Full
Outline
To study the optimal fermentation conditions of Enterobacter albieri and Cordyceps pupae for Shenling Baizhu Powder（参苓白术散），and evaluate the safety and efficacy of the fermentation solution on alcoholic gastric injury at cell level.
In this experiment，the contents of functional components in fermentation broth of the modified formula of Shenling Baizhu Powder after fermentation under different conditions were measured and comprehensively evaluated. The alcoholic gastric injury model of GES-1 cells was established after 24 h of alcohol intervention. The intervention effects of water extract（0.938 mg/g）and fermentation broth of the modified formula of Shenling Baizhu Powder at low，medium and high doses（0.469 mg/g，0.938 mg/g，1.876 mg/g）on basic apoptosis of GES-1 cells were investigated.
The optimal fermentation process of Enterobacter asburiae for Shenling Baizhu Powder was pH value 5，inoculation amount 1% and fermentation time1 day. The optimal fermentation process of Shenling Baizhu Powder was pH 6，inoculation amount 3% and fermentation time 3 days. The best inoculation sequence for multistrain fermentation was to vaccinate Enterobacter asburiae first. The contents of ginsenoside Re，hesperidin，total flavonoids and total polysaccharides were significantly increased under the optimal fermentation process. The fermentation solution of Shenling Baizhu Powder improved GES-1 cells at 48 h，and the fermentation solution of medium and high dose groups could reduce the total apoptosis rate of GES-1 cells.
After fermentation，the composition of the modified formula of Shenling Baizhu Powder had a great influence，the content changed obviously and the fermentation process was feasible. It had a proliferation effect on GES-1 cells，and at the same time it could reduce the overall apoptosis rate of GES-1 cells.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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