To evaluate the current status and development trends of Inflammatory Bowel Disease (IBD) in China, providing decision support for policy adjustments by government and health departments.

Data extraction from the 2024 Global Burden of Disease (GBD) database was conducted for indicators related to the incidence, prevalence, mortality, and Disability-Adjusted Life Years (DALYs) of IBD in China. Joinpoint regression analysis was used to calculate the Annual Percent Change (APC) and the Average Annual Percent Change (AAPC). Additionally, an Autoregressive Integrated Moving Average Model (ARIMA) was employed to forecast disease characteristics from 2022 to 2031.

From 1990 to 2021, the number of prevalent cases, incident cases, and deaths from IBD in China, as well as the age-standardized prevalence rate (ASPR), and age-standardized incidence rate (ASIR) showed an upward trend. By 2021, these figures stood at 168077 prevalent cases, 24 941 new cases, and 5 640 deaths, with ASPR and ASIR reaching 9.16 per 100 000 people and 1.4 per 100 000 people, respectively, representing a significant increase compared to 1990 levels. Meanwhile, the age-standardized mortality rate (ASMR) and age-standardized DALY rate (ASDR) exhibited a downward trend, standing at 0.33 per 100 000 people and 7.68 per 100 000 person-years in 2021, with notable differences observed across age groups and genders. The ARIMA model predicted that by 2031, the ASPR, ASIR, ASMR, and ASDR would decrease compared to 2021 levels, projecting figures of 5.23 per 100 000 people, 1.20 per 100 000 people, 0.21 per 100 000 people, and 5.41 per 100 000 person-years, respectively.

Currently, the incidence and prevalence of IBD in China are on the rise. Although this trend may change over the next decade, given China’s large population base and demographic structure, it is essential to strengthen primary and secondary prevention efforts among key populations, particularly males and the elderly.

To investigate the association between changes in frailty status and new-onset atrial fibrillation (AF).

Based on questionnaire data and anthropometric data collected from the baseline and second repeat surveys of the UK Biobank (UKB), frailty status was assessed by the Fried frailty phenotype, categorized as non-frailty, pre-frailty or frailty, and changes in frailty status were assessed by combining frailty status at baseline and at the second repeat survey. The association between change in frailty status and new-onset AF was assessed using a Cox proportional risk model, and subgroup analyses were performed according to frailty status at the time of the second repeat survey by sex, age, overweight, hypertension, dyslipidemia and diabetes.

A total of 56 394 study participants were included. In the non-frailty group, the risk of AF in those who progressed from non-frailty to pre-frailty or frailty was 1.23 times higher than in those who did not change (HR=1.23, 95% CI: 1.05-1.44, P=0.010). In the pre-frailty group, those who recovered to non-frailty and those who developed frailty had 0.74 (HR=0.74, 95% CI: 0.60-0.93, P=0.009) and 1.71 (HR=1.71, 95% CI: 1.16-2.54, P=0.007) times the risk of developing AF compared with the unchanged population, respectively. In the frailty group, the risk of AF was 0.38 times higher in those who returned to pre-frailty or non-frailty than in those who remained unchanged (HR=0.38, 95% CI: 0.16-0.87, P=0.022).

Worsening of frailty status increases the risk of AF occurrence, whereas recovery from frailty status decreases the risk of AF occurrence.

Toevaluate the association between insulin resistance and non-alcoholic fatty liver disease (NAFLD) using the insulin resistance metabolic score (METS-IR).

The study included 1 315 participants from the National Health and Nutrition Examination Survey (NHANES) database from 2017 to 2018, including 740 people with NAFLD and 575 people without NAFLD. Multivariate logistic regression analysis was used to assess the association between METS-IR and the risk of developing NAFLD. Restricted cubic spline regression analysis was performed to examine dose-response relationship after adjustment. Finally, receiver operatingcharacteristic curve analysis was conducted to evaluate the diagnostic performance of METS-IR for NAFLD.

The multivariate logistic regression analysis showed that each unit increase in METS-IR was associated with a 7% higher risk of developing NAFLD (OR=1.07; 95% CI:1.02-1.11). When categorizing METS-IR into quartiles, individuals in the highest quartile had a 3.35 times increased risk compared to those in the lowest quartile (OR=4.35;95% CI:1.38-13.75), showing a significant trend (P-trend <0.05). When the cutoff value is 39.767, the area under the ROC curve for METS-IR in diagnosing NAFLD was 0.788 (SE=0.0126; 95% CI:0.764-0.809).

There is a positive correlation between METS-IR and risk of developing NAFLD, suggesting that it could be used as a potential indicator in the diagnosis of NAFLD.

This study aimed to explore the causal relationship between Hashimoto's thyroiditis (HT) and ischemic stroke (IS) through Mendelian randomization (MR) and to identify key interacting genes using bioinformatics methods.

Single nucleotide polymorphisms (SNPs) significantly associated with exposure factors were selected as instrumental variables. The random-effects inverse-variance weighted method (IVW) was used as the main analysis method of MR analysis, and the odds ratio (OR) evaluated the causal association of HT and IS. The HT and IS datasets were downloaded from the GEO database. HT data were subjected to Weighted gene co-expression network analysis (WGCNA) and differential analysis and screened for overlapping genes between the two diseases by intersection of differential genes in IS. Hub genes were obtained by intersecting the top 20 genes in the five algorithms of the Cytoscape software cytoHubba package. LASSO regression was applied to identify key comorbidity genes.

