To compare the efficacy differences between traditional decoction and formula granules of different ratios of Huanglian（Coptidis Rhizoma）-Wuzhuyu（Evodiae Fructus）.

Various typical efficacy indicators were used for different ratios of Huanglian（Coptidis Rhizoma）-Wuzhuyu（Evodiae Fructus）in separate comparative experiments. Zuojin Pill（左归丸）group［Huanglian（Coptidis Rhizoma）；Wuzhuyu（Evodiae Fructus）＝6∶1］used an anhydrous ethanol-induced gastric ulcer experiment to measure the effectiveness in inhibiting gastric ulcers and gastric acid secretion of rats. Blood superoxide dismutase（SOD）and malondialdehyde（MDA）were analyzed. The Ganlu Powder（甘露散）group［Huanglian（Coptidis Rhizoma）：Wuzhuyu（Evodiae Fructus）＝2∶1］used dry yeast-induced hyperthermia in rats to determine the antipyretic efficacy. The Zhuyu Pill（茱萸丸）group［Huanglian（Coptidis Rhizoma）：Wuzhuyu（Evodiae Fructus）＝1∶1］used a small intestinal propulsion experiment in mice to determine the antidiarrheal efficacy. The Reverse Zuojin Pill（反左金丸）group［Huanglian（Coptidis Rhizoma）：Wuzhuyu（Evodiae Fructus）＝1∶6］used acetic acid-induced writhing in mice to determine the analgesic efficacy.

Both formulations in the Zuojin Pill group effectively inhibited gastric ulcers of the rats but were unable to inhibit gastric acid secretion，showing no significant difference between the two（P>0.05）. Both formulations in the Ganlu Powder group effectively reduced fever of rats，with significant differences between the formula granule group and the traditional decoction group（P<0.05）. Both formulations in the Zhuyu Pill group alleviated mouse diarrhea symptoms，showing significance compared to the formula granule group（P<0.05）. Both formulations in the Reverse Zuojin Pill group alleviated mouse pain sensation，with no significant difference between the two（P>0.05）.

When Zuojin Pill is used to treat gastric ulcers，the efficacy of the traditional decoction is equivalent to the formula granules. For Ganlu Powder in treating fever，the formula granules are superior to the traditional decoction. When Zhuyu Pill is used for treating diarrhea，the efficacy of the traditional decoction is superior to the formula granules. In the case of Reverse Zuojin Pill for analgesia，the efficacy of the traditional decoction is equivalent to the formula granules.