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To investigate the association between long-term exposure to atmospheric pollutants (PM2.5 and NO2) and the risk of developing type 2 diabetes, and the mediating role of abnormal lipid metabolism in the association.
Based on a China Multi-Ethnic Cohort and data collected from 2018—2019 on 15 573 participants in Sichuan Province and hospital discharge data in Sichuan Province from 2018—2022. Logistic regression and Cox proportional risk model were used to investigate the two-by-two associations between PM2.5 and NO2, dyslipidemia, and type 2 diabetes; regression-based causal mediator model was used to explore the mediating role of dyslipidemia in the association between PM2.5 and NO2 and type 2 diabetes.
For each 1 standard deviation (SD) increase in atmospheric PM2.5 and NO2 concentrations, the population Odds ratio (OR) (95% CI)for dyslipidemia was 1.042 (1.002-1.084) and 1.047 (1.003-1.093), respectively and the Hazard ratio (HR)(95% CI) for developing type 2 diabetes was 1.159 (1.044-1.288) and 1.330 (1.173-1.509), respectively. Patients with dyslipidemia had a higher risk of developing type 2 diabetes with a HR(95% CI) of 1.777 (1.418-2.227). Dyslipidemia partially mediated the association of chronic exposure to PM2.5 and NO2 on developing type 2 diabetes mellitus, with natural indirect effects HR (95% CI) of 1.004 (1.000 - 1.008) and 1.005 (1.000 - 1.010), respectively, corresponding to 3.1% and 2.0% of the total effect, respectively.
Long-term exposure to PM2.5 and NO2 was positively associated with dyslipidemia and increased risk of type 2 diabetes, and dyslipidemia partially mediated the association of air pollution on the risk of type 2 diabetes.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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