IVW results showed that HT was a risk factor for the development of IS (OR=1.087, 95% CI: 1.001-1.181, P=0.048) while IS did not increase the risk of HT (OR=1.159, 95% CI: 0.899-1.494, P=0.256). Integration analysis of HT and IS data identified 102 overlapping genes. A total of 11 Hub genes were identified by the five algorithms. LASSO regression ultimately identified SERBP1 and WDR75 as key comorbidity genes.

This study demonstrates that HT may be a risk factor for the development of IS through MR analysis and identified SERBP1 and WDR75 as key comorbidity genes for HT with IS using bioinformatics methods, which may be the potential therapeutic target for HT patients with IS.

To descriptively analyze the epidemiological and pathogenetic characteristics of influenza (flu) in Chaoyang District from 2016 to 2023, and to provide a basis for scientific prevention and control of influenza.

Through the China Influenza Surveillance Information System, the etiology of influenza cases and influenza-like cases were collected, and epidemiological descriptions and statistical analysis were carried out, and χ² tests were used for comparison between groups.

A total of 210 738 influenza cases were reported in Chaoyang District from 2016 to 2023, with an average annual reported incidence rate of 829.81/100 000, and the highest incidence rate in the age group of 0-4 years (4 619.07/100 000). A total of 21 480 pharyngeal swab specimens of influenza-like cases were tested, with a positive detection rate of 14.14%. The positive rate of specimens in 2017-2018 was the highest (22.82%), and the positive rate in 2020-2021 was the lowest (0.77%), and the difference in the positive rate in different monitoring years was statistically significant (χ²=857.804, P<0.001). Influenza A viruses were mostly prevalent in winter, and influenza B viruses were mostly prevalent in winter and spring, and different subtypes of influenza viruses were prevalent at the same time or alternately. Of the 50 influenza outbreaks reported in Chaoyang District from 2016 to 2023, 96.00% occurred in primary and secondary schools.

The intensity of influenza epidemics in Beijing’s Chaoyang District varies in different monitoring years, and influenza A and B viruses show alternating epidemics. Children aged 0-14 years are the key population for influenza prevention and control, and schools are the key prevention and control sites.

To describe and analyze the disease burden of dengue fever in China from 1990 to 2021, and to provide evidence for the prevention and control of the disease.

Using the open data of the Global Burden of Disease (GBD) database from 1990 to 2021, this study analyzed the trend of dengue disease burden. The Joinpoint regression model was used to reflect the change trend of dengue burden, and the ARIMA time series model was used to predict the dengue disease burden in China in the next ten years.

The incidence and prevalence of dengue fever in China increased from 0.37/100 000 and 0.02/100 000 in 1990 to 1.88/100 000 and 0.11/100 000 in 2021, and the DALYs rate decreased from 0.30/100 000 in 1990 to 0.04/100 000 in 2021. From 1990 to 2021, the age-standardized incidence and prevalence of dengue fever in China increased from 0.38/100 000 and 0.02/100 000 to 2.01/100 000 and 0.12/100 000, and the age-standardized DALYs rate decreased from 0.32/100 000 to 0.05/100 000. The Joinpoint regression model showed that, the age-standardized incidence rate (AAPC=5.59%, P<0.05) and age-standardized prevalence rate (AAPC=5.57%, P<0.05) of dengue fever in China from 1990 to 2021 showed an increasing trend, while the age-standardized DALYs rate (AAPC=-5.84%, P<0.05) showed a decreasing trend. The ARIMA forecast model showed a small decline in the burden of dengue in China from 2022 to 2031.

In China, the incidence and prevalence of dengue fever and its age-standardized rate showed an increasing trend, while the DALYs rate and age-standardized DALYs rate showed a decreasing trend. The burden of dengue fever in China is still relatively heavy, so preliminary screening and health education of dengue fever should be strengthened, and corresponding preventive measures should be formulated according to the characteristics of dengue disease burden.

To evaluate the current status of health-related quality of life (HRQoL) and its influencing factors in patients with Wilson’s disease (WD), and to compare them with the standards of the general population in China.

A cross-sectional study of 123 patients with WD from July 14, 2023, to March 14, 2024, was conducted to assess the HRQoL using the EuroQol five-dimensional three-level questionnaire (EQ-5D-3L) and converted using the Chinese value set. The Tobit regression model was used to identify potential factors associated with HRQoL.

The health utility value of WD patients grouped by age was significantly lower than that of the general population (P<0.001). Patients also reported more health problems in all dimensions of EQ-5D-3L than in the general population (P<0.001). The Tobit regression analysis shows that per capita monthly income, low-copper diet, phenotypes, and mental health status are significantly correlated with health utility values.

Patients with WD have a worse HRQoL than the general population in China. The HRQoL of patients can be improved by advocating a scientific low-copper diet, raising health awareness, and paying more attention to the psychological conditions of patients with WD, especially neuropsychiatric patients.

To analyze the epidemiological characteristics of hepatitis E in Heilongjiang Province from 2010 to 2022, and to provide scientific basis and data support for the prevention and control of hepatitis E in Heilongjiang Province.

The data of reported cases of hepatitis E in Heilongjiang Province from 2010 to 2022 were collected. Descriptive epidemiological methods were used to describe the temporal, spatial and population distribution characteristics of cases of hepatitis E. Joinpoint regression model was used to analyze the trend of hepatitis E. and to calculate the Annual Percentage Change (APC).

