ArchiveThe yin fire Theory is an important academic theory of Li Dongyuan, a physician of the Yishui school, and is in line with the theory of "spleen and stomach". The main causes of yin fire are irregular diet, irregular daily living, improper temperature and coldness, and excessive labor. Spleen and stomach deficiency is the essence of yin fire pathogenesis, and abnormal elevation is the core of yin fire pathogenesis. After abnormal elevation, there are three pathological states, namely, Shaoyang sinking, Dampness flowing down, and yin fire rising. Secondly, a comprehensive review was conducted on the relationship between yin fire theory and cardiovascular disease. The yin fire theory is closely related to cardiovascular diseases in terms of etiology, pathogenesis, and pathological status. In terms of treatment, the three methods proposed by Li Dongyuan, namely "strengthen the spleen and stomach, promoting yang qi, and clearing yin fire," can be used in diagnosis and treatment based on syndrome differentiation. This provides new ideas for the prevention and treatment of cardiovascular diseases. At the same time, it further enriched the connotation of yin Fire theory.
To investigate the difference of expression levels of IL-4 and IL-18 in the brain tissue of insomnia model rats with 'kidney failing to store willpower' Treated with the Processed Polygala tenuifolia.
A total of 40 male SD rats were randomly divided into normal group, model group, Esazolam group, Processed Polygala tenuifolia low-dose group and Processed Polygala tenuifolia high-dose group with 8 rats in each group. D-galactose (D-gal) combined with p-chlorophenylalanine (PCPA) was used to prepare the rats with 'kidney failing to store willpower'. After successful modeling, the western medicine group was given Esazolam 0.2mg/kg/d by gavage, and the low dose Chinese medicine group was given Processed Polygala tenuifolia 2.1g/kg/d by gavage, the high dose group was given 4.2g/kg/d gavage, and the normal group and model group were given equal volume normal saline gavage for 7 days. Morris water maze test was used to evaluate the learning and memory ability of rats. HE and Nissl staining were used to observe the cell morphology and structure of rat brain. The expression levels of IL-4 and IL-18 in rat brain were detected by IHC and Western blot.
Compared with normal group, incubation period and total motor distance of rats in model group were significantly increased (P <0.01), the percentage of exploration time in the target quadrant was significantly reduced (P <0.01). The neuronal nucleus was dislocated, the nucleolus was enlarged, the inflammatory cells were infiltrated, and the number of nissl was significantly decreased (P < 0.01). The intercellular spaces of neuron cells are widened, and the synaptic structure is incomplete, and the expression level of IL-4 was significantly decreased (P <0.01), the expression level of IL-18 was significantly increased (P < 0.01). Compared with model group, latency and total distance of movement of rats in low dose group and high dose group were significantly decreased (P < 0.01), the percentage of exploration time in the target quadrant significantly increased (P < 0.01). The neuronal damage and inflammatory cell infiltration were alleviated to varying degrees, and the number of nissl was increased to varying degrees (P < 0.01). The morphology and structure of neuronal nucleosomes were improved to varying degrees, and the expression level of IL-4 was significantly increased (P < 0.01), the expression level of IL-18 was significantly decreased (P <0.01).
The Processed Polygala tenuifolia can significantly improve the sleep, learning and memory ability of insomnia model rats with 'kidney failing to store willpower', and alleviate the inflammatory damage state of the neurons in rats with 'kidney failing to store willpower'. The mechanism of improving the sleep of the rats with insomnia model rats with 'kidney failing to store willpower' may be related to the increase of IL-4 and the decrease of IL-18 expression level in the brain tissue.
To explore the pharmacodynamic effects of Buxu Xiaoke Mixture combined with pyrroloquinoline quinone (PQQ) on type 2 diabetes mellitus (T2DM) rats and analyze its possible mechanism of action.
A T2DM rat model was established. Rats in the positive group, 1/4 Buxu Xiaoke Mixture + PQQ group, 1/2 Buxu Xiaoke Mixture + PQQ group, full-dose Buxu Xiaoke Mixture + PQQ group, Buxu Xiaoke Mixture group, and PQQ group were administered for 12 weeks. Blood glucose, urine volume, body weight, food intake, and water intake of rats were detected. ELISA was used to detect blood glucose, blood lipids, oxidative stress, and inflammatory factor-related indicators in rat serum, while HE staining was applied to observe pathological changes in kidney and pancreas tissues.
