Latest ArticlesTo compare the efficacy differences between traditional decoction and formula granules of different ratios of Huanglian（Coptidis Rhizoma）-Wuzhuyu（Evodiae Fructus）.
Various typical efficacy indicators were used for different ratios of Huanglian（Coptidis Rhizoma）-Wuzhuyu（Evodiae Fructus）in separate comparative experiments. Zuojin Pill（左归丸）group［Huanglian（Coptidis Rhizoma）；Wuzhuyu（Evodiae Fructus）＝6∶1］used an anhydrous ethanol-induced gastric ulcer experiment to measure the effectiveness in inhibiting gastric ulcers and gastric acid secretion of rats. Blood superoxide dismutase（SOD）and malondialdehyde（MDA）were analyzed. The Ganlu Powder（甘露散）group［Huanglian（Coptidis Rhizoma）：Wuzhuyu（Evodiae Fructus）＝2∶1］used dry yeast-induced hyperthermia in rats to determine the antipyretic efficacy. The Zhuyu Pill（茱萸丸）group［Huanglian（Coptidis Rhizoma）：Wuzhuyu（Evodiae Fructus）＝1∶1］used a small intestinal propulsion experiment in mice to determine the antidiarrheal efficacy. The Reverse Zuojin Pill（反左金丸）group［Huanglian（Coptidis Rhizoma）：Wuzhuyu（Evodiae Fructus）＝1∶6］used acetic acid-induced writhing in mice to determine the analgesic efficacy.
Both formulations in the Zuojin Pill group effectively inhibited gastric ulcers of the rats but were unable to inhibit gastric acid secretion，showing no significant difference between the two（P>0.05）. Both formulations in the Ganlu Powder group effectively reduced fever of rats，with significant differences between the formula granule group and the traditional decoction group（P<0.05）. Both formulations in the Zhuyu Pill group alleviated mouse diarrhea symptoms，showing significance compared to the formula granule group（P<0.05）. Both formulations in the Reverse Zuojin Pill group alleviated mouse pain sensation，with no significant difference between the two（P>0.05）.
When Zuojin Pill is used to treat gastric ulcers，the efficacy of the traditional decoction is equivalent to the formula granules. For Ganlu Powder in treating fever，the formula granules are superior to the traditional decoction. When Zhuyu Pill is used for treating diarrhea，the efficacy of the traditional decoction is superior to the formula granules. In the case of Reverse Zuojin Pill for analgesia，the efficacy of the traditional decoction is equivalent to the formula granules.
Lingzhi（Ganoderma）is the dried fruiting body of Zhenjun Chizhi［Ganoderma lucidum（Leyss.ex Fr.）Karst.］or Zizhi（Ganoderma sinense Zhao，Xu et Zhang）of the polyporeaceae fungus，which is a traditional Chinese precious medicinal material and is listed as the top grade. At present，the types of compounds isolated from Lingzhi（Ganoderma）mainly include polysaccharides，triterpenoids，proteins，sterols，vitamins and trace elements，etc.，which have a wide range of biological activities and pharmacological effects，such as regulating immunity，anti-cancer，anti-oxidation，anti-aging，anti-inflammatory，etc. In this paper，the chemical composition and pharmacological effects of Lingzhi（Ganoderma）were reviewed，and the quality markers（QMarker）were predicted from multiple aspects，and the polysaccharides of Lingzhi（Ganoderma），total triterpenoids of Lingzhi（Ganoderma），Ganoderic acid A，Ganoderic acid B，Ganoderic acid C2，Ganoderic acid E，Ganoderma lucidum kettotriol，Ganoderma lucidum terpene diol，ergosterol，ergosterol peroxide，Ganoderma lucidum uridine，uracil，protein，amino acids，trace elements，vitamin components and heavy metal elements（Pb，Cd，As，Hg）and other components may become Q-Markers of Lingzhi（Ganoderma），which provides a basis for the quality control and evaluation of Lingzhi（Ganoderma）.
