ArchiveMeiguihua（Rosae Rugosae Flos）as a Chinese medicine to slow down the aging process has a long history of dual-use，and is an anti-aging drug that appears frequently in anti-aging and liver preservation related formulae. Modern scientific research further reveals thatMeiguihua（Rosae Rugosae Flos）contains volatile oil，polysaccharides，flavonoids，polyphenols and a variety of essential amino acids，etc.，and the synergistic mechanism among the components produces significant biological effects. Through the removal of free radicals in the body，regulation of inflammatory signaling pathways，enhancement of immune defensemechanisms and other pathways，it can effectively enhance the body＇s ability to resistoxidative stress and anti-aging level，which can provide a scientific basis for its application in the field ofmodern anti-aging，a scientific basis for its application in modern anti-aging field. Traditional Chinesemedicine believes thatemotional disorders are themain cause of aging，and longterm accumulation will cause liver dysfunction. Liver，as an importantorgan that regulates emotions，is the starting pointof the aging process. Meiguihua（Rosae Rugosae Flos）has the effect of detoxifying liver and relieving depression，which can regulate liver Qi，relieve emotional depression and enable the function of liver to be normalized，thus slowing down aging. The aim of this paper was to integrate traditional Chinesemedicine theories and modern scientific research results，summarized the biological activities of roses，generalized their pharmacological effects and anti-agingmechanism，and analyzed the effects of liver detoxification and depressants on aging based on the theory of traditional Chinesemedicine，so as to provide new ideas andmethods for the study of Meiguihua（Rosae Rugosae Flos）in the anti-aging process.
Polycystic ovary syndrome（PCOS）is an important cause of female infertility worldwide. It is characterized by hyperandrogenism（HA），insulin resistance（IR），obesity，ovulation disorder and infertility，often accompanied by metabolic syndrome and chronic low-grade inflammation，which seriously affects women＇s physical and mental health. The disease is affected by a variety of factors，and its etiology and pathogenesis are not clear. Oxidative stress（OS）refers to the imbalance between the oxidative system and antioxidant system in the human body. Studies have found that OS is closely related to the occurrence and development of PCOS，and can drive other pathologicalmechanisms to promote the development of PCOS，such asmitochondrial dysfunction and inflammatory response. This article summarized the correlation between OSand themain clinical symptoms of PCOS，and summed up the traditional Chinese medicine monomer，traditional Chinese medicine compound，Chinese patentmedicine，acupuncture and moxibustion to reduce the status of OS in patients and improve the clinical symptoms of PCOS patients，in order to expand the application range of traditional Chinesemedicine in the treatmentof PCOSand provide reliable scientific theoretical basis.
Although an independent randomized controlled trial showed no difference between acupuncture and sham acupuncture in the treatment of polycystic ovary syndrome（PCOS）infertility，a comparison of historical data from evidence-based medicine trials shows thatacupuncture can significantly increase the live birth rate in PCOS infertility. In response to the growing infertility problem，acupuncture is likely to be a good natural fertility treatment and should be promoted accordingly. Rational analysis shows that acupuncture is a combination therapy with many influencing factors. The balloon theory can well explain the combination effect ofmultiple factors in acupuncture treatment，and quantitative effective analysis of acupuncture treatment for pain has provided precise data for various combination factors. Further understanding why acupuncture can significantly increase the live birth rate requires in-depth study of the principle of acupuncture＇s combination effect.
Graph neural networks are one of the frontier technologies in artificial intelligence，with the powerful ability to process graph-structured data. In the field of traditional Chinesemedicine diagnosis and treatment，syndrome differentiation and treatment involves complex syndrome inference，prescription compatibility，etc.，which manifest as complex relationships of“disease-syndrome-symptom-prescription-medicine”，showing significant graph structure characteristics. This paper analyzed the graph structure characteristics of traditional Chinese medicine diagnosis and treatment data，discussed the graph structure transformation of traditional Chinese medicine diagnosis and treatment data and the application scenarios of traditional Chinese medicine graph neural network，and preliminarily explored the application ideas of graph neural network in the field of traditional Chinesemedicine. Applying graph neural networks to the field of traditional Chinesemedicine diagnosis and treatment requires modeling for different data types and application scenarios，solving initial graph construction，knowledge learning and features，etc.，and then providing support for downstream syndrome prediction，prescription recommendation，etc.
This study innovatively developed an intelligentmodel of syndrome differentiation and machine learning trainingmethod with zero-clinical samples which could intuitively infer with diagnostic knowledge of traditional Chinesemedicine，and conducted case analysis on the syndrome differentiation of vertigo.
Based on the deep learningmodel Bert，a new inference algorithm was proposed to establish a new intelligent inferencemodel of TCM diagnosis. According to the key points of six types of dizziness syndrome differentiation（such as liver Yang hyperactivity and Qi-blood deficiency）in Internal Medicine of TCM，a random function was used to generate 400 samples of sentence sequences for each syndrome differentiation class，to let the model learn diagnostic knowledge directly. In order to compare the prediction performance of the newmodeland the random forest model，it used the 5-fold crossovermethod to evaluate themodel for all syndrome differentiation classes with indicators such as Accuracy，F1 score，ROC curve，P-R curve，etc. Furthermore，the reasoning diagrams outputted by the newmodelwere showed to demonstrate the algorithm reasoning process of simulations of TCM syndrome differentiation thinking. Based on the generated combination data of the symptoms and probabilities during the model reasoning process，the probability density distribution map of syndrome types，the correlation clustering heatmap of symptom types and the Pearson correlation analysismap of syndrome types were calculated and drawn to further verify the reliability of the syndrome differentiation results.
The average accuracies and F1 scores of the new model tested with the 5-fold crossmethod were 0.990 and 0.971，respectively. In all the syndrome types，the accuracy（0.975）and F1 score（0.923）of liver-kidney Yin deficiency were the lowest. The ROC curve and P-R curve showed that the newmodel had a little poor ability of prediction for liver-kidney Yin deficiency and liver Yang hyperactivity，while the random forestmodel had a little poor ability of prediction for Qi-blood deficiency syndrome. The data distribution of the probability density distributionmap and the correlation clustering heatmap were consistentwith the inference conclusion of the new model. The Pearson correlation map showed that the syndrome type diagnosed with the new model was negatively correlated with other syndrome types，and the P-value of the correlation coefficientwas less than 0.01，indicating that the newmodel had a good discrimination.
It can intelligently diagnose and demonstrate the reasoning process of dizziness based on the new intelligent diagnostic reasoningmodel，whichmay help to solve the bottleneck problems in the current field of artificial intelligence diagnosis in traditional Chinesemedicine.
To study the effectof Ganfei Bingzhi Formula（肝肺并治方）on gutmicrobiota of ratswith ulcerative colitis.
Thirty SD ratswere randomly divided into Ganfei Bingzhi Formula high dose group（A），Ganfei Bingzhi Formulamedium dose group（B），Ganfei Bingzhi Formula low dose group（C），model group（D）and blank group（E），with 6 rats in each group. A ratmodel of UC was established by using trinitrobenzenesulfonic acid solution（TNBS）/ethanol method. After gavage with different intervention factors，the intestinal contents of rats were taken out and the bacterial population was sequenced using 16S rRNA method.
The dominant bacteria in the intestinal contents of rats in each group were Firmicutes and Bacteroidetes. Aftermodeling，the number of Firmicutes decreased，while the number of Bacteroidetes increased. Intervention with Ganfei Bingzhi Formula can increase the number of Firmicutes and reduce the number of Bacteroidetes. The effectof themedium dose group was themost significant. The sparse curve ofα-diversity tended to flatten out as the sequencing depth increased. The difference between themedium dose group and the blank group in the PCoA analysis chartand the distancematrix ofβ-diversity were the smallest. The composition of intestinal contents in themiddle dose group was themost similar to that of the blank group in phylum level，species level and genus level. There was a significant difference in the phylum of actinomycetes among the groups.
Ganfei Bingzhi Formula can correct the distribution of intestinalmicrobiota in rats with UC，making it tend to the normal gutmicrobiota. Among them，the effect of themedium dose group ismost obvious.
In recentyears，with thewide application of antibacterial drugs，their drug resistance is rising，and the development of drug resistance is far greater than the development of antibacterial drugs，leading to a serious threat to human life and health and increasing the economic burden ofmedical and health care. The detection rate of carbapenem resistant Klebsiella pneumoniae（CRKP）in pediatric wards in China is increasing. CRPK sepsis in children lacks specific clinicalmanifestations，and its onset is hidden. But it has strong pathogenicity and rapid progression，and is prone tomultiple organ failure. Carbapenem antibiotics are still themainmeans to treat CRKP infection. With the in-depth study of CRKP sepsis in traditional Chinesemedicine，more and more attention has been paid to the treatment of CRKP sepsis with traditional Chinesemedicine. This article aimed to review the characteristics of carbapenem resistant Klebsiella pneumoniae sepsis in children and the research progress of traditional Chinese medicine treatment.
To investigate whether Xuguan Ruanhua Pill（血管软化丸）can improve atherosclerosis in APOE-/-mice by regulating the AMP-activated protein kinase（AMPK）/NOD-like receptor thermal protein domain associated protein 3（NLRP3）pathway and inhibiting cellular death.
Ten C57BL/6Jmicewere used as blank control group. Sixty apolipoprotein E knockout（APOE-/-）micewere random ly divided intomodel group，Xuguan Ruanhua Pill low-dose group，Xuguan Ruanhua Pill high-dose group，atorvastatin group，Xuguan Ruanhua Pill high dose＋AMPK inhibitor combination group and AMPK inhibitor group，and were given high-fatdiet to constructatherosclerosis（AS）mousemodel for18 weeks and were given different methods of intervention in the 13th week. Differentmethods of intervention were given，and the sampleswere taken 6 weeks after the intervention，and the levels of triglyceride（TG），total cholesterol（TC），low density lipoprotein-eholesterol（LDL-C）and high density lipoprotein-eholesterol（HDL-C）were detected respectively in each group. The pathological and morphological changes ofmouse aortic tissues were observed by HE and Oil Red O staining. The levels of interleukin（IL）-1βand IL-18 in aortic tissueswere determined by ELISA，and the protein expressions of AMPK，P-AMPK，NLRP3，Cleaved-Caspase1 and GSDMD-N were detected byWestern Blot. The P-AMPK and NLRP3 protein distribution in the aortic rootwas detected by immunofluorescencemethod and transmission electron microscopy was used for the observation of aortic endothelial ultrastructural changes.