In the full-dose Buxu Xiaoke Mixture + PQQ group, the FINS level was increased (P <0.01), the HOMA-β level was increased (P < 0.05), the GSP and HOMA-IR levels were decreased (P < 0.01), the TG, TC and LDL-C levels were decreased (P < 0.01), the HDL-C level was increased (P < 0.01), the MDA level was decreased (P <0.01), the SOD and GSH-Px levels were increased (P <0.01), and the IL-1and TNF-α levels were decreased (P <0.01). This treatment could significantly improve glucose and lipid metabolism, inflammation and oxidative stress in rats, alleviate kidney and pancreatic tissue damage, with a better efficacy than monotherapy and a dose-dependent effect. Analysis showed that the mechanism of action may involve pathways related to inflammation and oxidative stress in T2DM.
The combination of full-dose Buxu Xiaoke Mixture and PQQ can synergistically improve T2DM via multi-targets by increasing GSP and decreasing MDA, TG levels, and the mechanism of action may be related to inhibiting oxidative stress and inflammatory response.
To investigate the distribution of clinical characteristics and traditional Chinese medicine (TCM) syndrome patterns in patients with diabetes mellitus complicated with osteoporosis (DM-OP), and to explore the associations between TCM syndromes and laboratory indicators, so as to elucidate the intrinsic patterns of the "disease-syndrome-symptom-laboratory indicator" relationship.
Retrospectively collected medical records of patients with diabetes complicated by osteoporosis who were hospitalized in the Department of Endocrinology at Guang'anmen Hospital, China Academy of Chinese Medical Sciences, from January 1, 2015 to December 31, 2024. The distribution of TCM syndrome patterns was analyzed, and the associations between different syndromes and general characteristics, comorbidities, symptom profiles, tongue and pulse features, bone mineral density, and laboratory indicators were explored.
Among patients with DM-OP, spleen-kidney deficiency syndrome was the most common pattern, followed by liver-kidney yin deficiency syndrome, damp-heat accumulation syndrome, and spleen-stomach qi deficiency syndrome. Significant differences were observed among different TCM syndromes in terms of age, body mass index (BMI), blood pressure, comorbidities, certain symptoms and tongue-pulse features, femoral neck bone mineral density, and selected laboratory indicators. Patients with spleen-stomach qi deficiency syndrome were relatively younger and had higher BMI, whereas those with liver-kidney yin deficiency syndrome and spleen-kidney deficiency syndrome were older, had lower femoral neck bone mineral density, and showed higher incidences of fractures and chronic kidney disease.
The distribution of TCM syndromes in DM-OP reflects a progressive pathomechanism involving the spleen and kidney. Different TCM syndromes exhibit distinct characteristics in clinical manifestations, comorbidities, bone mineral density, and laboratory indicators.
Based on metabolomics methods, this study aims to explore the differential metabolites of different primitive Chinese medicinal herbs (such as Chinese medicinal herb, Chinese medicinal herb, and Chinese medicinal herb) and screen the main metabolites identified by primitive identification.
The chemical composition of different types of Platycodon grandiflorus was analyzed by ultra-high performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS). Principal component analysis, cluster heatmap, orthogonal partial least squares discriminant analysis, and other methods were used to compare the differences in metabolites among the three types of Platycodon grandiflorus. Differential metabolites were identified using a database.
A total of 691 compounds were identified in negative ion mode, with lipids, organic acids and their derivatives, and flavonoids being the main metabolites. Differential metabolites were significantly enriched in the flavonoid biosynthesis pathway. There are a total of 11 differential metabolites among the three groups, with flavonoids (3, 27.27%) and lipids (3, 27.27%) accounting for the largest proportion. Combined with the difference factor, rutin, anthocyanin B2, and isorhamnetin-3-O-rutinoside were identified as the three differential metabolites based on their respective origins.