From 2010 to 2022, the reported incidence of hepatitis E in Heilongjiang Province showed a decreasing trend, and the annual reported incidence was 1.27/100 000. There were reported cases of hepatitis E in every month, and the peak period of hepatitis E was from October to April of the following year. Hepatitis E cases were reported every year in all cities (places) of Heilongjiang Province, and the top five regions reported annual incidence were Qitaihe City (238/100 000), Hegang City (203/100 000), Shuangyashan City (194/100 000), Jixi City (156/100 000) and Yichun City (154/100 000). The reported incidence rates of both men and women decreased year by year, with APC of -8.41% (95% CI: -11.31%- -5.42%, P<0.001) for men and -5.22% for women (95% CI：-9.12% - -1.09%，P=0.013), the incidence of male was higher than that of female. The cumulative number of cases in the 45-55 age group was 1 430(30.45%). The results of occupation distribution showed that 1 380 cases (29.39%) were housework and unemployed, and 1 204 cases (25.64%) were farmers.

The reported incidence of hepatitis E in Heilongjiang Province from 2010 to 2022 shows a decreasing trend, but there arestill significant seasonal, regional and population characteristics. Winter and spring arethe peak of the incidence, and men, 45-65 years old age group, household workers and unemployed people and farmers arethe high incidence groups of hepatitis E. In the future, targeted health publicity activities should be carried out for key groups to promote hepatitis E vaccination, which is expected to further reduce the incidence of hepatitis E in Heilongjiang Province.

To investigate the association between long-term exposure to atmospheric pollutants (PM_2.5 and NO₂) and the risk of developing type 2 diabetes, and the mediating role of abnormal lipid metabolism in the association.

Based on a China Multi-Ethnic Cohort and data collected from 2018—2019 on 15 573 participants in Sichuan Province and hospital discharge data in Sichuan Province from 2018—2022. Logistic regression and Cox proportional risk model were used to investigate the two-by-two associations between PM_2.5 and NO₂, dyslipidemia, and type 2 diabetes; regression-based causal mediator model was used to explore the mediating role of dyslipidemia in the association between PM_2.5 and NO₂ and type 2 diabetes.

For each 1 standard deviation (SD) increase in atmospheric PM_2.5 and NO₂ concentrations, the population Odds ratio (OR) (95% CI)for dyslipidemia was 1.042 (1.002-1.084) and 1.047 (1.003-1.093), respectively and the Hazard ratio (HR)(95% CI) for developing type 2 diabetes was 1.159 (1.044-1.288) and 1.330 (1.173-1.509), respectively. Patients with dyslipidemia had a higher risk of developing type 2 diabetes with a HR(95% CI) of 1.777 (1.418-2.227). Dyslipidemia partially mediated the association of chronic exposure to PM_2.5 and NO₂ on developing type 2 diabetes mellitus, with natural indirect effects HR (95% CI) of 1.004 (1.000 - 1.008) and 1.005 (1.000 - 1.010), respectively, corresponding to 3.1% and 2.0% of the total effect, respectively.

Long-term exposure to PM_2.5 and NO₂ was positively associated with dyslipidemia and increased risk of type 2 diabetes, and dyslipidemia partially mediated the association of air pollution on the risk of type 2 diabetes.

To investigate the mediating effects and critical influences of triglyceride glucose (TyG) and triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) indices on the association of unhealthy lifestyle and hypertension in an occupational population, and to provide a scientific basis for hypertension in occupational populations.

A cross-sectional survey design was employed based on data from the Southwest Occupational Population Cohort. Unhealthy lifestyle was assessed based on scoring for smoking, alcohol consumption, unhealthy dietary patterns, low physical activity, and abnormal BMI. A multivariable logistic regression model was used to analyze the association between the unhealthy lifestyle score and hypertension. Causal mediation analysis was employed to estimate the mediating effects of TyG and TG/HDL-C. Additionally, network analysis was conducted to explore the correlation between among unhealthy lifestyle, TyG, TG/HDL-C, and hypertension.

A total of 24 545 study participants were included, with an average age of (37.37±10.60) years. Regression analysis revealed that the risk of hypertension increased with the number of unhealthy lifestyle factors. Compared with those with no unhealthy lifestyle factors, individuals with all five unhealthy lifestyle factors simultaneously had a 3.06-fold risk of developing hypertension (95% CI: 2.54-3.69). Mediation analysis indicated that TyG and TG/HDL-C mediated 34.25% and 6.64% of the effects, respectively, linking unhealthy lifestyle and hypertension. Among them, TyG emerged as the primary mediating factor and exhibited the highest bridge strength centrality in the network constructed for unhealthy lifestyle, TyG, TG/HDL-C, and hypertension.

Unhealthy lifestyle is associated with an increased risk of developing hypertension and shows a cumulative effect, and TyG is an important mediator and a key node in the network, suggesting that interventions should be carried out to target unhealthy lifestyle and TyG, which may contribute to hypertension prevention.

To understand the status of knowledge-attitude-practices (KAP) of meal replacement food among college students in Hainan Province.

From April 2023 to February 2024, a stratified random cluster sampling method was used to select 2,451 college students from three universities in Hainan Province for a questionnaire survey. The knowledge and attitude levels of students with different characteristics were analyzed by T-test or ANOVA, and multiple response analysis was used for multiple choice questions in practice.

Knowledge of meal replacement food scored (5.67±2.26) (51.5%), attitude (10.85±4.28) (60.3%). 77.7% of university students wanted to continue consuming and try meal replacement food. And 73.5% of students accepted meal replacement food at a price of ‘≤15 RMB/meal’. The college students were mainly concerned about the nutritional balance (21.1%) and safety (19.2%) of the products. Their preferred product types were mainly meal-replacement biscuits (19.2%) and meal-replacement shakes (18.7%). The key considerations for purchasing meal replacement food were brand awareness of the product (18.7%) and price (16.5%). The channels for learning about meal replacement food were mainly the Internet or self-media (36.3%), and purchasing them was mainly from online shopping malls or supermarkets (32.0%).

