To study the spatial characteristics and influencing factors of HIV/AIDS incidence in China based on surveillance data from 2005 to 2018, to provide support for scientific, orderly, sustainable, and accurate regional prevention and control strategies.

The spatial autocorrelation method was used to explore the characteristics of spatial-temporal differentiation, and then geographically and temporally weighted regression (GTWR) was used to investigate the influencing factors.

Since 2005, the overall spread speed of the AIDS epidemic was accelerating and showed obvious spatial differences demonstrated by unbalanced growth. After 2011, the unbalanced growth accelerated, and the agglomeration trend of the AIDS epidemic in various provinces became more obvious. The spatial nearest neighbor effect was more obvious, and there was an internal expansion trend in the areas below the Bole-Taipei line. Economy, transportation, health care, and education jointly affected the temporal and spatial evolution pattern of HIV/AIDS incidence. Economic factors had a great impact on the spread of AIDS, which was gradually weakening. Most of the traffic factors above the Bole-Taipei line were positive high-value areas and basically remained at a stable level. The influence of medical factors on the incidence of HIV/AIDS was obvious, but it tended to weaken gradually. Educational factors had a great influence on the incidence of HIV/AIDS, and the influence was basically stable.

From the perspective of spatial-temporal data mining, the spatial-temporal differentiation characteristics and neighborhood effects of the incidence of HIV/AIDS are analyzed, and the effects of economic, transportation, medical, and educational factors on the incidence of HIV/AIDS are discussed. This study helps the public understand AIDS visually from a new perspective and has important reference significance for controlling AIDS epidemic and optimizing the allocation of public health resources.

To study the causal relationship between rheumatoid arthritis (RA) and atherosclerosis (AS) by two-sample Mendelian randomized analysis.

The whole genomes of RA and different subtypes of AS were obtained from IEU Open GWAS (https://gwas.mrcieu.ac.uk/) database. Two-sample Mendelian randomized analysis was carried out using the inverse-variance weighted (IVW) method, MR-Egger regression, simple mode, weighted mode, and weighted median (WM),and the results were verified by multiple sensitivity analyses.

In total 86 single nucleotide polymorphisms (SNPs) strongly associated with RA were included as instrumental variables in this study. According to IVW, RA was associated with coronary atherosclerosis (OR=1.034, 95%CI: 1.010-1.058) and peripheral atherosclerosis (OR=1.083, 95%CI: 1.041-1.127, P=0.001). Heterogeneity test, horizontal multiple effect analysis, sensitivity analysis, and MR-PRESSO further clarified the causal relationship by Mendelian randomization analysis.

RA has positive causal correlations with coronary atherosclerosis and peripheral atherosclerosis, but there is no causal correlation between AS and RA by reverse MR analysis. RA increases the risk of coronary atherosclerosis and peripheral arteriosclerosis. It is suggested to actively control RA to reduce the risk of AS.

To analyze the incidence and mortality trend of stroke in Chinese population from 2005 to 2019, and to predict the incidence and death from 2020 to 2029.

The incidence and mortality data of stroke in Chinese population according to global burden of disease (GBD) were used. Joinpoint regression analysis was used to analyze the changing trend of stroke incidence and mortality in the population, and the annual change percentage and average annual change percentage and their 95% confidence interval were calculated. The GM（1，1）model was established by R, and the incidence and mortality of stroke in China from 2020 to 2029 were predicted.

The incidence of stroke in China showed an upward trend from 2005 to 2019. The incidence of stroke in men increased from 197.94/100 000 in 2005 to 269.17/100 000 in 2019, with an average annual increase of 2.196% and the fastest increase during 2010 and 2014. The stroke incidence in women rose from 198.57/100 000 in 2005 to 284.46/100 000 in 2019, with an average annual increase of 2.616% and the fastest increase during 2017 and 2019. The male mortality rate showed a slight upward trend. It was predicted that in 2029, the incidence of stroke in China may reach 340.93/100 000 for males and 376.67/100 000 for females, and the mortality rate may reach 191.44/100 000 for males and 126.52/100 000 for females.

The study shows that the incidence of stroke is on the rise in China, and the incidence of stroke in females is higher than that in males. The mortality rate of stroke is on the rise in males. Male and female incidence and male mortality may continue to rise from 2020 to 2029, and stroke prevention and control still need to be strengthened.

To investigate the risk factors related to the recurrence in patients with hemorrhagic stroke and to establish a corresponding risk prediction model to provide reference for reducing the recurrence rate of hemorrhagic stroke.

The patients with hemorrhagic stroke treated in the Department of Encephalopathy, the First Affiliated Hospital of Henan University of Chinese Medicine from January 1, 2020 to December 31, 2022 were included in the study. The clinical data of patients with recurrent hemorrhagic stroke were collected to explore the risk factors related to recurrence of hemorrhagic stroke. The original data were divided into modeling sequence and verification sequence by random grouping method, and the modeling sequence was analyzed by univariate and multivariate analyses and model construction. The C index, receiver operator characteristic (ROC) curve, standard curve, and clinical decision curve were used to evaluate the discrimination, accuracy, and clinical utility of the model, and the prediction accuracy of the model was verified by verification sequence.

A total of 1 571 patients with hemorrhagic stroke were included, including 253 patients with recurrent hemorrhagic stroke and 1 318 patients with initial hemorrhagic stroke. The original data set was constructed and randomly divided into modeling sequence and verification sequence according to 7:3 ratio. Logistic regression analysis showed that course of disease (OR=3.548, 95%CI: 2.852-4.415), smoking (OR=1.499, 95%CI: 1.136-1.978), drinking (OR=3.330, 95%CI: 2.356-4.709), male (OR=1.424, 95%CI:1.006-2.016), hyperlipidemia (OR=4.372, 95%CI: 2.227-8.584), cerebral infarction (OR=2.254, 95%CI: 1.294-3.928), high density lipoprotein cholesterol (OR=2.034, 95%CI: 1.220-3.389), prothrombin time (OR=1.103, 95%CI: 1.004-1.211), and homocysteine (OR=1.03, 95%CI: 1.014-1.047) were the influencing factors of recurrence in patients with hemorrhagic stroke, and a risk prediction model was established. The area under the ROC curve of the modeling sequence and the verification sequence was 0.834 (95%CI: 0.810-0.859) and 0.842 (95%CI: 0.804-0.880), respectively, and the standard curves were highly consistent. The results of Hosmer Lemeshow goodness-of-fit test were P=0.900 and P=0.736, respectively, and the thresholds of clinical decision curves were < 0.9 and <0.95, respectively, indicating that the model had high discrimination, calibration, and clinical effectiveness.