UPLC-Q-TOF-MS metabolomics technology can elucidate the differences in chemical composition of different basal components of Eucommia ulmoides, providing new ideas for differential analysis of different basal components of Eucommia ulmoides, and also providing references for the quality control, evaluation, and clinical use of medicinal materials of Eucommia ulmoides.
Parkinson's disease (PD) is a chronic neurodegenerative disease closely associated with multiple factors such as age, genetics and environment, characterized by progressive motor function impairment and a wide range of non-motor symptoms. This disease has a long course and diverse clinical symptoms, and the existing treatment regimens in modern medicine have many side effects and certain limitations. Traditional Chinese Medicine (TCM) has unique advantages in treating this disease and can serve as a powerful supplement and alternative for PD treatment. The etiology and pathogenesis of PD are complex. Professor Wang Shun innovatively applies the method of "Regulating spirit and easing the mind" to regulate the heart, brain and five viscera, relax tendons and stop tremors, and has achieved satisfactory curative effects, which provides a new idea for the treatment of this disease.
Treatment with biological agents may lead to eczema-like changes in patients with psoriasis and psoriasis-like changes in patients with eczema, and this phenotypic switching phenomenon is attracting more and more attention, whose molecular biological mechanism may be related to the dysregulation of the Th1/Th2 balance, and for which there is no clear therapeutic solution. Based on the Xuanfu qi fluids theory, this paper describes the evolution of the pathogenesis of psoriasis and eczema. In the course of treatment, the biological agents may improperly regulate qi and fluids transport, which ultimately leads to dampness on the outside and qi and blood dryness on the inside; dryness is present on the surface, while dampness is stagnant on the inside, which is manifested as the phenomenon of phenotypic transformation on the skin. For this complex dry-damp presentation, therapy must combine pungent-moistening agents to unblock the orifices with bland herbs to promote diuresis, thereby normalizing qi fluids dynamics without fostering pathogens or injuring upright qi. An illustrative case is presented to showcase this approach to managing pattern transition.
Based on the theory of "Head qijie", this paper explores the etiology, pathogenesis and treatment of post-stroke sequelae. The theory of Head qijie is an important part of acupuncture theory. Zang-fu organs, acupoints, and meridians are connected through the pathway of Qijie, expanding the treatment scope of acupuncture from points to surfaces. The pathological location of post-stroke sequelae is in the head, which is closely related to the theory of Head qijie. Based on the correlation between brain functions, the meridian system, and the etiology and pathogenesis of post-stroke sequelae, this paper integrates traditional medicine theories and modern medical research results, focuses on discussing the action mechanisms of main acupoints of Head qijie, Bladder-associated acupoints, and syndrome-specific acupoints in the treatment of post-stroke sequelae. Guided by this theory, it proposes the principles for selecting acupoints and formulating traditional Chinese medicine prescriptions, aiming to guide clinical acupuncture and Chinese materia medica treatment for post-stroke sequelae.
Through the records of Sophorae Tonkinensis Radix et Rhizoma(S. Tonkinensis) in ancient Chinese herbal medicines, medical books and modern literature, this paper examines the name, origin, producing areas, nature and flavor, efficacy and indications, collection and processing, usage, dosage, toxicityand compatibility taboos of S. Tonkinensis. The results showed that most of the ancient Chinese herbs were named after S. Tonkinensis, and their aliases were mostly derived from it's efficacy, morphology, nature and flavor and producing areas. The basic source of S. Tonkinensis recorded in ancient books was relatively confusing, and some of them were contrary to the basic source of S. Tonkinensis included in the modern Chinese Pharmacopoeia, and the source of S. Tonkinensis plants used in modern places was also different, showing certain regional differences. The geoherbalism, harvesting and efficacy of plants were basically as same as those of modern times, but the processing method and toxicity were different from modern research, and we think that it's processing method may affect it's toxicity, which needs further research.
To analyze the application value of mind-regulating acupuncture combined with sensory integration training in the language rehabilitation of children with autism.
