June 2022 to June 2023 were divided into two groups（observation group，45 cases）and control group，45 cases）by random number table method. All patients in the control group were treated with flunarizine. The observation group combined with Sanyin Zhitong Prescription and traditional Chinese acupuncture on the basis of drug treatment treatment. The clinical data of patients in each group was observed，including clinical efficacy after treatment，changes in scores of TCM symptoms（headache，distension and pain，insomnia and dreaminess，irritability，dizziness，sighing，etc.）before and after treatment，changes in visual analogue pain scale（VAS）score，changes in monthly headache frequency and duration of each headache before and after treatment，changes in patients'quality of life score［Medical Outcomes Study 36-Item Short-Form Health Survey（SF-36）］and adverse reactions.

The total effective rate of the observation group（95.56%）was significantly higher than that of control group（80.00%）（P<0.05）. Before treatment，the scores of TCM symptoms（headache，hypochondrial distending pain，insomnia and dreaminess，irritability，dizziness，sighing，etc.），VAS score，monthly frequency of headache occurrence，duration of each headache，SF-36 score and other indicators were significant between two groups（P>0.05）. After treatment，the scores of TCM symptoms（headache，distension and pain，insomnia and dreaminess，irritability，dizziness，sighing，etc.），VASscores，monthly headache frequency，duration of each headache，SF-36 scores and other indicators were significantly improved in each group. After treatment，the scores of TCM symptoms（headache，hypochondrial pain，insomnia and dreaminess，irritability，dizziness，sighing，etc.），VASscores，monthly frequency of headache and duration of each headache and SF-36 scores in the observation group were significantly better than those in the control group（P<0.05）. The adverse reaction rates of observation group and control group were 2.22% and 4.44%，respectively（P>0.05）.

Sanyin Zhitong Prescription combined with traditional Chinese acupuncture and moxibustion has good clinical effect in the treatment of migraine，with pain relief，symptoms improvement，quality of life increase，less adverse reaction and safe and reliable treatment，worthy of application.