College students in Hainan Province have a low level of knowledge about meal replacement food but have a positive attitude. They have a high willingness to consume meal replacement food. When shopping, the main factors they consider are the nutritional balance and safety of the product, brand awareness and price. They mainly obtain information about meal replacement food and purchase it online.

To assess the dietary nutrition status of patients with liver cirrhosis and to explore the relationship between dietary fiber and micronutrient intake and the prevalence of sarcopenia, providing a theoretical foundation for sarcopenia prevention in this patient population.

The current study was conducted among patients with liver cirrhosis in the gastroenterology department of Sichuan Provincial People’s Hospital by purposive sampling from September 2022 to December 2023. The 24-hour dietary recall method was used to collect information on the types and quantities of food consumed by the patients. Whole-body muscle mass was measured using bioelectrical impedance analysis (BIA), and sarcopenia was diagnosed in combination with handgrip strength and 6-meter walking speed. Multiple logistic regression analysis was used to analyze the correlation between energy and nutrient intake and sarcopenia.

A total of 203 patients with cirrhosis were included in the analysis, including 40.4% with sarcopenia. Negative correlations were observed between sarcopenia prevalence and the intake of dietary fiber (OR=0.85, 95% CI: 0.75-0.96), vitamin A (OR=0.87, 95% CI: 0.77-0.98), vitamin C(OR=0.91, 95% CI: 0.86-0.97), potassium (OR=0.88, 95% CI: 0.80-0.97), magnesium (OR=0.93, 95% CI: 0.87-0.99) and copper (OR=0.31, 95% CI: 0.14-0.67). Additionally, an interactive effect was identified between age and the intake of vitamin C, phosphorus, and iron (Pfor interaction<0.05).

Dietary fiber and micronutrient intake are closely related to sarcopenia in patients with cirrhosis. It is crucial to enhance nutritional education for patients with liver cirrhosis and their families, and to consider the use of nutritional supplements when necessary to prevent sarcopenia, particularly in the elderly.

To investigate the contamination levels of per- and polyfluoroalkyl substances (PFAS) in livestock meat, eggs, and dairy products in Chongqing, and to assess the exposure risk of population to PFAS through the consumption of these foods.

45 livestock meat, 45 eggs and 30 dairy products samples were randomly collected to determine 23 types of PFAS in Chongqing. Based on estimated food consumption data for Chongqing population in 2022, the dietary PFAS exposure risk was evaluated.

The detection rates of PFAS in the three categories of animal-derived foods in Chongqing were as follows: eggs > livestock meat > dairy products. Perfluorobutanoic acid (PFBA) was identified as the predominant PFAS, with detection rates of 95.6% in eggs, 37.8% in livestock meat, and 10.0% in dairy products. Both livestock meat and eggs were found to contain perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS), with PFOA detection rates (33.3% in eggs, 31.1% in livestock meat) higher than those of PFOS (2.2% in eggs, 4.4% in livestock meat). The total average exposure to PFAS through the consumption of these three animal-derived food categories for the population over 3 years old in Chongqing was 6.75-32.81 ng/(kg·week). The average exposure levels of PFOA, PFOS, and Σ₄ PFASs (PFOA, PFOS, perfluorohexane sulfonic acid, and perfluorononanoic acid) did not exceed the tolerable weekly intake (TWI) recommended by the European Food Safety Authority (EFSA). However, at high contamination levels of PFAS, the exposure levels of Σ₄ PFASs for children aged 3-5 and 6-11 ranged from 5.84 to 7.09 ng/(kg·week), which exceeded the TWI Σ₄ PFASs by 32.7%-61.1%.

PFAS were detected in all three categories of animal-derived foods in Chongqing, with eggs contributing the most. The average PFAS exposure from these foods for individuals over 3 years old do not pose a health risk, but high PFAS contamination presents a certain health risk to young children in Chongqing.

To explore the short-term effects of personalized nutritional support on serum albumin (ALB) levels in middle-aged and elderly patients using real-world data and multiple factors.

A retrospective study was conducted on patients aged 50 and above who were at nutritional risk in the nutrition consultation cases at the Second People’s Hospital of Chengdu from August 2020 to June 2024. Clinical data and laboratory test results were collected, and patients were grouped according to different nutritional intervention methods. The ALB decline of patients after 1week of nutritional intervention was analyzed, and the impact of different nutritional intervention methods on ALB decline was evaluated using a logistics regression model.

A total of 1 136 patients were included in the study, with 627 patients showing a decrease in ALB and 509 patients showing no decrease in ALB. Univariate analysis revealed statistically significant differences in age, tube feeding, nutritional intervention methods, chronic kidney disease, cerebral infarction, other site infections, and tumor morbidity. Multivariate analysis was conducted with the dietary guidance group as the control group. Oral nutritional supplementation (OR=0.683, 95%CI: 0.500-0.933), personalized nutritional support intervention (OR=0.409, 95% CI: 0.279-0.601), and other site infections (OR=0.776, 95% CI: 0.607-0.994) were protective factors for ALB decline; Tube feeding (OR=1.766, 95% CI: 1.317-2.369) and cerebral infarction (OR=1.866,95% CI: 1.424-2.444) are risk factors for the decline of ALB.

Personalized nutritional support can effectively prevent the decline of serum albumin in middle-aged and elderly hospitalized patients, and has potential clinical value.

To analyze the disease burden and trend of anxiety disorders in adolescents aged 10-24 in China from 1990 to 2021.