Compared with those in the control group，themodel group had significantly higher serum levels of TG，TC and LDL-C，significantly lower HDL-C levels（P<0.01），disorganised cellarrangement in the aortic rootand obvious fat vacuoles，significant atheromatous plaque deposition in the aorta，significantly lower levels of P-AMPK protein expression，and significantly lower levels of NLRP3，Cleaved-Caspase 1 and GSDMD-N proteinswere significantly increased（P<0.05 or P<0.01）. Compared with those of themodel group，the lipid disorderswere improved in the high and low dose groups of Xuguan Ruanhua Pill and the atorvastatin group，and the degree of aortic tissue and cytopathic lesions were reduced，with a significant increase in the expression level of P-AMPK，and a significant decrease in the expression levels of NLRP3，Cleaved-Caspase 1 and GSDMDN proteins（P<0.05 or P<0.01）. The expression levels were significantly reduced（P<0.05 or P<0.01），and the levels of IL-1βand IL-18 were significantly reduced（P<0.05 or P<0.01）. Compared with those of the Xuguan Ruanhua Pill high dose＋AMPK inhibitor group，the level of coagulopathy-associated proteins in the Xuguan Ruanhua Pill high-dose group was significantly reduced（P<0.05 or P<0.01），and the degree of damage to aortic endothelial cells was attenuated，while that in the AMPK inhibitor group in contrast.
Xuguan Ruanhua Pillmay exert a protective effect on atherosclerotic mice by regulating the AMPK/NLRP3 pathway to reduce cell death.
To study the effectof early electroacupuncture therapy on the recovery of nerve function after craniocerebral injury.
A total of270 patients diagnosed as craniocerebral injury were divided into two groups according to the random number table，135 patients in the control group received conventional Western medicine treatment，and 135 patients in the study group received electroacupuncture treatment based on the control group. The clinical efficacy，lower limb function，neurological function defect and walking ability of the two groupswere observed and compared.
The total effective rate of the study group was 97.78%（132/135），higher than that（73.33%，99/135）of the control group，and the difference was statistically significant（P<0.05）. After treatment，compared with thatof the control group，the TCM syndrome score of the study group was lower，and the difference was statistically significant（P<0.05）. Compared with those of the control group，the National Institute of Health Stroke Scale（NIHSS）score，Fugl-Meyer score，Berg score and Barthel index in the study group were higher，and the differences were statistically significant（P<0.05）. Compared with those of the control group，the levels of VILIP-1，NSE and S100βin the study group were lower，and the difference was statistically significant（P<0.05）.
Electroacupuncture can improve themotor function and nerve function of patients with craniocerebral injury and promote the recovery of patients as soon as possibly，which has high clinical application value.
To analyze the effect of Huaiqihuang Granule（槐杞黄颗粒）combined with Xiaoqinglong Decoction（小青龙汤）on immune function and prognosis of children with Qideficiency of lung and spleen syndrome in remission stage of asthma.
One hundred and six children with asthmawith deficiency of lung and spleen in remission stage admitted to the hospital from January 2021 to June 2022 were random ly divided into the combined group（53 cases）and the control group（53 cases）. Both groupswere given long-term asthma control drugs and Huaiqihuang Granule and the combined group added Xiaoqinglong Decoction for onemonth. The changes of humoral immunity，inflammatory factors，lung function，Chinese version of children asthma control questionnaire（Ch-CACT），TCM syndrome score and other indicators before and after treatmentwere compared between the two groups，and the clinical efficacy of the two groupswas compared.
After onemonth of treatment，the levels of immunoglobulin A（IgA），immunoglobulin G（IgG）and immunoglobulin M（IgM）in both groupswere higher than those before treatment，while immunoglobulin E（IgE）was lower than that before treatment. After onemonth＇s treatment，the levels of IgA，IgG and IgM in the combined group were higher than those in the control group，and the IgE was lower than that in the control group（P<0.05）. After onemonth of treatment，the levels of interferon-γ（IFN-γ）increased and the level sof eosinophil（EOS）and interleukin-4（IL-4）decreased in both groups. The level of IFN-γin the combined group was higher than that in the control group，and the levels of EOS and IL-4 were lower than those in the control group（P<0.05）. The values of forced expiratory volume in one second（FEV1%）and peak expiratory flow（PEF）in both groups increased after onemonth of treatment. And the values of FEV1% and PEF in the combined group were higher than those in the control group（P<0.05）. After onemonth of treatment，the Ch-CACT scores of the two groupswere higher than those before treatment，and the TCM syndrome scoreswere lower than those before treatment. The Ch-CACT score of the combined group was higher than that of the control group，and the TCM syndrome scorewas lower than thatof the control group（P<0.05）. After onemonth of treatment，the total effective rate of the combined group was 88.68%（47/53），which was higher than that of the control group（71.70%，38/53）（P<0.05）.
On the basis of routine westernmedicine treatment of Huaiqihuang Granule，Modified Xiaoqinglong Decoction is helpful to improve the immune function，inflammatory factors and lung function of children with asthmawith Qideficiency of lung and spleen in remission stage，thus alleviating clinical symptoms，improving clinical efficacy and the quality of prognosis of children.
To analyze the clinical effect of Modified Banxia Xiexin Decoction（半夏泻心汤）in the treatment of chronic gastritis.
A total of 128 patientswith chronic gastritis admitted to our hospital from February 2021 to July 2024 were included as the research objects. They were divided into two groups by the random number tablemethod.64 patients in the control group were treated with the Western medicine quadruple therapy，and 64 patients in the observation group were treated with themodified Banxia Xiexin Decoction on the basis of the above-mentioned treatment. The differences in curative effects，TCM syndrome scores，gastric mucosal function，inflammatory factors，and Helicobacter pylori（Hp）negative conversion rate were compared between the two groups.
The total effective rate of treatment in the observation group was 96.88%（62/64），which wasmuch higher than 82.81%（53/64）in the control group，and the difference between the two groups was significant（P<0.05）. After treatment，the scores of four symptoms，including epigastric pain，fullness and discomfort，epigastric burning，belching and acid reflux，bitter taste and drymouth in the observation group were lower than those in the control group（P<0.05）. After treatment，the levels of pepsinogen I（PG I），pepsinogenⅡ（PGⅡ），pepsinogen ratio（PGR），gastrin-17（G-17），and the levels of inflammatory factors such as tumor necrosis factor-α（TNF-α），interleukin-1β（IL-1β），and interleukin-6（IL-6）in the observation group were all lower than those in the control group（P<0.05）. One month after treatment，the Hp negative conversion rate in the observation group was 90.63%（58/64），which was significantly higher than 75.00%（48/64）in the control group，and the difference between the two groupswas significant（P<0.05）.
The application ofmodified Banxia Xiexin Decoction in the treatment of patientswith chronic.
To observe the regulation effect of Sini Hewei Formula（四逆和胃方）combined with triple therapy on visceral hypersensitivity and gastrointestinal hormone secretion disorder in patients with Helicobacter pylori（Hp）-positive gastroesophageal reflux disease（GERD）.
Ninety cases of Hp-positive GERD patients admitted to the hospital from February 2021 to May 2023 were selected as the study subjects and the patients who met the criteria were divided into two groups by simple randomization method. Forty-five cases in the control group were treated with triple therapy，and the other 45 cases in the Sini Hewei Formula group were treated with Sini Hewei Formula on the basis of triple therapy. The efficacy，Hp conversion rate，Gastroesophageal Reflux Disease Questionnaire（GERDQ）score，esophageal dynamics，traditional Chinese medicine syndrome score，Gastroesophageal Reflux Disease Related Quality of Life Scale（GERDQ）score，visceral hypersensitivity related factors and gastrointestinal hormones were compared between the two groups.
The total effective rate of the Sini Hewei Formula group was higher than that of the control group，and the Hp conversion rate was was not statistically significant compared with that of the control group by theχ2 test（P>0.05）. Comparison of esophageal dynamic function before treatment between the two groups showed no statistical difference（P>0.05）. The postreflux swallow-induced peristaltic wave（PSPW）index，esophageal mass clearance time and the number of acid reflux were lower than those before treatment in both groups，and they were lower in the Sini Hewei Formula group than that in the control group after treatment（P<0.05）. Comparison of TCM evidence score，GERDQ score and GERD-HROL score before treatment between the two groups did not show any statistical difference（P>0.05）. The above scores were lower than those before treatment in both groups after treatment，and were lower in the Sini Hewei Formula group than those in the control group（P<0.05）. Comparison of visceral hypersensitivity-related factors and gastrointestinal hormones between the two groups before treatment showed no statistical difference（P>0.05）. Substance P（SP），nerve growth factor（NGF），calcitonin gene-related peptide（CGRP）and vasoactive intestinal peptide（VIP）were all lower in both groups than those in the control group after treatment（P<0.05）. The levels of VIPwere lower than those before treatment，and they were lower in the Sini Hewei Formula group than those in the control group after treatment（P<0.05）. The levels of motilin（MTL）and gastrin（GAS）were higher than those in the control group after treatment in both groups，and they were higher in the Sini Hewei Formula group than those in the control group after treatment（P<0.05）.
The combination of Sini Hewei Formula and triple therapy can improve esophageal dynamic function，reduce visceral hypersensitivity，regulate gastrointestinal hormone secretion disorder and improve curative effect in Hp-positive GERD patients.
Dahuoluo Pills（大活络丸）originated from classic and famous recipes of the Ming dynasty of Wonderful Well-Tried Recipes，obtained after several increases and decreases，and were consisted of 48 kinds of herbs such as Mahuang（Ephedrae Herba），Qishe（Agkistrodon），Tiannanxing（Arisaematis Rhizoma），Shuiniujiao（Bubali Cornu）and so on. Tongren Dahuoluo Pills were added processed Fuzi（Aconiti Lateralis Radix Praeparata）and Fuling（Poria）. The dosage forms include honey pills，water pills，water honey pills，concentrated pills，etc. The whole prescription has the effects of dispelling wind，relaxing tendons，activating collateral and eliminating dampness，and could be used for the treatment of hemiplegia，rheumatic arthralgia，chest arthralgia and heartache. Through consulting and analyzing the relevant literature in recent years，the author has found that the Dahuoluo Pills have good effects of promoting blood circulation and removing blood stasis and neuroprotection，and could be used for osteoarthropathy（knee osteoarthritis，rheumatoid arthritis，lumbar disc herniation，osteonecrosis of femoral head），cerebrovascular diseases（cerebral apoplexy，insufficient blood supply），nerve injury（peripheral neuropathy，spinal cord injury），scapulohumeral periarthritis and so on. The quality control methods included spectrum detection，chromatography detection，multi-technology combination and so on，and were mainly based on high performance liquid chromatography and multi-technology combination. While the material basis and molecular mechanism still need to be improved. Here，the authors summarized and analyzed the findings about clinical applications，quality control and pharmacologic actions of Dahuoluo Pills，in order to provide more ideas and basis for their clinical application.
