To analyze the changes in lung cancer mortality and DALY attributed to tobacco in China from 1990 to 2019, providing scientific basis for formulating lung cancer prevention and control strategies attributed to tobacco.

Extract lung cancer mortality and DALY rates attributed to tobacco in China from the 2019 Global Burden of Disease database from 1990 to 2019, use Joinpoint software to analyze the trends in mortality and DALY rates, and use an age period cohort (APC) model to analyze age, period, and cohort effects.

The number of lung cancer deaths attributed to tobacco in China increased from 16 500 in 1990 to 51 800 in 2019, and the standardized mortality rate increased from 20.22/100 000 in 1990 to 26.27/100 000 in 2019, with an average annual increase of 0.92% (95% CI: 0.72%-1.11%). The DALY caused by lung cancer attributed to tobacco in China increased from 42.40 million person-years in 1990 to 113.90 million person-years in 2019. The standardized DALY rate increased from 474.81/100 000 in 1990 to 547.54/100 000 in 2019, with an average annual increase of 0.51% (95% CI: 0.27%-0.74%). Compared with the global and different SDI regions, China’s lung cancer standardized mortality rate and standardized DALY rate attributed to tobacco showed the largest increase from 1990 to 2019, reaching 29.93% and 15.32% respectively. The lung cancer mortality rate attributed to tobacco in China from 1990 to 2019 showed an increasing trend with age, with a period effect showing a first decreasing, then increasing, and then decreasing trend. The cohort effect showed a first increasing, then decreasing trend. The prediction model shows that from 2020 to 2030, the standardized mortality rate and standardized DALY rate caused by lung cancer attributed to tobacco in China are both showing a slow upward trend, and may reach 26.96/100 000 and 554.20/100 000 respectively by 2030.

The burden of lung cancer attributed to tobacco in China remained on the rise from 1990 to 2019. Further attention should be paid to the elderly male population, health education, popularization of cancer core knowledge, and early screening, diagnosis, and treatment of lung cancer.

This study aimed to analyze the prevalence of three types of cardiovascular diseases (hypertension, coronary heart disease, and stroke) and their relationships with depression symptoms among rural residents of Yiliang County, Yunnan Province.

A health interview and examination survey was conducted on 2 506 rural residents aged ≥35 years in Yiliang County, Yunnan province by utilizing a multistage stratified random sampling method. A binary logistic regression model was employed to analyze the relationships between depression symptoms and three types of cardiovascular diseases (CVDs): hypertension, coronary heart disease(CHD), and stroke.

The prevalence of hypertension, CHD, stroke, and depression symptoms in the surveyed population was 64.2%, 4.3%, 3.3%, and 5%, respectively. Prevalence of hypertension, CHD, stroke, and depression symptoms increased with age (χ²=106.237,χ²=21.084,χ²=27.135,χ²=43.556,P<0.001). Females exhibited a higher prevalence of both hypertension (67.6% vs. 60.8%,χ²=12.677,P<0.001) and depression symptoms (6.3% vs. 3.8%,χ²=8.080,P<0.05) compared to males. Individuals with lower educational levels and household per capita income had a higher prevalence of hypertension (χ²=23.362,χ²=9.249,P<0.05)and depression symptoms (χ²=16.191,χ²=6.665,P<0.05). The prevalence of depression symptoms were higher in the Han majority than in ethnic minority groups (χ²=14.231, P<0.001). Individuals with good access to medical services had a higher prevalence of depression symptoms than their counterparts (χ²=5.220, P<0.05). The results of logistic regression analysis revealed that individuals with CHD (OR=3.462, 95% CI:1.962-6.108), and stroke (OR=3.683, 95% CI:2.001-6.781) had a higher risk of developing depression symptoms.

The Prevalence of three types of CVDs higher among rural residents in Yiliang County of Yunnan Province compared to other regions. Targeted prevention and intervention efforts are warranted, particularly among females, individuals with lower educational levels, and those with lower incomes. Implementing effective strategies to mitigate the prevalence of CVDs will contribute to improverural residents’ mental health.

To analyze the effects of diabetes distress (DD) and depressive symptoms (DS) on self-efficacy in community patients with type 2 diabetes mellitus (T2DM), and to explore the mediating effect of DD on DS and self-efficacy.

A total of 648 community patients with T2DM in Nanjing were selected by convenience sampling method and investigated with the general information questionnaire, Diabetes Distress Scale, 9-item Patient Health Questionnaire and Diabetes self-efficacy Scale. A multiple linear regression model was used to analyze the influencing factors of self-efficacy, and mediating effect analysis was used to explore the mediating role of DD.

The prevalence of DD and DS was 27.5% and 40.4%, respectively, and the self-efficacy score was 3.82±0.60. DD and DS were significantly positively correlated (r=0.56, P<0.01), and both were negatively correlated with self-efficacy. DD (β=-0.34, P<0.01) and DS (β=-0.16, P<0.01) were the influencing factors of self-efficacy, and DD had a partial mediating effect between DS and self-efficacy, Bootstrap 95%confidence interval was -0.28--0.16 (P<0.01).

Community health workers need to conduct early screening and treatment of DD and DS in T2DM patients, which can help improve patients’ self-efficacy inmanaging the disease.

Toanalyze the application of CNN-BiLSTM combination model and intelligent algorithm optimization in the prediction and early warning of HFMD incidence and to discussthe optimization model for predicting the incidence of HFMD, so as to provide reference for relevant departments to formulate prevention and control measures.

The monthly incidence data of hand, foot and mouth disease in Shanxi Province from January 2009 to December 2019 and the year-end resident population data released by the Shanxi Statistical Yearbook 2008-2020 were collected from January 2009 to December 2019.The monthly incidence data of hand, foot and mouth disease in Shanxi Province from January 2009 to December 2019 were used as sample modeling data to construct the corresponding models in MATLAB 7.6 software, and the prediction effect of each model was compared, and the optimal model was selected according to the principle that the smaller the error value and the higher the accuracy.