A prospective study was conducted. A total of 93 children with autism admitted to the Department of Rehabilitation of Pingdingshan First People's Hospital from January 2024 to January 2025 were selected as the study subjects. They were randomly divided into a control group and an observation group using a random number table method, with 45 cases in each group. The control group received sensory integration training intervention, while the observation group received mind-regulating acupuncture combined with sensory integration training intervention. Both groups were continuously intervened for 6 months. The scores of the Autism Behavior Checklist (ABC), Children's Sensory Integration Development Rating Scale, Autism Treatment Evaluation Checklist (ATEC), and Childhood Autism Rating Scale (CARS) were compared between the two groups before treatment, at 3 months of treatment, and at 6 months of treatment.
Repeated measures ANOVA showed that the main effect of the group was statistically significant in the following scale scores (P <0.05) : Children's Sensory Integration Development Rating Scale, ATEC score, CARS score, and the sensory, social interaction, motor, language, and self-care dimensions of the ABC score. Further trend analysis indicated that the total ATEC score, total CARS score, and all dimension scores of the ABC showed a significant downward trend over time (P <0.05) ; the score of the Children's Sensory Integration Development Rating Scale showed a significant upward trend over time (P < 0.05).
Mind-regulating acupuncture combined with sensory integration training can improve the core symptoms of children with autism, enhance sensory integration ability, and has a good effect on language rehabilitation in these children.
To explore the mechanism of promoting awakening effect and prognosis of coma patients with severe craniocerebral injury based on meridian flow theory combined with acupuncture.
A total of 102 coma patients with severe craniocerebral injury admitted to Xinxiang Central Hospital from October 2021 to October 2024 were divided into observation group and control group. The control group was given routine intervention. On the basis of the control group, the observation group was given meridian flow theory combined with acupuncture treatment. The waking time, waking rate, GCS and FOUR scores and prognosis were compared between the two groups. The levels of neuron-specific enolase (NSE), S100B protein (S-100B) and myelin basic protein (MBP) were compared between the two groups before and after treatment. The improvement of cerebral blood flow (CBF) and cerebral blood volume (CBV) before and after treatment was compared between the two groups.
The awakening rate of observation group was 82.35% higher than that of control group 64.71%, and the awakening time was significantly lower than that of control group (P <0.05). After 10 and 30 days of treatment, GCS and FOUR scores of both groups significantly increased, and the observation group was significantly higher than the control group (P <0.05) ; After treatment, NSE, S-100B and MBP significantly decreased in both groups, and the observation group was significantly lower than the control group (P < 0.05). After treatment, CBF and CBV significantly increased in both groups, and the observation group was significantly higher than the control group (P <0.05). Compared with 68.63% of the control group, the total effective rate of the observation group was 86.27% (P < 0.05).
Acupuncture combined with meridian injection theory can significantly improve the awakening rate of coma patients with severe craniocerebral injury, improve nerve function and cerebral blood flow indexes, and the prognostic effect is better than conventional treatment.
To explore the effects of Qingyan Runhou (throat-clearing and moistening) tea on the clinical symptoms and recurrence of children with chronic pharyngitis (lung-kidney yin deficiency syndrome).
A total of 112 children with chronic pharyngitis from January 2023 to October 2024 were selected as the subjects of this trial. Randomly divide it into 2 groups, 56 children in the control group were given Xuanmai Ganju granules, and 56 children in the treatment group were given clear throat and throat tea. After treatment, the efficacy, clinical symptoms, pharyngeal sign scores, immunological function, adverse reactions and recurrence rates of the two groups were compared.
Treatment group demonstrated a higher clinical efficacy rate than control group (P < 0.05). After treatment, the clinical symptom scores and pharyngeal sign scores of the two groups were lower than before, and treatment group was lower than control group (P < 0.05). After treatment, the levels of immunoglobulin A and immunoglobulin M of the two groups were lower than before, and treatment group was higher than control group (P <0.05). No statistical difference was found in thyroid function and adverse reactions between two groups (P > 0.05). Recurrence rate of the treatment group was lower than the control group (P <0.05).
Throat-clearing and throat-moistening tea has obvious effects on children with chronic pharyngitis syndrome of lung and kidney yin deficiency. It can improve clinical symptoms, enhance immunological function, and reduce the recurrence rate while ensuring safety.