To compare and analyze the differences of the special odors of Jiucaizi（Semen Allii Tuberosi）under different processing methods，such as raw products，stir-fried products with wine，stir-fried products with salt，stir-fried products with vinegar，stir-fried products with nothing，stir-fried products with salt and wine，steamed products. And to establish a method for distinguishing different processed products of Jiucaizi（Semen Allii Tuberosi）from their odors to provide a reference for further study of chemical transformation of Jiucaizi（Semen Allii Tuberosi）.
GC-IMStechnology was used to detect volatile organic compounds in different processed products of Jiucaizi（Semen Allii Tuberosi）through the instrument combined with VOCal and plug-in Reporter，Gallery Plot and Dynamic PCA analysis from different angles including differential analysis，fingerprint analysis，dynamic principal component analysis，similarity analysis and qualitative analysis of differential substances.
The difference analysis of GC-IMSshowed that there were significant differences in the specific odor components of Jiucaizi（Semen Allii Tuberosi）under different processing methods. About 54 compounds had been identified. Among them，geraniol，1-hydroxy-2-propanone，1-pentanol，2-methylpropanol，diallyl sulfide，Methyl-3-but-3-en-1-ol，ehanol，propanoic acid，2-acetylfuran，5-dimethylfuran，ethyl acetate，diallyl disulfide M，2-pentylfuran，hexanoic acid M and ethyl hexanoate can be used as the characteristic volatiles of the special odors of raw products. Ethyl 2-hydroxypropanoate and beta-Ocimene can be used as the characteristic volatiles of the special odors of Jiucaizi（Semen Allii Tuberosi）processed with wine or salt and wine；pentanal can be used as the characteristic volatiles of the special odors of stir-fried products with vinegar；3-hydroxy-2-butanone，butyrolactone and linalool could be used as the characteristic volatiles of steamed Jiucaizi（Semen Allii Tuberosi），and octanol could be used as the characteristic volatiles of stir-fried products with nothing. The PCA results showed that the separation of the samples was good，and the similarity of the samples with the same excipients was greater.
There are obvious differences in the specific odor components of Jiucaizi（Semen Allii Tuberosi）processed by different methods. GC-IMStechnology can be used as a method to distinguish the specific odor of different processed products of Jiucaizi（Semen Allii Tuberosi）. It also provides reference for further study on the processing and transformation of Jiucaizi（Semen Allii Tuberosi）.
To investigate the effects of Shengyu Decoction（圣愈汤）and Zengye Decoction（增液汤）combined with recombinant human granulocyte colony-stimulating factor on myelosuppression and peripheral blood image after chemotherapy for epithelial ovarian cancer.
All 75 patients were randomly divided into treatment group and control group according to the order of enrollment for epithelial ovarian cancer，35 cases in each group. The control group was prophylactically treated with pegylated recombinant human granulocyte colony stimulating factor（PEG-rhG-CSF）or recombinant human granulocyte colony stimulating factor（rhG-CSF）after chemotherapy. The treatment group was treated with Shengyu Decoction and Zengye decoction orally in addition to the treatment of the control group. The degree of myelosuppression after chemotherapy and peripheral blood images were observed at 1 day before chemotherapy，1，2 and 3 courses after chemotherapy.
The incidence of myelosuppression in the treatment group after 1，2 and 3 courses was significantly lower than that in the control group，and the difference was statistically significant（P<0.05）. There was no statistically significant difference in the levels of white blood cells，neutrophils，platelets or hemoglobin between the two groups before treatment（P>0.05）. The above indexes were both decreased after treatment and the decrease degree in the control group was significantly greater than that in the treatment group，and the difference was statistically significant（P<0.05）.
Shengyu Decoction and Zengye Decoction combined with recombinant human granulocyte colony-stimulating factor can reduce myelosuppression in patients with epithelial ovarian cancer，improve the decline of peripheral blood cells and promote the recovery of blood cell levels after chemotherapy.
To investigate clinical efficacy of Modified Shenghua Decoction（加味生化汤）combined with medroxyprogesterone in treatment of patients with perimenopausal abnormal uterine bleeding-ovulatory dysfunction（AUB-O）.
Sixty cases patients with perimenopausal AUB-Owere selected and randomly divided into the observation group（30 cases）and control group（30 cases）. The control group received oral treatment with medroxyprogesterone. On the basis of the control group，the observation group was treated with a combination of Modified Shenghua Decoction orally. The treatment course was 3 menstrual cycles. The changes of sex hormone level，endometrial thickness，uterine volume，menstrual volume，menstrual duration，prothrombin time，activated partial thromboplastin time，hemoglobin level and traditional Chinese medicine syndrome score（TCM）symptom score before and after treatment were observed.
The levels of estradiol（E2），follicle stimulating hormone（FSH），luteinizing hormone（LH）and prolactin（PRL）decreased before and after treatment in both groups（P<0.05）and the levels of the observation group were lower than those of the control group（P<0.05）. The endometrial thickness，menstrual volume and menstrual duration of two groups decreased after treatment compared to those before treatment（P<0.05）. The degree of decrease in the observation group was greater than that in the control group（P<0.05）. There was no statistically significant difference in uterine volume between the two groups before and after treatment（P>0.05）. The prothrombin time and activated partial thromboplastin time of two groups decreased after treatment compared to those before treatment（P<0.05）. The degree of decrease in the observation group was greater than that in the control group（P<0.05）. The hemoglobin level increased compared to that before treatment（P<0.05）and the increase in the observation group was greater than that in the control group（P<0.05）. The incidence of adverse reactions was 36.67%in the control group and 43.33%in the observation group. There was no statistically significant difference in comparison（P>0.05）. The scores of TCM symptoms in both groups decreased after treatment（P<0.05），and scores of the observation group were lower than those of the control group（P<0.05）. The therapeutic effect of the observation group was significantly better than that of the control group（P<0.05）.
Modified Shenghua Decoction combined with medroxyprogesterone in treatment of patients with perimenopausal AUB-Ocan help to improve the levels of sex hormones，reduce endometrial thickness，menstrual volume and duration，improve coagulation function andclinical efficacy，and dose not significantly increase adverse reactions.
To investigate the mechanism of action of curculigoside（CUR）antioxidation in alleviating apoptosis of ovarian granulosa cells（GCs）in mice with premature ovarian failure（POF）.
Mice after acclimatization feeding were divided into blank，model，CUR low-dose，CUR mid-dose and CUR high-dose groups，and estradiol valerate group. The mouse model was replicated by intraperitoneal injection of cyclophosphamide（CTX）. After modeling，the mice were treated by gavage for 14 consecutive days and vaginal smears were performed daily，the body mass of the mice was weighed and the mice were killed 24 h after the last administration and the blood and ovary tissues were extracted，and the ovary tissues were weighed bilaterally to calculate the ovarian index. The levels of serum follicle stimulating hormone（FSH），anti-Müllerian hormone（AMH）and estradiol（E2）were measured. The ovaries were stained with hematoxylin-eosin（HE）staining to observe follicular development and corpus luteum morphology，and the apoptosis level of GCs was determined using terminal deoxynucleotidyl transferase-mediated dUTPNick-End Labeling（TUNEL），and the superoxide dismutase（SOD）activity and malondialdehyde（MDA）level were measured using protein peroxidase，glutathione peroxidase（GSH-Px）content and malondialdehyde（MDA）level in the ovary tissue. The protein expressions of ovarian protein kinase B（AKT），p-AKT，mammalian target of rapamycin（mTOR）and p-mTOR were detected using protein blotting（WB）.
Compared with the blank group，the mice in the model group showed disorganized estrous cycle，decreased ovarian index，large number of atretic follicles，high level of apoptosis of GCs and significantly upregulated levels of FSH，whereas AMH and E2 showed a significant decrease，suggesting a successful replication of the POF mouse model. Compared with the model group，the administration of CUR intervention was able to increase the antioxidant level，activate the AKT/mTOR signaling pathway，improve the estrous cycle and serum hormone levels，reduce apoptosis of GCs，and promote follicular development in POF mice，thus restoring the ovarian reserve function.
CUR ameliorated mouse POF caused by CTX，and the mechanism may be related to the activation of Akt/mTOR signaling pathway to exert antioxidant effects to alleviate the apoptosis of GCs in POF model mice.
Shengma Biejia Decoction（升麻鳖甲汤），recorded in the Synopsis of Prescriptions of Golden Chamber，consists of a combination of Shengma（Cimicifugae Rhizoma），Biejia（Trionycis Carapax），Danggui（Angelicae Sinensis Radix），Gancao（Glycyrrhizae Radix et Rhizoma），Shujiao（Zanthoxyli Pericarpium）and Xionghuang（Realgar），and can be used to treat Yang toxin. On the basis of this prescriptions，Shujiao（Zanthoxyli Pericarpium）and Xionghuang（Realgar）are subtracted to treat Yin toxin. Physicians in past dynasties held varying perspectives on the drug addition and subtraction of Shengma Biejia Decoction. The toxicity of Xionghuang（Realgar）in Shengma Biejia Decoction restricts its clinical applications. Physicians hold discrepant perspectives on the interpretation of“Yin-Yang”of the Yin-Yang toxin，with some linking it to the cold and heat nature of diseases and others connecting it to the differentiation between exterior and interior diseases，causing debate over drug addition and subtraction of Shengma Biejia Decoction. Ancient physicians thought that Yin-Yang toxin was exogenous diseases such as typhoid fever and epidemic disease，and treated it with Shengma Biejia Decoction. In modern clinic，Shengma Biejia Decoction is widely used to treat dermatological diseases，ophthalmological and otolaryngological diseases and internal diseases including hematological diseases and immunological diseases，and its pharmacodynamic mechanism is related to regulating immunity and inhibiting tumor cell viability. Most physicians believe that the usage of Xionghuang（Realgar）in this prescription should be taken with water in low doses for a short duration. Shengma Biejia Decoction with Xionghuang（Realgar）is commonly used for dermatological diseases，hematological diseases and immunological diseases，particularly for treating urticaria，leukemia and systemic lupus erythematosus. This paper addressed the problems of drug addition and subtraction of Shengma Biejia Decoction，reviewed the advancements in clinical application and pharmacodynamic mechanism of Shengma Biejia Decoction，and conducted statistical analysis on the clinical utilization of Shengma Biejia Decoction with Xionghuang（Realgar）. This review aimed to offer guidance for the clinical application of Shengma Biejia Decoction and inform future basic and theoretical research in this area.
To explore the effect of Wenyang Zhenshuai Granule（温阳振衰颗粒）medicated serum on adriamycin induced H9C2 myocardial cell injury based on long non-coding RNAs（LncRNA）metastasis associated lung adenocarcinoma transcript 1（malat-1）/microRNA-133（miR-133）pathway regulating p-ERK1/2.