By comparing the root mean square error and mean absolute error obtained by predicting the monthly incidence of foot and mouth disease of hand with different models, it can be seen that the CNN-BiLSTM model optimized based on intelligent algorithm is significantly better than the unoptimized CNN-BiLSTM combination model, that is, the values of RMSE and MAE of CNN-BiLSTM-PSO/GAPSO/SSA (1.943 3,1.309 7; 1.879 2, 1.240 2; 1.419 5, 1.169 1) is smaller than the corresponding CNN-BiLSTM model (2.066 3, 1.390 8), among which the CNN-BiLSTM-SSA combination model performs best.

The CNN-LSTM-SSA model has good predictive performance and accuracy in predicting the monthly incidence trend of HFMD, which can be used to predict the future incidence of HFMD in Shanxi Province.

To analyze the mortality trend of lung cancer in Sichuan Province from 2007 to 2021, and provide evidence for formulating lung cancer prevention and control policies in the new period.

Lung cancer mortality was obtained from Health Statistics Yearbook of Sichuan Province. A cohort age-period model was used to estimate the effect of age, period and birth cohort on lung cancer mortality in residents aged 20-84.

The mortality rates of lung cancer in male and female increased from 59.68/100 000 and 16.48/100 000 in 2007 to 75.14/100 000 and 30.49/100 000 in 2021 respectively. Compared with residents aged 20-24, male and female residents aged 75-79 were 101 times and 121 times higher than those aged 20-24 respectively; male and female lung cancer mortality risks from 2017 to 2021 were 1.29 times and 1.31 times higher than those from 2012 to 2016 respectively; male and female lung cancer mortality risks born in 1927—1931 were 73.42 times and 38.49 times higher than those born in 1992—1996 respectively.

Lung cancer mortality in Sichuan Province fluctuates from 2007 to 2021, and male mortality is higher. There were differences in lung cancer mortality risk by age, period, and birth cohort.

To analyze the change of disease burden of injury in China from 1990 to 2019, and to predict the change trend from 2020 to 2034, so as to provide basis for the formulation of injury prevention and control strategies.

Using the global disease burden research database in 2019, the change trends of age-standardized incidence, prevalence, mortality and disability-adjusted life expectancy rate of injuries in China were analyzed, and the average annual change percentage was calculated.The grey prediction model GM (1) was used to predict the annual DALY change trend from 2020 to 2034.

From 1990 to 2019, the incidence, prevalence, mortality and Daly rate of self-injury and interpersonal violence showed a downward trend, with the largest decrease among people aged 0-9 (AAPC=-2.27%,-0.26%,-4.72%,-6.00%). The incidence and prevalence of traffic injuries showed an upward trend, while mortality and DALY rates generally showed a downward trend, but those over 70 years old showed an upward trend (AAPC=0.26%, 0.88%). The incidence of accidental injuries showed an overall downward trend (AAPC=-0.08%), but showed an upward trend in 2006—2019 (AAPC=2.69%), and the mortality and DALY rates showed an overall downward trend, among which the morbidity, prevalence, mortality and Daly rates of people ≥ 70 years old showed an upward trend (AAPC=1.84%, 1.15%, 0.66%, 0.51%). The grey prediction model showed that the DALY of the three kinds of injuries will show a downward trend from 2020 to 2034. It is estimated that by 2035, the Daly rate will decrease to 166.304 / 100 000, 862.338 / 100 000 and 715.27 / 100 000 respectively.

The mortality rate and DALY rate of three kinds of injuries in China show a general downward trend from 1990 to 2019, but the incidence rate of traffic injuries and accidental injuries are still rising, and the disease burden of the elderly is still increasing.

To analyze the epidemiological characteristics and spatiotemporal clustering of hepatitis B virus (HBV)infection in China from 2011 to 2021, to provide a foundation for future HBV prevention and control initiatives.

Data on HBV incidence from 2011 to 2021 across different regions of China were gathered from the "China Health Statistical Yearbook" and the Chinese Center for Disease Control and Prevention. A descriptive analysis was performed to investigate the trends of HBV. Spatial autocorrelation analysis was utilized to explore both global and local spatial clustering of HBV incidence, while spatiotemporal scan analysis was employed to investigate the spatiotemporal clustering of HBV incidence.

Between 2011 and 2021, a total of 10 838 518 cases of HBV were reported in China, with an annual average incidence rate of 71.78 per 100,000 population. There was no statistically significant difference in the decreasing trend of hepatitis B incidence during this period (Z=-1.557, P=0.120). Spatial autocorrelation results identified 7 high-high clustering areas of HBV incidence, primarily in Guangdong, and 3 low-low clustering areas, mainly in Shanghai and Jiangsu. Spatiotemporal scan results revealed 2 high-incidence clusters in the northwest region from 2011 to 2015, shifting to 6 clusters in the south and its northern areas from 2017 to 2021. There were 14 low-incidence clusters from 2016 to 2021, mainly in the east and northeast regions.

From 2011 to 2021, HBV incidence in China displays spatial and spatiotemporal clustering, with a nonsignificant decreasing trend. Future efforts should enhance HBV monitoring and resource allocation for prevention and control in high-prevalence areas.

To investigate the relationship between Dietary Inflammatory Index (DII) and sarcopenia in older adults and to provide a scientific basis for the prevention and treatment of sarcopenia.

From January 2022 to January 2023, 253 older adults over 60 years old were recruited in Chengdu. DII were calculated according to the semi-quantitative food frequency questionnaire, and the groups were divided into Q1-Q4 according to the DII from low to high, sarcopenia was diagnosed according to Asian Working Group for sarcopenia 2019. The relationship between DII and sarcopenia was estimated by logistic regression analysis.

After controlling confounding factors, compared with the Q1 group, the risk of sarcopenia in the Q3 group and Q4 group was 3.94 times and 7.02 times higher than that in the Q1 group (P<0.05), and the risk of sarcopenia increases in older adults with higher DII.

Higher DII increases the risk of sarcopenia, and it is recommended to provide dietary guidance for older adults to reduce the risk of sarcopenia affected by DII.

To explore the vitamin D nutritional status and influencing factors of primary and middle school students in poverty areas of Guizhou Province, and to provide scientific basis for the development of targeted nutritional improvement measures.

A total of 2,519 students from 4 primary and 4 middle schools in 9 key monitoring counties (districts) in Guizhou Province, where the Nutrition Improvement Program for Rural Compulsory Education Students was implemented in 2023, were selected for questionnaire surveys, physical examinations, and blood biochemistry tests using multistage cluster sampling methods. Multifactorial logistic regression was used to analyze the current status of vitamin D nutrition and its influencing factors.

