To analyze the epidemiological characteristics of hepatitis E in Heilongjiang Province from 2010 to 2022, and to provide scientific basis and data support for the prevention and control of hepatitis E in Heilongjiang Province.

The data of reported cases of hepatitis E in Heilongjiang Province from 2010 to 2022 were collected. Descriptive epidemiological methods were used to describe the temporal, spatial and population distribution characteristics of cases of hepatitis E. Joinpoint regression model was used to analyze the trend of hepatitis E. and to calculate the Annual Percentage Change (APC).

From 2010 to 2022, the reported incidence of hepatitis E in Heilongjiang Province showed a decreasing trend, and the annual reported incidence was 1.27/100 000. There were reported cases of hepatitis E in every month, and the peak period of hepatitis E was from October to April of the following year. Hepatitis E cases were reported every year in all cities (places) of Heilongjiang Province, and the top five regions reported annual incidence were Qitaihe City (238/100 000), Hegang City (203/100 000), Shuangyashan City (194/100 000), Jixi City (156/100 000) and Yichun City (154/100 000). The reported incidence rates of both men and women decreased year by year, with APC of -8.41% (95% CI: -11.31%- -5.42%, P<0.001) for men and -5.22% for women (95% CI：-9.12% - -1.09%，P=0.013), the incidence of male was higher than that of female. The cumulative number of cases in the 45-55 age group was 1 430(30.45%). The results of occupation distribution showed that 1 380 cases (29.39%) were housework and unemployed, and 1 204 cases (25.64%) were farmers.

The reported incidence of hepatitis E in Heilongjiang Province from 2010 to 2022 shows a decreasing trend, but there arestill significant seasonal, regional and population characteristics. Winter and spring arethe peak of the incidence, and men, 45-65 years old age group, household workers and unemployed people and farmers arethe high incidence groups of hepatitis E. In the future, targeted health publicity activities should be carried out for key groups to promote hepatitis E vaccination, which is expected to further reduce the incidence of hepatitis E in Heilongjiang Province.