Based on the 2021 global burden of disease (GBD) database, the incidence, prevalence, and disability-adjusted life years (DALYs) rate of anxiety disorders in adolescents aged 10-24, along with their corresponding standardized rates, were extracted as indicators of disease burden. With 1990 as the baseline, the overall and gender- and age-specific changes in these indicators in 2021 were analyzed. Joinpoint regression analysis was used to dynamically analyze the changes in these three disease burden indicators from 1990 to 2021. The grey prediction model GM(1,1) was employed to estimate the disease burden trend of anxiety disorders in adolescents over the next decade.

In 2021, incident case number, prevalent case number, and DALYs of anxiety disorders in adolescents were 1 637 600, 10 267 500, and 12 793 000, respectively, which decreased by 30.51%, 33.91%, and 33.59%, as compared with 1990; however, the standardized incidence, standardized prevalence, and standardized DALYs rate of anxiety disorders in adolescents were 451.49/100 000, 3 481.74/100 000, and 418.95/100 000, respectively, which represented an increase of 2.29%, 2.03%, and 2.37%, as compared to 1990; there are differences in the disease burden for anxiety disorders between genders, which were manifested that girls are more likely to suffer from anxiety disorders than boys; and the standardized incidence of anxiety disorders among adolescents between the ages of 10-14 years was higher, while the standardized prevalence and the standardized DALYs rate among them between the ages of 15-19 years were higher. The Joinpoint regression model showed that the standardized incidence, standardized prevalence, and standardized DALYs rate of anxiety disorders in adolescents aged 10-24 increased from 1990 to 2021, with a larger increase from 2019 to 2021. The grey prediction model indicated that by 2031, the standardized incidence, standardized prevalence, and standardized DALYs rate would reach 559.44/100 000, 3 597.01/100 000, and 430.65/100 000, respectively.

The disease burden of anxiety disorders in adolescents aged 10-24 years is concerning, and interventions for anxiety disorders should be performedinadolescents of different genders and ages.

To explore the relationship between cardiovascular health (CVH) and depression in postmenopausal women.

Utilizing data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018, logistic regression analysis was conducted to examine the association between CVH and depression in postmenopausal women. Restricted cubic spline (RCS) models were employed to reveal potential nonlinear associations between the two.

After adjusting the covariates, the risk of depression was significantly reduced in the moderate and high CVH groups (OR=0.50, 95% CI: 0.34-0.72; OR=0.25, 95% CI: 0.07-0.90). A significant nonlinear association was also observed between CVH and depression (P-overall<0.001, P-nonlinear<0.001). Subgroup analysis results showed a significant negative association between high levels of CVH and depression among 18 to 59 years of age (OR=0.12, 95% CI: 0.02-0.55), non-Hispanic blacks (OR=0, 95% CI: 0.00-0.00), other races (OR=0.14, 95% CI: 0.04-0.55), below high school (OR=0.06, 95% CI: 0.01-0.33), above high school (OR=0.12, 95% CI: 0.02-0.89), married/cohabiting (OR=0.06, 95% CI: 0.01-0.25), overweight/obese (OR=0.06, 95% CI: 0.02-0.21), and non-users of hormone replacement therapy (OR=0.12, 95% CI: 0.04-0.42).

A significant negative correlation exists between CVH levels and the risk of depression in postmenopausal women. This underscores the importance of CVH in the mental health of postmenopausal women. Healthcare providers should prioritize the potential psychological impact of CVH on postmenopausal women and incorporate it into comprehensive strategies for depression prevention and intervention.

To evaluate the impact of family doctor contract on the utilization of services in primary medical and health institutions.

Logit model and propensity score matching method were used for analysis.

The signing rate of family doctors was 75.8%, and the service utilization rate of primary medical and health institutions was 65.28%. The propensity scores matching results showed that after kernel matching and radius matching, ATT of family doctor contract on utilization of primary medical and health institutions was 0.052 4 and 0.068 3. The contracted services of family doctors had increased the utilization rate of primary medical and health institutions of residents with chronic diseases by 13.84%. The contract services of family doctors had no statistical significance on the utilization rate of primary medical and health institutions of non-chronic residents. The contracted services of family doctors had increased the average utilization rate of elderly residents to primary medical and health institutions by 9.25%. The contracted services of family doctors increased the average utilization rate of non-elderly residents to primary medical and health institutions by 5.98%.

The signing rate of family doctors and the utilization rate of primary medical and health institutions are both good. Contracted family doctors can promote the utilization of primary medical and health institutions by residents, and the contracted service of family doctors is more obvious to the utilization of primary medical and health institutions by people with chronic diseases and the elderly.

To assess the impact of the utilization of basic public health services on residents’ willingness to the first choice of medical institutions for treatment.

This study utilized information from a resident survey conducted by the Provincial Natural Science Foundation Project. The project adopted a multi-stage sampling method and utilized the resident household survey questionnaire, which was conducted from January 2020 to October 2021 in Shandong Province. A total of 2 917 valid questionnaires were obtained, and the survey respondents were residents aged 15 and above. Binary logistic regression model and propensity score matching (PSM) method were used for analysis.

The proportion of residents who have established health records was 63.9%, and the utilization rate of health education was 49.6%.83.8% respondents preferred to choose primary healthinstitutions for treatment. The results of propensity score matching showed that under the three methods of kernel matching, radius matching, and nearest neighbor matching, the average treatment effect on the treated (ATT) for the utilization of health education in residents’ willingness to the first choice of healthcare institutions were 0.084 3, 0.088 9, and 0.090 3, respectively.