The average vitamin D level of primary and middle school students in poverty areas of Guizhou Province was (22.59±6.66)ng/ml, and the rate of low vitamin D was 37.51%. The prevalence of low vitamin D among female students (46.17%) was higher than that of male students (29.11%), and the difference was statistically significant (χ²=78.213, P<0.001). There was a significant difference in the rate of low vitamin D among students in different regions (χ²=23.454, P<0.001), and the rate of low vitamin D tended to increase with age (χ²=44.905, P<0.001). The results of multifactorial logistic regression analysis showed that, compared with the corresponding reference group, ethnic minorities (OR=0.706, 95% CI: 0.590-0.844), physical activity ≥60 min/d (OR=0.791, 95% CI: 0.663-0.943), and living in the countryside (OR=0.747, 95% CI: 0.616-0.906) were protective factors for low vitamin D levels; obesity (OR=2.133, 95% CI: 1.390-3.272), female students (OR=2.238, 95% CI: 1.882-2.662), the 11-13 years old group (OR=1.849, 95% CI: 1.521-2.248) and the 14-17 years old group (OR=2.000, 95% CI: 1.576-2.539) were risk factors for low vitamin D levels.

High rates of low vitamin D among primary and middle school students in poverty areas of Guizhou Province require the development of personalized nutritional interventions to improve vitamin D nutritional status.

To evaluate the relationship between dietary diversity and hypertension among residents aged 35-74 in the Guangxi Province, to analyze the association between dietary diversity and hypertension by assessing the Dietary Diversity Score (DDS), and to provide reference for improving dietary diversity and controlling hypertension in the local population.

This cross-sectional study included participants from the Prospective Cohort Study on Chronic Diseases in Guangxi Ethnic Minority Population. Baseline surveys and physical measurements were conducted on residents aged 35-74. A dietary diversity score (DDS) was calculated based on a food frequency questionnaire. Binary logistic regression models were used to explore the relationship between DDS and hypertension, and restricted cubic spline models were used to examine the dose-response relationship between DDS and hypertension.

A total of 12 896 participants were included, among whom 4541 (35.21%) were diagnosed with hypertension. The mean DDS of residents aged 35-74 in Guangxi was (5.45±1.39). The consumption frequency of cereals and tubers was high, while the intake of dairy products was relatively low. The binary logistic regression analysis showed that after adjusting for confounding factors, DDS was a protective factor for hypertension (OR=0.95, 95% CI: 0.92-0.98, P=0.001). The restricted cubic spline model demonstrated a linear dose-response relationship between DDS and hypertension (P_{overall trend}<0.05, P_{non-linearity}=0.787). As DDS increased, the risk of hypertension linearly decreased.

The prevalence of hypertension is high among residents aged 35-74 in the Guangxi Province, while the level of dietary diversity is relatively low. Increasing dietary diversity may help reduce the incidence of hypertension.

To investigate the effects of different high-fat diets with various types of oils on serum lipid levels and gut microbiota in mice.

Thirty SPF male C57BL/6J mice were randomly divided into three groups based on their body weight (n = 10 per group). The normal diet group (ND) was fed a basal diet while the palm oil high-fat group (PHFD) and soybean oil high-fat group (SHFD) were fed their respective high-fat diets for 17 weeks. Blood samples were collected to evaluate serum biochemical indexes. Bacterial RNA was extracted from the feces of mice, followed by 16S rRNA sequencing.

Compared with the ND group, the body weights of mice were significantly increased in the PHFD and SHFD groups (P<0.05). Additionally, body weights of the PHFD group were significantly higher than that of the SHFD group (P<0.05). Compared with the ND group, the levels of serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) were significantly increased in the PHFD group (P<0.05), the levels of serum TC and triglyceride (TG) were significantly increased in the SHFD group (P<0.05), the levels of serum TC and LDL-C were significantly higher in the PHFD group compared to the SHFD group (P<0.05). The results of gut microbiota showed that compared with ND, the PCA diagrams of the β diversity presented clear distinction, the Firmicutes/Bacteroidota ratio (F/B ratio) of the PHFD group was significantly increased (P<0.05), with the PHFD group having a significantly higher F/B ratio than the SHFD group (P<0.05). Moreover, the relative abundance of Muribaculaceae was significantly decreased (P<0.05). The PHFD group had significant increases in the relative abundance of characteristic bacteria, including Ileibacterium, Pseudomonas, and Bifidobacterium (P<0.05), whereas the SHFD group had significant increases in the relative abundance of characteristic bacteria, such as Mucispirillum, Allobaculum, and Colidextribacter (P<0.05). Additionally, the function of glucose metabolism-related pathways was significantly increased in the PHFD group (P<0.05), while function of lipid metabolism-related pathway was significantly decreased in the SHFD group (P<0.05).

Different types of high-fat diets with various types of oils lead to lipid metabolism disorder and significant differences in the composition and structural changes of gut microbiota in mice. The PHFD group shows increases in the relative abundances of genuses associated with glycolipid metabolism, while the SHFD group shows increases in the relative abundances of genuses associated with lipid-metabolism and decrease in the relative abundance of antioxidant capacity.

To explored the relationship between the Dietary Oxidative Balance Score (DOBS) and the risk of developing osteoporosis in patients with chronic kidney disease (CKD) based on data from the National Health and Nutrition Examination Survey (NHANES).

The study population was selected from CKD patients aged 40 years and above in a total of four survey cycles of NHANES 2007—2008, 2009—2010, 2013—2014, and 2017—2018, and the association between DOBS and the risk of developing osteoporosis in CKD patients was assessed using weighted logistic regression, with smoothed curve fitting demonstrating the dose-response relationship between the two and subgroup analyses based on age and gender.

A total of 2 281 participants were included in this study, and the fully adjusted model (Model 3) found that higher DOBS significantly reduced the risk of osteoporosis in CKD patients, with an OR of 0.400 (95% CI: 0.211-0.758) in the highest quartile group of DOBS (Q4) compared with Q1. Smoothed curve fitting revealed a negative linear dose-response relationship between DOBS and the prevalence of osteoporosis. Subgroup analysis revealed that the negative association between DOBS and osteoporosis was more significant in female and ≥65-year-old CKD patients, respectively.

