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Outline
Digestive system diseases are a common type of diseases in clinical practice，and the characteristics of these diseases are complex and related. Traditional Chinese medicine is guided by the concept of“holistic concept”and“syndrome differentiation and treatment”，which has the advantages of high safety，good efficacy and small adverse reactions in the treatment of digestive diseases. Huangqin Decoction（黄芩汤，HQD），originated from the ancestor of the formula book Treatiseon Miscellaneous Diseases of The Typhoid Fever，has been widely used in digestive system diseases because of its multiple pharmacological effects. Through reviewing the clinical application of HQD and experimental research literature，the author has found that HQD can regulate multiple signaling pathways to achieve anti-inflammatory effects. HQD can regulate inflammation-related signals such as JAK/STAT-related signaling pathway，MAPK related signaling pathway and NF-κB-related signaling pathway，as well as macrophage phenotypic changes to play an anti-inflammatory role，and the use of the above pathways can reduce the levels of pro-inflammatory factors in the serum in order to achieve the anti-inflammatory effect of the formula. The unique anti-inflammatory advantages of HQD are widely used in digestive system diseases，because the inflammatory environment of the human body plays an important role in the“inflammation-cancer transformation”in the process of disease development. Therefore，the formula is commonly used in the treatment of inflammatory diseases such as ulcerative colitis，primary hepatocellular carcinoma，gastric carcinoma，acute enteritis and other inflammatory diseases in the clinic. Therefore，this article summarized the anti-inflammatory effect and clinical application of HQD，with a view to providing reference and ideas for the expansion of clinical application and further in-depth study of this formula.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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