To investigate the mechanism of Yixiao Ointment（一效膏）in promoting the healing of skin ulcers in diabetic rats by inhibiting pyroptosis.

Seventy-two male SD rats of SPF grade were randomly divided into blank group and model group，and the diabetes model was induced by high-fat and high-sugar chow combined with small-dose streptozotocin（STZ）intraperitoneal injection in the model group. One month later，the rats in each group were cut into the skin to create open wounds to construct the diabetic rat ulcer model. After successful modeling，the model group was divided into a model control group（physiological sodium chloride injection），a Yixiao Ointment group（Yixiao Ointment）and an epidermal growth factor group（human epidermal growth factor gel）with 18 rats in each group. After intervention for 14 consecutive days，the healing of skin ulcerations was observed. Enzyme-linked immunosorbent assay（ELISA）was used for detecting the expression levels of interleukin-1（IL-1），interleukin-18（IL-18）and tumor necrosis factor-α（TNF-α）in serum，and the protein levels and mRNA expression levels of NOD-like receptor thermoprotein structural domain-associated protein 3（NLRP3），cysteine protease-1（Caspase-1），nuclear factorκB（NF-κB），apoptosis-associated speck-like protein（ASC）were detected by Western blot and reverse transcription-polymerase chain reaction（RT-PCR）.

Visual observation of the ulcer surface showed that the ulcerated skin of rats in the Yixiao Ointment group healed significantly. Compared with those of the model control group，the levels of IL-1，IL-18 and TNF-αwere significantly decreased in the Yixiao Ointment group，and the protein expressions of NLRP3，Caspase-1，NF-κB and ASCwere decreased in the Yixiao Ointment group.

Yixiao Ointment can promote the healing of diabetic ulcerated skin，and its mechanism of action may be related to its ability to reduce the inflammatory response and inhibit cellular death.