In this study, we found that the relationship between DOBS and the risk of osteoporosis in CKD patients was linearly negatively correlated and showed gender and age differences, but further studies are needed to confirm this.

To identify potential subtypes of attention deficit hyperactivity disorder (ADHD) symptoms among middle school students and further explore the association between these subtypes and internet gaming addiction.

A stratified random sampling method was used to select 2 100 students from six middle schools in Bijie City, Guizhou Province. The Internet Gaming Disorder Scale (IGDS) and the Barkley Current Symptom Scale (BCSS) were administered for assessment. Latent Profile Analysis (LPA) was employed to determine the latent classifications of ADHD symptoms, followed by the application of a robust three-step approach to analyze the relationship between these classifications and internet gaming addiction. To assess the relationship between ADHD symptom classifications and the risk of internet gaming addiction, binary Logistic regression analysis was conducted, controlling for demographic variables such as gender and age, to clarify the predictive effect of ADHD symptoms on the risk of internet gaming addiction.

The prevalence rate of internet gaming addiction among middle school students was found to be 4.57% (n=96). Latent profile analysis identified three potential subtypes of ADHD symptoms: low symptom subtype (n=1 058, 50.4%), moderate symptom subtype (n=829, 39.5%), and high symptom subtype (n=213, 10.1%). Further analysis indicated statistically significant differences in internet gaming addiction scores among the ADHD symptom subtypes (χ²=547.438, P<0.001), with the high symptom subtype scoring the highest, followed by the moderate symptom subtype, and the low symptom subtype(scores were 26.79±0.54, 19.47±0.26, 14.75±0.19, respectively). After adjusting for demographic variables such as gender and ethnicity and conducting multiple comparisons, the association between moderate and high levels of ADHD symptoms and the risk of internet gaming addiction remained significant (OR values respectively were (1.25, 95% CI:1.58-1.35) and (1.14, 95% CI:1.08-1.20)), while the impact of the low symptom level was not significant.

There is significant heterogeneity in ADHD symptoms among middle school students and different latent subtypes of ADHD symptoms are significantly associated with internet gaming addiction. Students with higher levels of ADHD symptoms are more likely to have higher internet gaming addiction scores. Schools and families should pay more attention to middle school students exhibiting more severe ADHD symptoms to promote mental health development.

To understand the changes of stunting among primary and secondary school students in the areas of Nutrition Improvement Programme for rural Compulsory Education Students in Henan Province from 2012 to 2021, so as to provide a basis for improving malnutrition and promoting healthy growth of students.

A stratified random cluster sampling method was used to select 10% of primary and junior high schools from 28 monitoring counties in Henan Province, with no less than 40 students in each grade, a total of 1 198 228 students were sampled in 8 years, and their heights were measured to analyse the stunting situation.

The rates of stunting among students in the monitoring areas of Henan Province were 1.33%, 1.23%, 1.08%, 0.74%, 0.87%, 0.71%, 0.80% and 0.43% from 2012 to 2021, showing a fluctuating downward trend. The overall rate was higher for girls (1.09%) than for boys (0.85%) (χ²=189.596, P<0.05), and for primary schools (0.99%) than for lower secondary schools (0.79%) (χ²=61.862, P<0.05). The rates of stunting in both boys and girls, in primary and junior high school, and in all age groups basically showed a fluctuating downward trend among different years (P<0.05). The rate of stunting in all years showed a decreasing and then increasing trend in the age group of 6～12 years old, then an increasing trend after a decrease in the age group of 13 years old, and then a maximum in the age group of 16 years old.

The rate of stunting among students in the Nutrition Improvement Programme for Rural Compulsory Education Students in Henan Province from 2012 to 2021 shows a fluctuating downward trend, but there is still a certain percentage, which requires targeted intervention policies.

To understand the satisfaction of diabetic patients to family doctor contract services and its influencing factors, and to provide evidence for further improving the contract services of family doctors for diabetic patients.

From August to September 2019, a total of 514 diabetic patients who had been contracted by their family doctors were investigated using a multi-stage stratified random sampling method in three cities of Shandong province. Descriptive analysis, chi-squared test and logistic regression analysis were used to study the degree of satisfaction with contracted services and its influencing factors.

71.8% diabetic patients were satisfied with family doctor contract services. Age (χ²＝7.025, P=0.030), familiarity with family doctor (χ²=13.227, P<0.001), change of life habit (χ²=15.217, P<0.001), change of medical cost (χ²＝4.904, P＝0.027), changes in convenience of medical treatment (χ²=16.578, P<0.001), change of waiting time (χ²=9.155, P=0.002), and other factors will affect the satisfaction of diabetes patients with the services signed by family doctors.Multivariate logistic regression results showed that diabetes patients with higher annual family income (OR=2.321, 95% CI: 1.298-4.148), knew their family doctor’s name (OR=1.804, 95% CI：1.041-3.126), believed that their living habits improved after signing the contract (OR=1.903, 95% CI: 1.081-3.350), and had more convenient medical consultation (OR=1.741, 95% CI: 1.037-2.920) were more satisfied with the service of signing the contract.

The overall satisfaction of diabetic patients to family doctor contract services in Shandong province is relatively high, but there is still room for further improvement. It is suggested that measures should be taken to optimize the contracting services for low-income and elderly diabetic patients, and the contact between family doctors and patients should be further strengthened. Emphasis should be placed on guiding patients to form healthy behaviour, and improving the convenience of healthcare in order to improve patients’ satisfaction.

To explore the current situation of disease prevention and control ability and training needs of grassroots public health personnel in Luzhou, to provide a reference for improving the disease prevention and control ability of grassroots public health personnel in Luzhou.

A questionnaire survey was conducted on 1 075 people engaged in disease control work in township health centers, village clinics, and community health service centers (stations) in Luzhou City to analyze their disease prevention and control ability and influencing factors.

