ArchiveSweat is one of the five fluids of the human body，and sweating is the first treatment methods among the eight traditional Chinese medicine（TCM）treatments.Starting from Huangdi Neijing，TCM has a rich understanding and expound on sweat，which has been continuously supplemented and improved by generations of medical practitioners，gradually forming a systematic and original theory of sweat.Sorting out and inheriting the original sweat theory of TCM is the foundation and prerequisite for innovating and developing sweat theory of TCM.This article systematically summarized the discussions of TCM on the generation，distribution，metabolism，pathogenesis，disease detection and sweating treatment，aiming to promote the continuous exploration and clinical application of sweat theory in future clinical practice，the scientific connotation of original sweat theory interpretation with the help of modern science and technology，and the development of sweat theory in adhering to principles and innovation.
To observe the effect of Guilu Erxian Glue（龟鹿二仙胶，GLE）on the prevention and treatment of postmenopausal osteoporosis（PMO）in ovariectomized rats（OVX），and to explore the biological effects of gut microbiota.
The female SD rats were divided into 6 groups by random number table method，thus as Sham，OVX，vancomycin（KSS），GLE-L，GLE-M and GLE-H groups.After 1 week of modeling，the drug was administrated by gavage，and the sample was collected 8 weeks later.HE staining was used to detect bone structure，bone cell morphology and number.Bone microstructure was detected by microCT.Bone metabolism was detected by ELISA.16Sr DNA was used to analyze the V3-V4 region of the gut microbiota.
The results of HE and microCT showed that different concentrations of GLE effectively increased bone trabecular percentage，restored bone microstructure，up-regulated the contents of serum ALP and PINP and down-regulated serumβ-CTX content（compared with OVX group，P<0.05）.OTU and PCoA analysis showed that GLE-M significantly restored the richness and diversity of intestinal flora and the composition of intestinal flora in OVX rats.At the phylum level，Firmicutes increased significantly in OVX group（compared with that in Sham group，P<0.01）and the flora abundance decreased significantly after GLE-M intervention（compared with that in OVX group，P<0.01）.At the genus level，the dominant bacteria in GLE group were lactobacillus，Klebsiella，Fusobacterium and so on.Eubacterium myxus increased in OVX group（compared with that in Sham group，P<0.01），and its abundance recovered significantly after GLE-M intervention（compared with that in OVX group，P>0.05）.
GLE may prevent postmenopausal osteoporosis by regulating gut microbiota.
This article systematically reviewed the development of acupuncture education in the United States over the past fifty years，analyzing the reasons for its fluctuations and the challenges it faces.Through case studies of the establishment，development，mergers and closures of various acupuncture schools，the article revealed the development model of the acupuncture education industry and its susceptibility to changes in policies，economic environment and market demand.In particular，after the implementation of the“gainful employment”rule，some schools faced a decrease in enrollment and financial pressures，leading to their closure.The deficiencies in teaching systems and research innovation in acupuncture education，the rise of dry needling techniques，and the changes in industry standards have also had a profound impact on the survival of these schools.This article aimed to provide insights and considerations for the sustainable development of acupuncture education in the future through an analysis of these factors.
To solve the problems of complicated rules of measurement of Chinese medicines in ancient books，inconvenience in finding formulaeand lack of modern intelligent applications for ancient books.
It summarized the measurement conversion standards and special meter measurement conversion standards in the past dynasties，proposed a similarity calculation method for medical cases based on the fusion of the features of＂mainevidence+formulaname+composition of traditional Chinese medicine＂，and adopted Enhanced Representation from Knowledge IntEgration（ERNIE）model based on deep learning for model training.Itdesigned and developed an intelligent ancient formula recommendation and measurement conversion system based on deep learning recommender engine，using MySQL database and Django framework.Using MySQL database and Django framework，it designed and developed an intelligent ancient prescription recommendation and measurement conversion system based on deep learning recommendation engine.
The overall recommendation accuracy rate obtained by this method reached 89.55%，the precision rate was 94.51%，and the recall rate was 83.97%，which achieved better results，and the system was able to achieve the intelligent retrieval of formulae and the conversion of Chinese medicine measurement units，recommend a series of ancient formulae with a high degree of matching of the main treatment efficacy according to the symptoms inputted by the user，and display the composition of formulas and the Chinese medicine dosage in accordance with the conversion rules of different dynasties.It also displayed the composition of the formula and the dosage ofChinese medicine according to the conversion rules of different dynasties，which conformed to the modern standard measurement.
The method of intelligent recommendation of prescriptions and conversion of Chinese medicine measurements achieves satisfactory results，provides a new way of thinking for the intelligent recommendation of ancient prescriptions，and has certain reference significance for the standardisation of Chinese medicine dosage and the reference significance for the clinical use of medicines.
Gastric cancer is one of the most common malignant tumors in the digestive tract and poses a serious threat to human health.Early warning and diagnosis can increase the 5-year survival rate by more than 60%.In recent years，machine learning methods have achieved rich results in predicting the precancerous state of gastric cancer.This article first discussed the significant features of the precancerous state of gastric cancer from the aspects of endoscopic images，biochemical markers，gene expression，and traditional Chinese medicine syndromes，and analyzed the advantages and disadvantages of traditional machine learning methods，deep learning methods and various fusion methods by combining the research results of the precancerous state of gastric cancer predicted by machine learning methods.It proposed three suggestions for carrying out multi-center，large-sample cohort studies and building shared data platforms，realizing multi-modal data fusion and enhancing the interpretability of the model，providing methodological references for the“early diagnosis and treatment”of gastric cancer.
To achieve the inter and intraspecific identification of Caohonghua（Carthamus tinctorius L.）from Asteraceae，Xihonghua（Crocus sativus L.）from Iridaceae（originating from Iran）and Zanghonghua（Crocus sativus L.）（originating from Xizang）by using spectroscopic technologies coupled with machine learning methods.
Raman spectroscopy（RS）and terahertz（THz）spectral data was used to identify and characterize Xihonghua（Crocus sativus L.）（origin Iran），Caohonghua（Carthamus tinctorius L.）（origin Gansu）and Zanghonghua（Crocus sativus L.）（origin Xizang）by using machine learning methods including Principal Component Analysis（PCA），Support-Vector Machine（SVM），Random Forest（RF）and deep learning methods including Multilayer Perceptron（MLP），Convolutional Neural Network（CNN），Long Short Term Memory（LSTM）and Genetic Algorithm-Back Propagation（GA-BP）to analyze the THz and RSspectra of three types of samples.The rapid classification and recognition of Chinese herbal medicine with small sample size was realized.
（1）The classification accuracies of the SVM method on the RS data of the three samples before and after dimensionality reduction by PCA were 83.33% and 94.44%，respectively.The MLP classified the THz data before and after dimensionality reduction by PCA with accuracies of 94.00% and 96.79%，respectively.The results indicated that the classification accuracy was further improved by PCA，and THz spectra for deep learning had a higher accuracy than RSspectra.（2）The classification accuracy of neural networks such as MLP，CNN，RBF，GA-BP and LSTM on THz spectral data was higher than that on RSspectra，among which the classification accuracy of LSTM and RF on THz raw data was as high as 100%.Also，these models had high classification accuracy，high speed and good stability.
The combination of spectroscopic and machine learning methods enables inter and intraspecific identification of Xihonghua（Crocus sativus L.），Caohonghua（Carthamus tinctorius L.）and Zanghonghua（Crocus sativus L.），with high accuracy of THz spectroscopic identification.
To explore the regulatory effect of Buyang Huanwu Decoction（补阳还五汤）on phenotypic polarization of microglia in cervical spinal cord injury.
Ninety-six female Sprague-Dawley（SD）rats were randomly divided into sham operation，model，low-dose Buyang Huanwu Decoction and high-dose Buyang Huanwu Decoction groups to establish an acute cervical spinal cord injury model.Motor function recovery of rats was assessed using the Forelimb Locomotor Scale（FLS）score and forelimb grip strength experiment Basso-Beattie-Bresnahan（BBB）score before surgery and at 1，3，7，14，21 and 28 d postoperatively.Animals were sacrificed at 7，28 d postoperatively.Hematoxylin and Eosin（HE）staining was used to evaluate the gross morphology of the injury site.Nissl staining was used to assess neuronal survival，and immunofluorescence staining was used to observe the expression of ionized calcium binding adapter molecule 1（Iba1），inducible nitric oxide synthase（iNOS），arginase 1（Arg1）at 7 days post-injury，and microtubule-associated protein 2（MAP2）at 28 days post-injury.Western blot was used to evaluate the expressions of Iba1，CD86，Arg1 and CD206 at 7 days post-injury，and Enzyme-Linked Immunosorbent Assay（ELISA）was used to measure the levels of tumor necrosis factor-alpha（TNF-α），interleukin-6（IL-6）and interleukin-1β（IL-1β）.
From day 3 to day 28 postoperatively，the motor function in the Buyang Huanwu Decoction groups began to recover significantly compared to the model group（P<0.05）.HE staining showed that compared with that in the model group，the spinal cord tissue structure in the Buyang Huanwu Decoction group was denser，with reduced edema，fewer vacuoles and reduced interstitial spaces，and decreased infiltration of immune/inflammatory cells.Nissl staining showed that the number of neurons in the gray matter was increased in the Buyang Huanwu Decoction groups compared with that in the model group，with some surviving neurons visible.The immunofluorescence staining showed that the fluorescence intensity of MAP2 was significantly increased，the fluorescence intensity of M1-type iNOSwas decreased，and the fluorescence intensity of M2-type Arg1 was increased in the Buyang Huanwu Decoction groups compared with those in the model group（P<0.05）.Western blot showed that the expression levels of iNOSand CD86 were significantly decreased，while the expression levels of Arg1 and CD206 were significantly increased in the Buyang Huanwu Decoction groups compared with those in the model group（P<0.05）.ELISA showed that the levels of TNF-α，IL-6 and IL-1βwere significantly lower in the Buyang Huanwu Decoction groups than those in the model group（P<0.05）.
Buyang Huanwu Decoction can effectively promote the phenotypic transition of microglia from M1 to M2 in rats with cervical spinal cord injury，alleviate neuroinflammatory responses，inhibit secondary injury，and thereby improve motor dysfunction after cervical spinal cord injury.
Atherosclerosis（AS）is a chronic vascular disease，which is the pathological basis of many cardiovascular and cerebrovascular diseases.The rupture of atherosclerotic plaque is prone to serious cardiovascular and cerebrovascular events.The formation mechanism of AS is complex，mainly involving endothelial damage and dysfunction，lipid metabolism disorder deposition，inflammatory response，platelet aggregation and oxidative stress.Xiebai（Allii Macrostemonis Bulbus）is an essential medicine used in the Treatise on Cold Damage and Miscellaneous Diseases to treat chest obstruction and heart pain.It has the functions of dredging Yang and dispersing mass，and promoting Qi circulation to relieve stagnation.Modern research has shown that Xiebai（Allii Macrostemonis Bulbus）contains multiple effective natural active ingredients that work synergistically on multiple signaling pathways.This article reviewed the mechanism of Xiebai（Allii Macrostemonis Bulbus）and its classic compatibility in anti-AS from multiple aspects such as regulating vasodilation function，anti-inflammation，antioxidant stress，anti-platelet aggregation and lowering lipids，by reviewing the relevant literature.This provided a reference for expanding its application scope，fully exerting its therapeutic effect，and developing clinical drugs and future basic research directions.
Wuzhuyu（Euodiae Fructus）is one of the“three seeds and one shell”of Jiangxi's authentic medicinal materials，with a long history and wide application.The author reviewed the historical evolution of the efficacy of Wuzhuyu（Euodiae Fructus）by consulting the works of materia medica.On this basis，taking the modern research of Wuzhuyu（Euodiae Fructus）as the starting point，the literature analysis has been carried out from the aspects of modern pharmacological effects，preparation design and clinical external research.According to the current status of its research，the existing problems were analyzed.For example，the research on the modern pharmacological effects of Wuzhuyu（Euodiae Fructus）focuses on anti-tumor，anti-inflammatory，hepatoprotective，anti-Alzheimer's disease，etc.，but now the research focuses on the corresponding cell model as the research object，and there is a lack of real-world research based on clinical needs.As an important medicine for acupuncture point application，Wuzhuyu（Euodiae Fructus）is often used externally to treat stubborn diseases，and can realize the“internal and external treatment”of a variety of nervous system diseases，cardiovascular system diseases and digestive system diseases.However，at present，there are many scattered clinical external use research reports，mostly focusing on some case reports，lacking in-depth mechanism exploration，and has not yet formed a standardized treatment system，and lacks a standardized collection and sorting of the experience of external use of Wuzhuyu（Euodiae Fructus）.In view of the problems of poor solubility，slow dissolution and low bioavailability of the main pharmacodynamic components such as evodiamine，rutaecarpine and limonin，it is expected to be devel-oped into a candidate drug for the effective treatment of tumors and inflammatory diseases through rational formulation design，such as nano-preparations，phospholipid complexes and inclusion complexes，but the research is limited to the bioavailability changes between the new preparation and the original drug and the quality evaluation of the preparation，and the lack of evaluation of the treatment effect of related diseases restricts the process of new drug creation.In this paper，the modern pharmacological effects，related dosage form design and clinical external use of Wuzhuyu（Euodiae Fructus）were systematically reviewed in recent years，in order to lay a foundation for the in-depth systematic research and development of topical preparations of Wuzhuyu（Euodiae Fructus）.
