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To investigate the association between changes in frailty status and new-onset atrial fibrillation (AF).
Based on questionnaire data and anthropometric data collected from the baseline and second repeat surveys of the UK Biobank (UKB), frailty status was assessed by the Fried frailty phenotype, categorized as non-frailty, pre-frailty or frailty, and changes in frailty status were assessed by combining frailty status at baseline and at the second repeat survey. The association between change in frailty status and new-onset AF was assessed using a Cox proportional risk model, and subgroup analyses were performed according to frailty status at the time of the second repeat survey by sex, age, overweight, hypertension, dyslipidemia and diabetes.
A total of 56 394 study participants were included. In the non-frailty group, the risk of AF in those who progressed from non-frailty to pre-frailty or frailty was 1.23 times higher than in those who did not change (HR=1.23, 95% CI: 1.05-1.44, P=0.010). In the pre-frailty group, those who recovered to non-frailty and those who developed frailty had 0.74 (HR=0.74, 95% CI: 0.60-0.93, P=0.009) and 1.71 (HR=1.71, 95% CI: 1.16-2.54, P=0.007) times the risk of developing AF compared with the unchanged population, respectively. In the frailty group, the risk of AF was 0.38 times higher in those who returned to pre-frailty or non-frailty than in those who remained unchanged (HR=0.38, 95% CI: 0.16-0.87, P=0.022).
Worsening of frailty status increases the risk of AF occurrence, whereas recovery from frailty status decreases the risk of AF occurrence.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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