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To evaluate the current status of health-related quality of life (HRQoL) and its influencing factors in patients with Wilson’s disease (WD), and to compare them with the standards of the general population in China.
A cross-sectional study of 123 patients with WD from July 14, 2023, to March 14, 2024, was conducted to assess the HRQoL using the EuroQol five-dimensional three-level questionnaire (EQ-5D-3L) and converted using the Chinese value set. The Tobit regression model was used to identify potential factors associated with HRQoL.
The health utility value of WD patients grouped by age was significantly lower than that of the general population (P<0.001). Patients also reported more health problems in all dimensions of EQ-5D-3L than in the general population (P<0.001). The Tobit regression analysis shows that per capita monthly income, low-copper diet, phenotypes, and mental health status are significantly correlated with health utility values.
Patients with WD have a worse HRQoL than the general population in China. The HRQoL of patients can be improved by advocating a scientific low-copper diet, raising health awareness, and paying more attention to the psychological conditions of patients with WD, especially neuropsychiatric patients.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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