The average self-evaluation score of basic disease prevention and control ability skills of primary public health personnel in Luzhou City was 57.93±27.30 points, with a score rate of 46.72%. Among them, "prevention and control of chronic non-communicable diseases" had the highest score rate of 56.94%, and "prevention and control of endemic and parasitic diseases" had the lowest score rate of 37.75%. Among the survey respondents, 92.37% had participated in basic knowledge or skills training in disease control, and the proportion of those who chose "on-site guidance" as the desired form of training was the highest, at 80.74%. The results of multiple linear regression analysis showed that the factors affecting the ability of primary public health personnel in disease prevention and control were mainly female (t=-3.425, P=0.001), outside the establishment (t=3.322, P=0.001), not having participated in training in basic knowledge or skills of disease control (t=-6.119, P<0.001), professional background (non-medical t=-2.083, P=0.038) and professional background (non-medical t=-0.083, P=0.038).

The disease prevention and control ability of grassroots public health personnel in Luzhou City is relatively weak, with gender, professional background, establishment, and whether they have participated in training being the main influencing factors, requiring targeted training in relevant knowledge and skills.

To understand the successful aging of the rural elderly in China and analyze its influencing factors.

The rural elderly aged 60 and above from the 2018 China Health and Retirement Longitudinal Study (CHARLS) were selected as the research object, it was determined that successful aging is achieved by simultaneously meeting the four dimensions of " no major chronic diseases"," no depression"," good cognitive and physical function" and "active social participation". Then multifactor logistic regression was used to analyze the successful aging of the rural elderly based on the social ecosystem theory.

The successful aging rate of the elderly in rural China was 6.79%. The results of multivariate logistic regression showed, self-rated health status in the hierarchy of personal characteristics (OR=0.426, 95% CI: 0.294-0.615), hearing (OR=0.605, 95% CI: 0.447-0.819), childhood health status (OR=0.635, 95% CI: 0.450-0.897), level of education (OR=7.571, 95% CI: 4.091-14.011), and personal annual income (OR=3.422, 95% CI:1.952-6.001), physical exercise in the individual behavioral hierarchy (OR=0.525, 95% CI: 0.291-0.948), daily duration of sleep (OR=0.615, 95% CI: 0.449-0.843), marriage status in the interpersonal level (OR=0.565, 95% CI: 0.349-0.917), financial support from children (OR=1.427, 95% CI: 1.053-1.934), internet use (OR=0.469, 95% CI:0.271-0.814), life satisfaction at the community level (OR=0.352, 95% CI:0.161-0.769), endowment insurance(OR=0.491, 95% CI: 0.245-0.983) in the policy level both were influencing factors for the successful aging of the elderly people in rural areas.

The degree of successful aging of the rural elderly in China is low, and good cognitive and physical functions and positive social participation dimensions are the main shortcomings for the successful aging of the rural elderly.

To measure China’s medical resources mismatch index, to analyze the differences in the spatial distribution of medical resources mismatch, and to clarify the specific path to improve the mismatch of medical resources.

Based on the 2009-2021 data, China’s medical capital and labor mismatch indices were measured, the spatial and temporal evolution characteristics and sources of differences were analyzed using Dagum’s Gini coefficient and its decomposition method, and the fsQCA method was used to analyze the conditional groupings of high or low medical resource mismatches.

There were different degrees of capital mismatch or labor mismatch in each region. The overall Gini coefficient showed an "inverted V" evolution trend, the overall Gini coefficient within the region showed a fluctuating downward trend, and the overall Gini coefficient between regions was more complicated. Inter-region differences were the most important factor in the differences in the spatial allocation of medical resources. There were two types of pathways that lead to a high medical resource mismatch, i.e., labor-labor mismatch index and labor-labor mismatch index. There were 2 types of paths, i.e., labor force-hospital structure dual-driven (H1) and service level auxiliary-driven (H2), and 2 types of paths leading to low medical resource mismatch, i.e., urbanization-hospital structure-service level linkage-restricted (L1, L2) and internal and external linkage-restricted (L3, L4).

It’s supposed to play themacro-controlrole for the government to promote the rational allocation of regional medical resources, take the medical association as an important hand to play the leading role of tertiary hospitals, and fully implement the development strategy of new type of urbanization and lower the threshold of population settlement.

This study applied the ecology of the medical care model to describe healthcare-seeking behaviors among community-based individuals and to examine the association between multimorbidity and various types of healthcare-seeking behaviors.

A cross-sectional survey was conducted in Fangshan District, Beijing and Wuyuan County, Jiangxi Province from July to September 2023. Community residents aged 20 years old and above were sampled by using a multistage stratified sampling approach and recruited to participate in the study. The number of individuals who had symptoms or had relevant healthcare-seeking behaviors was calculated per thousand people per month and relevant indicators were demonstrated by using the ecology of the healthcare model. Multivariate logistic regression analyses were applied to explore the association between self-reported multimorbidity and each level of healthcare-seeking behaviors, with key socio-demographic characteristics adjusted in the model.

A total of 6 004 records with completed surveys were included in the analysis (56.4% of participants were females, mean age: 50.4±14.7). On a thousand-person per month basis, about 382 participants self-report having symptoms, 162 had visited to healthcare facilities (including 61 visited to primary healthcare facilities, 47 visited to tertiary hospitals), 62 were self-medicated, 10 were hospitalized, 5 visited to emergency department, 4 had operations and 1 received tele-medicine. A higher proportion of healthcare seeking behaviors were observed among individuals with multimorbidity than those self-reported with no or one chronic condition. The results of multivariate logistic regression analyses showed that compared with individuals without chronic condition, individuals with one chronic condition or multimorbidity had higher likelihood of healthcare facility visits [(OR:1.67, 95% CI:1.38-2.02) and (OR:3.40, 95% CI:2.83-4.08)], and hospitalization [(OR:2.60, 95% CI:2.04-3.32) and (OR:5.17, 95% CI:4.10-6.51)].

Among all individuals with potential healthcare needs, less than half had healthcare seeking behaviors, and the proportion is higher among individuals with multimorbidity. Future research should further investigate the implication of findings on population medicine from the ecology of medical care model. Actions are also needed to further strengthen the healthcare system and optimize its integration and effectiveness in addressing the emerging challenge of multimorbidity and to reduce the unmet health needs.

To explore the focuses and potential issues of the current children’s health policy system for informing policy decision-making.

This study constructed a two-dimensional analysis framework of policy tools-stakeholders, and the content analysis method was used to quantitatively analyze 36 children’s health policies in China.

