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This study aimed to explore the causal relationship between Hashimoto's thyroiditis (HT) and ischemic stroke (IS) through Mendelian randomization (MR) and to identify key interacting genes using bioinformatics methods.
Single nucleotide polymorphisms (SNPs) significantly associated with exposure factors were selected as instrumental variables. The random-effects inverse-variance weighted method (IVW) was used as the main analysis method of MR analysis, and the odds ratio (OR) evaluated the causal association of HT and IS. The HT and IS datasets were downloaded from the GEO database. HT data were subjected to Weighted gene co-expression network analysis (WGCNA) and differential analysis and screened for overlapping genes between the two diseases by intersection of differential genes in IS. Hub genes were obtained by intersecting the top 20 genes in the five algorithms of the Cytoscape software cytoHubba package. LASSO regression was applied to identify key comorbidity genes.
IVW results showed that HT was a risk factor for the development of IS (OR=1.087, 95% CI: 1.001-1.181, P=0.048) while IS did not increase the risk of HT (OR=1.159, 95% CI: 0.899-1.494, P=0.256). Integration analysis of HT and IS data identified 102 overlapping genes. A total of 11 Hub genes were identified by the five algorithms. LASSO regression ultimately identified SERBP1 and WDR75 as key comorbidity genes.
This study demonstrates that HT may be a risk factor for the development of IS through MR analysis and identified SERBP1 and WDR75 as key comorbidity genes for HT with IS using bioinformatics methods, which may be the potential therapeutic target for HT patients with IS.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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