The consultation rate of primary health institutions is performing well. Essential public Health services usage had a positive effect on residents’ willingness to choose primary health institutions for medical treatment. It is recommended to increase constructive investment in primary health institutions, enhance the service supply capacity of providers and strengthen the relevanceof basic public health services for demanders.

To investigate the association between smoking behavior and diabetes among adult hypertensive patients aged 20 years and above.

Using annual health examination data from the National Basic Public Health Service Program for hypertensive patients in Jianye District, Nanjing (2019-2023), logistic regression was employed to analyze the association between smoking behavior and diabetes in adult hypertensive patients aged≥20 years. Restricted cubic spline curves were used to explore the dose-response relationships between daily cigarette consumption, smoking duration, and smoking index with diabetes.

Among 55 128 participants, 14 102 were identified as having diabetes. Multivariable logistic regression analysis showed that, compared with non-smokers, former smokers (OR＝1.17, 95% CI: 1.01-1.35) and current smokers (OR＝1.18, 95% CI: 1.10-1.26) were positively associated with diabetes. Compared with non-smokers, hypertensive patients who smoked≥30 cigarettes/day, had a smoking duration of ≥50 years, or had a smoking index of ≥20 pack-years showed higher proportions of diabetes, with corresponding OR values (95% CI) of 1.66 (1.23-2.21), 1.13 (1.01-1.26), and 1.21 (1.12-1.31). A U-shaped dose-response relationship was observed between smoking duration and diabetes prevalence (non-linear P＝0.029). Subgroup analysis revealed that the association between smoking status and diabetes was more pronounced in younger age groups (interaction P<0.050).

Among hypertensive patients aged≥20 years, smoking behavior is positively associated with diabetes prevalence, and smoking duration shows a U-shaped association with diabetes.

To study the coordinated development of healthcare resource allocation and service utilization in Jiangsu Province.

Using various statistical methods, its spatio-temporal evolution characteristics and driving factors were profiled.

The degree of coupling coordination showed an overall upward trend during 2015-2021, which declined in 2020 but quickly rebounded in the following year; the province’s entropy-weighted TOPSIS composite index was basically below 0.5, with Nanjing, Wuxi, and Suzhou’s composite scores significantly higher than those of other cities, and the service utilization index as a whole was significantly higher than that of the resource allocation index; Lianyungang, in terms of the value of the degree of relative development, was much higher than that of the province’s other cities, presenting an extremely significant resource over-advancement type; the influence factors selected in this paper can be better realistic and statistically significant in terms of selection objectives and significance.

The coordinated development of medical resource allocation and service utilization of health institutions in prefecture-level cities in Jiangsu Province has obvious geographical boundaries of spatial and temporal changes,2015-2021. In addition, although the better economically developed areas performs better than the relatively less economically developed areas in terms of healthcare resource allocation and service utilization but shows a regression in the composite scores, healthcare resource allocation may be an entry point for the balanced development of the province. The study also find that factors such as population distribution and level of economic development have a significant impact on the degree of coordination over the seven years.

To measure and evaluate the compatibility between the level of outpatient chronic special disease coverage under the basic health insurance and the level of healthcare resource service utilization in Shanxi Province, so as to provide reference for the coordinated development of the level of outpatient chronic special disease coverage under the basic health insurance and the level of healthcare resource service utilization in Shanxi Province.

Taking 11 cities in Shanxi Province as the study object, the fitness between the two was measured using the entropy weight-TOPSIS method and gray correlation analysis.

From the perspective of utilization level, the numerical intervals of breadth and depth of healthcare resource service utilization in Shanxi Province were 0.161-0.751 and 0.000-1.000, respectively, with a wide span of the intervals; from the perspective of protection level, the numerical intervals of breadth, width, and sustainability of outpatient chronic and special disease protection of the basic healthcare insurance in Shanxi Province were 0.761-0.994, respectively, 0.518-0.938 and 0.445-1.000; Taiyuan City had a comprehensive score of 0.734, which was the city with the highest degree of suitability.

This can be done by consolidating the stability of basic medical and healthcare human resources, enhancing the balance of medical resource allocation, strengthening the synergy between the breadth and depth of healthcare insurance coverage, and reinforcing the linkage between healthcare insurance policies and healthcare resources, so as to improve the level of coverage for outpatient chronic and special illnesses under the basic healthcare insurance scheme in Shanxi Province, as well as the level of utilization of healthcare resources and the degree of appropriateness of the two.

To explore the chain mediating roles of adult socioeconomic status and depression in the relationship between childhood friendship experiences and cognitive function in the elderly.

Based on the panel data of China Health and Retirement Tracking Survey (CHARLS) in 2014, 2018, and 2020, Partial correlation analysis was used to explore the correlation among childhood friendship experience, adult socioeconomic status, depression, and cognitive function of the elderly. The SPSS’s Process 4.1macro program was used to analyze the chain mediation effect, and Bootstrap method was used to verify the mediation variables.

The direct effect of childhood friendship experiences on cognitive function in the elderly was significant(β=0.226, 95% CI: 0.109-0.343). The simple mediating effects of adult socioeconomic status and depression between childhood friendship experiences and cognitive function were significant (β=0.095, 95% CI: 0.067-0.126; β=0.023,95% CI:0.009-0.040). The chain mediating effect of adult socioeconomic status and depression between childhood friendship experiences and cognitive function was significant (β=0.006, 95% CI:0.003-0.010). The total mediating effect and the chain mediating effect respectively account for 35.33% and 1.71% of the total effect.

Childhood friendship experience can directly and positively influence cognitive function in the elderly, and also can influence cognitive function in the elderly through the separate and chain mediating effects of socioeconomic status and depression in adulthood.