To analyze the effects of Jiangzi Decoction（降阻汤）combined with antihypertensive therapy on plasma asymmetric dimethylarginine in mild to moderate pregnancy hypertension（ADMA），soluble vascular endothelial growth factor receptor-1（sFlt-1）/placental growth factor（PIGF）and maternal and infant outcomes.
A total of 108 patients with mild to moderate gestational hypertension treated in the hospital from September 2020 to October 2023 were included as research objects.They were divided into two groups by random number table method.Fifty-four patients in the control group received routine antihypertensive treatment，and the other 54 patients in the observation group received Jiangzi Decoction combined with antihypertensive treatment.The efficacy，blood pressure，symptom scores，plasma levels of ADMA and sFlt/PIGF，ultrasound hemodynamic index of placenta and pregnancy outcome were compared between the two groups.
The total effective rate of the observation group was 96.30%，much higher than that of the control group（79.63%）（P<0.05）.After treatment，dizziness，waist and knee weakness，five upset and heat symptom scores and blood pressure levels in the observation group were lower than those in the control group（P<0.05）.After treatment，the values of pulsatility index（PI），resistance index（RI）and S/D in the observation group were lower than those in the control group.The levels of ADMA，sFlt-1 and sFlt-1/PIGF in the observation group were lower than those in the control group，and PIGF levels were higher than those in the control group（P<0.05）.The incidence of adverse pregnancy outcome was3.70% in the observation group，which was much lower than that（14.81%）in the con-trol group（P<0.05）.
Jiangzu Decoction can nourish Yin and suppress Yang，invigorate Qi and tonify kidney，tranquilize the mind and stabilize the fetus.And when combined with antihypertensive therapy for mild to moderate pregnancy hypertension，it can effectively control blood pressure，alleviate symptoms，regulate microcirculation，improve placental hemodynamic indexes，and reduce the levels of ADMA and sFlt/PIGF，improve pregnancy outcomes and ensure the safety of mothers and infants.
Danggui（Angelicae Sinensis Radix）-Huangqi（Astragali Radix）is one of the commonly used Chinese medicine prescriptions，which has a clear compatibility significance for the use of traditional Chinese medicine，and is one of the most representative drug combinations.It can not only be a formula by itself，but also be used as a combination of clinical basic drugs，so it has always been paid attention to by various doctors.Modern pharmacological studies have also shown that Danggui（Angelicae Sinensis Radix）-Huangqi（Astragali Radix）has a good effect on promoting hematopoietic production，inhibiting tumor growth and proliferation，protecting cardiovascular and cerebrovascular vessels，and regulating the immune system，and is often used in clinical treatment of vascular diseases and immunosuppression in tumor patients.Inflammatory factors mediated by nuclear transcription factor-κB（NF-κB）related signaling pathways play an important role in the formation and progression of disease.Studies have shown that TCM monomer and single drug can mediate the reduction of inflammatory response through NF-κB signaling pathway，including regulating the expressions of interleukin（IL）family，cycloceuxy-2（COX-2），vascular endothelial growth factor（VEGF），matrix protease（MMPs）family and other factors，and play an anti-inflammatory role in inhibiting cell adhesion and proliferation.In view of this，the pharmacology and efficacy of Danggui（Angelicae Sinensis Radix）-Huangqi（Astragali Radix）and the regulation of NF-κB signaling pathway were reviewed in this paper，so as to provide relevant reference for future clinical application.
To investigate the effect of Yangwei Granule（养胃颗粒）assisting enteral nutrition support on the nutritional status and Th1/Th2 cells of patients after gastric cancer surgery.
A total of 117 postoperative gastric cancer patients in the hospital from February 2018 to February 2023 were selected and divided into a control group（58 cases）and an experimental group（59 cases）by a random number table.Both groups were treated with routine treatment.The control group was given enteral nutrition support after operation，and the experimental group was given Yangwei Granule based on the control group for continuous treatment for 10 days.The recovery rate of gastrointestinal function，adverse events（including complications and adverse reactions）and TCM syndrome scores（constipation，abdominal distension，lack of food），nutritional status［hemoglobin（Hb），total protein（TP）］，nutritional risk screening 2002（NRS-2002）score，Th1/Th2 cells and their factors［interferonγ（IFN-γ），interleukin-10（IL-10），interleukin-12（IL-12）］were observed and compared before and after treatment between the two groups.
The gastrointestinal function recovery rate of the experimental group was 83.05% higher than that of the control group（65.52%）（P<0.05）.After treatment，the scores of stool，abdominal distension and lack of food in the experimental group were lower than those of the control group（P<0.05）.After treatment，the levels of TP and Hb in the experimental group were higher than those of the control group（P<0.05）.After treatment，the levels of Th1 and Th1/Th2 in the experimental group were higher than those in the control group，and the levels of Th2 cells were lower than those in the control group（P<0.05）.After treatment，the serum levels of IFN-γand IL-12 in the experimental group were higher than those in the control group，and IL-10 levels were lower than those in the control group（P<0.05）.There was no significant difference in the incidence of alkaline reflux gastritis，gastrointestinal discomfort and aspiration pneumonia between the two groups（P>0.05）.
Yangwei Granule assisting by enteral nutrition support applied to patients after gastric cancer surgery can regulate the expressions of Th1/Th2 cells and their factors，promote the recovery of gastrointestinal function，improve TCM syndromes and nutritional status，and has high safety.
To explore the effect of Jianpi Ziyin Decoction（健脾滋阴汤）combined with atorvastatin on the improvement of traditional Chinese medicine syndrome characteristics，hemorrheology and electrocardiogram in patients with coronary heart disease microcirculation disorders.
A hundred patients with coronary heart disease microcirculatory disorder of Qi deficiency and blood stasis syndrome were enrolled in the hospital，and the patients were randomly divided into an observation group and a control group according to the random number table method，50 cases in each.The control group was given atorvastatin calcium tablets，and the observation group was given Jianpi Ziyin Decoction on the basis of the treatment plan of the control group.After treatment，the clinical efficacy，TCM clinical symptom scores，microcirculatory function，hemorrheology，blood lipid levels and electrocardiogram efficacy of the two groups were observed before and after treatment.
After treatment，the total effective rate of the observation group was 92.00%，which was significantly higher than that（74.00%）in the control group（P<0.05）.After treatment，the TCM clinical symptom scores of the two groups were significantly improved compared with those before treatment（P<0.05）.The symptom scores of the observation group in terms of chest tightness，chest pain，fatigue，palpitations，shortness of breath，insomnia and night sweats were significantly better than those in the control group（P<0.05）.The coronary flow reserve（CFR）of the two groups after treatment was higher than that before treatment.There was a significant improvement（P<0.05），and the CFR improvement of the observation group was significantly better than that the control group（P<0.05）.After treatment，the index of microcirculatory（IMR）of both groups decreased significantly compared with those be-fore treatment（P<0.05）and the index of the observation group was significantly better than that of the control group（P<0.05）.After treatment，the blood rheology indexes of both groups were significantly lower than those before treatment（P<0.05）.The whole blood viscosity high shear，whole blood viscosity low shear，platelet aggregation rate and red blood cell aggregation index in the observation group were significantly better than those in the control group（P<0.05）.The blood lipid levels in both groups after treatment were significantly improved compared with those before treatment（P<0.05）.The observation group had lower levels of total cholesterol（TC），triglycerides（TG），low-density lipoprotein cholesterol（LDL-C）and highdensity lipoprotein cholesterol（HDL-C）than the control group（P<0.05）.After treatment，the total ST segment effective rate of the observation group was 92.00%，which was significantly higher than that（70.00%）in the control group（P<0.05）.After treatment，the total effective rate of T-band in the observation group was 90.00%，which was significantly higher than that in the control group（78.00%）（P<0.05）.
Jianpi Ziyin Decoction combined with atorvastatin can effectively improve the clinical treatment effect，the clinical symptoms and microcirculation function，reduce the blood rheology and blood lipid levels and improve the electrocardiogram of patients with coronary heart disease.
Based on the theoretical foundation of“ascending the clear and descending the turbid”，to investigate the pathogenesis of slow transit constipation（STC）by studying aquaporin-3（AQP3），aquaporin-4（AQP4）and aquaporin-9（AQP9）in the colon of rats with STC.
Sixty clean grade SD rats were provided by the Animal Experimental Center of North Sichuan Medical College.They were randomly divided into normal group，model group，itopride group，high，medium and low dose groups of Baizhu（Atractylodis Macrocephalae Rhizoma）.Firstly，a rat model of STCwas established，and its therapeutic effect was observed by administering the corresponding medication.The contents，distributions and expressions of AQP3，AQP4 and AQP9 in the colon of rats in each group were detected by immunohistochemistry，q-PCR and Western blot methods，and the average optical density（MOD）value of the region was measured.
After modeling，the content of AQP9 decreased，and the distal colon tissue decreased more significantly，while the content of AQP3 increased，and the proximal colon tissue became more significant.The content of AQP4 in colon tissue also increased significantly.After drug intervention treatment，the AQP4 contents in the high dose group of Baizhu（Atractylodis Macrocephalae Rhizoma）and the itopride group significantly decreased，the AQP3 content in the proximal colon significantly decreased，and the AQP9 content in the distal colon significantly increased，with statistically significant differences.There was a decreasing trend in proximal AQP3 and an increasing trend in AQP9 content in the distal colon of the medium and low dose groups of Baizhu（Atractylodis Macrocephalae Rhizoma），but the difference was not statistically significant.
An increase in AQP3 content（proximal colon），a decrease in AQP4 content（whole colon）and a decrease in AQP9 content（distal colon）may be one of the pathogenesis of STC.Baizhu（Atractylodis Macrocephalae Rhizoma）down-regulates the expressions of AQP3 and AQP4，and up-regulates the expression of AQP9，which may be one of the mechanisms by which it exerts its“ascending the clear and descending the turbid”effect to treat STC.
To study curative effect of Banxia Xiexin Decoction（半夏泻心汤）on gastric epithelial dysplasia and its influence on immune function and gastric mucosa inflammatory reaction.
Eighty cases with gastric epithelial dysplasia（dampness-heat syndrome of spleen and stomach）were divided into the control group and the study group with 40 cases in each by digital table method.The control group was treated with conventional western medicine，and the observation group was treated with Banxia Xiexin Decoction.The course was12 weeks.The changes of TCM syndrome scores，immune function and gastric mucosal inflammation were observed before and after treatment.
There was no significant difference in fullness，stomachache，fatigue，loose stool，belching，lethargy and lack of thirst between the two groups before treatment（P>0.05）.After treatment，the score decreased（P<0.001），and the degree of decline in the observation group was greater than that in the control group（P<0.001）.There was no significant difference in the levels of CD+3，CD+4 or CD+8 between the two groups before treatment（P>0.05），and the levels of CD+3 and CD+4 were higher than those before treatment（P<0.001），and the increases in the observation group were greater than those in the control group（P<0.001）.There was no significant difference in serum levels of interleukin-6（IL-6），interleukin-2（IL-2），interleukin-17（IL-17）or tumor necrosis factor-α（TNF-α）between the two groups before treatment（P>0.05），and the levels of IL-6，IL-17 and TNF-αwere decreased compared with those before treatment（P<0.001）.The decrease of IL-2 in the observation group was greater than that in the control group（P<0.001），and the increase of IL-2 in the observation group was greater than that in the control group（P<0.001）.The therapeutic effect of the observation group was better than that of the control group（P<0.05）.