To investigate the efficacy of modified Sangbaipi Decoction on patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) and its effect on pulmonary function.
A total of 120 patients with acute exacerbation of COPD admitted to Shunyi Hospital, Beijing Traditional Chinese Medicine Hospital, from June 2023 to June 2025 were selected and randomly divided into a control group (conventional Western medicine treatment) and an observation group (conventional Western medicine + modified Sangbaipi Decoction treatment) with 60 cases each. Observed and compared the TCM Syndrome Score, clinical efficacy, pulmonary function indices, inflammatory factors and the incidence of adverse reactions in both groups.
The total effectiveness rate of the observation group after treatment were higher than that of the control group (P < 0.05) ; The TCM syndrome score subjects group was lower than that of the control group (P <0.05). After treatment, the levels of FEV1, FVC and FEV1/FVC in both groups were increased and the levels of IL-6, CRP and PCT were decreased (P < 0.05), and the observation group was lower than that of the control group (P < 0.05). There was no apparent difference in the incidence of adverse reactions between both groups (P > 0.05).
Modified Sangbaipi Decoction has significant efficacy in patients with acute exacerbation of COPD (Phlegm-heat obstructing lung syndrome), can effectively improve the clinical symptoms and pulmonary function indices, reduce the level of inflammatory factors, and it has a high degree of safety.
To investigate the clinical effect of Huanglian Qingjie Granule combined with improved combination therapy on spleen and stomach damp-heat type patients with chronic gastritis whose eradication of Helicobacter pylori (Hp) failed.
The research subjects were 82 patients with chronic gastritis of the spleen and stomach damp-heat type who failed the initial eradication of Hp and were admitted to Zhengzhou Hospital of Traditional Chinese Medicine from January 2023 to April 2025. They were divided into two groups according to a randomized, parallel controlled design: the control group and the treatment group, with 41 patients in each group. The control group was treated with modified double therapy, and the treatment group was treated with Huanglian Qingjie Granule on the basis of the control group. Both groups were treated for 1 month. The clinical efficacy of the two groups was compared. The Hp clearance of the two groups was compared one month after treatment. The TCM syndrome scores of the two groups were compared before treatment and one month after treatment. The levels of inflammatory factors were compared between the two groups before and 1 month after treatment.
Compared with the control group, the total effective rate was significantly higher in the treatment group (P < 0.05). Compared with control group, Hp clearance rate in treatment group was significantly higher (P < 0.05). Compared with the control group, the main symptom score and secondary symptom score of TCM syndrome score were significantly decreased in the treatment group one month after treatment (P < 0.05). Compared with the control group, the levels of tumor necrosis factor-α (TNF-α) and interleukin-1 β (IL-1β) were significantly decreased in the treatment group one month after treatment, and the level of interleukin-10 (IL-10) was significantly increased in the treatment group (P < 0.05).
The combination of Huanglian Qingjie Granules and the modified dual therapy can effectively enhance the clinical efficacy of patients with chronic gastritis of spleen and stomach damp-heat type who have failed Hp eradication, increase the Hp eradication rate of patients, improve their TCM syndrome score and inflammatory factor levels, and can be widely applied in clinical practice.
To investigate the effects of Kongsheng Zhenzhong Pill Modified Formula on cognitive function, inflammatory factor and Chinese medicine syndrome score in patients with cerebral small vessel disease (CSVD) with kidney deficiency, phlegm and stasis type.
A retrospective selection was made of 210 inpatients with CSVD (kidney deficiency and phlegm-stasis type) from the Department of Neurology of Xi'an Hospital of Traditional Chinese Medicine from January 2020 to January 2025, among which 104 patients receiving conventional treatment were included in the basic group and 106 patients who received the modified formula of Kongsheng Zhenzhong Pill Modified Formula on the basis of conventional treatment were included in the study group, and the efficacy of the 2 groups, cognitive function [Montreal Scale (MoCA) and the Simple Mental State Evaluation (MMSE) scale], inflammatory factors (Hypercalcitrance and inflammation factor), and inflammatory factors (Hypercalcitrance and inflammation factor) were compared with those in the other group, inflammatory factors [Hypersensitive C-reactive protein (hs-CRP), interleukin (IL) -1β, IL-6] and TCM evidence score.
