Full
Outline
To explore the therapeutic effect of Bufei Xichuan Decoction（补肺息喘汤）on stable stage chronic obstructive pulmonary disease（SCOPD）patients and its impact on the levels of inflammatory factors，Toll like receptor 4（TLR4）and chemokine CXC ligand 13（CXCL13）in patients.
A total of 160 SCOPD patients from April 2022 to April 2024 in the hospital were divided into observation group and control group，each with 80 cases. The patients of the control group inhaled indatelopram bromide，while those of the observation group took Bufei Xichuan Decoction on the basis of the control group. The treatment period for both groups was 8 weeks. The therapeutic effects of two groups was compared. The changes in lung function，6-minute walking distance（6MWT），COPD assessment test（CAT）questionnaire scores，inflammatory factors，TLR4 and CXCL13 before and after treatment were compared.
The effective rate of the observation group was higher than that of the control group（P<0.05）. After 8 weeks of treatment，the values of FEV1/FVC，PEF，FEV1 and 6MWT of the two groups were higher than those before treatment，while the CAT score，the levels of tumor necrosis factor-α（TNF-α），interleukin-6（IL-6），interleukin-8（IL-8），TLR4 and CXCL13 were lower than those before treatment（P<0.05）. The values of FEV1/FVC，PEF，FEV1 and 6MWT of the observation group were higher than those of the control group，while the CAT score，the levels of TNF-α，IL-6，IL-8，TLR4 and CXCL13 were lower than those of the control group after treatment（P<0.05）.
-Bufei Xichuan Decoction has a significant therapeutic effect on SCOPD patients，reducing cellular inflammatory response and lowering the levels of TLR4 and CXCL13，which is worthy of clinical reference.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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