Course of disease, smoking, drinking, sex, hyperlipidemia, cerebral infarction, high density lipoprotein cholesterol, prothrombin time and homocysteine are independent risk factors of hemorrhagic stroke. The risk prediction model established in this study can timely identify high-risk patients with recurrent hemorrhagic stroke and prevent the occurrence of adverse events.

To analyze the epidemiological and spatial-temporal aggregation characteristics of other infectious diarrhea (OID) in Hubei Province from 2013 to 2022, to provide scientific basis for disease prevention and control.

The data were collected from the infectious disease surveillance and reporting system of China Disease Prevention and Control Information system. Descriptive epidemiological methods, seasonal index analysis, and spatial autocorrelation analysis were used.

A total of 393 817 OID cases were reported in Hubei Province from 2013 to 2022. The reported annual incidence rate was 49.2/100 000 to 89.2/100 000. The overall incidence increased at first and then decreased. There were two peaks of incidence in winter and summer every year. The incidence rate showed a high-to-low trend from west to east, and the high incidence area changed dynamically with time, mainly in northwest and southwest regions. The sex ratio of reported cases ranged from 1.20 to 1.31, mainly in children under 5 years old (55.3%) and elderly people aged 60 and above(34.0%). The occupational categories were mainly children living at home (53.1%) and farmers (23.0%). Of the reported cases, 43 020(10.9%) were laboratory confirmed cases, of which viral diarrhea accounted for 95.4% and bacterial diarrhea accounted for 4.4%. The results of seasonal index analysis showed that there was a seasonal backshift in the epidemic month of viral diarrhea. The results of spatial autocorrelation analysis showed that the Moran I index was between 0.307 and 0.401, and there was spatial aggregation in each year. The number of “high-high” aggregation areas fluctuated and decreased, and the distribution was mainly in the northwest.

The incidence of OID in Hubei Province fluctuates, and there are obvious characteristics of temporal and spatial aggregation. Attention should be paid to the high incidence areas and key populations in the northwest, and the surveillance, prevention, and control of OID should be strengthened.

To investigate the pollution status of arsenic and cadmium in the surrounding area of Daye copper and iron smelter in Huangshi city, Hubei Province, and to evaluate the health risk level of arsenic and cadmium exposure around the mining area.

The pollution status of arsenic and cadmium in environmental media was evaluated by single factor pollution index method and ground accumulation index method, and the health risk assessment model of human exposure pollutants was used to evaluate the health risk of arsenic and cadmium via different exposure pathways.

The single factor pollution index (P_i) of arsenic and cadmium in indoor air and atmosphere were 2.47 and 2.67 (2 < P_i < 3, moderate pollution), respectively, and the P_i of heavy metal arsenic and cadmium in surface water were 1.50 and 1.21, respectively (1 < P_i < 2, mild pollution) in the 10 km range of downwind to southeast of the smelter. The geoaccumulation index (I_geo) of arsenic in sediment samples was 3.87 (3 < I_geo < 4, severe pollution), the I_geo of cadmium was 9.07 (I_geo > 5, severe pollution), the Igeo of arsenic in dust samples was 1.89 (1 < I_geo < 2, moderate pollution), the I_geo of cadmium was 4.80 (4 < I_geo < 5, severe pollution), the I_geo of arsenic in soil samples was 0.27 (0 < I_geo < 1, no moderate pollution), and the I_geo of cadmium was 2.57 (2 < I_geo < 3, moderate-severe pollution). The hazard index (HI) of non-carcinogenic risk of arsenic and cadmium in residents was 11.75 and 1.03, respectively. Exposure to arsenic and cadmium in this area had a potential non-carcinogenic risk to human health. The hazard quotient (HQ) of non-carcinogenic risk of arsenic and cadmium ingested through the digestive tract was 9.89 and 1.03, respectively, and the HQ of respiratory intake was 1.86 and 8.74 × 10^-4, respectively. The HQ of skin contact was 7.47×10^-4 and 2.91×10^-4, respectively. The total carcinogenic risk index (TCR) of arsenic and cadmium was 1.53×10^-3 and 2.15×10^-3, respectively(TCR > 1.00×10^-4). The carcinogenic risk index (R) of arsenic and cadmium intake through digestive tract was 1.53×10^-3 and 2.15×10^-3, respectively. The R value through respiratory tract was 4.10×10^-5 and 1.89×10^-6 respectively, and the R value through skin contact was 4.72×10^-8 and 1.20×10^-7, respectively.

The environmental media in the range of 10 km to the southeast of the smelter are polluted by arsenic and cadmium, and the effects of arsenic and cadmium exposure on the health of residents in the area exceed the acceptable level. The non-carcinogenic risk level and carcinogenic risk level of arsenic and cadmium exposure to residents in this area are as follows: intake through digestive tract > inhalation through respiratory tract > exposure through skin.

To describe children’s unhealthy eating behavior, to explore the influence of individual and family factors on children’s unhealthy eating behavior, and to provide suggestions for children’s health education and promotion.

By using the method of random cluster sampling, a questionnaire survey was conducted among 2 452 fifth-grade students and their parents from 16 medium-sized primary schools in 4 administrative regions of Beijing.

The percentage of consumption frequency of sugary beverages, sweets, and fried puffed foods ≥ 4 days per week was 13.1%, 19.3%, and 11.0%,respectively. The results of multiple linear regression showed that the stronger ability of perceptual behavior control in personal factors (β=-0.17, P<0.01), stronger subjective supervision in family factors (β=-0.15, P<0.01), less food reserve (β=-0.14, P<0.01), and better parents’ dietary behavior (β=0.14, P<0.01) were associated with better eating behavior.

Children’s unhealthy eating behavior is affected by many family factors. Health education for parents and control and intervention of children’s unhealthy eating behavior should be strengthened.

To explore the nutritional status of chronic obstructive pulmonary disease (COPD) patients in Hengshui area and to explore the influencing factors of malnutrition in COPD patients.

A total of 321 COPD patients in our hospital from January 2018 to October 2022 were selected, including 189 males and 132 females, aged 49 to 62 years, with an average age of(55.23 ±3.01) years. Patients were divided into normal nutrition group and malnutrition group. Univariate analysis was used to compare the demographic characteristics, clinical data, and laboratory examinations between the two groups. Logistic regression was used to analyze the possible influencing factors of malnutrition in COPD patients.

