Full
Outline
The prevention and treatment of malignant tumors has always been a hot topic for oncologists around the world. Mitochondrion is a key organelle that can regulate the internal metabolism of tumor cells and always affect the occurrence and development of tumors. Apoptosis is an important regulatory mechanism for cells to maintain their internal environment. Mitochondrial apoptosis pathway is one of the main pathways to promote apoptosis，and the induction of mitochondrial apoptosis in tumor cells is an important target for anti-tumor. Studies have shown that the active ingredients of many Chinese medicines，such as flavonoids，lactones，alkaloids，terpenoids，glycosides and quinones，can increase the expressions of pro-apoptotic proteins such as Bax，Bad and Bim，and decrease the expressions of anti-apoptotic proteins such as Bcl-2 and Bcl-xL，down-regulate the mitochondrial membrane potential level，increase the permeability of mitochondrial membrane，release a large number of apoptotic factors，activate the Caspase cascade reaction，and finally induce the endogenous apoptotic pathway of tumor cells，and inhibit the proliferation and invasion of tumor cells by regulating PI3K/AKT，TLR9/MyD88，p38 MAPK，ERK1/2，Notch/JAK/STAT and other signaling pathways. This article summarized the research results of the specific mechanism of the active ingredients of Chinese medicines regulating the mitochondrial apoptosis pathway in recent years，and discussed the aspects of the active ingredients of Chinese medicines regulating the mitochondrial apoptosis pathway to enhance the anti-tumor effect，in order to provide new research ideas for the anti-tumor treatment of traditional Chinese medicine and further improve the effectiveness of clinical anti-tumor treatment.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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