The study coded a total of 542 nodes for policy tools. The environment-based policy tools, supply-based policy tools, and demand-based policy tools accounted for 43.7%, 36.5%, and 19.7%, respectively. There were 464 nodes of stakeholders, and administrative agencies, hospitals, primary health care facilities, children and families, health care workers, and other agencies accounted for 61.4%, 13.6%, 3.7%, 8.0%, 3.2% and 10.1%, respectively.Two-dimensional analysis revealed that children and families focused on demand-based policy tools (16 out of 34 nodes), primary healthcare/hospitals/health care providers focused on supply-based policy tools (20 out of 26, 41 out of 85, and 10 out of 15 nodes), and administrative agencies focused on environmental policy tools (170 out of 351 nodes).

The continuous launch of children’s health policies indicates that the government ensures the principle of Children First. However, the current policies on the supply of children’s health services, the training of pediatric personnel, and PHC are inadequate. The government should focus on improving the supply of children’s healthcare services, expanding the pediatric workforce, and constructing an integrated service system for children.

To investigate the changes in health risk behaviors among high-risk groups in the lung cancer screening cohort in Ma’anshan City, and to explore the association between lung cancer screening and health risk behavior changes.

Follow-up survey was conducted among the high-risk population participating in screening.Basic data and health risk behavior information were collected at baseline and during follow-up. Univariate analysis and multivariate logistic regression analysis were used to explore the association between lung cancer screening and changes in three kinds of health risk behaviors.

The results of multivariate logistic regression analysis showed that women(OR=4.24, 95% CI: 1.80-9.96,P=0.001), those with positive pulmonary nodules(OR=1.98, 95% CI: 1.23-3.20, P=0.005) and those who consulted the doctor after screening(OR=1.65, 95% CI: 1.08-2.52, P=0.020) were more likely to quit smoking. Persistent smokers who were 60 to 69 years old(OR=1.60, 95% CI: 1.14-2.24, P=0.007), had a history of lung-related diseases(OR=1.95, 95% CI: 1.13-3.39, P=0.017), and discussed their medical condition with relatives and friends after screening(OR=1.65，95% CI: 1.16-2.33，P=0.005) were more likely to smoke less. Women(OR=2.19, 95% CI: 1.20-4.02,P=0.011), patients with a history of lung related diseases(OR=1.91,95% CI: 1.13-3.22,P=0.015), patients with a history of malignant tumors(OR=3.07,95% CI: 1.18-8.01,P=0.022), and patients receiving medical advice(OR=1.69, 95% CI: 1.04-2.75, P=0.035) were more likely to abstain from alcohol. Women(OR=1.41, 95% CI: 1.02-1.94, P=0.037), older than 70 years(OR=1.70, 95% CI: 1.07-2.68, P=0.024) and those who had annual physical examination(OR=2.03, 95% CI: 1.44-2.86, P<0.001) were more likely to start physical exercise.

Lung cancer screening is closely related to changes in health risk behaviors of screening population such as smoking, drinking, physical exercise, etc. Health education should be strengthened to guide high-risk population to make changes in health risk behaviors.

To understand the impact and pathways of lifestyle behaviors on physiological sub-health of medical students, and to provide a basis for health management and health education in universities.

Under the use of stratified whole cluster random sampling method, 3 100 medical students from a medical university were selected as the study subjects, general situation questionnaire, lifestyle factor questionnaire and Sub-Health Measurement Scale Version 1.0 (SHMS V1.0) were used for questionnaire survey. Chi-square test, exploratory factor analysis and structural equation model were used for statistical analysis and path construction.

The total detection rate of medical students’ sub-health status was 62.2%. There were significant differences in the distribution of drinking (χ²=12.245,P<0.001), activity(Frequency of exercise(χ²=46.115, P<0.001);Frequency of activities between classes(χ²=7.179,P=0.028);Leisure promotes health(χ²=60.789,P<0.001)), dietary habits (Frequency of takeout orders(χ²=8.912, P=0.012);Frequency of consumption of sugar-sweetened beverages(χ²=23.437,P<0.001);Bad eating habits(χ²=82.863,P<0.001))and mobile phone and computer usage(Time spent on mobile phones and computers(χ²=12.350, P=0.002); Short video viewing time(χ²=9.291,P=0.026)) among medical students with different physiological health states. The direct effect of activity on physiological sub-health of medical students was 0.26(95% CI:0.137-0.366). The direct effect of dietary habits on physiological sub-health of medical students was -0.171 (95% CI:-0.233--0.035), and the indirect effect was -0.04(95% CI:-0.085--0.015). The indirect effect of mobile phone and computer usage on physiological sub-health of medical students was -0.043 (95% CI: -0.087--0.017).

The overall detection rate of sub-health status among medical students is relatively high. Physical activity is a significant influencing factor in the physiological sub-health status of medical students and serves as a mediator between dietary habits and mobile phone and computer usage with respect to the physiological sub-health status of medical students.

To explore the effect of arsenic on cell proliferation, the antagonism of PC against arsenic and the relationship associated to wnt/β-catenin signaling pathway by using Proanthocyanidins (PC) and sodium arsenite (NaAsO₂) to intervene human hepatocyte L-02.

We treated cells with different doses of PC alone or in combination with NaAsO₂. The cell activities were detected by Cell Counting Kit-8 (CCK-8) method. Cell scratch experiment and Transwell experiment were used to detect the ability of cell migration and invasion. Real-time Polymerase Chain Reaction (Real-time PCR) method and western blotting (WB) method were used to detect the expression levels of message RNA (mRNA) and protein.

NaAsO₂ increased the activity of cell proliferation (1.740±0.105), enhanced the ability of migration (556.000±3.606) and invasion (439.667±8.622). NaAsO₂ up-regulated the protein expression of proto-oncogene c-myc (0.739±0.012), cyclinD1 (0.943±0.002), Vascular Endothelial Growth Factor (VEGF) (1.020±0.019), apoptosis inhibitor gene survivin (0.571±0.033)and Matrix Metalloproteinase-7 (MMP-7) (0.695±0.059). NaAsO₂could also up-regulate the protein and mRNA levels of pathway core moleculars wnt3a (protein: 1.044±0.010, mRNA: 1.789±0.165) and β-catenin (protein: 0.958±0.037, mRNA: 1.596±0.217). Compared with NaAsO₂ group, when PC intervention was introduced, the levels of proliferation related proteins such as c-myc (0.438±0.046) decreased. The levels of mRNA and protein of wnt3a (mRNA: 1.181±0.018, protein: 0.822±0.015) and β-catenin (mRNA: 0.965±0.078, protein: 0.832±0.064) decreased. The expression of pathway inhibitors Glycogen synthase kinase-3β (GSK-3β) (0.885±0.058) and Axin (0.749±0.016) increased.