Logistic regression analysis showed that age (OR=2.496, 95%CI: 1.204-1.860), annual family income (OR=0.569, 95%CI: 0.386-0.839), COPD Assessment Test (CAT) score (OR=1.917, 95%CI: 1.288-2.854), 6-Minute Walk Test (6MWT) (OR=0.550, 95%CI: 0.350-0.865), modified Medical Research Council Dyspnea Scale (mMRC) score (OR=1.944, 95%CI: 1.076-3.515), number of acute exacerbations of COPD hospitalization (OR=1.788, 95%CI: 1.053-3.035), and sarcopenia (OR=2.782, 95%CI: 1.542-5.018) were independent influencing factors of malnutrition in patients with COPD in Hengshui area.

In total 47.35% of the 321 COPD patients in Hengshui area had malnutrition, and age, annual family income, CAT score, 6MWT, mMRC score, acute exacerbation of chronic obstructive pulmonary disease, and sarcopenia are the independent influencing factors of malnutrition in COPD patients. It is suggested to formulate feasible and targeted intervention measures according to the above factors in order to reduce the incidence of malnutrition in patients with COPD, reduce the clinical manifestations of sarcopenia, and prolong the survival time.

To investigate the effect of food intake on nutritional status of elderly patients with diabetes in a physical examination center.

In total 626 subjects who underwent physical examination in a physical examination center from November 20, 2021 to September 3, 2022 were divided into diabetic group (n=130) and non-diabetic group (n=496). The general information of the subjects was collected by questionnaire, the height and weight were measured by automatic monitor, and the body mass index (BMI) was calculated. The mini nutritional assessment short-form (MNA-SF) was used to evaluate the nutrition of the subjects. The cumulative illness rating scale for geriatrics (CIRS-G) was used to evaluate the type and grade of concomitant diseases. According to the BMI level of subjects, the subjects in non-diabetic group and diabetic group were divided into obesity group, overweight group, and normal weight group. Dietary retrospective method was used to investigate the nutritional intake of different obese subjects.

The CIRS-G score of the diabetic group was higher than that of the control group (t=19.827, P < 0.05). The malnutrition rate and malnutrition risk rate in the diabetic group were 13.85% and 46.15%, respectively, which were higher than those in the non-diabetic group (6.25% and 42.34%, χ²=10.676, P < 0.05). The proportion of total energy intake excess in the diabetic group was 70.00%, which was higher than that in the non-diabetic group (39.92%,χ²=41.653, P < 0.05). The proportion of obesity in the diabetic group was 23.08%, which was higher than that in the non-diabetic group (13.71%, χ²=9.982, P < 0.05). The average daily total energy intake of obese group and overweight diabetic group was 2 487.43 ± 135.23 kcal and 2 214.28 ±119.59 kcal, respectively, which was higher than that of normal weight group(2 048.56 ± 121.65, F=117.227, P<0.05). There were significant differences in carbohydrate intake, carbohydrate energy supply, protein intake, and protein energy supply among obesity group, overweight group, and normal weight group (P < 0.05).

The malnutrition rate of diabetic patients in this physical examination center is high, and food intake affects the nutritional status of diabetic patients.

To explore the effect of self-esteem on depression of left-behind children in rural areas, and to investigate the mediating effect of social anxiety and loneliness.

A total of 779 rural left-behind children (422 boys and 357 girls) in northern Jiangsu were selected by cluster random sampling. A questionnaire survey was conducted with the use of self-esteem scale, social anxiety scale for children, children’s loneliness scale and center for epidemiologic studies depression scale. The multiple mediating effects were analyzed by structural equation model test.

The self-esteem of left-behind children in rural areas was negatively correlated with social anxiety, loneliness, and depression (r=-0.38, -0.27, and -0.43, P <0.001), while social anxiety was positively correlated with loneliness and depression of left-behind children (r=0.25 and 0.50,P < 0.001). There was a positive correlation between loneliness and depression of left-behind children (r= 0.28, P < 0.001). Multiple mediating effect model analysis showed that social anxiety and loneliness could independently mediate the relationship between self-esteem and depression of left-behind children in rural areas, and the mediating effect values were -0.079(95%CI: -0.131 to -0.017) and -0.165 (95%CI: -0.253 to -0.110), respectively. It also played a chain mediating role through the intermediary chain of “social anxiety-loneliness”, and the mediating effect value was -0.124 (95%CI: -0.177 to -0.092).

The self-esteem of rural left-behind children can significantly reduce the level of social anxiety and loneliness, thus reducing the risk of depression of left-behind children.

To analyze the incidence of gestational hypertension in hospital delivery of obstetrics and gynecology from 2016 to 2022, understand its characteristics and changes, to explore the influencing factors of gestational hypertension, and to construct a predictive model of gestational hypertension, to provide basis for clinical prediction of gestational hypertension.

A total of 101 583 medical records of hospitalized parturient in a hospital of gynecology and obstetrics and children in Sichuan Province from 2016 to 2022 were collected. The χ² test was used for univariate analysis, logistic regression analysis was used to establish the prediction model of influencing factors, and ROC curve was used to evaluate the discrimination of the prediction model.

The incidence of gestational hypertension in hospital delivery of obstetrics and gynecology from 2016 to 2022 was 0.053. The results of logistic regression model showed that older age (OR=1.392, 95%CI: 1.243-1.559), local household registration (OR=0.760, 95%CI: 0.689-0.839), hypothyroidism (OR=1.443, 95%CI: 1.160-1.794), intrahepatic cholestasis of pregnancy (ICP) (OR=1.874, 95%CI: 1.570-2.237), and diabetes mellitus (OR=1.367, 95%CI: 1.230-1.519), multipara (OR=0.693, 95%CI: 0.623-0.770), multiple births (OR=2.443, 95%CI: 2.135-2.795), family history of hypertension (OR=3.347,95%CI: 2.666-4.203), and in vitro fertilization-embryo transfer (IVF-ET) assisted reproduction (OR=1.821, 95%CI: 1.594-2.080) were the influencing factors of gestational hypertension. The area under the ROC curve constructed by the predictive model of gestational hypertension was AUC=0.655 (95%CI: 0.645-0.665).

The risk factors of gestational hypertension are older age, hypothyroidism, ICP, diabetes, multiple births, family history of hypertension, and IVF-ET assisted reproduction. The protective factors of gestational hypertension are local household registration and multipara. The predictive model of gestationall hypertension established in this study has good discrimination ability and has certain predictive value.

