To investigate clinical efficacy of Modified Shenghua Decoction（加味生化汤）combined with medroxyprogesterone in treatment of patients with perimenopausal abnormal uterine bleeding-ovulatory dysfunction（AUB-O）.

Sixty cases patients with perimenopausal AUB-Owere selected and randomly divided into the observation group（30 cases）and control group（30 cases）. The control group received oral treatment with medroxyprogesterone. On the basis of the control group，the observation group was treated with a combination of Modified Shenghua Decoction orally. The treatment course was 3 menstrual cycles. The changes of sex hormone level，endometrial thickness，uterine volume，menstrual volume，menstrual duration，prothrombin time，activated partial thromboplastin time，hemoglobin level and traditional Chinese medicine syndrome score（TCM）symptom score before and after treatment were observed.

The levels of estradiol（E2），follicle stimulating hormone（FSH），luteinizing hormone（LH）and prolactin（PRL）decreased before and after treatment in both groups（P<0.05）and the levels of the observation group were lower than those of the control group（P<0.05）. The endometrial thickness，menstrual volume and menstrual duration of two groups decreased after treatment compared to those before treatment（P<0.05）. The degree of decrease in the observation group was greater than that in the control group（P<0.05）. There was no statistically significant difference in uterine volume between the two groups before and after treatment（P>0.05）. The prothrombin time and activated partial thromboplastin time of two groups decreased after treatment compared to those before treatment（P<0.05）. The degree of decrease in the observation group was greater than that in the control group（P<0.05）. The hemoglobin level increased compared to that before treatment（P<0.05）and the increase in the observation group was greater than that in the control group（P<0.05）. The incidence of adverse reactions was 36.67%in the control group and 43.33%in the observation group. There was no statistically significant difference in comparison（P>0.05）. The scores of TCM symptoms in both groups decreased after treatment（P<0.05），and scores of the observation group were lower than those of the control group（P<0.05）. The therapeutic effect of the observation group was significantly better than that of the control group（P<0.05）.

Modified Shenghua Decoction combined with medroxyprogesterone in treatment of patients with perimenopausal AUB-Ocan help to improve the levels of sex hormones，reduce endometrial thickness，menstrual volume and duration，improve coagulation function andclinical efficacy，and dose not significantly increase adverse reactions.