H9C2 myocardial cell injury model was established by coculture with 2.67μmol/L adriamycin（ADR）for 45 h and set up a normal control group，a normal＋W group（W：Wenyang Zhenshuai Granule medicated serum），an miR-133 overexpression group，an miR-133 overexpression＋W group，an ADR group，an ADR ＋W group，an ADR ＋miR-133 overexpression group，and an ADR ＋miR-133 overexpression＋W group. The cell proliferative activity was detected by MTT method，while the change of N-terminal B-type brain natriuretic peptide precursor（NT-proBNP）was detected by ELISA. The contents of lncRNA malat-1，miR-133 and ERK1/2 mRNA in H9C2 cardiomyocytes of each group were detected by RT-PCR. The protein expressions of ERK1/2 and p-ERK1/2 were detected by Western-blot.
The myocardial cell activities in the ADR group，the ADR＋miR-133 overexpression group，the ADR＋W group，the ADR＋miR-133 overexpression＋W group，the normal control group，the miR-133 overexpression group，the normal＋W group and the miR-133 overexpression＋W group were increased in sequence（P<0.05）. The content of NT-proBNP was decreased in sequence（P<0.05）. After the experiment，there was no significant difference in ERK1/2 mRNA expression in myocardial cells among different groups（P>0.05）. The expression of the miR-133 in ADR group，the ADR＋miR-133 overexpression group，the ADR＋W group，the ADR＋miR-133 overexpression＋W group，the normal control group，the miR-133 overexpression group，the normal＋W group and the miR-133 overexpression＋W group increased in sequence（P<0.05）. The expression of LncRNA malat-1 was decreased in sequence（P<0.05）. There was no significant difference in ERK1/2 protein expression in myocardial cells among different groups after the experiment（P>0.05）. The p-ERK1/2 protein expression levels in the ADR group，the ADR＋W group，the ADR＋miR-133 overexpression group，the ADR＋miR-133 overexpression＋W group，the normal control group，the miR-133 overexpression group，the normal＋W group and the miR-133 overexpression＋W group were decreased in sequence（P<0.05）.
Wenyang Zhenshuai Granule medicated serum can reduce the expression of p-ERK1/2 protein in myocardial cells and exert the curative effect on chronic heart failure，which may be achieved by regulating the lncRNA malat-1/miR-133 pathway in myocardial cells.
The term“Stomach Preponderance and Spleen Weakness”was initially used to explain the pathological mechanism of“spleen constipation syndrome”in which the spleen＇s inability to properly transport body fluids leads to abnormal fluid distribution，resulting in insufficient fluid supply to the intestines and causing constipation. Over time，this concept evolved to describe a broader state of impaired Qi dynamics，where spleen deficiency disrupts the proper transportation and transformation of fluids. This leads to fluid accumulation in the stomach，stagnation，and subsequent heat generation due to fluid retention. The pattern of“Stomach Preponderance and Spleen Weakness”is linked to dysfunction in the spleen and stomach in three key areas：transport and absorption，the regulation of ascending and descending，and the balance of moistening and drying. These dysfunctions form an important pathological basis for the onset of gastrointestinal and various visceral diseases. Gastrointestinal dysfunction is a common non-motor symptom（NMS）in Parkinson＇s disease（PD），manifesting in both the prodromal and disease stages. Key symptoms include difficulty swallowing，excessive salivation，delayed gastric emptying，bloating，and constipation. Gastrointestinal dysfunction is an important pathological factor in the development of PD，and its mechanisms are related to disturbances in the intestinal microbiota and its metabolites，damage to the intestinal barrier，inflammatory responses，and the aggregation ofα-synuclein（α-syn）in both the intestines and the central nervous system（CNS）. Excessive dietary intake or a deficiency in spleen Qi can lead to food stagnation in the stomach，preventing timely discharge and triggering pathological changes such as dysbiosis of the intestinal microbiota and activation of inflammatory responses. The failure of the stomach＇s descending function and obstruction can lead to the stagnation of heart and lung Qi in the upper body，while the spleen＇s weakened ability to lift results in dysfunction of liver and kidney essence. This may delay intestinal transit，increase intestinal permeability，and promote the translocation of pathogen metabolites，along with other pathological changes. Dampness in the spleen or excessive dryness in the stomach can damage the intestinal barrier，resulting in inflammation andα-syn accumulation.“Stomach Preponderance and Spleen Weakness”is closely associated with the occurrence of gastrointestinal dysfunction in PD. Exploring the relationship between these concepts can deepen the understanding of PD from a Traditional Chinese Medicine（TCM）perspective and offer new insights for clinical differentiation and treatment strategies.
The prevention and treatment of malignant tumors has always been a hot topic for oncologists around the world. Mitochondrion is a key organelle that can regulate the internal metabolism of tumor cells and always affect the occurrence and development of tumors. Apoptosis is an important regulatory mechanism for cells to maintain their internal environment. Mitochondrial apoptosis pathway is one of the main pathways to promote apoptosis，and the induction of mitochondrial apoptosis in tumor cells is an important target for anti-tumor. Studies have shown that the active ingredients of many Chinese medicines，such as flavonoids，lactones，alkaloids，terpenoids，glycosides and quinones，can increase the expressions of pro-apoptotic proteins such as Bax，Bad and Bim，and decrease the expressions of anti-apoptotic proteins such as Bcl-2 and Bcl-xL，down-regulate the mitochondrial membrane potential level，increase the permeability of mitochondrial membrane，release a large number of apoptotic factors，activate the Caspase cascade reaction，and finally induce the endogenous apoptotic pathway of tumor cells，and inhibit the proliferation and invasion of tumor cells by regulating PI3K/AKT，TLR9/MyD88，p38 MAPK，ERK1/2，Notch/JAK/STAT and other signaling pathways. This article summarized the research results of the specific mechanism of the active ingredients of Chinese medicines regulating the mitochondrial apoptosis pathway in recent years，and discussed the aspects of the active ingredients of Chinese medicines regulating the mitochondrial apoptosis pathway to enhance the anti-tumor effect，in order to provide new research ideas for the anti-tumor treatment of traditional Chinese medicine and further improve the effectiveness of clinical anti-tumor treatment.
To investigate the curative effect of regulating Du meridian and harmonizing stomach acupuncture combined with warm needle moxibustion at Zusanli（ST36）in the treatment of wind-cold type of peripheral facial paralysis and its influence on H-B grading.
A total of 132 patients with wind-cold type of peripheral facial paralysis admitted to the hospital from July 2020 to October 2022 were randomly divided into two groups with 66 cases in each group. The control group was given warm needle at Zusanli（ST36），and the treatment group was given regulating Du meridian and harmonizing stomach acupuncture on the basis of the control group. The clinical efficacy，H-B grading，facial disability index（FDI）score，Portmann score，TCM syndrome score and safety analysis after treatment were compared.
After treatment，the curative effect of treatment group was higher（P<0.05）. After treatment，H-B grading，FDIPscore，FDISscore and Portmann score were significantly improved in two groups（P<0.05），and the improvement was more significant in the observation group（P<0.05）. The scores of incomplete eyelid closure，frontal striae disappearance，mouth angle skew and shallow nasolabial groove were significantly decreased in two groups（P<0.05），and were more significantly decreased in the observation group（P<0.05）. In the control group，there were 2 cases of headache and nausea，1 case of drowsiness，1 case of local congestion and swelling，and 1 case of acupuncture dizziness. The total incidence of adverse reactions was 7.58%（5/66）. In the treatment group，headache and nausea in 1 case，drowsiness in 2 cases，local congestion and swelling in 2 cases，and acupuncture dizziness in 1 case. The total incidence of adverse reactions was 9.09%（6/66）. There was no significant difference between the two groups（P>0.05）.
The treatment of wind-cold type of peripheral facial paralysis by regulating Du meridian and harmonizing stomach acupuncture combined with warm needle moxibustion at Zusanli（ST36）has good therapeutic effect，which can improve the function of facial nerve.
Simiao Pill（四妙丸）is a representative prescription for the treatment of dampness-heat pouring down syndrome，which has the effects of clearing heat and dampness，relaxing muscles and strengthening bones，and is mostly used in the treatment of gout，rheumatoid arthritis，synovitis，Henoch-Schonlein purpura，eczema，vaginitis and other diseases. On the basis of summarizing the research progress of the chemical composition，pharmacological effects and clinical application of Simiao Pill，the prediction analysis of quality marker（Q-Marker）was carried out according to the“five principles”of Q-Marker of traditional Chinese medicine，and the results showed that phellodendrine，magnolidine，rhizoline，parmatine，berberine，phellodenolide，phellodenone，atractylodes，atractylodes，β-eucalyptol，triglyceride palmitate，γ-sitosterol，adenosine，oleanolic acid，hyssosterol and β-ecdysterol can be used as Q-markers for Simiao Pill，which can provide a reference for follow-up studies such as the quality control of Simiao Pill and their related preparations.
Mitochondria are important organelles of the cell and the sites where the cell produces energy. Studies have shown that mitochondria have the ability to induce apoptosis，and mitochondria-targeted therapy is a new tumor treatment with potential ability. Tumor mortality rate is increasing year by year，seriously threatening people＇s physical and mental health. Clinical and fundamental research studies have already proved that Chinese medicine is effective in tumor treatment，and its advantages of low toxicity and high efficiency，multi-pathway and multi-targeting have made it more and more popular in the clinic. Chinese medicine monomer saponins，such as ginsenoside，escin，α-hederin，Polyphyllin，Platycodin D and so on，can induce apoptosis of tumor cells by endogenous pathway through the regulation of mitochondria，promotion of the expressions of Bax，caspases，cytochrome Cand inhibition of the expression of the Bcl-2 family of proteins，thus exerting an anti-tumor effect. In this paper，it summarized and screened the research results on the regulation of mitochondrial apoptosis by monomer saponins of traditional Chinese medicine in recent years，and took mitochondrial apoptosis as the starting point to introduce the mechanism of mitochondrial apoptosis in detail by monomer saponins of Chinese medicine with a view to exploring the new direction of Chinese medicine in the field of tumor therapy，and helping to promote the modernization of traditional Chinese medicine in the development of the field of tumor therapy.
Mass spectrometry imaging technology is a combination of mass spectrometry and imaging technology，which converts mass spectrometry signals into visualized images with spatial distribution characteristics through imaging software. In recent years，mass spectrometry imaging technology has been widely used for the analysis of plant tissue metabolites，providing new ideas and methods for the research of traditional Chinese medicinal plants. This article provided a review in three parts. Firstly，it reviewed matrix assisted laser ionization desorption mass spectrometry imaging（MADLI）technology，secondary ion mass spectrometry imaging（SIMS）technology，Desorption Electrospray Ionization Mass Spectrometry Imaging（DESI）technology and the principle of nanostructure induced mass spectrometry imaging technology were summarized. Secondly，the application examples of mass spectrometry imaging technology in the visualization analysis and identification of metabolites in traditional Chinese medicinal plants as well as the biosynthesis pathways of active ingredients were reviewed. Finally，the advantages and limitations of mass spectrometry imaging technology were summarized，and further prospects were made for the application of mass spectrometry imaging technology in traditional Chinese medicinal plants.