NaAsO₂ induce L-02 cell proliferation, which may be due to its activation of wnt/β-catenin signaling pathway. PC can down-regulate wnt/β-catenin pathway, thereby antagonizing the cell proliferation induced by NaAsO₂.

To explore the clustering of drug-resistant Mycobacterium tuberculosis (MTB) in Zigong from 2018 to 2020, analyze the genetic relationship between strains, and speculate whether there is a potential correlation between drug-resistant strains isolated from different patients, so as to provide a reference for the prevention and treatment of drug-resistant tuberculosis in Zigong.

The drug-resistant MTB strains isolated from Zigong from 2018 to 2020 were used as the research objects and the standard MIRU-VNTR 12-loci method was used for typing study. The band sizes of the amplified products were analyzed by PCR and agarose gel electrophoresis to obtain the number of replicates of different loci of the strains. The data were imported into the MIRU-VNTRplus database and the SITVIT2 website to construct the phylogenetic tree diagrams and the minimum spanning trees, and the global source analysis of the isolated strains was performed. The discriminatory ability of the 12-locus method was evaluated by locus polymorphism analysis, and the local prevalence and transmission of drug-resistant TB were analyzed by calculating the cluster formation rate and recent transmission rate.

The overall resolution HGI index of MIRU-VNTR standard 12-loci typing was 0.974. MIRU26 and MIRU31 showed high polymorphism; MIRU10, MIRU16, MIRU39, and MIRU40 showed moderate polymorphism, and the remaining loci showed low polymorphism. The most concentrated locus was MIRU2, and the most dispersed locus was MIRU26. The 120 drug-resistant strains contained 77 genotypes, with a clustering rate of 46.67 % and a recent transmission rate of 34.17 %. The minimum spanning tree showed that 120 drug-resistant strains could be divided into three clonal complexes, CC1, CC2, and CC3, according to the VNTR typing results. Among the 120 valid strains, 12 genotypes of 32 strains could be found on the SITVIT2 website, and the corresponding 12 MIT numbers were distributed in 14 countries on five continents worldwide.

The standard VNTR-12 locus method resolves drug-resistant tuberculosis strains well. There is a certain range of transmission of drug-resistant TB in Zigong, and the recent transmission rate is high, targeted surveillance is helpful in the prevention and control of tuberculosis.

To systematically review the willingness to use pre-exposure prophylaxis (PrEP) and related factors among men who have sex with men (MSM) in China.

CNKI, VIP, Wanfang Data, CBM, EMbase, CINAHL, Pubmed, The Cochrane Library and Web of Science were searched from inception to August 16, 2023.

A total of 31 articles with 31 390 participants were included. The results of meta-analysis showed that the awareness rate of PrEP was 46.70% (95% CI: 34.14-59.47), the willingness rate of PrEP use was 61.49% (95% CI: 51.58-70.95), and the use rate of PrEP was 3.41% (95% CI:0.07-10.62). Age≥40 years (OR=1.90, 95% CI:1.47-2.57), HIV testing history (OR=2.13, 95% CI:1.63-2.80), awareness of PrEP (OR=2.80, 95% CI:1.86-4.24), online sexual partner seeking (OR=1.44, 95% CI:1.04-2.00), no regular sexual partner (OR=1.69, 95% CI:1.32-2.17), oral sex/anal sex behavior (OR=1.86, 95% CI:1.32-2.61), number of homosexual anal sex partners in the past 6 months>5 (OR=1.86，95% CI:1.32-2.61), Having oral or anal sex in the past year (OR=1.40，95% CI:1.19-1.65) was the promoting factor of PrEP use, while uncertain sexual orientation (OR=0.60, 95% CI:0.41-0.89) and always using condom in the past 6 months (OR=0.47, 95% CI:0.29-0.75) were the barriers.

The rate of MSM PrEP awareness and willingness to use is high in China, but the rate of PrEP use is low; more factors influence the willingness to use PrEP.

To analyze the trend of health-care seeking delay and influencing factors among pulmonary tuberculosis patients and provide a reference basis for prevention and control measures in Yantai.

The current status and trend of health-care seeking delay among pulmonary tuberculosis patients in Yantai from 2012 to 2021 were described. Additionally, multivariate logistic regression was employed to analyze the influencing factors of health-care seeking delay.

From 2012 to 2021, the median of health-care seeking days was 28 (10, 61) days. The health-care seeking delay rate was 66.47% and exhibited an upward trend (, P<0.001). Multivariate logistic regression analysis revealed that compared with the age group over 61 years old, the following factors were associated with reduced risk for delayed treatment: individuals under 20 years old (OR=0.65, 95% CI: 0.56-0.75), aged 21-40 years (OR=0.80, 95% CI: 0.74-0.88), serving public places and businesses (OR=0.66, 95% CI: 0.49-0.90), children and students (OR=0.73, 95% CI: 0.61-0.87), employees of enterprises and institutions (OR=0.80, 95% CI: 0.66-0.97), engaged in other physical labor (OR=0.83, 95% CI: 0.74-0.92), and belonging to the native population (OR=0.68, 95% CI: 0.60-0.78). On the other hand, the age group of 41-60 years old (OR=1.12, 95% CI: 1.03-1.22), symptomatic treatment (OR=4.30, 95% CI: 3.63-5.10), referral (OR=3.40, 95% CI: 2.87-4.03), follow-up (OR=5.59, 95% CI: 4.69-6.66), and pathogen positive results (OR=1.33, 95% CI: 1.24-1.43) were identified as risk factors for delayed treatment.

The health-care seeking delay rate among tuberculosis patients showed an upward trend from 2012 to 2021 in Yantai. Medical institutions should pay attention to the wrinkly or elderly, passive detection, and pathogen positive patients regarding the health-care seeking delay.