Banxia Xiexin Decoction in the treat-ment of gastric mucosal dysplasia（dampness-heat syndrome of spleen and stomach）can help to alleviate disease-related symptoms，improve the immune function，inhibit the inflammatory response and improve the therapeutic effect.
To analyze the effect of Feipingxiao Decoction（肺平哮汤）combined with respiratory rehabilitation on pulmonary function and immune function in children with bronchial asthma.
A total of 150 children with bronchial asthma admitted to the hospital were selected and randomly divided into control group and observation group，75 cases in each group.The control group was treated with inhaled glucocorticoids，and the observation group was given Feipingxiao Decoction combined with respiratory rehabilitation on this basis，and both groups were treated for 7 days.After treatment，the clinical treatment effect，symptom disappearance time，lung function，inflammatory factors and immune function were compared between the two groups.
The total effective rate of the treatment observation group was 90.67%，which was significantly higher than that of the control group（73.33%）（P<0.05）.After treatment，the disappearance time of wheezing，rales，asthma and cough symptoms in the observation group was significantly shorter than that of the control group（P<0.05）.The levels of forced expiratory volume in 1 second（FEV1），forced vital capacity（FVC）and FEV1/FVC in both groups were significantly improved after treatment（P<0.05）.The improvement of each index in the observation group was significantly better than that in the control group（P<0.05）.The levels of C-reactive protein（CRP）and transforming growth factorβ1（TGF-β1），tumor necrosis factor-α（TNF-α）and interleukin-4（IL-4）were significantly lower than those before treatment（P<0.05）.The improvement of the indicators in the observation group was significantly better than that in the control group（P<0.05）.After treatment，the levels of immunoglobulin G（IgG），immunoglobulin A（IgA）and immunoglobulin M（IgM）were significantly higher than those before treatment（P<0.05），and the improvement of various indicators in the observation group was significantly better than that in the control group（P<0.05）.
Feipingxiao Decoction combined with respiratory rehabilitation can significantly improve the clinical treatment effect of children with bronchial asthma，promote the improvement of clinical symptoms，reduce the levels of inflammatory factors，and improve the pulmonary function and immune function of children.
Yiyiren（Coicis Semen）is a traditional Chinese medicinal and edible herb，possessed the dual functions of promoting diuresis to drain dampness and tonifying spleen to arrest diarrhea.Yiyiren（Coicis Semen）is rich in many constituents，including fatty acids and esters，polysaccharides，flavonoids，triterpenoids，etc.Among these constituents，polysaccharides are served as a vital material foundation for its therapeutic effects.Currently，the principal extraction methods for Yiyiren（Coicis Semen）polysaccharides include hot water extraction，ultrasonic-assisted extraction，microwave-assisted extraction and flash extraction.The previous research has demonstrated that Yiyiren（Coicis Semen）polysaccharides are rich in a diverse monosaccharide composition，primarily containing glucose，galactose，xylose and mannose.Yiyiren（Coicis Semen）polysaccharides have various biological activities，such as hypoglycemic effect，anti-tumor，anti-inflammation，anti-oxidation，regulating intestinal flora，etc.This article presented a systematic review of recent advances in the extraction，purification，structural characterization and biological activities of Yiyiren（Coicis Semen）polysaccharides domestically and internationally，aiming to provide a scientific reference for further in-depth systematic research and efficient exploitation of Yiyiren（Coicis Semen）polysaccharides.
To analyze the clinical effect of Danggui Shaoyao Powder（当归芍药散）assisted by massage along meridian on pelvic floor rehabilitation of chronic pelvic pain with Qi deficiency and blood stasis.
One hundred and twelve patients with chronic pelvic pain of Qi deficiency and blood stasis were enrolled in the hospital from January 2021 to June 2022.They were randomly divided into the study group（56 cases）and the control group（56 cases）.Both groups received pelvic floor rehabilitation intervention and massage along the meridian，and the study group was given Danggui Shaoyao Powder orally.The treatment of both groups lasted for 12 weeks.The clinical symptom score，pain visual analogue scale（VAS），pelvic floor resting potential and quality of life of the two groups were compared before and after treatment，and the clinical efficacy of the two groups was evaluated.
After 12 weeks of treatment，the symptom scores of lower abdominal pain，lumbosacral pain，abnormal leukorrhagia，aggravation after fatigue and mental fatigue in the two groups decreased，and the rest potential of pelvic floor decreased before and after treatment，and the scores of various dimensions of quality of life increased.After 12 weeks'treatment，the scores of clinical symptoms and resting potential before and after pelvic floor in the study group were lower than those in the control group，and the scores of quality of life in all dimensions were higher than those in the control group，with statistical significance（P<0.05）.After 1，4，8 and 12 weeks of treatment，the VASscores of the two groups decreased compared with those before treatment，and the VASscores of the study group were lower than those of the control group at all time points after treatment with statistical significance（P<0.05）.After 12 weeks of treatment，the total clinical effective rate in the study group was 92.86%，which was higher than that in the control group（76.79%），and the difference was statistically significant（P<0.05）.
On the basis of pelvic floor rehabilitation and massage along meridians，Danggui Shaoyao Powder can further improve patients'clinical symptoms，relieve pain and regulate pelvic floor resting potential，which is of positive significance for improving patients'quality of life and clinical efficacy.
To analyze the clinical value of Modified Xiaoji Yinzi（小蓟饮子加减）combined with Compound Mufurong Nasal Ointment（复方木芙蓉涂鼻软膏）in treating epistaxis in Little's area.
Seventy children with epistaxis in Little's area admitted to the hospital from January 2022 to May 2022 were randomly divided into a combined group and a control group，with 35 cases in each group.The two groups were treated with nasal irrigation with normal saline，erythromycin eye ointment and Compound Mufurong Nasal Ointment，while the combined group was treated with Modified Xiaoji Yinzi.The therapeutic effects，symptoms and changes of blood routine test results of the two groups were compared，and the clinical value of the two treatment schemes was analyzed.
After 7 days of treatment，the symptoms of epistaxis，nasal cavity ulcer and nasal cavity erosion in the two groups were significantly improved compared with those before treatment.After 7 days of treatment，the incidence of epistaxis，nasal cavity ulcer and nasal cavity erosion in the combined group was lower than that in the control group，with statistical significance（P<0.05）.After 7 days of combined treatment，the total clinical effective rate of group A was 100.00%，which was higher than that of the control group（82.86%）with statistical significance（P<0.05）.After 7 days of treatment，the levels of white blood cells（WBC）and C-reaction protein（CRP）in both groups decreased compared with those before treatment.After 7 days of treatment，the levels of WBC and CRP in the combined group were lower than those in the control group with statistical significance（P<0.05）.There was no recurrence in the two-month follow-up of the effective group，but there were 5 cases in the control group，with a recurrence rate of 17.24%（5/29），and the difference between the two groups was statistically significant（P=0.037）.
On the basis of Compound Mufurong Nasal Ointment，the clinical effect of treating epistaxis in Little's area by combined application of Modified Xiaoji Yinzi is more significant，and there are obvious advantages in improving children's symptoms，alleviating inflammatory reaction，preventing anemia and reducing the risk of recurrence.
Identification，content determination and characteristic spectrum analysis of different Chenxiang（Aquilariae Lignum Resinatum）components obtained by artificial induction method were carried out using thin layer chromatography（TLC）and high performance liquid chromatography（HPLC）to evaluate the quality and quantity of Chenxiang（Aquilariae Lignum Resinatum）.
This article used chloroform-ether（10：1）as the developing agent to perform TLC identification on this batch of Chenxiang（Aquilariae Lignum Resinatum）samples.Content determination and characteristic spectrum were performed using HPLC under the following chromatographic conditions.Waters Symmetry Shield TM RP18 column（4.6 mm×250 mm，5μm）was used.The acetonitrile 0.1% formic acid water was as the mobile phase.The column temperature was 30℃.The flow rate was 0.7 mL·min-1.The detection wavelength was 252 nm.The injection volume was 10μL.Finally，similarity evaluation，Principal Component Analysis（PCA）and Orthogonal Partial Least Squares Discriminant Analysis（OPLS-DA）were used to screen for chromatographic peaks that caused significant differences in different parts（trunk and branch）.
The results of TLC showed that the spots of the Chenxiang（Aquilariae Lignum Resinatum）samples were basically the same as those of the control herb.Examining the test product under the UV lamp at 254 nm，it was found that the color of the sample spots was more obvious in the branch than that in the main trunk when the Rf value was 0.38.The content determination results showed that the content of agarotetrol in Chenxiang（Aquilariae Lignum Resinatum）samples from different aroma forming parts ranged from 0.02% to 0.58%，and the average content of agarotetrol in the branches was higher than that in the stems.The characteristic spectrum results showed that there were 6 common characteristic peaks in the Chenxiang（Aquilariae Lignum Resinatum）sample，with a significant difference in the peak area of agarotetrol.Except for No.4，No.9，No.12 and No.13，the content of agarotetrol in the branches of the other groups was higher than that in the trunk.The similarity value of Chenxiang（Aquilariae Lignum Resinatum）trunk was between 0.842 and 0.999，and the similarity value of Chenxiang（Aquilariae Lignum Resinatum）branch was between 0.901 and 0.994，indicating a good branch similarity effect.The results of PCA and OPLS-DA analysis by chemometrics showed that peak 4 and peak 6 were the symbolic components of the quality difference of Chenxiang（Aquilariae Lignum Resinatum）aroma.
The present study comprehensively and effectively analyzed the chemical components of Chenxiang（Aquilariae Lignum Resinatum）samples obtained from the trunk and branch parts using TLC，content determination and characteristic chromatographic fingerprint analysis methods under the same artificial induction method.Apart from some samples showing significant individual differences，the Chenxiang（Aquilariae Lignum Resinatum）samples from the branch parts demonstrated more pronounced aroma effects，which provides a basis for future optimization of methods and in-depth research on aroma mechanisms.
Renshen Guipi Pills（人参归脾丸）originated from Jishengfang of the Song dynasty，and were consisted of 10 kinds of herbs such as Renshen（Ginseng Radix et Rhizoma），Baizhu（Atractylodis Macrocephalae Rhizoma），Fuling（Poria），Gancao（Glycyrrhizae Radix et Rhizoma），Huangqi（Astragali Radix），Danggui（Angelicae Sinensis Radix），Muxiang（Aucklandiae Radix），Yuanzhi（Polygalae Radix），Longyan（Longan Arillus），Suanzaoren（Ziziphi Spinosae Semen）and so on.The dosage forms include big honey pill and water honey pill.The whole prescription has the effects of tonifying energy and enrich blood，strengthening spleen and nourishing heart，and could be used for the treatment of insomnia，fatigue and anemia.Through consulting and analyzing the relevant literature，the author found that Renshen Guipi Pills showed good effects for nervous system diseases（insomnia，fatigue），hematological diseases（anemia，leukopenia and hypersplenism），gynecological diseases（bleeding，pelvic floor dysfunction and hypomenorrhea），circulatory system diseases and immune system diseases.Quality control mainly focused on content testing and quality standard researches.While there were not many researches on related pharmacology.Here，the authors summarized and analyzed the findings about clinical applications，quality control and pharmacologic actions of Renshen Guipi Pills，in order to provide more ideas and basis for their clinical application.
To explore the effect of joint fumigation and washing instrument combined with Duhuo Jisheng Decoction（独活寄生汤）on knee joint function，pain and serum inflammatory factors in patients with knee osteoarthritis（KOA）.
Sixty patients were randomly divided into a control group and an observation group，30 cases in each group.The control group received intra-articular injection of sodium hyaluronate for treatment，while the observation group received joint fumigation and washing instrument combined with Duhuo Jisheng Decoction for treatment on the basis of the medication in the control group.The treatment period was 4 weeks.Traditional Chinese medicine syndrome scores，knee joint function，pain and serum inflammatory factor levels were compared between the two groups before treatment and 4 weeks after treatment.
There was no significant difference in traditional Chinese medicine syndrome scores between the two groups before treatment（P>0.05）.The scores decreased after treatment（P<0.05）and the degree of decrease in the observation group was greater than that in the control group（P<0.05）.There was no significant difference in Lysholm score，The Western Ontario and McMaster Universities（WOMAC）score or Hospital for Special Surgery（HSS）score between the two groups before treatment（P>0.05）.The Lysholm score and HSSscore increased after treatment compared to those before treatment（P<0.05），and the increase in the observation group was greater than that in the control group（P<0.05）.The WOMACscores decreased after treatment compared to those before treatment（P<0.05）and the decrease in the observation group was greater than that in the control group（P<0.05）.There was no significant difference in VAS score，levels of serum substance P（SP），5-hydrox-ytryptamine（5-HT），prostaglandin E2（PGE2），tumor necrosis factor-α（TNF-α），interleukin-6（IL-6），interleukin-10（IL-10），insulin-like growth factor 1（IGF-1）or transforming growth factor-β（TGF-β）between the two groups before treatment（P>0.05）.The VASscore decreased after treatment（P<0.05）and the degree of decrease in the observation group was greater than that in the control group（P<0.05）.The therapeutic effect of the observation group was significantly better than that of the control group（P<0.05）.