Zhuling Decoction（猪苓汤）was first created by the medical sage ZHANG Zhongjing，with the main functions of promoting diuresis，nourishing Yin and clearing heat. The descendants continuously add，subtract and innovate on the basis of the original formula，and the treatment scope has been widely expanded. This article summarized the modern clinical application of Zhuling Decoction by sorting and analyzing modern literature related to it，and found that it mainly treated urinary system diseases and was widely used in clinical departments such as digestion，respiration and tumors. At the same time，it explained that Zhuling Decoction could exert therapeutic effects by reducing the deposition of inflammatory factors and immune complexes，and improving microcirculation and anti-coagulating mechanisms.
It is to summarize Professor GAO Shuzhong＇s clinical experience in the treatment of epilepsy. Professor GAO emphasizes the holistic concept and systematic treatment，believing that the basic pathogenesis of epilepsy is the imbalance of Qi，obstruction of the brain orifice，and disorder of the spirit，not solely caused by phlegm，blood stasis and other turbidity. He also emphasizes the importance of the neck-pass. Professor GAO advocates for equal emphasis on regulating Qi and spirit，dredging the neck-pass and opening up the brain orifice，nurturing and enlightening the spirit. Internal and external therapy，acupuncture and medication are always advocated. The external therapy includes GAO＇s method of dredging pass，the group of acupoints for regulating the spirit and umbilical moxibustion，as well as emergency external treatment. The internal treatment is mainly oral Chinese medicine based on Chaihu Guizhi Decoction（柴胡桂枝汤）and Chaihu Jia Longgu Muli Decoction（柴胡加龙骨牡蛎汤）. Characteristic syndrome differentiation and compatibility approaches of opening depression，unblocking collaterals，removing blood stasis，and resolving phlegm have been formed.
To study the ecological suitability of Roumao Yinyanghuo（Epimedium pubescens Maxim.），explore the potential suitable cultivation sites of Roumao Yinyanghuo（Epimedium pubescens Maxim.）and promote the development and utilization of the resources of Roumao Yinyanghuo（Epimedium pubescens Maxim.）.
Based on field research，literature collection and the Chinese Digital Herbarium，a total of 68 items of valid point data were collected，and 54 ecological factors were selected according to the physiological habits of Roumao Yinyanghuo（Epimedium pubescens Maxim.），and the potential climatic suitability zones of Roumao Yinyanghuo（Epimedium pubescens Maxim.）in China were investigated by the Maximum Information Entropy（MaxEnt）model.
CI index，April precipitation，annual sunshine duration，elevation，January mean temperature and HI index were six ecological factors that had a greater impact on the distribution of Roumao Yinyanghuo（Epimedium pubescens Maxim.），which was mainly distributed in Gansu and southern Shaanxi，north-central Sichuan，north-central Guizhou，southeastern Chongqing and southern Hunan in China.
The climatic suitability zones of Roumao Yinyanghuo（Epimedium pubescens Maxim.）in this experiment was basically consistent with the range described in Flora of China（2004 Edition），which can provide a reference for the investigation，exploitation and sustainable development of Roumao Yinyanghuo（Epimedium pubescens Maxim.）in China.
The quantitative models of fructose，glucose，sucrose，raffinose and polysaccharide in Huaidihuang（Rehmannia glutinosa）were established based on mid-infrared spectroscopy technology.
The fructose，glucose，sucrose and raffinose in 50 batches of genuine Huaidihuang（Rehmannia glutinosa）were determined by high performance liquid chromatography（HPLC），the polysaccharide was determined by ultraviolet-visible spectroscopy（UV-Vis），and the infrared spectra of Huaidihuang（Rehmannia glutinosa）were collected by mid-infrared spectrometer. HPLCmethod，UV-Vis method and mid-infrared spectroscopy technology were combined to establish a determination model for the sugar component contents of in Huaidihuang（Rehmannia glutinosa）using TQ analysis software.
The model of principal component regression（PCR）＋mutiplicative signal correction（MSC）＋first derivative（1st Der）＋Savitzky-Golay fler（SG）was the best for fructose，the model of partial least squares（PLS）＋CONSTANT＋1st Der＋SG best for glucose，the model of stepwise multiple linear regression（SMLR）＋CONSTANT＋second derivative（2nd Der）＋SG best for sucrose，the model of SMLR＋standard normal variate（SNV）＋2nd Der＋Noris derivative fliler（ND）best for raffinose and the model of PLS＋SNV＋2nd Der＋ND best for polysaccharide. The correlation coefficients were 0.786 2，0.927 8，0.838 8，0.782 4 and 0.964 8，respectively，with an average absolute deviation of-0.05%，0.04%，0.07%，-0.02% and-0.02%，respectively. It is verified that the prediction effect of the model is good.