To analyze the risk factors related to the development of adolescent myopia to identify the risk factors and protective factors, to provide basis for implementing prevention and control measures for adolescent myopia.

From September 2021 to April 2022, a questionnaire survey was conducted among junior and senior high school students in a middle school group in Chengdu by stratified cluster sampling, including personal basic information and risk factors related to the development of myopia. A total of 2 072 participants were included. SAS9.4 software was used for univariate analysis, and R4.2.3 software was used to analyze the statistically significant factors using multiple logistic regression.

The results of univariate analysis showed that there were 15 factors including sex (χ²=25.56, P<0.001), age (F=62.11, P<0.001), and grade (χ²=192.7, P<0.001) were significantly associated with myopia. The results of multiple logistic regression showed that among the 15 independent variables, seven variables including gender, grade, and frequency of doing eye exercises were statistically significant. The protective factors included doing eye exercises every day (OR=0.64, 95%CI: 0.42-0.98) and doing physical exercise for more than 1.5 hours (OR=0.52, 95%CI: 0.33-0.83). The risk factors included female students (OR=1.47, 95%CI: 1.20-1.81), average daily time of using electronic products > 5 hours to 7 hours (OR=3.10, 95%CI: 1.42-6.80), and average time of doing homework per day > 3 hours to 4 hours (OR=1.57, 95%CI: 1.16-2.12).

There are multiple risk factors related to the development of adolescent myopia. It is suggested to implement targeted prevention and control measures to prevent and control the risk factors.

To explore the self-rated health status and influencing factors of the elderly in rural areas of China, and to provide decision-making reference for relevant departments to formulate healthy aging strategies for the elderly in rural areas.

Using the data of China family panel studies (CFPS) in 2020, descriptive analysis, univariate analysis, and multivariate logistic regression were used to analyze the self-rated health status and its influencing factors of the elderly in rural areas of China.

In total 72.6% of the 2 717 elderly in rural areas of China rated themselves as healthy. The age group of 60 to 74 years old (OR=0.694, 95%CI: 0.501-0.961), lower income (OR=0.503, 95%CI: 0.372-0.681), no smoking or no current smoking (OR=0.682, 95%CI: 0.538-0.865), and no alcohol or less alcohol now (OR=0.672, 95%CI: 0.491-0.920) were associated with poor self-rated health status. Normal BMI index (OR=1.868, 95%CI: 1.298-2.687), no hospitalization within one year (OR=2.537, 95%CI: 2.015-3.194), no physical discomfort within two weeks (OR=4.205, 95%CI: 3.422-5.167), and no chronic diseases (OR=2.530, 95%CI: 2.051-3.121) were associated with better health status.

The self-rated health status of the elderly in rural areas of China is good, but it is still necessary to strengthen the economic support, improve the construction of medical and health service system, improve the family support and social support system, and actively carry out specialized health education for the elderly in rural areas to promote their health management and quality of life.

To investigate the depression status of de facto orphan caregivers in Sichuan and analyze its influencing factors.

By using the social support rating scale and the simplified version of depression scale, a questionnaire survey was conducted on the social support and depression status of 374 de facto orphan caregivers in a city of Sichuan Province. A structural equation model was used to explore the factors influencing depression and their function routes.

The depression score of orphan caregivers was (13.76 ±5.24) points, and 286 (76.5%) had depressive symptoms. The prevalence of chronic diseases in caregivers (β=0.316, P<0.001), gender (β=0.098, P=0.038), education (β=-0.154, P=0.002), current residence (β=-0.150, P=0.001), care time (β=0.117, P=0.011), and relationship with de facto orphans (β=-0.141, P=0.013) had direct effects on depression. Caregivers who suffered from chronic diseases, female, poorly educated, residence in rural areas, long-term care, and being the orphan’s grandparents had high depression scores. Caregivers’ marital status(β=-0.027, P=0.030), personal monthly income (β=-0.042, P=0.001), and care style (β=-0.037, P=0.004) had indirect effects on depression through social support (β=-0.190, P < 0.001). Caregivers in marriage, with higher monthly income, and assistance from others had higher scores of social supports. The better the status of social support, the lower the score of depression.

The prevalence rate of depressive symptoms of de facto orphan caregivers in Sichuan is high, and the situation of depression is severe, which calls for the attention of the whole society and early intervention.

To investigate the choice of hospitalization location of floating population and analyze the influencing factors, to provide suggestions for further improving the fairness and accessibility of health services used by floating population and improving the urban medical and health service system.

The data of 4 547 floating people who had used hospitalization service in the 2018 national floating population health and family planning dynamic monitoring questionnaire were analyzed. The main analysis methods were statistical description, χ² test, and binary logistic regression analysis.

Among the 4 547 floating people who used hospitalization services, 3 435 people chose to stay in local hospital, accounting for 75.5%. Binary logistic regression analysis showed that people with education of junior high school and primary school or below (OR=0.732, 95%CI: 0.578-0.927; OR=0.673, 95%CI: 0.514-0.883), inter-provincial mobility (OR=0.784, 95%CI: 0.647-0.949), occupation as production and transportation workers (OR=0.644, 95%CI: 0.462-0.897), and no contracted family doctor (OR=0.782, 95%CI: 0.615-0.994) were more likely to choose non-local hospitals for hospitalization. Those who did not have medical insurance (OR=1.516, 95%CI: 1.071-2.146) and with self-assessed health and basic health (OR=1.813, 95%CI: 1.450-2.268;OR=1.353, 95%CI: 1.095-1.671) were more likely to be hospitalized in the inflow area.

The level of hospitalization service utilization of floating population in China has been improved, but there is still room for improvement. Attention should be paid to the demands of floating population for medical treatment and hospitalization and health security. We should constantly narrow the gap in the utilization of public health services between the floating population and the local population and improve the fairness and accessibility of access to medical and health resources.

To measure the fairness and efficiency of primary health resource allocation in Guangxi in 2021, and to explore its spatial autocorrelation pattern.

The degree of aggregation and data envelopment analysis (DEA) were used to analyze the fairness and efficiency of primary health resource allocation in Guangxi, and the spatial autocorrelation method was used to study the characteristics of spatial distribution of fairness and efficiency.

In 2021, the agglomeration degree of primary health resources in Guangxi cities and prefectures ranged from 0.451 to 2.961, and only 4 of the 14 prefectures and cities were DEA effective. There was a certain spatial aggregation effect in the fairness and efficiency of primary health resources allocation (except scale efficiency).