The joint fumigation and washing instrument combined with Duhuo Jisheng Decoction has significant effect on the treatment of KOA.It can effectively alleviate discomfort symptoms such as pain，inhibit pain and the levels of inflammatory factors，and improve knee joint function and treatment efficacy.
To investigate the clinical value of Tongfu Xingshen Decoction（通腑醒神汤）Combined with Western Medicine treatment of hypertensive intracerebral hemorrhage.
A hundred patients with hypertensive intracerebral hemorrhage，they were randomly divide into the control group and the observation group，50 cases in each group.Both groups were treated with conventional Western medicine，while the observation group was treated with Tongfu Xingshen Decoction as an auxiliary treatment on the basis of the control group，with treatment course of 4 weeks.The changes of traditional Chinese medicine syndrome scores，neurological and cognitive functions，serum brain injury and free radical indicators，and the levels of anti-inflammatory factors were observed before and after treatment.
There was no statistically significant difference in the scores of traditional Chinese medicine symptoms between the two groups before treatment（P>0.05）.The scores decreased after treatment（P<0.05），and the degree of decline in the observation group was greater than that in the control group（P<0.05）.There was no statistically significant difference in the scores of Glasgow Coma Scale（GCS），the National Institutes of Health Stroke Scale（NIHSS），Mini-mental State Examiniation（MMSE）or Montreal Cognitive Assessment（MoCA）between the two groups before treatment（P>0.05）.The scores of GCS，MMSE and MoCA increased after treatment（P<0.05），and the degree of increase in the observation group was greater than that in the control group（P<0.05）.The NIHSSscores decreased after treatment（P<0.05），and the degree of decline in the observation group was greater than that in the control group（P<0.05）.There was no statistically significant difference in the serum neuron specific enolase（NSE）or astrocyte derived protein（S100β）between the two groups before treatment（P>0.05）.They were decreased after treatment（P<0.05），and the degree of decline in the observation group was greater than that in the control group（P<0.05）.There was no statistically significant difference in the serum superoxide dismutase（SOD），malondialdehyde（MDA），endothelin-1（NT-1）or nitric oxide（NO）between the two groups before treatment（P>0.05）.The levels of MDA and NT-1 were decreased after treatment（P<0.05），and the degree of decline in the observation group was greater than that in the control group（P<0.05）.The levels of SOD and NO increased after treatment（P<0.05），and the degree of increase in the observation group was greater than that in the control group（P<0.05）.There was no statistically significant difference in the serum interleukin-6（IL-6）and tumor necrosis factor-α（TNF-α）between the two groups before treatment（P>0.05）.They were decreased after treatment（P<0.05），and the degree of decline in the observation group was greater than that in the control group（P<0.05）.
Tongfu Xingshen Decoction in assisting the treatment of hypertensive intracerebral hemorrhage can significantly improve clinical symptoms，neurological function and cognitive function of patients，and its effect may be related to inhibiting brain damage caused by inflammatory mediators and free radicals.
To study the clinical efficacy of Ginkgolide Dispersible Tablets combined with hyperbaric oxygen in the treatment of acute cerebral infarction（ACI）.
A total of 326 patients with ACIwho were treated in the hospital from April 2019 to October 2022 were selected as the study subjects.They were divided into treatment group（163 cases）and control group（163 cases）according to different intervention methods.Both groups received symptomatic treatment such as oxygen inhalation，blood pressure reduction and lipid regulation，and anti-platelet aggregation.On this basis，the treatment group was treated with Ginkgolide Dispersible Tablets and hyperbaric oxygen，while the control group was only treated with hyperbaric oxygen，and the patients in both groups were treated continuously for 2 weeks.The levels of carotid atherosclerosis indicators［carotid intimamedia thickness（IMT），carotid plaque area］，NF-κB signaling pathway-related factors（NF-κB p50，p65 mRNA and protein），and downstream inflammatory factors［interleukin-8（IL-8），interleukin-1β（IL-1β），tumor necrosis factor-alpha（TNF-α）］were measured before and after treatment.Simultaneously，Barthel Index（BI）scores，National Institutes of Health Stroke Scale（NIHSS）scores，traditional Chinese medicine syndrome scores were assessed.Additionally，the clinical efficacy was evaluated after the course of treatment and the drug-related adverse events during the trial period were recorded.
After treatment，the total effective rate of the treatment group was 95.71%，higher than that of the control group（84.66%）.There was a significant difference between the two groups（P<0.05），but there was no significant difference in adverse events between the two groups（P>0.05）.At the same time，the BI scores of the two groups were significantly higher after treatment，and BI score of the treatment group was higher than that of the control group（P<0.05）.The NIHSS score，traditional Chinese medicine syndrome points，IMT，plaque area and the levels of TNF-α，IL-8，IL-1β，NF-κB p50，p65 mRNA and protein were significantly lower in the treatment group than those in the control group（P<0.05）.
Ginkgolide Dispersible Tablets combined with hyperbaric oxygen can significantly inhibit the activation of NF-κB inflammatory signal pathway in patients with ACI and improve its inflammatory damage status，further stabilizing the atherosclerotic plaque，significantly improving the clinical efficacy，with less adverse reactions.And at the same time，it is conducive to the optimization of neurological function and quality of prognosis.
To study the effect of Yiqi Yangyin Quyu Decoction（益气养阴祛瘀汤）on parotid radionuclide dynamic imaging index and immune function in patients with Sjogren's syndrome.
Eighty-four patients with Sjogren's syndrome treated in the hospital from January 2022 to January 2023 were selected and randomly divided into two groups according to the random number table method，with 42 cases in each group.The patients in the control group were treated with conventional western medicine and those in the observation group were treated with Yiqi Yangyin Quyu Decoction on the basis of the control group.The treatment course of the two groups was3 months.The quantitative scores of TCM symptoms，changes in disease activity［Sjgren's syndrome disease activity index（ESSDAI）and EULAR Sjgren's syndrome patient reporting index（ESSPRI）］，parotid radionuclide dynamic imaging indicators［uptake fraction（IF），excretion fraction（EF）］，immune function indicators［erythrocyte sedimentation rate（ESR），C-reactive protein（CRP），immunoglobulin G（IgG），anti-Sjgren's syndrome antigen A（SSA）antibody，anti-Sjögren's syndrome antigen B（SSB）antibody］and adverse reactions were compared between the two groups.
Before treatment，there was no significant difference in the observation indexes between the two groups（P>0.05）.After treatment，the scores of TCM symptoms such as red tongue and less body fluid，no coating/less coating/peeling，dry mouth and desire to drink，dry eyes and less tears in the observation group were significantly lower than those in the control group［（1.72±0.53）points，（1.96±0.70）points，（2.03±0.91）points，（1.70±0.84）points vs（1.98±0.61）points，（2.36±0.59）points，（2.89±0.72）points，（2.13±0.77）points］（P<0.05）.The ESSDAI and EULAR scores of the observation group were significantly higher than those of the control group［（5.92±1.60）points，（4.36±1.02）points vs（6.87±1.54）points，（5.39±0.96）points］（P<0.05）.The levels of IF and EF of parotid radionuclide dynamic imaging were significantly higher than those of the control group［（1.87±0.26）%，（21.07±4.20）% vs（1.74±0.19）%，（17.96±3.75）%］.The immune function indexes（ESR，IgG，positive rate of anti-SSA antibody and positive rate of anti-SSB antibody）were significantly better than those of the control group［（19.83±1.84）mm/h，（6.90±1.37）g/L，（41.28±5.69）%，（28.91±4.03）% vs（21.05±1.69）mm/h，（8.81±1.19）g/L，（53.47±5.18）%，（6.28±3.71）%］（P<0.05）.There was no significant difference in the incidence of adverse reactions between the observation group（7.14%）and the control group（11.90%）（P>0.05）.
Yiqi Yangyin Quyu Decoction is effective in the treatment of Sjogren's syndrome.It can relieve the symptoms of patients more effectively，improve the body's immune function and parotid radionuclide dynamic imaging indicators.It is safe and reliable，and has application value.
To study the effects of Yiqi Huoxue Fuyuan Decoction（益气活血复元汤）combined with minimally invasive surgery on bone metabolism and bone healing of calcaneal fracture.
Eighty patients diagnosed as calcaneal fracture were selected and divided into two groups according to random number table.Forty patients in the reference group were treated with minimally invasive surgery，and forty patients in the study group were treated with Yiqi Huoxue Fuyuan Decoction combined with minimally invasive surgery.The clinical efficacy，TCM syndrome score，bone metabolism index，bone healing index and imaging index of the two groups were observed and compared.
Compared with that（77.50%）of the reference group，the total effective rate of the study group was97.50%，and the difference was statistically significant（P<0.05）.Compared with that of the reference group，the TCM syndrome score of the study group was lower，and the difference was statistically significant（P<0.05）.Compared with those of the reference group，the levels of osteocalcin（OC）and bone alkaline phosphatase（BALP）in the study group were higher，and the levels of pyridinoline（PYD）and tartrate resistant acid phosphatase（TRAP）were lower，with statistical significance（P<0.05）.Compared with those of the reference group，the levels of alkaline phosphatase（ALP），propeptide of typeⅠprocollagen（PICP），insulin-like growth factor（IGF）and bone morphogenetic protein（BMP）in the study group were higher，and the differences were statistically significant（P<0.05）.Compared with those of the reference group，Bohler Angle，Gissane Angle and calcaneus height in the study group were higher，and calcaneus width was lower，with statistical significance（P<0.05）.
The combination of minimally invasive surgery and Yiqi Huoxue Fuyuan Decoction can effectively improve the clinical symptoms of patients with calcaneal fracture and promote fracture healing，with high clinical application value.
Zhimu（Anemarrhenae Rhizoma）-Huangbai（Phellodendri Chinensis Cortex）is a commonly used drug pair for nourishing Yin and clearing heat in modern clinical practice.After the compatibility of the two drugs，they are good at eliminating dampness and heat in the lower Jiao，and play an important role in clinical medication.This article summarized the best extraction process of Zhimu（Anemarrhenae Rhizoma）-Huangbai（Phellodendri Chinensis Cortex）and the effective components of this drug pair，such as anemarsaponin C，mangiferin，palmatine，tetrandrine and so on.Different compatibility ratios of Zhimu（Anemarrhenae Rhizoma）-Huangbai（Phellodendri Chinensis Cortex）also affect the dissolution，exposure and absorption of different active ingredients.Modern pharmacological studies have found that Zhimu（Anemarrhenae Rhizoma）-Huangbai（Phellodendri Chinensis Cortex）has multi-target characteristics in the treatment of different diseases.It has pharmacological activities such as hypoglycemic and lipid-lowering effect，anti-inflammatory，anti-oxidation，reversal of muscle atrophy and protection of neurons.It may involve AMPK，AKT，NF-κB，mTOR and many other pathways to exert its pharmacological effects.In modern clinical practice，prescriptions composed of Zhimu（Anemarrhenae Rhizoma）-Huangbai（Phellodendri Chinensis Cortex）are also commonly used to treat prostatitis，seminal emission caused by seminal vesiculitis and menopausal syndrome，such as Zhibai Dihuang Pills（知柏地黄丸），Sizhi Huangbai Pills（四制黄柏丸），Dabuyin Pills（大补阴丸），Zishen Pills（滋肾丸），etc.This article mainly reviewed Zhimu（Anemarrhenae Rhizoma）-Huangbai（Phellodendri Chinensis Cortex）from the aspects of chemical composition，pharmacological action and modern clinical application，in order to provide reference for the further development and utilization of Zhimu（Anemarrhenae Rhizoma）-Huangbai（Phellodendri Chinensis Cortex），and provided ideas and basis for the future clinical application and related research of the drug pair.
To study the effect of TCM constitution types on stress response of general anesthesia combined with epidural block in elderly patients with cervical cancer undergoing laparoscopic hysterectomy.