Among the 210 patients with CSVD (kidney deficiency and phlegm-stasis type) in this study, 106 cases were included in the study group and 104 cases in the control group. The total effective rate of the study group was higher than that of the basic group, and the difference was statistically significant (P <0.05). Comparison of various scores of cognitive function before treatment between the two groups showed no significant difference (P >0.05), and the MoCA score and MMSE score of patients in the study group were higher than those in the basic group after treatment (P < 0.05). Comparison of inflammatory factors before treatment between the two groups, there was no significant difference (P >0.05), and the levels of hs-CRP, IL-1β and IL-6 were lower than those of the basic group after treatment in the study group (P < 0.05). There was no significant difference between the two groups when comparing the points of Chinese medicine symptoms before treatment (P > 0.05), and the points of symptoms such as diminished intelligence, phlegm, nausea and epigastric distension, and sticky stools were lower than those of the basic group after the treatment in the research group (P < 0.05).
The application of Kongsheng Zhenzhong Pill Modified Formula for CSVD (kidney deficiency, phlegm and stasis type) patients can achieve significant therapeutic effects, improve cognitive function and Chinese medicine symptoms, and reduce the level of inflammatory factors in the patients. The therapeutic effect is superior to that of conventional treatment alone.
To explore the effect of electroacupuncture combined with traditional Chinese medicine fumigation on skin barrier function in patients with moderate to severe atopic dermatitis (AD) of blood deficiency and wind dryness type.
Selected from April 2020 to October 2024, The case data of 96 AD patients admitted to the acupuncture and moxibustion and Massage Department of the First Affiliated Hospital of Xinjiang Medical University were selected, they were randomly divided into two groups, with 48 cases in each group. The control group received Western medicine treatment, while the observation group received electroacupuncture combined with traditional Chinese medicine fumigation treatment. The SCORAD score, skin barrier function indicators, immune function treatment before and after treatment were compared between the two groups, and the clinical efficacy and recurrence rate after 6 months of follow-up and adverse reaction incidence rate were also compared.
After treatment, the water content, sebum content, and interleukin-2 (IL-2) in the stratum corneum of both groups were significantly increased compared to before treatment (P < 0.05). SCORAD scores, transcutaneous water loss (TEWL), eosinophils (EOS), serum immunoglobulin E (IgE), and interleukin-4 (IL-4) were significantly reduced compared to before treatment (P <0.05), and the improvement was more significant in the observation group (P < 0.05). In terms of treatment efficiency, 97.92% in the observation group was significantly better than 81.25% in the control group (P < 0.05) ; The therapeutic effect efficiency was better in the observation group at 97.92% compared to the control group at 81.25% (P <0.05) ; The recurrence rate after 6 months of follow-up was significantly lower in the observation group at 16.67% compared to the control group at 56.25% (P <0.05) ;The incidence of adverse reactions in the observation group (4.17%) was lower than that in the control group (16.67%) (P < 0.05).
The combination of electroacupuncture combined with traditional Chinese medicinal fumigation for treating moderate to severe AD patients with blood deficiency and wind dryness is more effective than using Western medicine alone. It can effectively alleviate symptoms, improve skin barriers, regulate immune function, and prevent recurrence.
To observe the efficacy of Shufeng Zhisou Decoction combined with montelukast sodium in the treatment of patients with cough variant asthma (CVA) and its influence on the airway inflammatory factors levels, pulmonary function and T lymphocyte immune balance.
104 CVA patients with pattern of wind pathogen attacking the lung were selected from September 2023 to July 2024 in Beijing Hepingli Hospital, and were divided into western medicine group (montelukast sodium on the basis of routine treatment) and combined group (Shufeng Zhisou Decoction on the basis of Western medicine group) according to the random number table method, 52 cases in each group. The clinical efficacy, TCM symptoms scores, airway inflammatory factors [fractional exhaled nitric oxide (FeNO), sputum eosinophil (EOS), sputum eosinophil cationic protein (ECP)], pulmonary function [forced vital capacity (FVC), peak expiratory flow (PEF), forced expiratory volume in the first second as a percentage of predicted value (FEV1)] and T lymphocyte immune balance [interleukin-4 (IL-4), interferon-γ (IFN-γ), IFN-γ/IL-4] before and after treatment, adverse reactions and recurrence rate within 1 months of follow-up were compared between groups.