There is a large gap in the fairness and efficiency of primary health resource allocation in Guangxi, and other indicators except scale efficiency show spatial differentiation distribution to varying degrees. It is suggested that Guangxi strengthen the function of overall planning and promote the reasonable quota and complementary advantages of inter-regional primary health resources based on spatial autocorrelation.

To explore the coordination relationship and spatial pattern of health resource allocation and socioeconomic development in Sichuan Province, to provide references for promoting the high-quality development of health and social economy.

Entropy method, comprehensive evaluation index, and coupling coordination degree model were used to evaluate the level and coupling coordination degree of health resources and socio-economic development. Hot spot analysis was used to explore the characteristics of spatial agglomeration.

From 2017 to 2021, the development level of health resource allocation in different economic regions of Sichuan Province was in the following order: northwest Sichuan Ecological Demonstration Zone (0.59), Panxi Economic Zone (0.35), Chengdu Plain Economic Zone/Southern Sichuan Economic Zone(0.30), and Northeast Sichuan Economic Zone (0.23). The order of social and economic development level was as the follows:Chengdu Plain Economic Zone (0.25), Panxi Economic Zone (0.16), South Sichuan Economic Zone (0.15), Northeast Sichuan Economic Zone (0.10), and Northwest Sichuan Ecological demonstration Zone (0.08). In the past five years, most of the coupling coordination degree of different economic regions showed an increasing trend. Only the average coupling coordination degree of northeast Sichuan economic zone was less than 0.4, which was in a maladjusted recession, while the average coupling coordination degree of the remaining four economic zones was between 0.4 and 0.5, which was in transition harmony and generally subject to the lag of social and economic development. The level of coupling coordination showed a spatial pattern of“high in the west and low in the east”, and the agglomeration characteristics were mainly “high-high” agglomeration area in western Sichuan and “low-low” agglomeration area in northeastern Sichuan.

There are obvious regional differences in the allocation of health resources and the level of socio-economic development in Sichuan Province. The trend of coupling and coordination between the two systems is gradually improving, but the degree of coordination is not high. In addition, the coupling coordination level has significant spatial characteristics, and the local area shows agglomeration effect.

To analyze the basic situation and supply equity of child health services in 31 provinces and cities in China from 2010 to 2020.

The relevant data of economic level and child health care of 31 provinces and cities from 2010 to 2020 in China Statistical Yearbook, China Health Statistical Yearbook, and China Health and Family Planning Statistical Yearbook published by the National Bureau of Statistics and the National Health Commission were retrospectively analyzed, and the concentration index(CI) was used to evaluate the supply equity of child health services in 31 provinces and cities in China. The cluster analysis was performed to investigate the child health care services in various provinces and cities in 2020.

In the child health care service projects of 31 provinces and cities in China from 2010 to 2020, the neonatal visit rate and the systematic management rate of children under three years old showed an overall upward trend (χ²_trend = 7.602, P=0.006; χ²_trend = 8.233, P=0.004). Perinatal mortality decreased year by year (χ²_trend = 9.493, P=0.002) but fluctuated slightly in 2016 and 2020. The perinatal mortality rate was the highest in the western region, and the level of child health care service in the central region was lower than the average, but the gap between regions was decreasing. The CIs of neonatal visit rate and systematic management rate of children under three years old were 0.003-0.035 and 0.004-0.065, respectively. The utilization of child health services was mainly distributed in provinces and cities with high economic level, and the CI of perinatal mortality ranged from -0.080 to -0.125. Among them, the unfairness of perinatal mortality was the highest and there was no significant improvement. The results of cluster analysis showed that except for Qinghai, Xinjiang, Anhui, Hainan, Henan, and Xizang, the similarities and differences in the utilization of child health services in other provinces and cities could be classified into similar categories.

The level of child health service and the fairness of service utilization in 31 provinces and cities in China have improved steadily in the past 20 years, which may be affected by the second-child policy and COVID-19. It is suggested that we continue to pay attention to perinatal mortality and give priority to improving the level of child health services in Qinghai, Xinjiang, Anhui, Hainan, Henan, and Xizang.

To explore the chain mediating effect of self-efficacy and anxiety on social support and well-being in elderly patients with chronic diseases.

In total 2 177 elderly patients with chronic diseases ≥ 60 years old in the 2022 psychological and behavioral survey of Chinese residents were investigated using perceived social support scale (PSSS), World Health Organization Five item Well-being Index (WHO-5), New General self-efficacy scale (NGSES), and Generalized Anxiety Disorder (GAD-7). The Process plug-in of SPSS was used, and the chain mediating effect test was carried out by Bootstrap method.

Self-efficacy and anxiety played a chain mediating role in the relationship between social support and well-being. Among them, the direct effect of social support on well-being was significant (β=0.345, 95%CI: 0.330-0.432), the individual mediating effect of self-efficacy was significant (β=0.201, 95%CI: 0.164-0.240), the single mediating effect of anxiety was significant (β=0.029, 95%CI: 0.006-0.016), and the chain mediating effect of self-efficacy-anxiety was significant (β=0.006, 95%CI: 0.002-0.013).

Social support can affect the well-being of elderly patients with chronic diseases through the individual or chain mediation of self-efficacy and anxiety, which provides a theoretical basis for improving the well-being of this population.

To analyze the effects of watching short videos on the mental health of the middle-aged and elderly in China, to provide scientific basis for improving the mental health of the middle-aged and elderly.

Based on the data of China family panel studies (CFPS) in 2020, the linear regression model and propensity score matching method were used to explore the average effect of watching short videos on the mental health of the middle-aged and elderly.

Watching short videos could significantly improve the mental health level of middle-aged people (β=-0.217, P < 0.05). Watching short videos had a more significant effect on women, rural areas, and middle-aged and elderly people with an education level of junior high school or below (women: β=-0.323, P<0.05; rural areas: β=-0.309, P<0.05; junior high school: β =-0.387, P <0.01; middle-aged people: β=-0.270, P<0.05). The nearest neighbor matching, radius matching, and kernel matching all passed statistical tests.

Watching short videos has to some extent improved the mental health of middle-aged and elderly people, and it is necessary to further increase the internet penetration rate of the elderly population and expand the coverage of smartphone usage training. Attention should be paid to the mental health of women, rural registered residence, middle-aged and elderly people with low education and income levels as well as physical diseases.