To understand children’s parents’ cognition and behavior of antibacterial drugs, so as to provide reference for promoting rational use of antibacterial drugs in children, reducing bacterial drug resistance and adverse drug reactions.

From April 2022 to April 2023, 517 parents of pediatric inpatients at Pingshan District People’s Hospital in Shenzhen were surveyed on the cognition and behavior of antibacterial drug use. Descriptive analysis, univariate analysis and multiple linear regression analysis were used to explore the possible factors affecting parents’ cognition and behavior of rational use of antibiotics.

A total of 517 questionnaires were collected, of which 482 were valid, with an effective recovery rate of 93.23%. The scores of parents’ knowledge and practice on antibacterial drugs were (7.06±3.91) and (28.02±4.32), and the scoring rates were (44.11±24.46)% and (80.06±12.34)%, respectively. The cognitive score was positively correlated with senior high school or technical secondary school (β=0.180, 95% CI: 0.677-2.569), junior college (β=0.244,95% CI: 1.177-3.125), undergraduate degree or above (β=0.353, 95% CI: 2.035-4.333), and was negatively correlated with parents’ with medical background (β=-0.109, 95% CI: -2.800--0.371). The behavioral score was positively correlated with the mother (β=0.123, 95% CI: 0.358-2.198) and parents’ with medical background (β=0.090, 95% CI: -0.006-2.874).

The overall awareness of antimicrobial drugs among parents of children in this urban area is relatively low, and the score rate for rational use of antibiotics is relatively high. However, there are still some misconceptions. It is recommended that relevant departments should strengthen the education of antimicrobial knowledge to the public, strengthen the management of grassroots medical institutions and retail pharmacies, strictly regulate access channels, standardize medication behavior, and try to eliminate the hidden dangers of unreasonable use of antibiotics.

To investigate the survival situation and influencing factors of patients receiving antiretroviral therapy (ART) in Jinjiang district, Chengdu, and to evaluate the effect of ART and optimize follow-up management mode.

The follow-up data of HIV/AIDS patients were collected from the National HHART reporting system during 2012-2022. Life table method was used to describe the survival status, and Cox proportion hazard regression model was used to identify the factors related to survival time.

A total number of 2 113 cases was enrolled, the average age of the study subjects was (38.65±15.65) years old, and the average survival time was 132.41 months. By the time of the follow-up observation was terminated, 71 cases died. The accumulated survival rates of 1, 3, 5 and 10 year after initiating ART were 97.86%, 96.78%, 96.43% and 95.73%, respectively. The multivariable Cox proportional hazards regression analysis indicated that the risk of death. The HR of 40-49 years, 50-59 years, and ≥60 years group were 4.233(95% CI: 1.608-11.139), 3.997(95% CI: 1.265-12.623), 19.994(95% CI: 7.424-53.846) relative to <30 years group, respectively. The HR of unmarried group was 3.359(95% CI: 1.495-7.546) relative to married group. The HR of interval time between diagnosis and treatment 31-60 days, 61-90 days group were 2.337(95% CI: 1.311-4.165), 3.430(95% CI: 1.608-7.319) relative to ≤30 days group. The HR of 200-349 cells/μl and ≥350 cells/μl baseline CD₄⁺T cells counts group were 0.262(95% CI: 0.135-0.509), 0.206(95% CI: 0.080-0.530) relative to <200 cells/μl group. The HR of related symptoms before treatment group was 2.088(95% CI: 1.051-4.148) relative to no related symptoms before treatment group.

The effect of patients receiving ART in Jinjiang District is remarkable. ART coverage should be extended, and corresponding follow-up management measures and intervention means should be developed according to the actual situation in Jinjiang District.

To explore the mediating effect of pain condition between the number of chronic diseases and handgrip strength and the moderating role of sleep quality among middle-aged and elderly people over 45 years old in China.

Based on the data from the 2015 China Health and Elderly Tracking Survey, model 4 and model 59 in the Process 4.1 program were used to analyze and construct the mediator model and the mediator model with moderation.

A total of 13 930 Chinese middle-aged and older adults were included after screening, with handgrip strength values of (30.81 ± 10.03), number of chronic diseases (1.33 ± 1.44), number of pain sites (1.60 ± 3.23), and sleep quality (2.98 ± 1.21). Chronic conditions inversely predicted handgrip strength (B=-0.212, P<0.001). Number of pain sites partially mediated the relationship between chronic conditions and handgrip strength (B=-0.177, P<0.001). Sleep quality moderated the first half of the mediating pathway (chronic diseases → pain conditions), and simple slope plots showed that the number of chronic diseases had a more significant effect on pain conditions in middle-aged and older adults with low sleep quality than in middle-aged and older adults with high sleep quality.

Chronic diseases can affect grip strength directly or indirectly through pain conditions, and sleep quality moderates the mediating effect of pain conditions. Reduced grip strength due to chronic diseases in middle-aged and older adults can be mitigated by reducing pain conditions and improving sleep quality.

To investigate the incidence and influencing factors of mental disorders in people living with HIV/AIDS and to provide reference for clinical prevention of HIV associated mental disorders.

People living with HIV/AIDS who were diagnosed in our hospital from May 2017 to March 2023 were stratified randomly selected according to the year of admission. The first hospitalization records and laboratory test data from the medical record management systemwere reviewed and then relevant parameters were extracted as baseline data and were followed up regularly. Cox regression was used to analyze the influencing factors of HIV associated mental disorders.

A total of 503 people living with HIV/AIDS meeting the study criteria were included, 71 patients were diagnosed with mental disorders during follow-up, with an incidence of 14.1%. Multivariate analysis showed poor sleep (HR=3.813, 95% CI: 2.237-6.501), ART side effects (HR=1.740, 95% CI: 1.047-2.891), poor insight (HR=7.213, 95% CI: 4.277-12.163), abnormal CD4/CD8 cell ratio (HR=2.772, 95% CI: 1.246-6.163) and abnormal creatine kinase (HR=1.765, 95% CI: 1.086-2.871)were risk factors for HIV associated mental disorders.

People living with HIV/AIDS have a relatively high incidence of mental disorders within the first year of diagnosis, the influencing factors should be identified as early as possible when HIV/AIDS patients are diagnosed, and corresponding intervention plans should be formulated to prevent the occurrence and development of HIV associated mental disorders.