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Outline
Qingqianliu［Cyclocarya paliurus（Batal.）Ijinskaja］is a plant of the genus Cyclocarya of the Juglandaceae family，and it is a rare and precious species found only in China. Its roots，branches and leaves all have medicinal value and are known to have insect-killing，itch-stopping，anti-inflammatory and pain-relieving properties. Its chemical composition mainly includes polysaccharides，flavonoids，triterpenoids，phenolic acids and so on. It has a variety of pharmacological effects such as hypoglycemia，hypotension，hypolipidemia，antioxidant，anti-inflammatory and hepatoprotective. By summarizing the research progress of chemical composition and pharmacological effects of Qingqianliu［Cyclocarya paliurus（Batal.）Ijinskaja］and combining with the theory of quality marker（Q-Marker），the Q-Marker of Qingqianliu［Cyclocarya paliurus（Batal.）Ijinskaja］was predicted and analyzed from various perspectives，such as chemical composition uniqueness，traditional medicinal efficacy，chemical composition measurability，blood-entry components and network pharmacological evaluation. The results revealed that polysaccharides，flavonoids and triterpenoids can be used as potential species of Qingqianliu［Cyclocarya paliurus（Batal.）Ijinskaja］quality markers. It was initially hypothesized that dammarane-type triterpenoids（such as cyclocarioside A，cyclocarioside I and cyclocarioside Z5-Z8），isoquercitrin，quercetin-3-O-β-D-glucuronide，kaempferol-3-O-β-D-glucuronide，luteolin，apigenin，arjunolic acid，cyclocaric acid B，p-coumaric acid，4，5-O-dicaffeoylquinic acid，chlorogenic acid and rosmarinic acid can be used as the Q-Marker of Qingqianliu［Cyclocarya paliurus（Batal.）Ijinskaja］. The results provided a reference for the establishment of a systematic quality evaluation system of Qingqianliu［Cyclocarya paliurus（Batal.）Ijinskaja］and a guiding role in ensuring the quality of Qingqianliu［Cyclocarya paliurus（Batal.）Ijinskaja］，and further promoted the rational development and application of Qingqianliu［Cyclocarya paliurus（Batal.）Ijinskaja］.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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