A total of 420 elderly patients with cervical cancer admitted to the hospital from January 2021 to December 2022 were selected.The laparoscopic hysterectomy was successfully completed under general anesthesia combined with epidural block，and there were 140 cases of mild constitution，140 cases of Yin deficiency constitution and 140 cases of Yang deficiency constitution.The anesthesia conditions of patients with different constitution types，vital signs and stress response at 5 min before anesthesia，30 min after anesthesia and 6 h after operation were compared.The anesthesia conditions included remifentanil dosage，propofol dosage，anesthesia induction time，recovery time，vital signs indexes included body temperature，heart rate，respiratory rate）and stress response indexes included norepinephrine，epinephrine and cortisol.
There was no significant difference in remifentanil dosage，propofol dosage or anesthesia induction time among the three groups（P>0.05）.The recovery time of patients with mild constitution was shorter（P<0.05）.There was no significant difference in body temperature，respiratory rate and heart rate among the three groups at 5 min before an-esthesia（P>0.05）.The body temperature，respiratory rate and heart rate of the three groups decreased at 30 min after anesthesia，and returned to be normal at 6 h after operation.There was no significant difference among the three groups（P>0.05）.The above indexes of the three groups were significantly increased at 30 min after anesthesia，and significantly decreased at 6 h after operation.The levels of norepinephrine，epinephrine and cortisol in patients with mild constitution were significantly better than those in patients with Yin deficiency constitution and Yang deficiency constitution at 30 min after anesthesia and 6 h after operation（P<0.05）.
The elderly patients with cervical cancer with gentle constitution can better regulate the stress response of general anesthesia combined with epidural block in laparoscopic hysterectomy，which is beneficial to the postoperative rehabilitation of patients.
The pathogenesis of atherosclerosis（AS）is complex，among which lipid metabolism plays an important role in the development of AS，and the regulation of cholesterol homeostasis has become one of the strategies for the prevention and treatment of AS.The purpose of reverse cholesterol transport（RCT）is to return extrahepatic cholesterol to the liver through the blood circulation，where it is metabolized and then excreted from the body，and to inhibit the development of ASby removing excess cholesterol from the arterial blood vessel wall.However，studies on RCT mainly focus on the metabolic transformation of cholesterol，and studies on cholesterol transport are rare.Lymphatic vessels exist in the outer membrane of the arterial wall，and lymphangiogenesis is critical in the pathologic process of AS.When lymphatic vessels are dysfunctional，the transport of immune cells，immune response and absorption of dietary fat are impeded，which then accelerate the development of AS.More and more studies have confirmed that lymphatic vessels serve as important channels for RCT and that intraplaque cholesterol efflux is dependent on lymphatic transport，so this review hypothesized that increasing the neogenesis of periarterial lymphatic vessels may be a response to alleviate the excessive accumulation of cholesterol in plaques.Linggui Zhugan Decoction（苓桂术甘汤）is originated from The Essentials of the Golden Chamber，and the group proved its efficacy on ASin the preliminary stage，and this review was about the influence of Linggui Zhugan Decoction on lymphangiogenesis involved in m-RCT to prevent and treat AS.
To explore the effect of Xiaojia Decoction（消瘕汤）combined with denogestrin on sexual hormone levels and ovarian function in patients with adenomyosis.
Ninety patients with kidney deficiency and blood stasis type of adenomyosis who were treated in the hospital from January 2021 to December 2022 were collected and randomly divided into A group and B group，with 45 patients in each group.Group A was treated with dinoprotein，while Group B was treated with Xiaojia Decoction combined with dinoprotein.The treatment effects，traditional Chinese medicine symptom scores，sex hormone levels and serum indicators were compared between the two groups.
The effective rate of treatment in Group B was significantly higher than that in Group A（P<0.05）.After treatment，the scores of menstrual cycle，menstrual volume，menstrual abdominal pain，mental depression，chest and flank fullness and tongue purple dark in Group B were significantly lower than those before treatment（P<0.05），and the scores of Group B were significantly lower than those of Group A（P<0.05）.After treatment，the levels of testosterone（T），follicle stimulating hormone（FSH）and luteinizing hormone（LH）in Group B were significantly lower than those before treatment（P<0.05），and the levels of Group B were significantly lower than those of Group A（P<0.05）.The level of estradiol（E2）was significantly higher than that before treatment（P<0.05），and the level of Group B was significantly higher than that of Group A（P<0.05）.After treatment，the levels of matrix metalloproteinase-9（MMP-9），vascular endothelial growth factor（VEGF）and matrix metalloproteinase-2（MMP-2）in Group B were significantly lower than those before treatment（P<0.05），and the levels of group B were significantly lower than those of Group A（P<0.05）.
The combina-tion of Xiaojia Decoction and dinoregestone has good clinical efficacy in treating patients with adenomyosis，which is beneficial for slowing down the progression of adenomyosis，regulating the levels of sexual hormones in patients，improving ovarian function and effectively alleviating clinical symptoms.
To investigate the effects of Qishen Yiqi Dropping Pills（芪参益气滴丸）combined with non-invasive positive pressure ventilation on clinical symptoms，cardiac function and oxidative stress in patients with acute heart failure（AHF）.
A total of 110 patients with acute heart failure admitted to the hospital from November 2017 to November 2022 were selected as study subjects.According to different treatment methods，they were divided into study group and control group，55 cases in each group.Both groups received conventional western medicine treatment plus non-invasive positive pressure ventilation.The study group combined with Qishen Yiqi Dripping Pills.The changes of physical signs，clinical efficacy，cardiac function indexes（EF），B-type brain natriuretic peptide precursor（NT-probNP）and oxidative stress indexes［serum superoxide dismutase（SOD），glutathione peroxidase（GSH-Px），malondialdehyde（MAD）］were compared between the two groups.
24 h after treatment，the values of heart rate（HR），respiratory rate（RR），mean arterial pressure（MAP）and oxygenation index（PO2/FiO2）in both groups were significantly improved compared with those before treatment（P<0.05），and the improvement degree of all indexes in the study group was significantly higher than that in the control group（P<0.05）.The total effective rate of the study group was significantly higher than that of the control group（P<0.05）.In the study group，4 cases were ineffective，3 cases were improved and 1 case died after endotracheal intubation and invasive ventilation.In the control group，12 cases were ineffective，8 cases were improved and 4 cases died after endotracheal intubation and invasive ventilation.After 3 d treatment，the levels of EF and NT-probNP in both groups were significantly improved compared with those before treatment（P<0.05），and the improvement degree in the study group was significantly higher than that in the control group（P<0.05）.After 3 d treatment，the levels of SOD，GSH-Px and MAD in both groups were significantly improved compared with before treatment（P<0.05），and the improvement in the study group was significantly higher than that in the control group（P<0.05）.Serious adverse reactions occurred in both groups during treatment.
Qishen Yiqi Dropping Pills combined with non-invasive positive pressure ventilation can significantly improve the therapeutic effect of acute heart failure，and has significant effects on improving clinical symptoms，cardiac function and oxidative stress of patients，and has a high safety，suitable for promotion.
The incidence and mortality rate of breast cancer have ranked first among female malignant tumors in China，and its prevention and treatment have become a major scientific problem urgently needed to be solved.Immune cells play an important role in the immune microenvironment of breast cancer and always affect the occurrence and development of breast cancer.In recent years，traditional Chinese medicine（TCM）has been effective in the comprehensive treatment of breast cancer patients，improving the quality of life and prolonging the survival period.Studies have shown that a variety of traditional Chinese medicine active ingredients can improve the immune microenvironment of breast tumors and enhance the immune response by regulating immune cells such as macrophages，natural killer cells，dendritic cells，myeloid-derived suppressor cells，T lymphocytes，regulatory T cells and B lymphocytes in the immune microenvironment of breast tumors，thus playing a role in anti-breast cancer.In this paper，it collected the relevant research on the anti-breast cancer treatment of the active ingredients of traditional Chinese medicine in recent years，and discussed the mechanism of the active ingredients of traditional Chinese medicine in regulating immune cells against breast cancer，in order to provide a new theoretical basis for the treatment of breast cancer with traditional Chinese medicine and lay a solid theoretical foundation for the development of related clinical research in the later stage.
To explore the mechanism of electroacupuncture intervention in treating myofascial pain syndrome rats based on brain-derived neurotrophic factor（BDNF）-tropomyosin receptor kinase B（TrkB）-p38/c-Jun N-terminal kinase（JNK）signal pathway.
Twenty-four SD rats were randomly divided into blank group，model group，electroacupuncture group and Western medicine group，with 6 rats in each group.The MPSrat model was established using a combination of striking and centrifugal movements.After successful modeling，the electroacupuncture group received electroacupuncture intervention for 7 consecutive days.The Western medicine group was intervened with celecoxib（21 mg· kg-1）for 5 consecutive days and stopped for 2 days.After treatment，the latent period of left lower limb thermal contraction foot and spontaneous electrical activity were measured in each group.HEstaining was used to observe the pathological and morphological changes of local muscle tissue.ELISA method was used for detecting the levels of interleukin-6（IL-6），interleukin-10（IL-10），tumor necrosis factor-α（TNF-α）and interleukin-1β（IL-1β）in serum of each group.Immunofluorescence was used to observe the positive expressions of glial fibrillary acidic protein（GFAP）and microglia specific marker（OX-42）in spinal cord tissue.Reverse Transcription Polymerase Chain Reaction（RT-PCR）was used to detect the mRNA expression levels of BDNF，TrkB，p38 and JNK in spinal cord tissue.The Wes method was used to detect the protein expression levels of BDNF，TrkB，p38，phospho-p-p38MAPK（p-p38），JNK，phospho-c-Jun N-terminal kinases（p-JNK）in spinal cord tissue.
Electroacupuncture and Western medicine intervention can increase the latent period of thermal contraction in rats，improve local muscle tissue morphology and inflammatory status，inhibit serum pro-inflammatory factor release，promote anti-inflammatory factor secretion，reduce GFAP and OX-42 positive expressions in spinal cord tissue，reducing mRNA expression levels of BDNF，TrkB，P38 and JNK，and protein expression levels of BDNF，TrkB，P38，p-p38，JNK and p-JNK，and the efficacy of electroacupuncture was better than that of the Western medicine.
Both electroacupuncture and celecoxib can significantly improve the pain threshold in MPS rats，but electroacupuncture has advantages in local tissue pathological morphology and spontaneous potential recovery.Its mechanism may be related to inhibiting BDNF-TrkB-p38/JNK signal pathway，reducing the release of inflammatory factors，and reducing glial cell activation.
To observe the application of Shenqi Fuzheng Injection（参芪扶正注射液）in laparoscopic radical resection of rectal cancer in elderly patients with Qi deficiency and its effect on anesthesia recovery.
A total of 68 elderly patients with Qi deficiency who underwent laparoscopic radical resection of rectal cancer from January 2021 to December 2022 were selected as the research objects.According to the random number table method，they were divided into two groups，34 cases in each group.The control group underwent laparoscopic radical resection of rectal cancer under general anesthesia.The observation group was given intravenous infusion of Shenqi Fuzheng Injection（250 mL）30 min before the end of the operation，and other operations were the same as that in the control group.The postoperative vital signs，recovery time，pain，immune function and adverse reactions of the two groups were observed.Vital signs included blood pressure and heart rate，recovery time indicators included wake-up recovery time，anal exhaust time，liquid food intake time and defecation time were observed.Pain indicators included visual analogue scale（VAS）scores at 12，24 and 48 hours after surgery.Immune function indicators included peripheral blood lymphocyte subsets（CD+4，CD+4/CD+8）and natural killer（NK）cells.
There was no significant difference in diastolic blood pressure，systolic blood pressure or heart rate between the two groups before operation（P>0.05）.There was no significant difference in diastolic blood pressure，systolic blood pressure or heart rate between the two groups on the first day after operation（P>0.05）.The recovery time，anal exhaust time，feeding time and defecation time of the observation group were shorter than those of the control group，and the differences were statistically significant（P<0.05）.The VASscores of the observation group at 12，24 and 48 h after operation were significantly lower than those of the control group（P<0.05）.There was no significant difference in the levels of CD+4，CD+4/CD+8 or NK between the two groups before operation（P<0.05）.The levels of CD+4，CD+4/CD+8 and NK in the observation group were significantly higher than those in the control group（P<0.05）.The incidence of adverse reactions in the observation group and the control group was 8.82%（3/34）and 14.71%（5/34），respectively and the difference was not statistically significant（P>0.05）.