The quantitative model of sugar components in Huaidihuang（Rehmannia glutinosa）established by mid-infrared spectroscopy is stable and objective，which can provide a basis for rapid evaluation of sugar components in Huaidihuang（Rehmannia glutinosa）.
Banmao（Mylabris）is a well-known animal Chinese medicine in China，which has the effect of breaking blood and eliminating blood stasis，dispersing knots and eliminating mass，and attacking toxin and eroding sores，and is widely used to disperse blood stasis and eliminate carbuncles. Because of its violent toxicity，it often needs to be processed to reduce toxicity and improve the safety of medication. As early as in the Eastern Jin Dynasty，the processing methods of Banmao（Mylabris），such as net preparation and firing method，were recorded，and later a variety of processing methods such as rice frying，stir-frying and vinegar boiling were gradually developed. Modern studies have found that the main components of Banmao（Mylabris）are terpenoids and their derivatives，metal elements，fatty acids，fatty compounds，amino acid compounds and so on，which have antitumor，anti-fibrotic，cardiotonic，antiviral，anticoagulant，immune enhancement and other pharmacological effects. In this paper，it reviewed Chinese medical books and related Chinese and foreign materials and literature，and discussed the historical evolution，chemical composition and pharmacological effects of Banmao（Mylabris），in order to provide reference for the related research of Banmao（Mylabris）.
To observe the clinical effect of Xieqing Pill（泻青丸）combined with clearing heart and soothing liver acupuncture on children with multiple tic syndrome（hyperactivity of liver and wind movement syndrome）.
In this study，106 children with multiple tic syndrome（hyperactivity of liver and wind movement syndrome）admitted from September 2021 to June 2023 were divided into control group and observation group by random number table method，with 53 cases in each group. The control group received conventional treatment（haloperidol tablets），and the observation group received haloperidol tablets and Xieqing Pill combined with clearing heart and soothing liver acupuncture. The data of each group before and after treatment was observed，including changes in Yale Comprehensive Tic Severity Scale（YGTSS）score，clinical efficacy，adverse reactions，changes in traditional Chinese medicine symptom score，changes in serum dopamine（DA），5-hydroxytryptamine（5-HT）and gamma-aminobutyric acid（GABA），Achenbach changes in Child Behavior Scale（CBCL）and quality of life scale（short form 36 questionnaire，SF-36）scores.
The total effective rate of the observation group（96.23%，51/53）was higher than that of the control group（84.91%，45/53）（P<0.05）. Before treatment，YGTSSscore，traditional Chinese medicine syndrome scores，the levels of DA 5-HT and GABA，CBCL and SF-36 scores were not significant between two groups（P>0.05）. After treatment，YGTSSscore，traditional Chinese medicine syndrome scores，the levels of DA 5-HT and GABA，CBCL and SF-36 scores of two groups were improved. After treatment，YGTSSscore，traditional Chinese medicine syndrome scores，the levels of DA 5-HT and GABA，CBCL and SF-36 scores in the observation group were better than those in the control group（P<0.05）. The adverse reaction rate in the observation group（3.77%，2/53）was lower than that in the control group（16.98%，9/53）（P<0.05）.
Xieqing Pill combined with clearing heart and soothing liver acupuncture has significant clinical effect in the treatment of children with multiple tic syndrome（hyperactivity of liver and wind movement syndrome）. The symptoms are relieved，the recovery is better，the behavior and the quality of life are improved，and the adverse reaction rate is reduced. The treatment is relatively safe and reliable.
To explore the clinical effect of midnight-noon ebb-flow acupuncture combined with Buqi Quyu Decoction（补气祛瘀汤）in the treatment of post-stroke cricopharyngeal muscle atrophy type dysphagia.