The combined group had higher total effective rate of treatment (90.38% vs 75.00%) than the Western medicine group (P <0.05). After treatment, the scores of cough, expectoration and pharyngeal pruritus in the two groups were decreased (P <0.05), and the scores in combined group [(0.60 ± 0.11) points vs(0.84 ± 0.14) points]、[(0.64 ± 0.11) points vs(0.87 ± 0.14) points]、[(0.68 ± 0.12) points vs(0.79 ± 0.14) points] were lower after treatment (P <0.05). The levels of FeNO, sputum EOS, ECP and serum IL-4 were reduced in both groups after treatment (P <0.05), FVC, PEF, FEV1, IFN-γ and IFN-γ/IL-4 in the two groups were enhanced (P <0.05), and there were statistical differences between groups after treatment (P <0.05).
Shufeng Zhisou Decoction combined with montelukast sodium can effectively improve the clinical symptoms and pulmonary function of CVA, relieve the airway inflammation, regulate the T lymphocyte immune imbalance, and improve the prognosis.
To explore the therapeutic effect of Banxia Gualou Xiebai Decoction on patients with qi deficiency and blood stasis syndrome after percutaneous coronary intervention (PCI) for coronary heart disease.
A total of 154 patients with CHD who were treated with PCI in Affiliated Hospital of Gansu Medical College were selected from May 2023 to April 2024, and were randomized into control group (n=77, routine treatment after PCI) and observation group (n = 77, Conventional treatment + Banxia Gualou Xiebai Decoction) by lottery method. The TCM syndromes scores, cardiac function indexes, blood lipid indexes and hemorheological indexes before and after treatment and occurrence of adverse events during treatment were compared between groups.
Compared with the control group, the scores of TCM syndromes in the observation group were lower after treatment (P < 0.05). The LVESV and LVEDP in the observation group after treatment were lower while the LVEF was higher compared to the control group (P < 0.05). The improvements of blood lipid indexes in the observation group were significantly better, which showed that the levels of TC, LDL-C and TG were significantly decreased while the level of HDL-C was significantly increased (P < 0.05). Compared with the control group, the levels of hemorheology indexes were lower in the observation group after treatment (P < 0.05). No significant difference was exhibited in the total incidence rate of adverse reactions between both groups (P > 0.05).
Banxia Gualou Xiebai Decoction can improve the clinical symptoms, cardiac function, blood lipid levels and hemorheological levels of patients with qi deficiency and blood stasis syndrome after PCI for coronary heart disease, and it is safe at the same time.
To explore the clinical efficacy of modified Yanggan Powder combined with Sini Powder in the treatment of chronic hepatitis B (CHB) with liver depression, spleen deficiency, and blood stasis obstructing the collaterals.
A total of 122 CHB patients diagnosed in the Hai'an Traditional Chinese Medicine Hospital from April 2021 to December 2023 were randomly divided into an observation group (n=61) and a control group (n = 61) using a computer-generated random number method. The control group was treated with entecavir, while the observation group received a combination of modified Yanggan Powder and Sini Powder. After 6 months of treatment, the two groups were compared for TCM syndrome scores, liver function, HBV-DNA load, inflammatory factors (IL-1β, IL-6), liver function ultrasound indicators, therapeutic efficacy, and adverse reactions.
After treatment, both groups showed a reduction in TCM syndrome scores, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (TBiL), HBV-DNA load, IL-1β, and IL-6, with the observation group showing lower values than the control group (P <0.05). Both groups had an increase in albumin (ALB), with the observation group showing a higher increase than the control group. There were no significant changes in the hepatic portal vein diameter, splenic vein diameter, or spleen thickness before and after treatment in both groups (P > 0.05). The therapeutic efficacy rate in the observation group was higher than that in the control group (P <0.05). No serious adverse reactions were observed in either group.