The application of Shenqi Fuzheng Injection in laparoscopic radical resection of rectal cancer in elderly patients with Qi deficiency is satisfactory.It can promote the recovery of anesthesia，reduce the degree of postoperative pain，improve the immune function of the body，and facilitate the postoperative rehabilitation of patients.
To study the therapeutic effect of traditional Chinese medicine（TCM）on nasosinusitis induced by radiotherapy of nasopharyngeal carcinoma（NPC）and its effect on the indexes of hypersensitive C-reactive protein（hs-CRP），interleukin-17（IL-17）and tumor necrosis factor-α（TNF-α）.
From December 2019 to November 2022，108 patients with nasosinusitis caused by radiotherapy of spleen-stomach deficiency，dampness-heat invading the upper syndrome and lung-stomach Yin deficiency and evil toxin retention syndrome were selected and divided into two groups according to different treatment methods.The patients in the routine treatment group were treated with saline rinse and roxithromycin orally.The TCM syndrome differentiation group was combined with TCM syndrome differentiation treatment on the basis of routine treatment and analyzed the clinical curative effect of the two groups after treatment.
The total effective rate was 96.30%（52/54）in the TCM syndrome differentiation group and 85.19% （46/54）in the routine treatment group.The total effective rate of the patients in the TCM syndrome differentiation group was higher than that in the routine treatment group（P<0.05）.The levels of hs-CRP，IL-17 and TNF-αin the two groups before treatment were compared between the two groups.The difference was not statistically significant（P>0.05）.After treatment，the levels of hs-CRP，IL-17 and TNF-αin TCM syndrome differentiation group were lower than those in the routine treatment group（P<0.05）.There was no significant difference in cilia transmission rate，Lund-Mackay score or pain score between two groups before treatment（P>0.05）.After treatment，the cilia transmission rate in the TCM syndrome differentiation group was（4.58±0.61）mm/min，higher than that in the routine treatment group.The Lund-Mackay score［（3.89±0.54）points］and the pain score［（1.14±0.75）points］in the TCM syndrome differentiation group were lower than those in the routine treatment group（P<0.05）.
The treatment of nasosinusitis caused by radiotherapy of NPCby TCM syndrome differentiation can inhibit the expressions of inflammatory factors，improve the cilia transmission rate，alleviate the pain degree of patients and improve the therapeutic effect.
To study the effect of acupuncture therapy based on the theory of five movements and six Qi on glaucoma intraocular pressure control and optic nerve function repair.
A total of 140 patients with glaucoma who were treated in the hospital from January to December 2022 were randomly divided into two groups，with 70 patients in each group.The patients in the control group were treated with conventional western medicine.On the basis of the control group，the patients in the observation group were treated with acupuncture therapy based on the theory of five movements and six Qi.After 4 weeks of treatment，the treatment efficiency，intraocular pressure，visual field index［mean defect（MD），mean light sensitivity（MS），loss variance（LV）］，optic nerve index［amplitude and latency of pattern visual evoked potential（P-VEP）］and adverse reactions were compared between the two groups.
The total effective rate of the observation group was97.14%，which was significantly higher than that of the control group（87.14%），and the difference between the groups was statistically significant（P<0.05）.After treatment，the intraocular pressure of the two groups decreased significantly（P<0.05），and the intraocular pressure of the observation group was lower than that of the control group（P<0.05）.After treatment，the value of MSin the two groups was signifi-cantly increased，while the values of MD and LV were significantly decreased，and the difference was statistically significant compared with those before treatment（P<0.05）.After treatment，the value of MSin the observation group was significantly higher than that in the control group，the values of MD and LV were significantly lower than those in the control group，and the difference between the two groups was statistically significant（P<0.05）.After treatment，the amplitude of P-VEPin the two groups was increased，and the latency of P-VEP was shortened，and the difference was statistically significant compared with that before treatment（P<0.05）.After treatment，the amplitude of P-VEPin the observation group was significantly higher than that in the control group，and the latency of P-VEPwas significantly shorter than that in the control group，the differences were statistically significant（P<0.05）.The incidences of adverse reactions in the observation group and the control group were 8.57% and 5.71%，respectively and the difference was not statistically significant（P>0.05）.The symptoms of adverse reactions could be relieved by themselves.
The acupuncture therapy based on the theory of five movements and six Qi is applied to glaucoma patients with satisfactory results.It can better control intraocular pressure and repair optic nerve function.It is a safe and effective treatment plan and is worthy of reference and application.
The aim of this study is to investigate the regulatory mechanism of LncRNA（UCA1）on the miRNA-331-3p/bromine domain protein 4（BRD4）axis through acupuncture，in order to ameliorate colonic inflammation in rats with spleen deficiency.Additionally，this study seeks to explore the contemporary mechanism of“strengthening spleen and benefiting Qi”acupuncture therapy in improving symptoms of spleen deficiency and loose stools.
Sixty male SD rats were randomly assigned to four groups：normal group，model group，non-meridian non-acupuncture group and acupuncture group，with 15 rats in each group.With the exception of the normal group，the remaining three groups were utilized to establish a rat model of spleen deficiency through the compound method of overwork and irregular diet.Following successful modeling，the acupuncture group re-ceived electro-acupuncture at“Zusanli（ST36）”and“Pishu（BL20）”，while the non-meridian non-acupuncture group was treated with electro-acupuncture at the tail tip as a control.The treatment was administered once daily for 20 minutes over a period of 14 days.After treatment，serum and colonic tissues were collected from the rats.The expressions of LncRNA（UCA1）and miRNA-331-3p/BRD4 axis-related genes in rat colon tissue were detected by qPCR.The contents of interleukin-1β（IL-1β）and interleukin-6（IL-6）in rat serum were detected by ELISA.The pathological morphological changes of rat colon tissue were observed by HE staining.The staining of BRD4 in colon was observed by immunohistochemistry method.The immunoactivities of IL-1β，IL-6，tumor necrosis factor-α（TNF-α）and NFκB p65 expression levels were detected by immunofluorescence histochemistry.The apoptosis in colon tissues of each group was detected by TUNEL staining.
Compared with those of the normal group，the expression levels of miRNA-331-3p in colon tissues of rats in the model group and non-meridian non-acupuncture group were significantly decreased（P<0.05），and the mRNA expression levels of LncRNA（UCA1），BRD4，nuclear factor kappa-B（NF-κB）p65，IL-1β，IL-6，IL-8 and TNF-αwere increased（P<0.05）.Compared with those of the model group，the expression levels of miRNA-331-3p in the colon tissue of rats were significantly increased（P<0.05）in the acupuncture group，and the mRNA expression levels of LncRNA（UCA1），BRD4，NF-κB p65，IL-1β，IL-6，IL-8 and TNF-αwere decreased（P<0.05）.Compared with those of the normal group，the expression levels of IL-1βand IL-6 in the serum of rats in the model group were significantly increased（P<0.05），and the expression levels of IL-1βand IL-6 in the colon tissue of rats in the acupuncture group were decreased（P<0.05）compared with those in the model group.Immunohistochemical results showed that the expression of BRD4 in the colon tissue of rats in the model group was increased compared with that in the normal group（P<0.05）.Compared with that in the model group，the expression of BRD4 in the acupuncture group was decreased（P<0.05）.The immunofluorescence histochemistry results showed that the mean absorbance values of IL-1β，IL-6，TNF-αand NF-κB p65 immunofluorescence in colon tissues of the model group and non-meridian non-acupuncture group were increased compared with those of the normal group（P<0.05）.Compared with those of the model group，the mean absorbance values of IL-1β，IL-6，TNF-αand NF-κB p65 immunofluorescence in colon tissues of rats in the acupuncture group were decreased（P<0.05）.In addition，HE staining results showed that acupuncture could effectively reduce inflammatory cell infiltration and loss of cupped cells in colonic mucosal tissues.TUNEL staining results showed that acupuncture could improve colonic inflammation and inhibit apoptosis of colonic mucosal cells in spleen deficiency rats.
Electro-acupuncture at“Zusanli（ST36）”and“Pishu（BL20）”can interfere with the LncRNA（UCA1）regulating miRNA-331-3p/BRD4 axis，inhibit the expressions of intestinal inflammation and pro-inflammatory mediators，and then inhibit the apoptosis of colonic mucosal cells and improve the immunity of the body，thus improving the symptoms of spleen deficiency and loose stools.
To investigate the therapeutic effect of Feikang Chuanning Pills（肺康喘宁丸）on chronic obstructive pulmonary disease（COPD）with prolonged lung-kidney Qi deficiency syndrome and its influence on protein kinase B（AKT）/mammalian target of rapamycin（mTOR）pathway.
A total of 84 patients with chronic COPD with prolonged lung-kidney Qi deficiency syndrome who were treated in Ningbo Hospital of Traditional Chinese Medicine from May 2021 to May 2023 were selected and divided into conventional group（42 cases）and traditional Chinese medicine group（42 cases）by random number table method.The conventional group was treated with conventional treatment，and the traditional Chinese medicine group was treated with Feikang Chuanning Pills on this basis.TCM syndrome scores，lung function，AKT/mTOR pathway protein，clinical efficacy and occurrence of adverse reactions in two groups were observed.
After treatment，TCM syndrome scores，the levels of AKT，p-AKT，mTOR and p-mTOR in the traditional Chinese medicine group were lower than those in the conventional group（P<0.05）.The levels of forced vital capacity（FVC），forced expiratory volume in 1 second（FEV1），peak expiratory flow（PEF）and FEV1/FVC in the traditional Chinese medicine group were higher than those in the conventional group（P<0.05）.The total effective rate of traditional Chinese medicine group was higher than that of the conventional group（P<0.05）.There was no significant difference in the total incidence of adverse reactions between the two groups（P>0.05）.
Feikang Chuanning Pills can improve the lung function，reduce the TCM syndrome scores，improve the clinical efficacy and reduce the level of AKT/mTOR pathway protein of the patients，with high safety.
To investigate the curative effect of Huayu Xiaozhi Decoction（化瘀消癥汤）on polycystic ovary syndrome with hyperandrogenemia prospectively.
From October 2022 to October 2023，86 patients with hyperandrogenemia of polycystic ovary syndrome of The First Affiliated Hospital of Zhengzhou University were divided into the control group（43 cases）and the combination group（43 cases）randomly.The control group was treated with drospirenone ethinylestradiol tablets（Ⅱ），and the combination group was treated with drospirenone ethinylestradiol tablets（Ⅱ）combined with Huayu Xiaoshi Decoction for 3 menstrual cycles.The efficacy of the two groups after 3 menstrual cycles，glucose and lipid metabolism，reproductive hormone，ovarian function before and after 3 menstrual cycles，and the occurrence of adverse reactions during treatment were compared.
After 3 menstrual cycles，the total effective rate（90.70%，39/43）in the combination group was higher（P<0.05）.Compared with those before treatment，menstrual cycle score，ovarian follicle number，ovarian volume，the levels of serum luteinizing hormone（LH），estrogen（E2），testosterone（T），androstenedione（ASD），fasting blood glucose（FPG），fasting insulin（FINS），triglyceride（TG）and total cholesterol（TC）decreased in both groups after 3 menstrual cycles，and the difference between two groups was lower than that in the combination group（P<0.05）.The incidence of adverse reactions was similar between the two groups［9.30%（4/43）vs 4.65%（2/43），P>0.05］.
Huayu Xiaoshi Decoction in the treatment of polycystic ovary syndrome with hyperandrogenemia could regulate the secretion of reproductive hormone，improve the ovarian function，control the abnormal glucose and lipid metabolism，improve the efficacy and has good safety.
To investigate the clinical effect of Modified Dachaihu Decoction（大柴胡汤加味）combined with pioglitazone in the treatment of type 2 diabetes mellitus and its influence on vascular endothelial function.
A total of 114 patients with type 2 diabetes mellitus admitted from January 2022 to June 2023 were included in the study.The patients were divided into single drug group and combined traditional Chinese medicine group by random number table method，with 57 cases in each group.The patients in the single drug group were treated with pioglitazone，while those in the combined traditional Chinese medicine group were treated with pioglitazone combined with Modified Dachaihu Decoction.One case fell off in the combined traditional Chinese medicine group，and the data of each group was compared，including efficacy，blood glucose indexes such as glycosylated hemoglobin（HbAlc），fasting blood glucose（FPG）and 2 hours postprandial blood glucose（2 h PG）before and after treatment，changes in TCM syndrome scores，oxidative stress indexes such as malonaldehyde（MDA），superoxide dismutase（SOD），glutathione peroxidase（GSH-Px）and hemodynamic indexes such as early reverse diastolic blood flow peak velocity（PRV），systolic peak velocity（PSV），end-diastolic blood flow velocity（EDV）and arterial pulse index（PI），and adverse reactions.
