To investigate effect of Modified Dihuang Pill（加味地黄丸）combined with anti-vascular endothelial growth factor（VEGF）in the treatment of proliferative diabetic retinopathy（DR）and its effect on intraocular inflammatory factors.

A total of 104 patients with proliferative DR admitted from January 2020 to June 2023 were prospectively selected and divided into study group and control group，52 in each.The control group was given anti-VEGF treatment，and the study group was given Modified Dihuang Pill on the basis of the control group.The effect of the two groups was observed for 3 months.TCM symptom scores，symptom improvement，vision-related indicators，curative effect，intraocular inflammatory factors and adverse reactions were compared in two groups.

TCM syndrome scores after treatment was lower in the two groups than those before treatment（P<0.05），and those were significantly lower in the study group（P<0.05）.The absorption time，exudation absorption time and macular edema improvement time of the study group were lower（P<0.05）.After treatment，the thickness of macular fovea（CMT）and the gray value of visual field were lower than those before treatment，and the best corrected visual acuity（BCVA）was higher than that before treatment（P<0.05）.After treatment，CMT and the gray value of visual field of the study group were lower than those of the control group，BCVA was higher（P<0.05）.The total effective rate of the study group was higher（P<0.05）.The levels of VEGF，erythropoietin（EPO）and insulin-like growth factor-1（IGF-1）were all lower in two groups after treatment than those before treatment（P<0.05），and lower in the study group after treatment（P<0.05）.There was no significance in the incidence of total adverse reactions between two groups（P>0.05）.

Modified Dihuang Pill combined with anti-VEGF has significant efficacy in the treatment of proliferative DR，which can significantly improve the clinical symptoms and visual acuity of patients，regulate the expressions of intraocular inflammatory factors（VEGF，EPO and IGF-1），and is safe and reliable.