Full
Outline
To observe the clinical effect of Xieqing Pill（泻青丸）combined with clearing heart and soothing liver acupuncture on children with multiple tic syndrome（hyperactivity of liver and wind movement syndrome）.
In this study，106 children with multiple tic syndrome（hyperactivity of liver and wind movement syndrome）admitted from September 2021 to June 2023 were divided into control group and observation group by random number table method，with 53 cases in each group. The control group received conventional treatment（haloperidol tablets），and the observation group received haloperidol tablets and Xieqing Pill combined with clearing heart and soothing liver acupuncture. The data of each group before and after treatment was observed，including changes in Yale Comprehensive Tic Severity Scale（YGTSS）score，clinical efficacy，adverse reactions，changes in traditional Chinese medicine symptom score，changes in serum dopamine（DA），5-hydroxytryptamine（5-HT）and gamma-aminobutyric acid（GABA），Achenbach changes in Child Behavior Scale（CBCL）and quality of life scale（short form 36 questionnaire，SF-36）scores.
The total effective rate of the observation group（96.23%，51/53）was higher than that of the control group（84.91%，45/53）（P<0.05）. Before treatment，YGTSSscore，traditional Chinese medicine syndrome scores，the levels of DA 5-HT and GABA，CBCL and SF-36 scores were not significant between two groups（P>0.05）. After treatment，YGTSSscore，traditional Chinese medicine syndrome scores，the levels of DA 5-HT and GABA，CBCL and SF-36 scores of two groups were improved. After treatment，YGTSSscore，traditional Chinese medicine syndrome scores，the levels of DA 5-HT and GABA，CBCL and SF-36 scores in the observation group were better than those in the control group（P<0.05）. The adverse reaction rate in the observation group（3.77%，2/53）was lower than that in the control group（16.98%，9/53）（P<0.05）.
Xieqing Pill combined with clearing heart and soothing liver acupuncture has significant clinical effect in the treatment of children with multiple tic syndrome（hyperactivity of liver and wind movement syndrome）. The symptoms are relieved，the recovery is better，the behavior and the quality of life are improved，and the adverse reaction rate is reduced. The treatment is relatively safe and reliable.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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