A total of 60 patients with post-stroke cricopharyngeal muscle atrophy type dysphagia were randomly divided into two groups，including an experimental group（30 cases）and a control group（30 cases）. Two groups received basic therapy，while the control group received Buqi Quyu Decoction. The experimental group received midnight-noon ebb-flow acupuncture on the basis of the control group. The surface electromyographic changes of the submandibular muscle group between two groups as well as the results of water swallow test（WST），standardized swallowing assessment（SSA），swallowing disorder specific quality of life（SWAL-QOL）and swallowing X-ray fluoroscopy（VFSS）were compared. The clinical efficacy and overall incidence of complications were observed. Statistical analysis was conducted using SPSS 26.0.
After treatment，the root mean square（RMS）values of the submandibular muscle group in two groups decreased（P<0.05）. Compared with that in the control group，the RMSvalue of the submandibular muscle group in the experimental group was lower（P<0.05）. After treatment，the results of WST examination of the two groups decreased，and the result of WST examination of the experimental group was lower than that of the control group（P<0.05）. After treatment，the SSA scores of the two groups decreased，while the scores of SWAL-QOL and VFSS increased. The experimental group had lower SSA scores and higher scores of SWAL-QOL and VFSS（P<0.05）. The total clinical effective rate of the treatment experimental group was higher than that of the control group，and the incidence rate was lower than that of the control group（P<0.05）.
The treatment of Buqi Quyu Decoction combined with midnight-noon ebb-flow acupuncture has a good therapeutic effect on patients with post-stroke cricopharyngeal muscle atrophy type dysphagia，with advantages in improving swallowing function and high safety.
To investigate the clinical effect of Qingwei Guchi Prescription（清胃固齿方）combined with tinidazole on inflammation and the distribution of periodontal plaque in elderly patients with chronic periodontitis.
A total of 101 elderly patients with chronic periodontitis admitted from January 2021 to February 2023 were divided into two groups by random number table method，namely control group（50 cases）and observation group（51 cases）. The control group received periodontal basic treatment and tinidazole and the observation group was combined with Qingwei Guchi Prescription on the basis of the control group. During the study，1 patient fell off in the control group and 1 fell off in the observation group. The clinical efficacy，symptom improvement time（swollen gums，bad breath，loose teeth），changes of TCM syndrome scores（gum pain，bleeding，hot breath，thirst for cold drinks，dry stool，etc.）before and after treatment，plaque index（PLI）and probing depth（PD）of periodontal pockets，sulcus bleeding index（SBI），attach loss（AL）and other periodontal related indicators，the levels of interleukin-6（interleukin-6）and tumor necrosis factor-α（TNF-α）in gingival crevicular fluid，changes in the score of Oral Health Impact Profile（OHIP-14）and adverse reactions were compared.
The clinical effect of the observation group（94.00%，47/50）was better than that of control group（79.59%，39/49）（P<0.05）. Compared with that in the control group，the improvement time of symptoms（swollen gums，bad breath，loose teeth）in the observation group was shorter（P<0.05）. Before treatment，TCM syndrome scores（gingival pain，bleeding，hot breath，thirst for cold drinks，dry stool，etc.），periodontal related indexes（PLI，PD，SBI and AL），the levels of IL-6 and TNF-αand OHIP-14 scale scores were not significant between two groups（P>0.05）. After treatment，TCM syndrome scores（gum pain，bleeding，hot breath，thirst for cold drinks，dry stool，etc.），periodontal related indexes（PLI，PD，SBI and AL），the levels of IL-6 and TNF-αand OHIP-14 scale scores were improved in both groups. After treatment，TCM syndrome scores（gingival pain，bleeding，hot breath，thirst for cold drinks，dry stool，etc.），periodontal related indexes（PLI，PD，SBI and AL），the levels of IL-6 and TNF-αand OHIP-14 scale scores in the observation group were superior to those in the control group（P<0.05）. The total adverse reaction rate of the observation group was lower than that of the control group（P<0.05）.
In elderly patients with chronic periodontitis，Qingwei Guchi Prescription combined with tinidazole has good clinical effect，which can effectively reduce the inflammatory response of the body and improve the distribution of periodontal plaque in patients，so as to improve the condition and quality of life of patients. The treatment is safe and reliable and less adverse reaction.
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