To observe the regulation effect of Sini Hewei Formula（四逆和胃方）combined with triple therapy on visceral hypersensitivity and gastrointestinal hormone secretion disorder in patients with Helicobacter pylori（Hp）-positive gastroesophageal reflux disease（GERD）.

Ninety cases of Hp-positive GERD patients admitted to the hospital from February 2021 to May 2023 were selected as the study subjects and the patients who met the criteria were divided into two groups by simple randomization method. Forty-five cases in the control group were treated with triple therapy，and the other 45 cases in the Sini Hewei Formula group were treated with Sini Hewei Formula on the basis of triple therapy. The efficacy，Hp conversion rate，Gastroesophageal Reflux Disease Questionnaire（GERDQ）score，esophageal dynamics，traditional Chinese medicine syndrome score，Gastroesophageal Reflux Disease Related Quality of Life Scale（GERDQ）score，visceral hypersensitivity related factors and gastrointestinal hormones were compared between the two groups.

The total effective rate of the Sini Hewei Formula group was higher than that of the control group，and the Hp conversion rate was was not statistically significant compared with that of the control group by theχ² test（P>0.05）. Comparison of esophageal dynamic function before treatment between the two groups showed no statistical difference（P>0.05）. The postreflux swallow-induced peristaltic wave（PSPW）index，esophageal mass clearance time and the number of acid reflux were lower than those before treatment in both groups，and they were lower in the Sini Hewei Formula group than that in the control group after treatment（P<0.05）. Comparison of TCM evidence score，GERDQ score and GERD-HROL score before treatment between the two groups did not show any statistical difference（P>0.05）. The above scores were lower than those before treatment in both groups after treatment，and were lower in the Sini Hewei Formula group than those in the control group（P<0.05）. Comparison of visceral hypersensitivity-related factors and gastrointestinal hormones between the two groups before treatment showed no statistical difference（P>0.05）. Substance P（SP），nerve growth factor（NGF），calcitonin gene-related peptide（CGRP）and vasoactive intestinal peptide（VIP）were all lower in both groups than those in the control group after treatment（P<0.05）. The levels of VIPwere lower than those before treatment，and they were lower in the Sini Hewei Formula group than those in the control group after treatment（P<0.05）. The levels of motilin（MTL）and gastrin（GAS）were higher than those in the control group after treatment in both groups，and they were higher in the Sini Hewei Formula group than those in the control group after treatment（P<0.05）.

The combination of Sini Hewei Formula and triple therapy can improve esophageal dynamic function，reduce visceral hypersensitivity，regulate gastrointestinal hormone secretion disorder and improve curative effect in Hp-positive GERD patients.