To observe the clinical effect of Shenqi Guben Pobi Decoction（参芪固本破壁饮）combined with moxibustion at Du meridian on liver cancer fatigue.

A total of 120 patients with fatigue due to liver cancer admitted to the hospital from October 2020 to May 2023 were divided into traditional Chinese medicine（TCM）group and conventional group by means of random number table，with 60 patients in each group. The conventional group received routine treatment such as sleep management，nutritional guidance，exercise therapy and psychological counseling. On the basis of conventional treatment，the patients in the TCM group were given Shenqi Guben Pobi Decoction combined with moxibustion at Du meridian treatment. In the course of treatment，3 cases fell off in the conventional group and 5 cases in the TCM group. There were 57 cases remained in the conventional group and 55 cases in the TCM group. The clinical data observation of patients in each group included the clinical efficacy，the changes of TCM symptom scores（fatigue，shortness of breath，spontaneous sweating，lazy speech，insomnia palpitation，dizziness，etc.）and Piper's Fatigue Scale（PFS）scores before and after treatment. Hamilton Anxiety Scale-14（HAMA-14）and Hamilton Depression Scale-17（HAMD-17）were used to assess the negative emotions of the patients in each group. The Pittsburgh sleep quality index（PSQI）was used to evaluate the sleep quality of the patients before and after treatment，and the Spitzer Quality of life index（SQLI）was used to evaluate the changes of patients'quality of life before and after treatment，and voluntary treatment satisfaction questionnaire was adopted to investigate the satisfaction rate of patients in each group.

The total effective rate of the TCM group（96.36%）was higher than that of the conventional group（84.21%）（P<0.05）. Before treatment，TCM syndrome scores（fatigue，shortness of breath，spontaneous sweating，lazy speech，insomnia palpitation，dizziness，etc.），PFSscore，HAMA-14 score，HAMD-17 score，PSQI score and SQLI score were not significant between two groups（P>0.05）. After treatment，TCM syndrome scores（fatigue，shortness of breath，spontaneous sweating，lazy speech，insomnia palpitation，dizziness，etc.），PFSscores，HAM-14 scores，HAMD-17 scores，PSQI scores and SQLI scores were significantly improved in both groups. After treatment，TCM syndrome scores（fatigue，shortness of breath，spontaneous sweating，lazy speech，insomnia palpitation，dizziness，etc.），PFSscores，HAMA-14 scores，HAMD-17，PSQI scores，SQLI scores and other indicators in the TCM group were better than those in the conventional group（P<0.05）. The treatment satisfaction rate of the TCM group（93.36%）was higher than that of the conventional group（84.21%）（P<0.05）.

Shenqi Guben Pobi Decoction combined with moxibustion at Du meridian in the treatment of liver cancer fatigue has better clinical effect. After treatment，the symptoms，negative emotions，sleep quality and quality of life of the patients all improved and the patients were satisfied and recognized. It is worthy of applying.