To investigate the combined effects of sleep duration and muscle strength on depressive symptoms in Chinese middle-aged and elderly adults, and to provide reference for mental health promotion.

A total of 4 225 participants from the China Health and Retirement Longitudinal Survey (CHARLS) who participated in both 2011 and 2018 waves. Sleep duration and depressive symptoms were assessed using a questionnaire, and muscle strength (grip strength and chair-rising time) was measured. Multivariable adjusted cox regression models were used to explore the combined effects of sleep duration and muscle strength on depressive symptoms.

In total 1 465 (34.67%) participants reported depressive symptoms in 2018. After adjusting for confounding factors, participants with non-recommended sleep duration (> 9 h/d or < 7 h/d), lower grip strength, and longer chair-rising time had significantly increased risk of depressive symptoms. Compared with those with recommended sleep duration (7 to 9 h/d) and high muscle strength (high grip strength and short chair-rising time) group, individuals with non-recommended sleep duration and low muscle strength showed significantly increased risk of depressive symptoms (HR=1.99, 95%CI: 1.38-2.87).

Non-recommended sleep duration and low muscle strength are significant risk factors for depressive symptoms. Thus, increasing muscle strength and improving sleep duration should be recommended for mental health promotion in middle-aged and elderly people.

To explore the mediating effect of activities of daily living (ADL) between arthritis and depression in the elderly, and to provide reference for preventing and intervening the occurrence and development of depression in the elderly.

Based on the 2018 China Health and Retirement Longitudinal Study (CHARLS) data, stepwise regression analysis and Bootstrap intermediary test were used to analyze the mediating effect of ADL between arthritis and depressive symptoms in the elderly.

The prevalence rate of arthritis was 8.12%, and the detection rate of depressive symptoms was 44.60%. Arthritis was positively correlated with ADL (r=0.025, P<0.05), arthritis was positively correlated with depression symptoms (r=0.036, P<0.01), and ADL was positively correlated with depression symptoms (r=0.348, P<0.001). ADL plays a mediating role in the relationship between arthritis and depressive symptoms. The mediating effect of ADL on depressive symptoms was 0.009,and the mediating effect accounted for 25.71% of the total effect.

Arthritis has a certain influence on the depressive symptoms of the elderly through ADL. Comprehensive intervention measures should be taken to improve the joint health of the elderly, reduce the prevalence of arthritis, and improve ADL of the elderly, to prevent the occurrence of depression in the elderly.

To explore the relationship between body mass index (BMI), household fuel type, and peak expiratory flow(PEF) in middle-aged and elderly Chinese people aged 45 and above.

Based on the data of China Health and Retirement Longitudinal Study in 2013 and 2015, the BMI and PEF of the participants were measured and evaluated. According to the self-reported household fuel types, cooking and heating fuels were divided into solid fuel and clean fuel. Linear mixed model was used to analyze the relationships of BMI and household solid fuels using with PEF changes, and residential location was included as a random term. Subgroup analysis and interaction analysis were conducted by gender, urban-rural setting, smoking status, and fuels types.

There was a significant correlation between the reduction of BMI and PEF (β=-1.33,95%CI: -2.31 to -0.33). Compared with the group using clean fuel, the PEF of the group using solid fuel decreased faster than that of the group using clean fuel (cooking: β=-10.16, 95%CI: -16.78 to -3.55; heating: β=-10.13, 95%CI: -18.70 to -1.46). Solid fuels use for heating increased the magnitude of BMI-related PEF decline (interaction P=0.030).

High BMI and solid fuel use are the risk factors for the reduction of PEF in the middle-aged and elderly in China, and there is an interaction between BMI and solid fuel for heating on the reduction of PEF.

To investigate the correlation model between 8 kinds of leisure activities and 8 physical and mental health indexes of the elderly.

Outcome-wide analysis was performed based on 15 771 samples aged over 65 years old from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) data in 2018.

Lack of housework increased the risk of cognitive impairment (RR=1.892, 95%CI: 1.666-2.148), physical function (RR=1.323, 95%CI: 1.228-1.425), and activity of daily living (ADL) disability (RR=5.004, 95%CI: 4.159-6.019) in the elderly. Feeding activity was associated with mental health, but lack of feeding activity increased the risk of instrumental activity of daily living (IADL) disability (RR=1.279, 95%CI: 1.180-1.387), while the association with disease risk was not robust (E=1.322, CI=1.185). In terms of cognitive activities, less friends talk was associated with higher risk of cognitive impairment (RR=1.214, 95%CI: 1.061-1.390); reading activities were only related to cognitive function (RR=1.413, 95%CI: 1.123-1.778); playing cards/mahjong was related to depression (β=-0.043,-0.868 to -0.237) and cognitive function (RR=1.752, 95%CI: 1.387-2.212). Watching TV was significantly correlated with emotional health, depression, anxiety, cognitive function, ADL, and physical function.

Leisure activities are beneficial to maintain and promote the physical and mental health and physical function of the elderly, and cognitive activities are beneficial to maintain and improve the cognitive function and mental health of the elderly. Physical activity is more effective in improving living ability and physical function.

To study the effect of short-term antibiotics cocktail exposure on the intestinal flora induced by azomethane (AOM) in mice.

Forty male ICR mice aged 3 to 4 weeks were randomly divided into control group (Control group), AOM group (AOM group), antibiotic group (Abx group), and antibiotic + AOM group (AbxAOM group). During the gavage period, AbxAOM group and Abx group were administered with antibiotic solution, meanwile Control group and AOM group were administrated with corresponding volume of pure water twice a day for 2 weeks. During the period of intraperitoneal injection,AOM group and AbxAOM group were intraperitoneally injected with AOM solution, the Abx group and Control group were intraperitoneally injected with sterile 0.9% NaCl solution once a week for 4 weeks. The feces of mice were collected 5 weeks after intraperitoneal injection, and the intestinal flora of feces was analyzed by 16SrRNA sequencing.

The Chao1 index and ACE index in AbxAOM group were higher than those in AOM group. Compared with AOM group, the relative abundance of Firmicutes in AbxAOM group was significantly higher (P<0.05), while that of Bacteroidetes was significantly lower at the phylum level (P<0.05). Compared with AOM group, the relative abundance of Bacteroides and Prevotella in AbxAOM group decreased significantly (P<0.05), and the relative abundance of Alistipes, Clostridium XIVa and Blautia increased significantly at the genus level (P<0.05).

The changes of intestinal flora after antibiotic treatment suggest that specific microbial groups rather than single strains may play an important role in the occurrence and development of CRC induced by AOM in mice.