Renshen（Ginseng Radix et Rhizoma）is the dried root and rhizome of plant Renshen（Panax ginseng C. A. Mey.）. The main chemical components include saponins，polysaccharides，polyynols，volatile oils，proteins，peptides，amino acids，etc. In this paper，based on the summary of the chemical composition and pharmacological effects of Renshen（Ginseng Radix et Rhizoma）regulating immune function and the principle of quality marker（Q-Marker），the plant affinity，the effectiveness of chemical components，the specificity and the compatibility of compound formulae were predicted and analyzed. Ginsenosides，polysaccharides，proteins and volatile oils were the Q-Markers of Renshen（Ginseng Radix et Rhizoma）regulating immune function，and ginsenosides Rg1，Re，Rb1，Rg3，Rh1，Rh2，Rd，CK，Ro，Rg5，ginseng D-glucose，galactose，arabinose and ginsekyl can be selected as alternative substances for a single component，which can provide a certain quality control method reference.
Digestive system diseases are a common type of diseases in clinical practice，and the characteristics of these diseases are complex and related. Traditional Chinese medicine is guided by the concept of“holistic concept”and“syndrome differentiation and treatment”，which has the advantages of high safety，good efficacy and small adverse reactions in the treatment of digestive diseases. Huangqin Decoction（黄芩汤，HQD），originated from the ancestor of the formula book Treatiseon Miscellaneous Diseases of The Typhoid Fever，has been widely used in digestive system diseases because of its multiple pharmacological effects. Through reviewing the clinical application of HQD and experimental research literature，the author has found that HQD can regulate multiple signaling pathways to achieve anti-inflammatory effects. HQD can regulate inflammation-related signals such as JAK/STAT-related signaling pathway，MAPK related signaling pathway and NF-κB-related signaling pathway，as well as macrophage phenotypic changes to play an anti-inflammatory role，and the use of the above pathways can reduce the levels of pro-inflammatory factors in the serum in order to achieve the anti-inflammatory effect of the formula. The unique anti-inflammatory advantages of HQD are widely used in digestive system diseases，because the inflammatory environment of the human body plays an important role in the“inflammation-cancer transformation”in the process of disease development. Therefore，the formula is commonly used in the treatment of inflammatory diseases such as ulcerative colitis，primary hepatocellular carcinoma，gastric carcinoma，acute enteritis and other inflammatory diseases in the clinic. Therefore，this article summarized the anti-inflammatory effect and clinical application of HQD，with a view to providing reference and ideas for the expansion of clinical application and further in-depth study of this formula.
Qingqianliu［Cyclocarya paliurus（Batal.）Ijinskaja］is a plant of the genus Cyclocarya of the Juglandaceae family，and it is a rare and precious species found only in China. Its roots，branches and leaves all have medicinal value and are known to have insect-killing，itch-stopping，anti-inflammatory and pain-relieving properties. Its chemical composition mainly includes polysaccharides，flavonoids，triterpenoids，phenolic acids and so on. It has a variety of pharmacological effects such as hypoglycemia，hypotension，hypolipidemia，antioxidant，anti-inflammatory and hepatoprotective. By summarizing the research progress of chemical composition and pharmacological effects of Qingqianliu［Cyclocarya paliurus（Batal.）Ijinskaja］and combining with the theory of quality marker（Q-Marker），the Q-Marker of Qingqianliu［Cyclocarya paliurus（Batal.）Ijinskaja］was predicted and analyzed from various perspectives，such as chemical composition uniqueness，traditional medicinal efficacy，chemical composition measurability，blood-entry components and network pharmacological evaluation. The results revealed that polysaccharides，flavonoids and triterpenoids can be used as potential species of Qingqianliu［Cyclocarya paliurus（Batal.）Ijinskaja］quality markers. It was initially hypothesized that dammarane-type triterpenoids（such as cyclocarioside A，cyclocarioside I and cyclocarioside Z5-Z8），isoquercitrin，quercetin-3-O-β-D-glucuronide，kaempferol-3-O-β-D-glucuronide，luteolin，apigenin，arjunolic acid，cyclocaric acid B，p-coumaric acid，4，5-O-dicaffeoylquinic acid，chlorogenic acid and rosmarinic acid can be used as the Q-Marker of Qingqianliu［Cyclocarya paliurus（Batal.）Ijinskaja］. The results provided a reference for the establishment of a systematic quality evaluation system of Qingqianliu［Cyclocarya paliurus（Batal.）Ijinskaja］and a guiding role in ensuring the quality of Qingqianliu［Cyclocarya paliurus（Batal.）Ijinskaja］，and further promoted the rational development and application of Qingqianliu［Cyclocarya paliurus（Batal.）Ijinskaja］.
The objective of this study was to investigate the mechanism of Huangqi（Astragali Radix）-Tinglizi（Descurainiae Semen）improving cardiac function in rats with heart failure by modulating AMP-activated protein kinase（AMPK）/mammalian target of rapamycin（mTOR）pathway and influencing autophagy.
Sixty male SD rats of SPF grade were selected，with 8 randomly assigned to the control group（CON）. The remaining rats received subcutaneous injections of isoproterenol solution at a dose of 3 mg·kg-1 on the back of their shoulders for 10 consecutive days to induce heart failure. Forty heart failure rats were randomly allocated into five groups：model control group（MC），Huangqi（Astragali Radix）-Tinglizi（Descurainiae Semen）low-dose group（HTL），Huangqi（Astragali Radix）-Tinglizi（Descurainiae Semen）medium-dose group（HTM），Huangqi（Astragali Radix）-Tinglizi（Descurainiae Semen）high-dose group（HTH），enalapril group（ENA）. Each group consisted of eight rats. Following a 14-day period of drug administration，B-ultrasound was used to measure the left ventricular ejection fraction（LVEF）and left ventricular short axis shortening rate（LVFS）. The left ventricle was then isolated and weighed，and the length of the tibia was measured. The levels of type B natriuretic peptide（BNP）and atrial natriuretic peptide（ANP）in serum of rats were determined by enzyme-linked immunosorbent assay（ELISA）. Histopathological changes in the myocardium were observed using Hematoxylin-eosin（HE）and Masson staining. Western blot analysis was employed to assess the activation status of autophagy-associated protein sequestosome 1（SQSTM1/p62），microtubule associated protein 1 light chain 3（LC3）and AMPK/mTORpathway proteins.
The results of the study indicated that in MCgroup，there was a significant decrease in LVEF and LVFScompared to those in CON group（P<0.01）. Additionally，the heart index，left ventricular mass index and heart to shin ratio were found to be significantly increased in MCgroup（P<0.01，P<0.01，P<0.05）. Furthermore，the serum levels of BNPand ANPwere significantly increased（P<0.01）. MCgroup also exhibited aggravated myocardial tissue pathological injury and fibrosis as well as increased expressions of p-AMPK/AMPK and LC3-Ⅱ/LC3-I（P<0.01）. Conversely，the expressions of p-mTOR/mTOR and p62 were decreased（P<0.01）. In comparison to MC group，the HTH group and ENA group exhibited significant increases in LVEF and LVFS（P<0.01）. Additionally，there were significant decreases in heart index and heart-tibial ratio（P<0.01，P<0.05）as well as significant decreases in serum levels of ANP and BNP（P<0.01，P<0.05）. Moreover，the degree of myocardial tissue pathological injury and fibrosis was alleviated. The expressions of p-AMPK/AMPK and LC3-Ⅱ/LC3-I were decreased（P<0.01），while the expressions of p-mTOR/mTOR and p62 were increased（P<0.01，P<0.05）.
By modulating the AMPK/mTOR signaling pathway，Huangqi（Astragali Radix）-Tinglizi（Descurainiae Semen）is able to attenuate the hyperactive autophagic flux in rats with heart failure and ameliorate their cardiac function.
Ruxiang（Frankincense）is a traditional Chinese medicine that enhances blood circulation，reduces swelling and promotes muscle growth. It is rich in triterpenes，diterpenes，volatile oils and other chemical compounds. However，raw Ruxiang（Frankincense）is toxic and can cause adverse reactions such as allergic rhinitis，eczema，nausea，joint pain，diarrhea and fever. Ruxiang（Frankincense）shows toxicity in liver，heart，kidneys and embryos of experimental animals. This presents a significant challenge to its safe use and development in clinical settings.“Vinegar-processing into liver”as a traditional Chinese medicine processing theory is widespread in clinical applications. Nowadays，the toxicity of raw Ruxiang（Frankincense）is reduced by vinegar processing. Vinegar-processing Ruxiang（Frankincense）is the only processed product in Chinese Pharmacopoeia. It has lower irritability than raw Ruxiang（Frankincense）. However，the toxic components of Ruxiang（Frankincense）are currently unknown，and the quality of the processed products is uneven. This paper reviewed a large number of ancient books and modern literature to study the toxicity and processing of Ruxiang（Frankincense）. It collated and inducted relevant literature，elaborating on the clinical adverse reactions of Ruxiang（Frankincense），the toxic components，the current status of toxicology research and the research on processing technology and vinegar-processing for toxicity reduction mechanisms. It is expected to provide research ideas for quality evaluation，rational development，safe application and the mechanism of vinegar-processing to reduce the toxicity of Ruxiang（Frankincense）. It is of great theoretical importance and practical value for the scientific interpretation of traditional processing theory and the optimization of the processing in traditional Chinese medicine.
To compare the efficacy differences between traditional decoction and formula granules of different ratios of Huanglian（Coptidis Rhizoma）-Wuzhuyu（Evodiae Fructus）.
Various typical efficacy indicators were used for different ratios of Huanglian（Coptidis Rhizoma）-Wuzhuyu（Evodiae Fructus）in separate comparative experiments. Zuojin Pill（左归丸）group［Huanglian（Coptidis Rhizoma）；Wuzhuyu（Evodiae Fructus）＝6∶1］used an anhydrous ethanol-induced gastric ulcer experiment to measure the effectiveness in inhibiting gastric ulcers and gastric acid secretion of rats. Blood superoxide dismutase（SOD）and malondialdehyde（MDA）were analyzed. The Ganlu Powder（甘露散）group［Huanglian（Coptidis Rhizoma）：Wuzhuyu（Evodiae Fructus）＝2∶1］used dry yeast-induced hyperthermia in rats to determine the antipyretic efficacy. The Zhuyu Pill（茱萸丸）group［Huanglian（Coptidis Rhizoma）：Wuzhuyu（Evodiae Fructus）＝1∶1］used a small intestinal propulsion experiment in mice to determine the antidiarrheal efficacy. The Reverse Zuojin Pill（反左金丸）group［Huanglian（Coptidis Rhizoma）：Wuzhuyu（Evodiae Fructus）＝1∶6］used acetic acid-induced writhing in mice to determine the analgesic efficacy.