To investigate the prevalence and influencing factors of insufficient sleep and excessive sleep among Chinese adults from 2010 to 2020, thereby providing a basis for policies aimed atimproving sleep conditions for adults.

Data from the China Family Panel Studies (CFPS) between 2010 and 2020 were utilized. Self-reported nighttime sleep duration was measured, with less than 7 hours classified as insufficient sleep and 9 hours or more classified as excessive sleep. Chi-square tests and Poisson regression models were employed to analyze the frequency and influencing factors.

A total of 9,505 individuals were included in the study. The results indicated that 45.84% of adults reported never experiencing insufficient sleep, while 48.27% of adults reported never experiencing excessive sleep. Poisson regression analysis indicated that females (RR=1.073, 95% CI: 1.028-1.119), increasing age (RR=1.404, 95% CI: 1.305-1.511; RR=1.887, 95% CI: 1.755-2.030; RR=2.092, 95% CI: 1.934-2.263), urban areas (RR=1.219, 95% CI: 1.178-1.260), eastern region (RR=1.346, 95% CI: 1.287-1.409) and central region (RR=1.430, 95% CI: 1.370-1.492), general health (RR=1.114, 95% CI: 1.075-1.154) and unhealthy status (RR=1.164, 95% CI: 1.109-1.221), and higher depression symptom scores (RR=1.018, 95% CI: 1.014-1.022) are risk factors for increased frequency of insufficient sleep. Married/cohabiting (RR=0.894, 95% CI: 0.816-0.980), high school (RR=0.951, 95% CI: 0.904-1.000) and college or above (RR=0.894, 95% CI: 0.828-0.965), BMI<18.5 kg/m² (RR=0.932, 95% CI: 0.871-0.996) are protective factors against increased frequency of insufficient sleep. Aged 30-44 years (RR=0.757, 95% CI: 0.712-0.806) and aged 45-59 years (RR=0.834, 95% CI: 0.783-0.888), married/cohabiting (RR=0.920, 95% CI: 0.847-0.999), junior high school (RR=0.822, 95% CI: 0.789-0.856), high school (RR=0.667, 95% CI: 0.627-0.709) and college or above (RR=0.416, 95% CI: 0.371-0.467), urban (RR=0.737, 95% CI: 0.709-0.766), eastern region (RR=0.698, 95% CI: 0.667-0.730) and central region (RR=0.768, 95% CI: 0.737-0.799) are protective factors against increased frequency of excessive sleep, while unhealthy (RR=1.100, 95% CI: 1.046-1.158) is a risk factor for increased frequency of excessive sleep.

The frequency of insufficient sleep and excessive sleep among Chinese adults is closely related to various sociodemographic factors, physical and mental health conditions, and smoking habits. The government and all sectors of society should prioritize high importance on the sleep conditions of adults and take effective measures to improve sleep health literacy among adult population, ultimately promoting overall health and well-being.

To investigate the effect of subchronic benzo[a]pyrene (BaP) toxicity on tau protein phosphorylation and mild cognitive dysfunction in HAPOE4 mice.

24 male C57BL/6 wild-type and HAPOE4 mice were used in this study, 12 of each type. The mice were randomly divided into three groups: vehicle group (olive oil), low-dose BaP-treated group (2.5 mg/kg), and high-dose BaP-treated group (6.25 mg/kg), with 8 mice in each group. The mice were injected with BaP via the peritoneal cavity and weighed before and after injection. The exposure period was 90 days. The Morris water maze test was used to detect the mice’s learning and memory abilities, the tail suspension test was used to detect the mice’s depressive state, the silver glycinate dip staining was used to observe the neurofibrillary tangles in mouse brain tissue sections, and immunohistochemistry was used to detect the protein expression of APOE, LRP1, tau, p-tau (Ser199), and p-tau (Ser396) in the hippocampus of the mice. ANOVA was used for the comparison of the above count data, the two-sample t-test was used for the comparison between genotypes, and the factorial analysis method was used to verify the interaction between the treatment and genotype.

The results of the water maze behavior experiment: the results of the positioning navigation experiment: the escape latency length of each group decreased with the increase of training days, and the escape latency of HAPOE4 mice with the same dose of poison was higher than that of WT type. There were differences in escape latency between groups on the 4th and 5th days. Both genotype and toxicity could lead to a decrease in the number of crossings of the platform and the residence time in the target quadrant, but there was no significant interaction between genotype and toxicity. The results of tail suspension experiment: genotype and poisoning had an interactive effect on the immobility time of mice, and both of them would lead to an increase in the immobility time of mice. The results of silver glycinate dipping experiment: both genotype and poisoning would cause the dyeing to deepen and increase in mice. The results of immunohistochemistry showed that genotype and poisoning had an interactive effect on the MOD values of APOE, LRP1, tau, p-tau (ser199) and p-tau (ser396), and all of them led to an increase in MOD values.

BaP and APOE4 genes affected spatial learning and memory ability and depression in mice, and BaP and APOE4 genes interacted with the immobility time of tail suspension experiments, indicating that the combined effect of BaP and APOE4 genes may have an effect on the depressed state of mice; and BaP and APOE4 genes interacted with abnormal phosphorylation of tau protein in mice, indicating that subchronicBaP infection could lead to tau protein phosphorylation and mild cognitive dysfunction in mice with HAPOE4 genotype, which may be caused by the combined effect of BaP and APOE4 genes resulting in the increase of APOE and LRP1 in mice.

To explore the relationship between muscle mass and disability in the elderly.

This study is based on the tracking survey data from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) from 2008 to 2018, utilizing Cox regression and constructing restricted cubic spline models to analyze the dose-response relationship between muscle mass and disability in the elderly.

