To evaluate the clinical efficacy and mechanism of Anchang Lishi Xiehao Prescription（安肠利湿泄浊方）combined with Compound Glutamine Enteric-Coated Capsule in the treatment of active ulcerative colitis.

A total of 100 patients with active ulcerative colitis admitted to the hospital from March 2020 to March 2023 were selected as the research objects. According to the randomized control method，the patients were divided into observation group and reference group，with 50 cases in each group. The reference group was treated with mesalazine combined with Compound Glutamine Enteric-Coated Capsules. In the observation group，the basis of treatment in the reference group was oral treatment with Anchang Lishi Xiehao Prescription. The treatment cycle was 7 days，and there was a total of 4 cycles of treatment. The diarrhea，pus and blood stool before and after treatment were compared between the two groups. The changes of TCM syndrome scores such as abdominal pain，nausea and abdominal distension were compared between the two groups. The serum levels of diamine oxidase（DAO），D-lactic acid（D-LA），hypoxic-induced-factor-1α（HIF-1α），interleukin-6（IL-6），C-reactive protein（CRP）and tumor necrosis factor-α（TNF-α）were compared between the two groups before and after treatment.

The therapeutic effect of the observation group was 94%（47/50），which was better than that（80%，40/50）of the reference group（P<0.05）. Diarrhea，pus and blood stool were relieved in both groups. The scores of TCM syndromes such as abdominal pain，nausea and abdominal distension were significantly lower than those before treatment，and the reduction of the observation group was better than that of the reference group（P<0.05）. The antidiarrheal time，febrile time and disappearance time of symptoms and signs in the observation group were better than those in the reference group（P<0.05）. The indexes related to intestinal mucosal barrier function（DAO，D-LA and HIF-1α）were significantly decreased after treatment in both groups compared with those before treatment，and the decreases in the observation group were better than those in the reference group（P<0.05）. After treatment，the levels of inflammatory factors（IL-6，CRP and TNF-α）in two groups were lower than those before treatment，and the reduction range in the observation group was better than that in the control group（P<0.05）.

It is more feasible and effective to treat ulcerative colitis with Anchang Lishi Xiehao Prescription combined with Compound Glutamine Enteric-Coated Capsule，which can significantly improve the clinical symptoms of patients，shorten the time of diarrhea prevention，fever reduction and disappearance of symptoms and signs，and improve the therapeutic effect. The mechanism of action is speculated to be related to reducing the levels of inflammatory factors in the body and promoting the repair of intestinal mucosa.