Both formulations in the Zuojin Pill group effectively inhibited gastric ulcers of the rats but were unable to inhibit gastric acid secretion，showing no significant difference between the two（P>0.05）. Both formulations in the Ganlu Powder group effectively reduced fever of rats，with significant differences between the formula granule group and the traditional decoction group（P<0.05）. Both formulations in the Zhuyu Pill group alleviated mouse diarrhea symptoms，showing significance compared to the formula granule group（P<0.05）. Both formulations in the Reverse Zuojin Pill group alleviated mouse pain sensation，with no significant difference between the two（P>0.05）.
When Zuojin Pill is used to treat gastric ulcers，the efficacy of the traditional decoction is equivalent to the formula granules. For Ganlu Powder in treating fever，the formula granules are superior to the traditional decoction. When Zhuyu Pill is used for treating diarrhea，the efficacy of the traditional decoction is superior to the formula granules. In the case of Reverse Zuojin Pill for analgesia，the efficacy of the traditional decoction is equivalent to the formula granules.
Lingzhi（Ganoderma）is the dried fruiting body of Zhenjun Chizhi［Ganoderma lucidum（Leyss.ex Fr.）Karst.］or Zizhi（Ganoderma sinense Zhao，Xu et Zhang）of the polyporeaceae fungus，which is a traditional Chinese precious medicinal material and is listed as the top grade. At present，the types of compounds isolated from Lingzhi（Ganoderma）mainly include polysaccharides，triterpenoids，proteins，sterols，vitamins and trace elements，etc.，which have a wide range of biological activities and pharmacological effects，such as regulating immunity，anti-cancer，anti-oxidation，anti-aging，anti-inflammatory，etc. In this paper，the chemical composition and pharmacological effects of Lingzhi（Ganoderma）were reviewed，and the quality markers（QMarker）were predicted from multiple aspects，and the polysaccharides of Lingzhi（Ganoderma），total triterpenoids of Lingzhi（Ganoderma），Ganoderic acid A，Ganoderic acid B，Ganoderic acid C2，Ganoderic acid E，Ganoderma lucidum kettotriol，Ganoderma lucidum terpene diol，ergosterol，ergosterol peroxide，Ganoderma lucidum uridine，uracil，protein，amino acids，trace elements，vitamin components and heavy metal elements（Pb，Cd，As，Hg）and other components may become Q-Markers of Lingzhi（Ganoderma），which provides a basis for the quality control and evaluation of Lingzhi（Ganoderma）.
Zhuling Decoction（猪苓汤）was first created by the medical sage ZHANG Zhongjing，with the main functions of promoting diuresis，nourishing Yin and clearing heat. The descendants continuously add，subtract and innovate on the basis of the original formula，and the treatment scope has been widely expanded. This article summarized the modern clinical application of Zhuling Decoction by sorting and analyzing modern literature related to it，and found that it mainly treated urinary system diseases and was widely used in clinical departments such as digestion，respiration and tumors. At the same time，it explained that Zhuling Decoction could exert therapeutic effects by reducing the deposition of inflammatory factors and immune complexes，and improving microcirculation and anti-coagulating mechanisms.
It is to summarize Professor GAO Shuzhong＇s clinical experience in the treatment of epilepsy. Professor GAO emphasizes the holistic concept and systematic treatment，believing that the basic pathogenesis of epilepsy is the imbalance of Qi，obstruction of the brain orifice，and disorder of the spirit，not solely caused by phlegm，blood stasis and other turbidity. He also emphasizes the importance of the neck-pass. Professor GAO advocates for equal emphasis on regulating Qi and spirit，dredging the neck-pass and opening up the brain orifice，nurturing and enlightening the spirit. Internal and external therapy，acupuncture and medication are always advocated. The external therapy includes GAO＇s method of dredging pass，the group of acupoints for regulating the spirit and umbilical moxibustion，as well as emergency external treatment. The internal treatment is mainly oral Chinese medicine based on Chaihu Guizhi Decoction（柴胡桂枝汤）and Chaihu Jia Longgu Muli Decoction（柴胡加龙骨牡蛎汤）. Characteristic syndrome differentiation and compatibility approaches of opening depression，unblocking collaterals，removing blood stasis，and resolving phlegm have been formed.
To study the ecological suitability of Roumao Yinyanghuo（Epimedium pubescens Maxim.），explore the potential suitable cultivation sites of Roumao Yinyanghuo（Epimedium pubescens Maxim.）and promote the development and utilization of the resources of Roumao Yinyanghuo（Epimedium pubescens Maxim.）.
Based on field research，literature collection and the Chinese Digital Herbarium，a total of 68 items of valid point data were collected，and 54 ecological factors were selected according to the physiological habits of Roumao Yinyanghuo（Epimedium pubescens Maxim.），and the potential climatic suitability zones of Roumao Yinyanghuo（Epimedium pubescens Maxim.）in China were investigated by the Maximum Information Entropy（MaxEnt）model.
CI index，April precipitation，annual sunshine duration，elevation，January mean temperature and HI index were six ecological factors that had a greater impact on the distribution of Roumao Yinyanghuo（Epimedium pubescens Maxim.），which was mainly distributed in Gansu and southern Shaanxi，north-central Sichuan，north-central Guizhou，southeastern Chongqing and southern Hunan in China.
The climatic suitability zones of Roumao Yinyanghuo（Epimedium pubescens Maxim.）in this experiment was basically consistent with the range described in Flora of China（2004 Edition），which can provide a reference for the investigation，exploitation and sustainable development of Roumao Yinyanghuo（Epimedium pubescens Maxim.）in China.
The quantitative models of fructose，glucose，sucrose，raffinose and polysaccharide in Huaidihuang（Rehmannia glutinosa）were established based on mid-infrared spectroscopy technology.
The fructose，glucose，sucrose and raffinose in 50 batches of genuine Huaidihuang（Rehmannia glutinosa）were determined by high performance liquid chromatography（HPLC），the polysaccharide was determined by ultraviolet-visible spectroscopy（UV-Vis），and the infrared spectra of Huaidihuang（Rehmannia glutinosa）were collected by mid-infrared spectrometer. HPLCmethod，UV-Vis method and mid-infrared spectroscopy technology were combined to establish a determination model for the sugar component contents of in Huaidihuang（Rehmannia glutinosa）using TQ analysis software.
The model of principal component regression（PCR）＋mutiplicative signal correction（MSC）＋first derivative（1st Der）＋Savitzky-Golay fler（SG）was the best for fructose，the model of partial least squares（PLS）＋CONSTANT＋1st Der＋SG best for glucose，the model of stepwise multiple linear regression（SMLR）＋CONSTANT＋second derivative（2nd Der）＋SG best for sucrose，the model of SMLR＋standard normal variate（SNV）＋2nd Der＋Noris derivative fliler（ND）best for raffinose and the model of PLS＋SNV＋2nd Der＋ND best for polysaccharide. The correlation coefficients were 0.786 2，0.927 8，0.838 8，0.782 4 and 0.964 8，respectively，with an average absolute deviation of-0.05%，0.04%，0.07%，-0.02% and-0.02%，respectively. It is verified that the prediction effect of the model is good.
The quantitative model of sugar components in Huaidihuang（Rehmannia glutinosa）established by mid-infrared spectroscopy is stable and objective，which can provide a basis for rapid evaluation of sugar components in Huaidihuang（Rehmannia glutinosa）.
Banmao（Mylabris）is a well-known animal Chinese medicine in China，which has the effect of breaking blood and eliminating blood stasis，dispersing knots and eliminating mass，and attacking toxin and eroding sores，and is widely used to disperse blood stasis and eliminate carbuncles. Because of its violent toxicity，it often needs to be processed to reduce toxicity and improve the safety of medication. As early as in the Eastern Jin Dynasty，the processing methods of Banmao（Mylabris），such as net preparation and firing method，were recorded，and later a variety of processing methods such as rice frying，stir-frying and vinegar boiling were gradually developed. Modern studies have found that the main components of Banmao（Mylabris）are terpenoids and their derivatives，metal elements，fatty acids，fatty compounds，amino acid compounds and so on，which have antitumor，anti-fibrotic，cardiotonic，antiviral，anticoagulant，immune enhancement and other pharmacological effects. In this paper，it reviewed Chinese medical books and related Chinese and foreign materials and literature，and discussed the historical evolution，chemical composition and pharmacological effects of Banmao（Mylabris），in order to provide reference for the related research of Banmao（Mylabris）.
To observe the clinical effect of Xieqing Pill（泻青丸）combined with clearing heart and soothing liver acupuncture on children with multiple tic syndrome（hyperactivity of liver and wind movement syndrome）.
In this study，106 children with multiple tic syndrome（hyperactivity of liver and wind movement syndrome）admitted from September 2021 to June 2023 were divided into control group and observation group by random number table method，with 53 cases in each group. The control group received conventional treatment（haloperidol tablets），and the observation group received haloperidol tablets and Xieqing Pill combined with clearing heart and soothing liver acupuncture. The data of each group before and after treatment was observed，including changes in Yale Comprehensive Tic Severity Scale（YGTSS）score，clinical efficacy，adverse reactions，changes in traditional Chinese medicine symptom score，changes in serum dopamine（DA），5-hydroxytryptamine（5-HT）and gamma-aminobutyric acid（GABA），Achenbach changes in Child Behavior Scale（CBCL）and quality of life scale（short form 36 questionnaire，SF-36）scores.
The total effective rate of the observation group（96.23%，51/53）was higher than that of the control group（84.91%，45/53）（P<0.05）. Before treatment，YGTSSscore，traditional Chinese medicine syndrome scores，the levels of DA 5-HT and GABA，CBCL and SF-36 scores were not significant between two groups（P>0.05）. After treatment，YGTSSscore，traditional Chinese medicine syndrome scores，the levels of DA 5-HT and GABA，CBCL and SF-36 scores of two groups were improved. After treatment，YGTSSscore，traditional Chinese medicine syndrome scores，the levels of DA 5-HT and GABA，CBCL and SF-36 scores in the observation group were better than those in the control group（P<0.05）. The adverse reaction rate in the observation group（3.77%，2/53）was lower than that in the control group（16.98%，9/53）（P<0.05）.
