Full
Outline
To evaluate the clinical efficacy of Simo Decoction Oral Liquid（四磨汤口服液）in the treatment of functional bloating（FB）.
Sixty cases of FB patients included in four hospitals from March 2022 to May 2023 were randomly divided into two groups，30 cases in the treatment group were given oral administration of Simo Decoction Oral Liquid，and the other 30 cases in the control group were treated with Simo Decoction Oral Liquid simulant for a period of 8 weeks. The response rate of visual analogue scale（VAS），gastrointestinal symptoms rating scales（GSRS），each individual symptom score，overall disease effectiveness rate，hospital anxiety and depression scale（HAD）score and adverse reactions were observed in the two groups.
The bloat VASresponse rate［Full Analysis Set（FAS）：80.00%；Per Protocol Set（PPS）：82.10%］and GSRSeffective rate（FAS：96.67%；PPS：96.40%）in the treatment group were higher than those of the control group［the bloat VASresponse rate（FAS：23.33%；PPS：24.1%）and GSRSeffective rate（FAS：86.67%；PPS：86.20%），and the difference was statistically significant（P<0.05）. The change value of abdominal distension VASscore in the treatment group（FAS：-4.37±2.08；PPS：-4.27±2.07）was greater than that in the control group（FAS：-1.34±1.32；PPS：-1.34±1.32），and the difference was statistically significant（P<0.05）. The GSRSscores and change values of the treatment group before and after treatment，the scores and change values of each single symptom of FB（severity and frequency of episodes of bowel sounds，bowel irregularity，bloating，nausea，and flatulences），the effective rate of overall evaluation of the disease，as well as the change values of the anxiety of the HAD scores（FAS and PPS）were better than those of the control group，and the differences were statistically significant（P<0.05）. No adverse reactions related to the study drug occurred in either group.
Simo Decoction Oral Liquid can improve the symptoms of abdominal distension and other symptoms of FB patients，the efficacy is exact，and the medication is safe. At the same time，to a certain extent，it can relieve the patient's anxiety and depression，and improve the patient's quality of life.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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