The therapeutic effect of combined traditional Chinese medicine group was better than that of single drug group（P<0.05）.The levels of HbAlc，FPG and 2 h PG，TCM syndrome scores，the levels of MDA，SOD and GSH-Px，the values of PRV，PSV，EDV and PI and other indexes were not significant in two groups before treatment（P>0.05）.After treatment，The levels of HbAlc，FPG and 2 h PG，TCM syndrome scores，the levels of MDA，SOD and GSH-Px，the values of PRV，PSV，EDV and PI and other indexes were improved in both groups.The levels of HbAlc，FPG and 2 h PG，TCM syndrome scores，the levels of MDA，SOD and GSH-Px，and the values of PRV，PSV，EDV and PIin the combined traditional Chinese medicine group were better than those in the single drug group（P<0.05）.The adverse reaction rate of the combined traditional Chinese medicine group and single drug group was lower（P>0.05）.
Modified Dachaihu Decoction combined with pioglitazone has significant clinical effect in the treatment of type2 diabetes mellitus，which can effectively reduce the blood sugar level of patients and improve clinical symptoms and hemodynamics of patients，and the treatment has fewer adverse reactions，which is relatively safe.
To investigate the effects of Xuanbai Chengqi Decoction（宣白承气汤）combined with budesonide formoterol inhalant on lung function and related inflammatory factors in children with rhinitis in remission of bronchial asthma.
A total of 188 children with asthma combined with rhinitis admitted to the hospital from January to December 2020 were divided into control group（94 cases，budesonide formoterol inhalant）and observation group（94 cases，Xuanbai Chengqi Decoction combined with budesonide formoterol inhalant）according to different treatment methods.The patients were treated for consecutive 8 weeks.The clinical efficacy（rale resolution time，cough resolution time and gasping relief time），lung function［lung capacity（FVC），forced expiratory volume at the end of the first second（FEV1），peak expiratory flow rate（PEF）］and inflammatory indicators［C-reactive protein（CRP），interleukin-6（IL-6），tumor necrosis factor-α（TNF-α）］of the two groups were observed and compared.Murray Lung injury score，acute physiological and chronic health score，serum leukotriene（LTD4），nerve growth factor（NGF）and TCM symptom and sign scores were compared.
The time of rales disappearance，cough disappearance and gasping relief in the observation group were faster than those in the control group（P<0.05）.After treatment，the levels of FVC，FEV1 and PEF in the observation group were significantly increased compared with those in the control group（P<0.05）.After treatment，the levels of CRP，IL-6 and TNF-αin the observation group were significantly decreased compared with those in the control group（P<0.05）.After treatment，Murray lung injury score and APACHEⅡscore of the two groups were lower than those before treatment，and the difference between the two groups was statistically significant（P<0.05）.Compared with those before treatment，the levels of LTD4 and NGF in both groups were significantly decreased after treatment（P<0.05），and the levels of LTD4 and NGF in the observation group were significantly decreased（P<0.05）.The scores of phlegm，nasal discharge，cold limbs，tongue quality and tongue coating in the observation group were significantly lower than those in control group（P<0.05）.
Xuanbai Chengqi Decoction combined with budesonide formoterol inhalation has a significant effect in the treatment of children with bronchial asthma complicated with rhinitis，and can quickly relieve the clinical symptoms，improve the lung function，reduce the levels of inflammatory factors，Murray lung injury score and TCM symptom and sign scores.
To observe the effect of Kechuan Zhending Decoction（咳喘镇定汤）in the treatment of children with cough variant asthma and the effect on eosinophil count（EOS）and interleukin-23（IL-23）/Helper T cells17（Th17）axis.
A total of 104 cases of paediatric cough variant asthma admitted from August 2020 to February 2023 were selected and divided into two groups by simple random method.The conventional group was given the conventional treatment of relieving cough，resolving phlegm，anti-inflammatory，relieving asthma，etc.，and the Kechuan Zhending Decoction group was given the auxiliary treatment of Kechuan Zhending Decoction on the basis of the conventional group.T-lymphocyte subpopulations，EOS，macrophage inflammatory protein-1α（MIP-1α），Clara cell secreted protein 16（CC-16），eosinophil-activated chemokine（Eotaxin），IL-23/Th17 axis and small airway function were detected between and within the groups.Differences in cough symptom scores and TCM symptom scores were assessed between and within groups.The efficacy and adverse reactions were analyzed between groups.
There was no difference in T-lymphoid subgroups，CC-16 or Eotaxin before treatment（P>0.05）.The levels of CD+8，EOS，MIP-1αand Eotaxin decreased and the levels of CC-16，CD+4 and CD+4/CD+8 increased after treatment in both groups，and the levels of CD+8，EOS，MIP-1αand Eotaxin in the Kechuan Zhending Decoction group were lower than those in the conventional group，and the levels of CC-16，CD+4 and CD+4/CD+8 in the Kechuan Zhending Decoction group were higher than those in the conventional group after treatment（P<0.05）.There was no difference in IL-23/Th17 axis comparing that before treatment（P>0.05）.The levels of IL-23，Th17 and interleukin-17（IL-17）decreased after treatment in both groups，and the IL-23/Th17 axis was lower in the Kechuan Zhending Decoction group than that in the conventional group after treatment（P<0.05）.There was no difference in the relevant scores before treatment（P>0.05）.Cough symptom scores and TCM symptom scores decreased after treatment in both groups，and cough symptom scores and TCM symptom scores were lower in the Kechuan Zhending Decoction group than those in the conventional group after treatment（P<0.05）.There was no difference in small airway function before treatment（P>0.05）.Small airway function was elevated after treatment in both groups，and the small airway function was higher in the Kechuan Zhending Decoction group than that in the conventional group（P<0.05）.In the Kechuan Zhending Decoction group，there were 13 cases cured，with a total of 35 cases showing significant effective results.The total effective rate was 92.31%，significantly higher than that in the conventional group（P<0.05）.
Kechuan Zhending Decoction can improve T-lymphoid subsets and small airway function by regulating IL-23/Th17 axis in children with cough variant asthma，reduce the cough symptoms and improve the curative effect.
To observe the therapeutic effect of icariin derivative YS-10 on testicular radiation injury，and to explore its potential mode of action.
Eighteen 10-week-old male SD rats were selected and randomly divided into three groups，six in each group，which were blank control group（Control group），radiation injury group（Model group）and YS-10 treatment group（YS-10 group）.The testicular index and serum testosterone content of each group were detected.HE staining was used to observe the pathological changes of testicular tissue.Histochemical kit method was used to detect the levels of superoxide dismutase（SOD），malondialdehyde（MDA）and reduced glutathione（GSH）in testicular tissue.GC-2 cells were selected and divided into Control group，Model group and YS-10 group.Mouse spermatocyte cell line GC-2 cells were induced by 8 Gy X-ray irradiation（2 Gy/min）for 24 h to construct a radiation injury model，and the treatment group was also intervened with YS-10.CCK-8 was used to detect cell viability in each group.Fluorescent probe was used to detect reactive oxygen species（ROS）and Western blot was used to determine the levels of Kelch-like ECH-associated protein 1（Keap1），GSH，nuclear factor erythroid-derived-2-like 2（Nrf2）and heme oxygenase-1（HO-1）in GC-2 cells were determined by Western blot.
Animal experiments confirmed that compared with those in the Control group，the testicular index and testosterone secretion level of rats in the Model group were significantly reduced（P<0.05），the MDA content in testicular tissues was elevated，and the levels of SOD and GSH were reduced（P<0.05）.Compared with that of the Model group，the testicular index of the YS-10 group increased from about 0.81% to 1.25%.The testosterone secretion level increased from about 4.203 U/mg to 5.042 U/mg（P<0.05）.The MDA content decreased from about 36.559 nmol/g to 26.882 nmol/g，and the SOD activity of the testicular tissue increased from about 14.727 U/mg increased to 18.417 U/mg，and GSH content approximately increased from 20.21μmol/L to 32.922μmol/L（P<0.05）.The cellular experiments confirmed that compared with that of the Control group，the viability of GC-2 cells in the Model group was significantly decreased（P<0.01）.The fluorescent probe showed that the average fluorescence intensity of ROSwas increased about 5-fold（P<0.01），the protein expression of Keap1 was elevated about 1.35-fold，and the protein expressions of Nrf2 and HO-1 were decreased about 1.46-fold each（P<0.05）.Compared with that in the Model group，the viability of GC-2 cells in the YS-10 group approximately increased from 73.564% to 86.427%（P<0.01），the average fluorescence intensity of ROS approximately decreased from 255 to 78.378（P<0.01），the level of Keap1 protein expression approximately decreased from 0.951 to 0.73，the level of Nrf2 protein expression approximately increased from 0.498 to 0.805，and HO-1 protein expression level approximately increased from 0.492 to 0.599（P<0.05）.
YS-10，a derivative of icariin，can effectively alleviate radiation-induced oxidative stress and protect testicular tissue to reduce the effects of radiation.The mechanism of action may be achieved through the Keap1/Nrf2/HO-1 signaling pathway.
To explore the clinical efficacy of combined application of Bailing Capsule（百令胶囊）and vitamin D in the treatment of autoimmune thyroiditis in women of childbearing age，as well as the effects on serum 25（OH）D and Th1/Th2.
Ninety-four female patients with autoimmune thyroiditis of childbearing age admitted to the hospital from January 2020 to August 2022 were selected as the research subjects and randomly divided into a study group and a control group，with 47 cases in each group.The control group received thyroxine sodium tablets and vitamin D oral treatment，and the study group was combined with Bailing Capsule oral treatment on the basis of the control group.The treatment lasted for 6 months.The levels of free triiodothyronine（FT3），free thyroxine（FT4），thyroid stimulating hormone（TSH），thyroid stimulating hormone receptor antibody（TRAb），thyroid peroxidase antibody（TPO-Ab），25（OH）Dand Th1/Th2 were measured and compared in two groups at different stages.
After 6 months of treatment，the levels of FT3 and FT4 in the study group were slightly lower than those in the control group（P>0.05），and the TSH level in the study group was significantly higher than that in the control group（P<0.05）.After 3 and 6 months of treatment，there was no significant difference in TRAb or TPO-Ab in the control group（P>0.05）.After 3 months of treatment，the levels of TRAb and TPO-Ab in the study group were significantly lower than those before treatment（P<0.05）.After 6 months of treatment，the levels of TRAb and TPO-Ab in the study group were significantly lower than those before treatment and after 3 months of treatment，and both were lower than those of the control group（P<0.01）.After 6 months of treatment，the serum 25（OH）D levels in the study group were significantly higher than those before treatment and those of the control group during the same period（P<0.05）.After 6 months of treatment，the levels of interferon（INF）-γmRNA and interleukin（IL）-10 mRNA in the study group were significantly higher than those in the control group，with statistically significant differences（P<0.01）.
The combination of Bailing Capsule and vitamin D can significantly improve the serum 25（OH）D levels and autoimmune antibody titers in women with autoimmune thyroiditis of childbearing age，providing an effective adjuvant therapy for autoimmune thyroiditis patients with low vitamin D levels.
To observe the clinical efficacy of Tiaoqi Yangxue Decoction（调气养血方）in the treatment of dawn phenomenon in patients with type 2 diabetes mellitus.
Sixty-four patients with type 2 diabetes admitted to the hospital from January 2022 to June2023 were randomly assigned into two groups using random methods.The control group（32 cases）was treated with Western medicine.The observation group（32 cases）added Tiaoqi Yangxue Decoction.Then the clinical efficacy，TCM syndrome scores，blood glucose indexes and the occurrence of adverse reactions were compared between two groups.
No statistical difference was reported in blood glucose indexes and TCM syndrome scores between two groups before treatment（P>0.05）.After treatment，the total clinical efficacy rate was 96.88% in the observation group，which was higher than 82.15% in the control group（P<0.05）.After treatment，the scores of TCM syndromes in both groups were lower than those before treatment，and score of the observation group was lower than that of the control group（P<0.05）.After treatment，a reduction in the fasting blood glucose（FPG），absolute increment from nocturnal nadir to prebreakfast value，2 h postprandial blood glucose（2 h PG），mean blood glucose（MBG）and mean amplitude of glycemic excursions（MAGE），and an reduce in increase of 2 h PG and FPG were observed in both groups，and the above improvements were both more remarkable in the observation group than those in the control group（P<0.05）.The incidence of adverse reactions in the observation group was 6.25%，while that in the control group was 15.63%（P>0.05）.