Xieqing Pill combined with clearing heart and soothing liver acupuncture has significant clinical effect in the treatment of children with multiple tic syndrome（hyperactivity of liver and wind movement syndrome）. The symptoms are relieved，the recovery is better，the behavior and the quality of life are improved，and the adverse reaction rate is reduced. The treatment is relatively safe and reliable.
To explore the clinical effect of midnight-noon ebb-flow acupuncture combined with Buqi Quyu Decoction（补气祛瘀汤）in the treatment of post-stroke cricopharyngeal muscle atrophy type dysphagia.
A total of 60 patients with post-stroke cricopharyngeal muscle atrophy type dysphagia were randomly divided into two groups，including an experimental group（30 cases）and a control group（30 cases）. Two groups received basic therapy，while the control group received Buqi Quyu Decoction. The experimental group received midnight-noon ebb-flow acupuncture on the basis of the control group. The surface electromyographic changes of the submandibular muscle group between two groups as well as the results of water swallow test（WST），standardized swallowing assessment（SSA），swallowing disorder specific quality of life（SWAL-QOL）and swallowing X-ray fluoroscopy（VFSS）were compared. The clinical efficacy and overall incidence of complications were observed. Statistical analysis was conducted using SPSS 26.0.
After treatment，the root mean square（RMS）values of the submandibular muscle group in two groups decreased（P<0.05）. Compared with that in the control group，the RMSvalue of the submandibular muscle group in the experimental group was lower（P<0.05）. After treatment，the results of WST examination of the two groups decreased，and the result of WST examination of the experimental group was lower than that of the control group（P<0.05）. After treatment，the SSA scores of the two groups decreased，while the scores of SWAL-QOL and VFSS increased. The experimental group had lower SSA scores and higher scores of SWAL-QOL and VFSS（P<0.05）. The total clinical effective rate of the treatment experimental group was higher than that of the control group，and the incidence rate was lower than that of the control group（P<0.05）.
The treatment of Buqi Quyu Decoction combined with midnight-noon ebb-flow acupuncture has a good therapeutic effect on patients with post-stroke cricopharyngeal muscle atrophy type dysphagia，with advantages in improving swallowing function and high safety.
To investigate the clinical effect of Qingwei Guchi Prescription（清胃固齿方）combined with tinidazole on inflammation and the distribution of periodontal plaque in elderly patients with chronic periodontitis.
A total of 101 elderly patients with chronic periodontitis admitted from January 2021 to February 2023 were divided into two groups by random number table method，namely control group（50 cases）and observation group（51 cases）. The control group received periodontal basic treatment and tinidazole and the observation group was combined with Qingwei Guchi Prescription on the basis of the control group. During the study，1 patient fell off in the control group and 1 fell off in the observation group. The clinical efficacy，symptom improvement time（swollen gums，bad breath，loose teeth），changes of TCM syndrome scores（gum pain，bleeding，hot breath，thirst for cold drinks，dry stool，etc.）before and after treatment，plaque index（PLI）and probing depth（PD）of periodontal pockets，sulcus bleeding index（SBI），attach loss（AL）and other periodontal related indicators，the levels of interleukin-6（interleukin-6）and tumor necrosis factor-α（TNF-α）in gingival crevicular fluid，changes in the score of Oral Health Impact Profile（OHIP-14）and adverse reactions were compared.
The clinical effect of the observation group（94.00%，47/50）was better than that of control group（79.59%，39/49）（P<0.05）. Compared with that in the control group，the improvement time of symptoms（swollen gums，bad breath，loose teeth）in the observation group was shorter（P<0.05）. Before treatment，TCM syndrome scores（gingival pain，bleeding，hot breath，thirst for cold drinks，dry stool，etc.），periodontal related indexes（PLI，PD，SBI and AL），the levels of IL-6 and TNF-αand OHIP-14 scale scores were not significant between two groups（P>0.05）. After treatment，TCM syndrome scores（gum pain，bleeding，hot breath，thirst for cold drinks，dry stool，etc.），periodontal related indexes（PLI，PD，SBI and AL），the levels of IL-6 and TNF-αand OHIP-14 scale scores were improved in both groups. After treatment，TCM syndrome scores（gingival pain，bleeding，hot breath，thirst for cold drinks，dry stool，etc.），periodontal related indexes（PLI，PD，SBI and AL），the levels of IL-6 and TNF-αand OHIP-14 scale scores in the observation group were superior to those in the control group（P<0.05）. The total adverse reaction rate of the observation group was lower than that of the control group（P<0.05）.
In elderly patients with chronic periodontitis，Qingwei Guchi Prescription combined with tinidazole has good clinical effect，which can effectively reduce the inflammatory response of the body and improve the distribution of periodontal plaque in patients，so as to improve the condition and quality of life of patients. The treatment is safe and reliable and less adverse reaction.
To explore the clinical therapeutic effect of Mongolian medicine Anshen Buxin Liuwei Pills（安神补心六味丸）and Shugan Jieyu Capsules（舒肝解郁胶囊）on post-stroke depression.
A total of 120 patients with post-ischemic stroke depression due to liver stasis and phlegm coagulation syndrome were selected and randomly divided into a control group and an observation group，with 60 cases in each group. On the basis of conventional treatment，the control group was treated with fluoxetine hydrochloride dispersible tablets while the observation group was treated with Anshen Buxin Liuwei Pills and Shugan Jieyu Capsules. The course of treatment for both groups was 8 weeks. The clinical treatment effects，traditional Chinese medicine（TCM）syndrome scores，Hamilton Depression Scale（HAMD）scores，Modified Edinburgh Scandinavian Survival Score（MESSS），serum levels of 5-hydroxytryptamine（5-HT），norepinephrine（NE），brain-derived neurotrophic factor（BDNF）and Brarthel index（BI）between the two groups before treatment and at the 4th and 8th week of treatment were compared.
The total effective rate of the observation group reached 93.33%（56/60）after treatment，which was significantly better than that（80.00%，48/60）of the control group（P<0.05）. The TCM syndrome scores of the patients in both groups showed a trend of significant reduction at the 4th and 8th week of treatment（P<0.05），and at the same time，it could be seen that the scores of the observation group were significantly lower than those of the control group（P<0.05）. The scores of HAMD and MESSSwere significantly lower than those before treatment（P<0.05），while the scores of the observation group were significantly lower than those of the control group（P<0.05）. In both groups，the serum levels of 5-HT，NE and BDNF were significantly higher than those before treatment at the 4th and 8th week of treatment（P<0.05），while the serum levels of 5-HT，NE and BDNF in the observation group were also higher than those in the control group（P<0.05）. BI indexes were higher than those before treatment at the 4th and 8th week of treatment in both groups（P<0.05），while BIindex in the observation group was significantly higher than that in the control group（P<0.05）.
Mongolian medicine Anshen Buxin Liuwei Pills combined with Shugan Jieyu Capsules can significantly improve the clinical efficacy of patients with post-ischemic stroke depression due to liver stasis and phlegm coagulation syndrome，reduce the degree of depression，promote the recovery of neurological function and increase the serum levels of 5-HT，NE and BDNF，thereby improving the quality of life and improving prognosis.
To observe the clinical efficacy of Daxianxiong Decoction（大陷胸汤）in the treatment of severe acute pancreatitis and acute lung injury.
Eighty patients with severe acute pancreatitis and acute lung injury who met the inclusion criteria for this study were randomly divided into two groups using a random number table method. The control group received symptomatic treatment with conventional western medicine，while the observation group combined with oral administration of Daxianxiong Decoction in addition. After 7 days of continuous treatment，the Murray lung injury scores and modified Marshall scores，the blood gas indexes［blood oxygen partial pressure（PaO2），blood oxygen saturation（SaO2），partial pressure of carbon dioxide（PCO2），oxygenation index］，the respiratory mechanics indexes［airway resistance（Raw），work of breath（WOB），dynamic lung compliance（Cdyn）］and the serum inflammatory indexes［C-reactive protein（CRP），tumor necrosis factor-α（TNF-α），interleukin-6（IL-6），procalcitonin（PCT）］between two groups were compared，and the total effective rate and drug safety between the two groups were compared.
After treatment，the scores of Murray lung injury and modified Marshall，the values of PaCO2，Raw and WOB，the serum levels of CRP，PCT，IL-6 and TNF-αwere all lower than those before treatment（P<0.05），and the scores，values and levels of the observation group were lower than those the control group（P<0.05）. The values of PaO2，SaO2 and oxygenation index and Cdyn were higher in both groups（P<0.05），the values of the observation group were higher than those of the control group（P<0.05）. The total effective rate of the observation group（92.5%）was higher than the control group（75.0%）（P<0.05）. There were no adverse reactions related to medication during the treatment in both groups.
The application of Daxianxiong Decoction can reduce serum inflammatory cytokine levels，improve respiratory mechanical parameters and increase oxygen partial pressure and blood oxygen levels in patients with severe acute pancreatitis and acute lung injury，which help to alleviate organ damage in patients with definite therapeutic effects.
To observe the effect of Fuling Sini Decoction（茯苓四逆汤）combined with Danggui Shaoyao Powder（当归芍药散）on serum cardiac troponin levels in patients with chronic heart failure of Yang deficiency and blood stasis syndrome.
Ninety-eight patients with chronic heart failure of Yang deficiency and blood stasis syndrome treated in the hospital from September 2022 to June 2023 were selected as the research objects. All patients were randomly divided into two groups according to the order of admission. There were49 patients in the control group and the observation group. The patients in the control group were treated with conventional anti-heart failure treatment，and the observation group was treated with Fuling Sini Decoction and Danggui Shaoyao Powder on the basis of the control group. After 2 weeks of treatment，the cardiac function classification，TCM syndrome scores，cardiac ultrasound indexes［left ventricular end-systolic diameter（LVESD），left ventricular end-diastolic diameter（LVEDD），left ventricular ejection fraction（LVEF）］，serum detection indexes［high-sensitivity cardiac troponin I（hs cTnI），plasma N-terminal pro-brain natriuretic peptide（NTproBNP）］and adverse reactions were compared between the two groups.
There was no significant difference in cardiac function classification between the two groups before treatment（P>0.05）. After treatment，the cardiac function classification of the observation group was better than that of the control group（P<0.05）. After treatment，the scores of TCM syndromes in the two groups were significantly decreased，and the score of the observation group was significantly lower than that of the control group（P<0.05）. There was no significant difference in cardiac ultrasound indexes between the two groups before treatment（P>0.05）. After treatment，the values of LVESD and LVEDD decreased and LVEF increased in both groups. The above indexes in the observation group were significantly better than those in the control group（P<0.05）. After treatment，the levels of serum hs cTnI and NT proBNP in the two groups decreased significantly，and those in the observation group were significantly lower than those in the control group（P<0.05）.
