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A two-sample Mendelian randomized study on rheumatoid arthritis and atherosclerosis
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Ying-zhu DUAN, Hai-jun MA, Ping NI, Jian LIANG, Ying ZHANG, Huan ZHANG, You YU, Rui YU
Modern Preventive Medicine | 2024, 51(1) : 8 - 14
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Modern Preventive Medicine | 2024, 51(1): 8-14
• Epidemiology and Statistical Methods •
A two-sample Mendelian randomized study on rheumatoid arthritis and atherosclerosis
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Ying-zhu DUAN, Hai-jun MA, Ping NI, Jian LIANG, Ying ZHANG, Huan ZHANG, You YU, Rui YU
Affiliations
  • Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning 110847, China
Published: 2024-01-10 doi: 10.20043/j.cnki.MPM.202306460
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Objective

To study the causal relationship between rheumatoid arthritis (RA) and atherosclerosis (AS) by two-sample Mendelian randomized analysis.

Methods

The whole genomes of RA and different subtypes of AS were obtained from IEU Open GWAS (https://gwas.mrcieu.ac.uk/) database. Two-sample Mendelian randomized analysis was carried out using the inverse-variance weighted (IVW) method, MR-Egger regression, simple mode, weighted mode, and weighted median (WM),and the results were verified by multiple sensitivity analyses.

Results

In total 86 single nucleotide polymorphisms (SNPs) strongly associated with RA were included as instrumental variables in this study. According to IVW, RA was associated with coronary atherosclerosis (OR=1.034, 95%CI: 1.010-1.058) and peripheral atherosclerosis (OR=1.083, 95%CI: 1.041-1.127, P=0.001). Heterogeneity test, horizontal multiple effect analysis, sensitivity analysis, and MR-PRESSO further clarified the causal relationship by Mendelian randomization analysis.

Conclusion

RA has positive causal correlations with coronary atherosclerosis and peripheral atherosclerosis, but there is no causal correlation between AS and RA by reverse MR analysis. RA increases the risk of coronary atherosclerosis and peripheral arteriosclerosis. It is suggested to actively control RA to reduce the risk of AS.

Mendelian randomization  /  Rheumatoid arthritis  /  Atherosclerosis  /  Coronary atherosclerosis  /  Peripheral arteriosclerosis
Ying-zhu DUAN, Hai-jun MA, Ping NI, Jian LIANG, Ying ZHANG, Huan ZHANG, You YU, Rui YU. A two-sample Mendelian randomized study on rheumatoid arthritis and atherosclerosis[J]. Modern Preventive Medicine, 2024 , 51 (1) : 8 -14 . DOI: 10.20043/j.cnki.MPM.202306460
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Year 2024 volume 51 Issue 1
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Article Info
doi: 10.20043/j.cnki.MPM.202306460
  • Receive Date：2023-06-22
  • Online Date：2026-03-19
  • Published：2024-01-10
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  • Received：2023-06-22
Funding
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    Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning 110847, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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