Application of Modified Tiaoqi Yangxue Decoction in the treatment of dawn phenomenon in patients with type 2 diabetes mellitus can reduce blood glucose levels and alleviate clinical symptoms，and has a good safety profile.
To analyze the effect of Qingre Lishi Decoction（清热利湿汤）combined with Babaodan（八宝丹）in the treatment of hemorrhoids with dampness-heat pouring down syndrome and its influence on inflammation and immune response.
A hundred and two patients with hemorrhoids from June 2020 to April 2023 were selected as the research objects.The patients were divided into study group and control group by random number table method，with 51 cases in each group.The control group was given Babaodan，and the study group was given Qingre Lishi Decoction on the basis of the control group.The effect was evaluated after continuous treatment for 8 weeks in both groups.TCM symptom scores，improvement of main symptoms and clinical efficacy were compared between the two groups.Changes of inflammatory factors and immune response factors in peripheral blood were compared between the two groups.Adverse reactions of the two groups were recorded during treatment.
The TCM syndrome scores of the main and secondary symptoms of two groups after treatment were lower than those before treatment（P<0.05），and the scores of the study group after treatment were lower than those of the control group（P<0.05）.The disappearance time of bleeding，anal swelling and anal pain in the study group were shorter than those in the control group（P<0.05）.The total effective rate of the study group was higher than that of the control group（P<0.05）.The serum levels of interferon-γ（IFN-γ），interleukin-4（IL-4）and interleukin-17（IL-17）in two groups after treatment were lower than those before treatment（P<0.05）.The levels of IFN-γ，IL-4 and IL-17 in the study group after treatment were lower than those of the control group（P<0.05）.The levels of immunoglobulin G（IgG），IgM，C3 and C4 in two groups after treatment were higher than those before treatment（P<0.05），and the levels of IgG，IgM，C3 and C4 in the study group after treatment were higher（P<0.05）.There were no obvious adverse reactions in both groups during treatment.
In the treatment of hemor-rhoids with dampness-heat pouring down syndrome，Qingre Lishi Decoction combined with Babaodan can enhance the therapeutic effect，reduce the levels of inflammatory factors and improve the immune response function，with good safety.
To investigate effect of Modified Dihuang Pill（加味地黄丸）combined with anti-vascular endothelial growth factor（VEGF）in the treatment of proliferative diabetic retinopathy（DR）and its effect on intraocular inflammatory factors.
A total of 104 patients with proliferative DR admitted from January 2020 to June 2023 were prospectively selected and divided into study group and control group，52 in each.The control group was given anti-VEGF treatment，and the study group was given Modified Dihuang Pill on the basis of the control group.The effect of the two groups was observed for 3 months.TCM symptom scores，symptom improvement，vision-related indicators，curative effect，intraocular inflammatory factors and adverse reactions were compared in two groups.
TCM syndrome scores after treatment was lower in the two groups than those before treatment（P<0.05），and those were significantly lower in the study group（P<0.05）.The absorption time，exudation absorption time and macular edema improvement time of the study group were lower（P<0.05）.After treatment，the thickness of macular fovea（CMT）and the gray value of visual field were lower than those before treatment，and the best corrected visual acuity（BCVA）was higher than that before treatment（P<0.05）.After treatment，CMT and the gray value of visual field of the study group were lower than those of the control group，BCVA was higher（P<0.05）.The total effective rate of the study group was higher（P<0.05）.The levels of VEGF，erythropoietin（EPO）and insulin-like growth factor-1（IGF-1）were all lower in two groups after treatment than those before treatment（P<0.05），and lower in the study group after treatment（P<0.05）.There was no significance in the incidence of total adverse reactions between two groups（P>0.05）.
Modified Dihuang Pill combined with anti-VEGF has significant efficacy in the treatment of proliferative DR，which can significantly improve the clinical symptoms and visual acuity of patients，regulate the expressions of intraocular inflammatory factors（VEGF，EPO and IGF-1），and is safe and reliable.
To explore the effect of total ginsenoside（TG）on HepG2 cell proliferation and apoptosis via inhibiting M2 polarization of tumor-associated macrophages.
Cells were induced to differentiate into macrophages by phorbol-12-myristate-13-acetate（PMA）treatment.After in-vitro identification and culture，M0 macrophages were interfered with TG.Its cytotoxicity on M0 macrophages and its effect on phenotypes of macrophages and M2 polarization were tested and verified.M0 macrophages were assigned to either TG treatment（study group）or no treatment（control group）.Then the expression of CD163，a marker of M2 macrophages，and related factors was measured，and the changes in the proliferation，migration and invasion ability of HCC cells after TG treatment were observed.
Flow cytometry assay revealed that the TG treatment could induce a reduction of apoptosis rate of M0 cells in a dose-dependent manner and the apoptosis rate dropped to less than 50% at a TG concentration of 73.17μM.The expression of CD163 was remarkably lower in the study group than that in the control group.The expression levels of M2 macrophage-related genes were notably lower in the study group than those in the control group（P<0.05）.CCK-8 assay suggested that M2 macrophages significantly inhibited the proliferation of HepG2 cells in the study group compared with those in the control group（P<0.05）.Transwell chamber assay showed that co-culture of macrophages and HepG2 cell significantly enhanced the inhibitory ability of M2 macrophages on the migration and invasion of HepG2 cells（P<0.05）.
TG inhibits the phenotypic polarization of macrophage from M1 to M2 and the inhibition also occurs in hepatocellular carcinoma tumor microenvironment.Therefore，it is hypothesized that TG can inhibit the proliferation，migration and invasion of HepG2 cells by inhibiting macrophage M2 polarization.
To evaluate the effect of Jiawei Daotan Decoction（加味导痰汤）and acupoint application on lung rehabilitation in patients with acute exacerbation of chronic obstructive pulmonary disease（COPD）.
A prospective controlled trial was conducted，selecting 110 patients with acute exacerbation of COPD who visited the hospital.They were randomly divided into two groups，each with 55 cases.The control group received physical therapy.The observation group received physical therapy combined with Jiawei Daotan Decoction and acupoint application.All patients were intervened for 2 weeks as a course of treatment，totally 2 courses.The therapeutic effect after two courses，the lung function indicators and inflammatory factors were evaluated before and after intervention，continuous follow-up and observation were conducted，and adverse reactions were recorded.
There was no statistically significant difference in gender，average age，average onset time，smoking history or hypertension history between the two groups（P>0.05）.The total effective rate（85.45%）in the control group was lower than that in the observation group（96.36%），with a statistically significant difference（P<0.05）.After intervention，the values of forced vital capacity（FVC），forced expiratory volume in one second（FEV1）and FEV1/FVCincreased in both groups（P<0.05）.After intervention，the values of FVC，FEV1 and FEV1/FVC in the observation group were significantly higher than those in the control group（P<0.05）.In the two groups，the serum levels of tumor necrosis factor-α（TNF-α），interleukin-6（IL-6）and C-reactive protei（CRP）after intervention decreased（P<0.05）.After intervention，the serum levels of TNF-α，IL-6 and CRPin the observation group were lower than those in the control group，with statistically significant differences（P<0.05）.There was no statistically significant difference in the total adverse reaction rate between the control group（16.36%）and the observation group（14.55%）（P>0.05）.
The combination of Jiawei Daotan Decoction and acupoint application can improve the pulmonary rehabilitation effect during acute exacerbation of COPD，which may be related to improving lung function and inhibiting inflammatory reactions，and can be tolerated.
To investigate the effect and mechanism of Poria cocos polysaccharides on doxorubicin-induced myocardial cell injury.
AC16 cardiomyocytes were randomly divided into 5 groups：control group，model group，low dose group，medium dose group and high dose group.The cells in the model group，low dose group，medium dose group and high dose group were stimulated with adriamycin（1μmol/L）for 12 hours.The cells in the low，medium and high dose groups were treated with 5，10 and 20μmol/L Poria cocos polysaccharides for 24 hours，respectively.Methyl thiazol tetrazolium（MTT）assay was used to analyze the proliferation ability of each group of cells.The levels of inflammatory factors，superoxide dismutase（SOD）and malondialdehyde（MDA）in cell culture medium were detected by enzyme-linked immunosorbent assay（ELISA）.The level of reactive oxygen species in each group was detected by reactive oxygen species fluorescence probe.The apoptosis rate of each group was detected by flow cytometry.Protein immunoblot tested the protein expressions of nuclear factor erythroid 2-related factor 2（Nrf2）and hemoxygenas-1（HO-1）in each cell.
Compared with those of the control group，the cell proliferation ability，SOD level，Nrf2 and HO-1 protein expressions were decreased，and inflammatory factors，MDA level and apoptosis rate were increased in the model group（P<0.05）.Compared with those of the model group，the proliferation ability，SOD level，Nrf2 and HO-1 protein expressions of AC16 cells were gradually increased，and the inflammatory factors，MDA level and apoptosis rate were gradually decreased with the increase of the dose of Poria cocos polysaccharides（P<0.05）.
Poria cocos polysaccharides can alleviate doxorubicin-induced myocardial cell injury by inhibiting inflammation and oxidative stress，and this process is related to the activation of Nrf2/HO-1 signaling pathway.
To evaluate the effect of the combination of clearing heat，promoting blood circulation and treating phlegm and blood stasis methods with N-acetylcysteine on serum inflammatory factors and sex hormones in polycystic ovary syndrome（PCOS）.
A total of 120 patients with PCOSwho received diagnosis and treatment were selected.Survey data was randomly divided into equal proportion groups，with 60 cases in each group.The control group received N-acetylcysteine.The observation group was treated with Yikang Decoction（抑亢汤）combined with N-acetylcysteine.Both groups continued treatment for 3 months.After the intervention，the efficacy of both groups was evaluated and inflammatory factors such as hypersensitive C-reactive protein（hs-CRP），interleukin-6（IL-6）and tumor necrosis factor-α（TNF-α），hormones［follicle stimulating hormone（FSH），luteinizing hormone（LH）and estradiol（E2）］，insulin resistance index（HOMA-IR），body mass index（BMI）and waist to hip ratio（WHR）before and after 3 months of treatment were measured.
The effective rate of the observation group was better than that of the control group，and the difference was statistically significant（P<0.05）.After 3 months of intervention，the levels of serum hs-CRP，IL-6 and TNF-αin the observation group were lower than those of the control group and the difference was statistically significant（P<0.05）.After 3 months of intervention，the serum LH level in the observation group was lower than that in the control group，and the difference was statistically significant（P<0.05）.After 3 months of intervention，the values of HOMA-IR，BMI and WHR in the observation group were lower than those in the control group，with statistically significant differences（P<0.05）.
The combination of clearing heat，promoting blood circulation and treating phlegm and blood stasis methods with N-acetylcysteine has a definite therapeutic effect on PCOS，inhibiting inflammatory factors and improving endocrine function and various metabolic indicators.It is worthy of vigorously promoting in clinical practice.
Intracerebral haemorrhage（ICH）poses a serious threat to public health and impacts economic and social development.Leveraging the unique advantages of traditional Chinese medicine in the treatment of ICH is of significant importance for its prevention and control.The use of activating blood circulation and removing blood stasis therapy in ICH treatment has accumulated a wealth of clinical evidence.However，there are varying opinions on its safety in clinical practice.Current guidelines lack standardized recommendations and advice on the application of activating blood circulation and removing blood stasis therapy and specific medicinal formulas for treating ICH，as well as guidelines on their application principles and timing.This document，in accordance with GB/T1.1-2020 Guidelines for Standardization-Part 1：Structure and Drafting Rulesof Standard Documents and others，integrates the findings from literature research，expert interviews，the Delphi method and nominal group techniques.By consolidating clinical experiences and existing evidence-based knowledge，following the principle of“evidence-based first，consensus-based second，experience-based as reference”，this document addresses 17 consensus issues of widespread clinical concern.It clarifies the indications，precautions，contraindications，commonly used medicinal formulas，advantages，application principles and timing，and safety issues of blood-activating and stasis-resolving therapy for ICH treatment.The aim is to provide guidance and reference for clinicians to use activating blood circulation and removing blood stasis therapy in treating ICH effectively，to enhance the clinical efficacy，mitigate the safety risks and promote the clinical benefits.This document is intended as a reference for physicians at all levels of healthcare institutions when using the activating blood circulation and removing blood stasis therapy for treating ICH.
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