To analyze the molecular network characteristics of the transmission relationship of newly confirmed human immunodeficiency virus type 1 (HIV-1) infection in Jinan, to provide basis for epidemic trend and prevention.

A total of 168 blood samples newly reported to be infected with HIV-1 in Jinan in 2021 were collected. The pol region gene of HIV-1 was amplified by nested PCR, the evolutionary tree was constructed by neighbor-joining method, and the molecular network was constructed by gene distance < 1.5%. The related factors of the network were analyzed. The mutation sites of drug resistance were analyzed by the online software tool of HIV drug resistance database of Stanford University.

There were 9 subtypes in the sample sequence. The dominant subtypes were two epidemic recombination types circulating recombinant form (CRF), CRF01_AE subtype (41.7%, 70/168), and CRF07_BC subtype (36.3%, 61/168). The other subtypes were B, CRF68_01B,CRF55_01B, CRF65_CPX, CRF67_01B, CRF96_CPX, and C. When the gene distance was 1.50%, a total of 15 molecular clus ters were formed, with a total of 51 sequences, and the network entry rate was 30.4%. Surveillance drug-resistance mutations(SDRM) were monitored in 7 samples, with drug resistance transmission rate of 4.2%, focusing on drug resistance site mutations of nucleoside reverse transcriptase inhibitors and non-nucleoside reverse transcriptase inhibitors.

There are abundant HIV-1 subtypes in Jinan, mainly CRF01_AE and CRF07_BC subtypes. A molecular transmission network should be established for long-term monitoring to take targeted measures to block its spread.

To analyze the incidence trend and epidemic characteristics of infectious diseases among kindergarten children in Shenzhen, to provide reference for scientific prevention and control of infectious diseases.

Descriptive epidemiological methods and Joinpoint regression model were used to analyze the surveillance data of infectious diseases among children in Shenzhen from 2013 to 2022.

A total of 249 614 cases of 31 infectious diseases were reported in Shenzhen from 2013 to 2022, with an average annual reported incidence of 4 981.47/100 000, showing a stable trend [annual percentage change (APC)=7.19%, P>0.05]. The main diseases were respiratory and intestinal infectious diseases, accounting for 53.93% and 46.00% of the total cases, respectively. The top five cumulative reported cases were hand-foot-mouth disease, influenza, chicken pox, other infectious diarrheal diseases, and mumps. Among them, the incidence of hand-foot-mouth disease and mumps decreased slowly, but the trend test was not statistically significant (APC was -9.70% and -3.98%, respectively, P > 0.05). Influenza and chickenpox showed a “rising-falling”trend, with the turning point in 2019. The rising trend of influenza from 2013 to 2019 was statistically significant (APC=166.11%, P=0.005), and the downward trend of chickenpox from 2019 to 2022 was statistically significant (APC=-52.42%, P=0.022). Other infectious diarrheal diseases showed an upward trend (APC=19.15%, P=0.002). The incidence of infectious diseases in kindergarten children showed a bimodal type, with a peak in summer and winter-spring. The proportion of intestinal infectious diseases in girls was lower than that in boys (P < 0.001). The proportion of intestinal infectious diseases in children aged 3 years and above was lower than that in children under 3 years old (P < 0.001).

The overall incidence of infectious diseases among kindergarten children in Shenzhen is relatively high. The vaccination rate of EV71, influenza, and varicella vaccine should be further improved. At the same time, comprehensive prevention and control measures such as monitoring and early warning, health education, and institutional health management should be taken to effectively control the occurrence and prevalence of common infectious diseases among kindergarten children.

To analyze the results of influenza sentinel surveillance in Sichuan Province from 2020 to 2022, to provide basis for influenza prevention and control in Sichuan.

The surveillance data of influenza-like illness (ILI) reported by 30 national influenza surveillance sentinel hospitals in Sichuan Province were collected through China Influenza Surveillance Information System, and the results of influenza sentinel surveillance in Sichuan Province from 2020 to 2022 were analyzed retrospectively by descriptive epidemiological methods.

From 2020 to 2022, there was a correlation between the proportion of ILI to the total number of outpatient and emergency surveillance cases (ILI%) and the detection rate of influenza in ILI samples (r_s=0.626, P < 0.001). From 2020 to 2022, a total of 103 544 influenza samples were collected and tested in Sichuan Province, of which 8 798 were tested positive, with a positive rate of 8.50%. In 2020, the epidemic level of influenza in Sichuan Province was low, and the epidemic peak was in January, which was co-epidemic of subtype A (H3N2) and strain B (Victoria). In 2021, the epidemic peak was in autumn and winter, and the dominant strain was strain B (Victoria). In 2022, there was an obvious summer epidemic peak in Sichuan Province, and the dominant strain was subtype A (H3N2). There were significant differences in the positive rate of ILI among different years, age groups, and cities and states (P<0.001).

Influenza B (Yamagata) was not detected in Sichuan Province from 2020 to 2022, and the main epidemic strain were A(H3N2) and B(Victoria). The epidemic strains in Sichuan Province displayed decreased epidemic levels at the end of 2020 and 2022, which may be attributed to the COVID-19 preventive and control efforts and the occurrence of viral interference. It is necessary to continue influenza surveillance and strengthen the prevention and control of influenza in children and students.

To investigate the reporting quality of notifiable infectious diseases in Jiangxi Province, analyze the problems in the reporting of infectious diseases, and explore the countermeasures to further standardize the reporting and management of infectious diseases.

The report card information and quality evaluation data of notifiable infectious diseases in Jiangxi Province from 2016 to 2021 were collected and sorted out. The database was established by Excel2013, and the normal operation rate, timely reporting rate, timely audit rate, and reporting accuracy rate of the institutional network were calculated with the use of SPSS22.0. The quality was evaluated comprehensively by Technique for Order Preference by Similarity to an Ideal Solution (TOPSIS) method.

The timely reporting rate of notifiable infectious diseases in Jiangxi Province from 2016 to 2021 was 99.95%, the timely audit rate was 99.97%, and the accuracy rate was 97.86%. The comprehensive quality of legal infectious disease reports increased year by year during 2016 and 2021.

The information reporting of notifiable infectious diseases in Jiangxi Province from 2016 to 2021 is generally good, but there are still some problems such as untimely reporting, untimely examination, and non-standard reporting. Standardized management should be further strengthened and the informatization construction of medical institutions should be promoted to improve the quality of infectious disease information reporting and provide timely and accurate surveillance information for disease prevention and control.