Modified Yanggan Powder combined with Sini Powder is effective in treating HBV with liver qi stagnation, spleen deficiency, and blood stasis obstructing the channels, helping to relieve liver function symptoms, reduce inflammatory responses, and achieve good therapeutic effects.
To investigate the clinical efficacy of ZHU's chiropractic manipulation combined with Jianyao Pill in patients with lumbar disc herniation (LDH) accompanied by liver and kidney deficiency syndrome.
A retrospective analysis was conducted on the clinical data of 201 patients with liver-kidney deficiency type of lumbar disc herniation (LDH) treated at the Cervical-Lumbar Pain Diagnosis and Treatment Center of Changzhou Hospital of Traditional Chinese Medicine between February 2024 and December 2024. Patients were divided into an observation group and a control group based on treatment protocols. The control group (100 cases) received Jianyao Pill therapy, while the observation group (101 cases) received ZHU's spinal manipulation therapy in addition to the control group's treatment. Both groups underwent a 4-week treatment course. Clinical efficacy, lumbar function [modified Oswestry Disability Index (ODI), lumbar flexion range (LFR), and lumbar flexion/extension muscle strength], pain status [Simplified McGill Pain Questionnaire (SF-MPQ), pressure pain threshold (PPT) at tender points], and adverse reaction rates were evaluated.
The total effective rate was significantly higher in the observation group than in the control group (P <0.05). Post-treatment, both groups showed reduced ODI and SF-MPQ scores compared to baseline (P < 0.05), with greater reductions in the observation group (P < 0.05). LFR, lumbar flexion/extension muscle strength, and PPT levels increased in both groups (P <0.05), with higher values in the observation group (P <0.05). No significant difference in adverse reaction rates was observed between groups (P >0.05).
ZHU's chiropractic manipulation combined with Jianyao Pill demonstrates significant efficacy in improving lumbar function and alleviating pain in LDH patients with liver-kidney deficiency syndrome, with a favorable safety profile.
Endometriosis (EMs) is a chronic inflammatory and estrogen-dependent disease with obvious adverse reactions and a high recurrence rate in clinical treatment. The MAPK signaling pathway plays an important role in the occurrence and development of EMs. Studies have shown that traditional Chinese medicine exhibits the characteristics of multiple targets and multiple mechanisms in the treatment of EMs. It can exert an anti-EMs effect by regulating the MAPK signaling pathway, inhibiting the production of inflammatory factors, promoting cell apoptosis, suppressing abnormal proliferation, migration and invasion of EMs, and inhibiting pathological angiogenesis. This article explored the mechanism of action of active ingredients of traditional Chinese medicine and compound and patent traditional Chinese medicine in treating EMs by regulating the MAPK signaling pathway, with the aim of providing a certain theoretical basis for the prevention and treatment of EMs with traditional Chinese medicine.
Chronic kidney disease (CKD) is a common chronic condition characterized by structural damage or functional decline of the kidneys due to various causes. According to Traditional Chinese Medicine (TCM) theory, the primary pathogenesis of CKD is "spleen-kidney qi deficiency and turbid toxin accumulation" and "tonifying qi and dispelling turbidity" is the fundamental treatment principle. Astragali Radix and Rhei Radix et Rhizoma are classically served as a herb pair for "tonifying qi and dispelling turbidity" and are frequently used in CKD treatment. With the rapid advancement of TCM modernization, an in-depth analysis of the mechanisms of herbal comination is of great significance for enriching the scientific connotation of TCM theory and guiding clinical diagnosis and treatment. This article first summarizes the main chemical components and pharmacological effects of Astragali Radix and Rhei Radix et Rhizoma from the perspective of modern medicine. It then analyzes the TCM understanding of their roles in treating CKD. On this basis, integrating modern medical and TCM theories, it discusses the research progress on the Astragali Radix-Rhei Radix et Rhizoma combination in CKD treatment. Furthermore, it highlights current limitations and future research directions, aiming to provide new insights for the clinical management and drug development of CKD.
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