The treatment of chronic heart failure with Yang deficiency and blood stasis syndrome by Fuling Sini Decoction and Danggui Shaoyao Powder can better improve the cardiac function and TCM syndromes，promote the recovery of cardiac ultrasound indexes and the levels of serum hs cTnI and NT proBNP，and the application effect is satisfactory.
To evaluate the clinical application of Xiaozhong Zhitong Decoction（消肿止痛汤）combined with crude fire needle cauterization in the treatment of perineal abscess in diabetes.
Eighty patients with perineal abscess of diabetes who were definitely diagnosed and systematically treated in the hospital were selected，all of whom met the criteria for inclusion. The data of the patients was collected，with an equal proportion grouping structure，to randomly touch the white and black balls to determine the grouping，a total of two groups. The control group（40 cases）received systemic antibiotics and local sitz baths. The observation group（40 cases）was treated with Xiaozhong Zhitong Decoction fumigation and sitz bath combined with coarse fire needle cauterization. All patients received continuous intervention for 2 weeks as a course of treatment. After all treatment courses were completed to evaluate the clinical efficacy. The inflammatory factor indicators before and after treatment，including C-reactive protein（CRP），interleukin-6（IL-6）and tumor necrosis factorα（TNF-α），visual analog scale（VAS）and quality of life were compared.
The total effective population in the control group accounted for 85.00%（34/40）and that in the observation group accounted for 97.50%（39/40），and the difference was statistically significant（P<0.05）. Serum inflammatory factor indicators（CRP，IL-6，TNF-α）in the observation group after 2 weeks of treatment were lower than those in the control group，and the difference was statistically significant（P<0.05）. The VASscore of the observation group was lower than that of the control group after 3 days of treatment，1 and 2 weeks of treatment，with a statistically significant difference（P<0.05）. After 2 weeks of treatment，the observation group showed better health perception，lifestyle，emotional control，daily living ability，interpersonal relationships and social activities than the control group，with statistically significant differences（P<0.05）.
Xiaozhong Zhitong Decoction combined with coarse fire needle cauterization can improve the efficacy of perineal abscess in diabetes，continuously relieve pain，inhibit inflammation and improve quality of life.
To observe the effects of Qufeng Tongluo Jianshen Prescription（祛风通络健肾方）on the expression levels of p38 mitogen-activated protein kinase（p38MAPK），intercellular adhesion molecule-1（ICAM-1）and monocyte chemotactic protein-1（MCP-1）in patients with chronic glomerulonephritis（CGN）.
A total of 108 CGNpatients treated in the hospital from August 2020 to February 2023 were divided into two groups by simple random method. The conventional group was given conventional symptomatic treatment with Western medicine，while the observation group was given Qufeng Tongluo Jianshen Prescription on the basis of symptomatic treatment，all of which were treated continuously for 8 weeks. The levels of renal function related indexes，renal fibrosis related factors，p38MAPK，ICAM-1，urine red blood cell count（RBC），MCP-1 and high sensitivity C-reactive protein（hs-CRP）were compared between the two groups before and after treatment，and the efficacy，adverse reactions and TCM syndrome scores were recorded between the two groups.
There was no statistical significance in renal function or renal fibrosis before treatment between the two groups（P>0.05）. The levels of serum creatinine（SCr），transforming growth factor-β1（TGF-β1），urea nitrogen（BUN），fibronectin（FN），24 h urinary protein quantity（24 h Upro），cystatin C（CysC），tissue inhibitor of metalloproteinase-（TIMP-1）were lower in two groups after treatment than those before treatment（P<0.05）. The renal function indexes and factors related to renal fibrosis in the observation group were lower than those in the conventional group（P<0.05）. There was no statistical significance in the relative expression levels of p38MAPK，ICAM-1，MCP-1，urinary RBC and hs-CRPbetween the two groups before treatment（P>0.05）. The relative expression levels of p38MAPK，ICAM-1，MCP-1，urinary RBC and hs-CRP in the two groups after treatment were lower than those before treatment，while the levels of the observation group were lower than those of the conventional group after treatment（P<0.05）. There was no statistical significance in the scores of 4 major and 5 secondary symptoms before treatment between the two groups（P>0.05）. After treatment，the scores of four major symptoms（edema of limbs，sore waist and knees，fatigue，abdominal distension），and 5 secondary symptoms（cold appearance and cold limbs，thirst and unwilling to drink，pale complexion，loose stools，frequent urination or nocturia）in the two groups were lower than those before treatment，while the scores of the observation group were lower than those of the conventional group after treatment（P<0.05）. The total effective rate of the observation group was 94.44%（51/54），which was higher than that（81.48%，44/54）of the conventional group，with statistical significance（P<0.05）. The cumulative adverse reaction rate of diarrhea，nausea and abnormal liver function in the observation group was not statistically significant compared with that in the conventional group（P>0.05）.
Qufeng Tongluo Jianshen Prescription can improve the renal function，inhibit renal fibrosis，regulate ICAM-1，MCP-1 and other factors in the treatment of CGN，and improve the curative effect.
To explore the effects of Yishen Paidu Formula（益肾排毒方）combined with Sanqi（Notoginseng Radix et Rhizoma）on serum leptin，blood lipids，oxidative stress and endothelial function in renal failure based on the theory of“intestine-kidney axis”.
A total of 60 cases of renal failure admitted to the traditional Chinese medicine and nephrology department of the hospital from June 2020 to June 2022 were selected as the research subjects. The patients in the control group received levocarnitine injection combined with compoundα-ketonic acid tablets，and those in the experimental group combined Yishen Paidu Formula combined with Sanqi（Notoginseng Radix et Rhizoma）on this basis. The clinical efficacy，blood glucose，blood lipids，leptin，vascular endothelial function，oxidative stress indicators，inflammation indicators and safety were compared between the two groups.
Compared with the control group，the experimental group had a higher overall effective rate（P<0.05）. After treatment，the levels of serum fasting plasma glucose（FPG），total cholesterol（TC），triglyceride（TG），leptin，soluble intercellular adhesion molecule-1（sICAM-1），endothelin-1（ET-1），malondialdehyde（MDA），C-reactive protein（CRP），tumor crossing factor alpha（TNF-α）and interleukin-6（IL-6）were measured in the experimental and control groups decreased compared to those before treatment，while the levels of superoxide dismutase（SOD）increased compared to those before treatment（P<0.05）. The experimental group had the levels of serum FPG，TC，TG，leptin，sICAM-1，ET-1，MDA，CRP，TNF-αand IL-6 were lower than those of the control group（P<0.05），and the level of SOD was higher than that of the control group（P<0.05）. There was no statistically significant difference in the incidence of adverse reactions between the two groups of drugs（P>0.05）.
Yishen Paidu Formula combined with Sanqi（Notoginseng Radix et Rhizoma）exert good therapeutic effects on renal failure，and the improvement of its therapeutic effect may be closely related to the improvement of endothelial and oxidative stress functions.
To explore the clinical efficacy and safety of Qi acupuncture treating osteoporosis of kidney deficiency type.
A total of 100 patients with osteoporosis of kidney deficiency type（admitted from June 2021 to June 2023）were included in the study. The patients were randomly divided into acupuncture and moxibustion group and control group，with 50 cases in each group. The patients in the control group were treated with alendronate tablets and calcium carbonate D3 tablets. Those in the acupuncture and moxibustion group were treated with Qi acupuncture on the basis of the treatment in the control group. During the treatment，4 patients in the acupuncture and moxibustion group fell off and 2 in the control group fell off. The clinical efficacy of each group and the integral changes of traditional Chinese medicine symptoms（lower back pain，foot weakness，tinnitus，deafness，skeletal weakness，forgetfulness and confusion）of patients before and after treatment were compared. The visual analog scale（VAS）was used to evaluate the degree of back pain in each group before and after treatment，and the oswestry disability index（ODI）to evaluate the back pain dysfunction. The changes in serum calcium（Ca）and phosphorus（P），N-terminal mid segment osteocalcin（N-MID），alkaline phosphatase（ALP），human Beta-Crossstraps（β-CTX）and changes in bone density of lumbar spine and femoral neck were observed. The adverse reactions were observed.
The effective rate of patients in the acupuncture and moxibustion group was higher than that in the control group（P<0.05）. Before treatment，the scores of traditional Chinese medicine symptoms（lower back pain，foot weakness，tinnitus，deafness，skeletal weakness，forgetfulness and confusion），VASand ODIscores，serum levels of Ca，P，N-MID，ALPandβ-CTX，lumbar spine and femoral neck bone density between two group had no significant（P>0.05）. After treatment，there were no significant changes in serum Ca or P in each group. The scores of traditional Chinese medicine symptoms（lower back pain，foot weakness，tinnitus，deafness，skeletal weakness，forgetfulness and confusion），VASand ODI scores，the levels of N-MID，ALP andβ-CTX，bone density of lumbar vertebrae and femoral neck were all improved，while in the acupuncture and moxibustion group，the scores of TCM symptoms（lower back pain，foot weakness，tinnitus，deafness，skeletal weakness，forgetfulness and confusion），VAS and ODI scores，the levels of N-MID，ALP andβ-CTX，lumbar spine and femoral neck bone density were superior to those in the control group（P<0.05）. There were fewer adverse reactions in each group（P>0.05）.
The clinical effect of Qi acupuncture on osteoporosis of kidney deficiency type is very good. The pain of patients is relieved，the symptoms are improved and the bone density is increased. There are fewer adverse reactions and it is safe and reliable.
Shuxuetong Injection（疏血通注射液）promotes blood circulation，removes blood stasis and activates channels and collaterals. It is primarily used during the acute phase of ischemic stroke caused by blood stasis obstructing the meridians and collaterals，with demonstrated clinical efficacy and safety. This consensus adheres to the compilation process of the expert consensus on the clinical application of Chinese patent medicines by the Chinese Association of Traditional Chinese Medicine，following the principle of evidence-based medicine as the mainstay，supplemented by consensus and experience. It integrates the best available evidence with expert experience in real-world clinical practice，collecting clinical application recommendations through questionnaire surveys and expert interviews，identifying clinical questions based on the PICOSprinciple，and conducting evidence evaluation and GRADE grading. Through the nominal group method，seven recommendations（including three strong and four weak recommendations）and 23 consensus suggestions were formed，addressing the indications，timing of administration，dosage and treatment course of Shuxuetong Injection. This update also enhances safety information and revises the pharmacological and toxicological content of the first edition of the Expert Consensus on the Clinical Application of Shuxuetong Injection in the Treatment of Ischemic Cerebrovascular Diseases，providing a reference for the rational clinical use of Shuxuetong Injection. This consensus has been reviewed and published by the Chinese Association of Traditional Chinese Medicine（document number GS/CACM345-2024）.
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