To explore the risk factors of early neurological deterioration (END) in patients with acute ischemic stroke(AIS) and establish a predictive model.

In total 622 AIS patients treated in Baiyun Hospital affiliated to Guizhou Medical University from January 2018 to December 2022 were selected and divided into END group (n=127) and non-END group (n=495) according to the diagnostic criteria of outcome events. The clinical baseline data, laboratory data, and imaging data of the patients were retrospectively collected. Based on the Logistic regression algorithm, risk factors for the development of END were investigated. The prediction model was constructed and nomogram was drawn, and the prediction value of the model was evaluated by discrimination, calibration, and clinical applicability.

Multivariate Logistic regression analysis showed that heart rhythm, middle cerebral artery stenosis, carotid artery stenosis, admission NHISS score, fibrinogen, albumin, and brain natriuretic peptide (BNP) were independent risk factors for END. The prediction model was developed using Stata software, and a nomogram was created. Verification set analysis revealed that the predictive model predicted the risk of END with good discrimination, accuracy, and clinical applicability, with an AUC of 0.888 (95%CI: 0.821-0.955), slope of the calibration curve which was close to 1, and net benefit of the clinical decision curve that exceeded the two reference lines.

The model constructed in this study has high degree of discrimination, calibration, and clinical applicability and has good comprehensive prediction efficiency, which has a certain clinical application value for the early prediction of END.

To systematically evaluate the risk of estrogen use and ovarian cancer in postmenopausal women.

PubMed, Cochrane, Embase databases and Chinese databases such as CNKI, VIP, and Wan fang were searched by computer. Studies on the correlation between estrogen replacement therapy and ovarian cancer in postmenopausal women up until January 2023 were collected. The methodological quality of the study was evaluated by Stata software and the effective data were extracted for meta-analysis. We used the odds ratio (OR) and its corresponding 95% confidence interval (CIs) to evaluate the relationship between hormone replacement therapy and ovarian cancer. When there was statistical heterogeneity between studies (P≤0.1 and I²≥ 40%), random effect model was used for meta-analysis; otherwise, fixed effect model was used for analysis.

A total of 14 retrospective studies including 10 cohort studies and 4 case-control studies were identified. Meta-analysis showed that postmenopausal estrogen therapy increased the risk of ovarian cancer in women (OR=1.27, 95%CI: 1.14-1.43). Stratified analysis showed that there was no significant increase in the risk of ovarian cancer in postmenopausal women who took estrogen for less than 5 years (OR=1.04, 95%CI: 0.90-1.20). Postmenopausal women who received estrogen treatment for 5 to 10 years had a significantly increased risk of developing ovarian cancer (OR=1.27, 95%CI: 1.06-1.53). Postmenopausal women who had been treated with estrogen for more than 10 years had a significantly increased risk of ovarian cancer (OR=1.69, 95%CI: 1.42-2.02).

The risk of ovarian cancer in postmenopausal women treated with estrogen replacement therapy is related to the course of estrogen therapy. There is no significant increase in the risk of ovarian cancer within 5 years, but the risk of ovarian cancer is significantly increased when the course of treatment exceeds 5 years.

To analyze the cost-effectiveness of carotid endarterectomy carotid endarterectomy (CEA) and medical therapy for asymptomatic carotid stenosis in Chinese patients over 70 years old.

Based on the data of different outcomes of asymptomatic carotid stenosis patients who were followed up by CEA and drug therapy for 10 years, a Markov model was established to simulate the cost-effectiveness of the two treatments for 10 years. The outcome index was incremental cost-effectiveness ratio (ICER), which was the ratio of increased cost to increased quality-adjusted life years (QALY), and the thresholds of ICER and willingness to pay (WTP) were compared. In this paper, scenario analysis was carried out, and uncertainty test was carried out by single factor sensitivity analysis and probability sensitivity analysis.

In the basic case analysis, the patients who received CEA could get 7.53 QALYs, the corresponding cost was 67 079.61 yuan and 31 982.38 yuan, and the ICER was 129 435.97 yuan / QALY, which was lower than the threshold of WTP. In scenario analysis, the ICER was 127 946.82 yuan / QALY and 240 283.17 yuan / QALY, respectively. The annual mortality of patients after CEA, the operation cost of CEA, and the perioperative mortality after CEA had great influence on the fluctuation of ICER.

According to the economic evaluation recommendation of WHO, the increased cost of CEA compared with drug therapy is acceptable for Chinese patients with asymptomatic carotid artery stenosis over 70 years old.

To analyze the current situation and influencing factors of post competency of full-time staff in nosocomial infection management in different levels of medical institutions in Guizhou Province.

Based on the principle of convenience sampling, 69 tertiary hospitals and 151 secondary hospitals in 9 cities (regions) of Guizhou Province were selected, and 766 full-time staff of nosocomial infection management were investigated by questionnaire. Multiple linear regression method was used for multivariate analysis.

The total score of post competence of full-time staff of nosocomial infection management in tertiary medical institutions (5.287 ±1.074) was higher than that in secondary medical institutions (4.835 ±1.194). The full-time staff of the third-level medical institutions outperformed those of the second-level medical institutions in terms of the overall level of competency, the self-evaluation scores of 4 core items, and self-evaluation scores of 11 sub-items (t=5.580, P<0.001). The scores of tertiary medical institutions and secondary medical institutions had the lowest score in comprehensive knowledge items, which were (4.394 ±1.401) and (3.614 ±1.529), respectively. The results of multiple regression analysis showed that the professional titles of the full-time staff of nosocomial infection management (B=-0.541, 95%CI:-1.024 to -0.058), the application level of office software (B=-0.854, 95%CI: -1.108 to -0.599), the importance degree the hospital attached to infection control (B=-0.393, 95%CI: -0.707 to -0.078), and the construction of the nosocomial infection control management system (B=-0.759, 95%CI: -1.314 to -0.204) were the independent factors for the post competency in tertiary medical institutions. The age of the full-time staff in the secondary medical institution (B=0.942, 95%CI: 0.435-1.449), the average monthly income (B=0.535, 95%CI: 0.165-0.905), and the application level of office software (B=-0.657, 95%CI: -0.909 to -0.405) were independent factors for the post competency in secondary medical institutions.

The overall post competency of the full-time staff of nosocomial infection management in Guizhou Province is at the upper-middle level, and the full-time staff of the tertiary medical institutions are obviously better than the secondary medical institutions.