A total of 2 165 elderly patients were followed up 4 times for an average of 10 years. Among them, 603 (27.8%) developed disability. After adjusting for confounders, muscle mass affected disability in the elderly(HR=0.879,95%CI:0.822-0.939). The RCS results showed that the association between muscle mass and disability risk in older adults was non-linear in both older men(P_{overall trend}<0.05,P_non-linear<0.05) and older women(P_{overall trend}<0.05, P_non-linear<0.05). It is suggested that ASMI level of 7.2 (kg/m²) and above should be maintained in elderly men and 5.2 (kg/m²) and above in elderly women.

Muscle mass is associated with disability in the elderly. Maintenance or improvement of muscle mass can improve the quality of life in the elderly.

To explore the impact of hypertension diagnosis and measured blood pressure on depressive symptoms in middle-aged and older adults, providing evidences for depression prevention in this population.

Data from four waves (2013-2020) of the China Health and Retirement Longitudinal Study (CHARLS) were analyzed, including a total of 4 106 participants aged 45 and older. A linear mixed-effects model was used to examine the effect of hypertension on depressive symptoms.

In the univariate analysis, compared to respondents who with undiagnosed hypertension (32.64%), those diagnosed with hypertension showed a higher proportion of depressive symptoms (33.51%). After adjusting for covariates in the multivariate analysis, diagnosed hypertension (OR=1.05, P=0.003) remained associated with a higher risk of depression. However, elevated blood pressure without diagnosis did not have a significant effect on depressive symptoms (OR=0.99, P=0.454).

Hypertension diagnosis is associated with an increased risk of depressive symptoms among middle-aged and elderly individuals. Therefore, clinicians are advised to monitor not only blood pressure control in hypertensive patients but also their mental health, providing psychological support to prevent emotional issues that may arise from the diagnosis, thus enhancing patients’ quality of life.

To analyze the survival time of HIV/AIDS patients in Hebei province, and to explore the influencing factors, so as to provide basis for improving the quality of life of patients.

Retrospective cohort study was used to collect information of HIV/AIDS in Hebei province from 1989 to 2022. Life table was used to describe the survival status. Log-rank test and Cox regression were used to analysis the influencing factors of survival time.

There were 22 563 cases of HIV/AIDS, with males accounting for 88.7% and homosexual transmission accounting for 62.1%. The average age at the time of discovery was 38.1±13.9. The 1-year,3-year,5-year and 10-year cumulative survival rates of HIV/AIDS patients were 91.46%,88.03%, 85.56% and 79.34%. The risk of death in female was lower than that in male (HR=0.824, 95% CI: 0.713-0.953). The risk of death in patients receiving antiviral treatment was lower than in those who have not received treatment (HR=0.079, 95% CI:0.069-0.091). Baseline CD4 cell counts ranging from 200 to 349 cells/μl (HR=0.451, 95% CI: 0.222-0.914), 350 to 499 cells/μl (HR=0.354, 95% CI: 0.175-0.719), and above 500 cells/μl (HR=0.342, 95% CI: 0.168-0.693) have a lower risk of death. People over 50 years old have a higher risk of death (HR=2.585, 95% CI: 2.143-3.117). Among the sources of case samples, the case death risk of those from HIV testing and counseling was lower than the cases from medical institutions(HR=0.444,95% CI: 0.387-0.510). And the case death risk of those from detainees was lower than the cases from medical institutions(HR=0.417,95% CI: 0.297-0.584).

Gender, educational level, baseline CD4 cell count, sample source, age at discovery, and antiviral treatment were influencing factors on survival time. Early detection, early treatment, strengthening the publicity and education of key groups, paying attention to the elderly cases over 50 years old, and strengthening medical personnel to actively carry out AIDS testing and consulting services have a positive effect on prolonging the survival time of HIV/AIDS cases.

To explore the association between depressive symptoms and all-cause mortality and cardiovascular disease mortality in patients with chronic comorbidity.

Single-factor analysis was performed using chi-square test, and the relationship between PHQ-9 scores, depressive symptoms, and all-cause mortality as well as cardiovascular disease mortality in patients of multimorbidity were analyzed using COX proportional hazards regression model.

The results of the multivariable COX regression showed that as compared to those without depressive symptoms, patients of multimorbidity with depressive symptoms had HR=1.665 (95% CI: 1.135-2.444) for all-cause mortality and HR=2.090 (95% CI: 1.216-3.594) for cardiovascular mortality. With an increase in PHQ-9 score, the risks of all-cause mortality (HR=1.060, 95% CI: 1.014-1.107) (P_trend<0.010) and cardiovascular mortality (HR=1.072, 95% CI: 1.005-1.144) (P_trend<0.010) gradually increased. Subgroup analysis by urban and rural areas showed that there was an interaction between different urban and rural depressive symptoms on the risk of all-cause mortality in patients of multimorbidity (P interaction <0.05). In rural areas, patients of multimorbidity with depressive symptoms had 2.637 times (95% CI: 1.639-4.243) higher risk of all-cause mortality and 3.207 times (95% CI: 1.686-6.101) higher risk of cardiovascular mortality compared to those without depressive symptoms. With an increase in PHQ-9 score, the risks of all-cause mortality (P_trend<0.001) and cardiovascular mortality (P_trend<0.001) also increased. However, these associations were not significant in urban areas.

Depressive symptoms is a risk factor for all-cause mortality and cardiovascular disease mortality in patients of multimorbidity, and more attention should be paid to psychological interventions for patients of multimorbidity in rural areas to reduce the risk of mortality in patients of multimorbidity.