Full
Outline
To investigate the clinical effect of Qingwei Guchi Prescription（清胃固齿方）combined with tinidazole on inflammation and the distribution of periodontal plaque in elderly patients with chronic periodontitis.
A total of 101 elderly patients with chronic periodontitis admitted from January 2021 to February 2023 were divided into two groups by random number table method，namely control group（50 cases）and observation group（51 cases）. The control group received periodontal basic treatment and tinidazole and the observation group was combined with Qingwei Guchi Prescription on the basis of the control group. During the study，1 patient fell off in the control group and 1 fell off in the observation group. The clinical efficacy，symptom improvement time（swollen gums，bad breath，loose teeth），changes of TCM syndrome scores（gum pain，bleeding，hot breath，thirst for cold drinks，dry stool，etc.）before and after treatment，plaque index（PLI）and probing depth（PD）of periodontal pockets，sulcus bleeding index（SBI），attach loss（AL）and other periodontal related indicators，the levels of interleukin-6（interleukin-6）and tumor necrosis factor-α（TNF-α）in gingival crevicular fluid，changes in the score of Oral Health Impact Profile（OHIP-14）and adverse reactions were compared.
The clinical effect of the observation group（94.00%，47/50）was better than that of control group（79.59%，39/49）（P<0.05）. Compared with that in the control group，the improvement time of symptoms（swollen gums，bad breath，loose teeth）in the observation group was shorter（P<0.05）. Before treatment，TCM syndrome scores（gingival pain，bleeding，hot breath，thirst for cold drinks，dry stool，etc.），periodontal related indexes（PLI，PD，SBI and AL），the levels of IL-6 and TNF-αand OHIP-14 scale scores were not significant between two groups（P>0.05）. After treatment，TCM syndrome scores（gum pain，bleeding，hot breath，thirst for cold drinks，dry stool，etc.），periodontal related indexes（PLI，PD，SBI and AL），the levels of IL-6 and TNF-αand OHIP-14 scale scores were improved in both groups. After treatment，TCM syndrome scores（gingival pain，bleeding，hot breath，thirst for cold drinks，dry stool，etc.），periodontal related indexes（PLI，PD，SBI and AL），the levels of IL-6 and TNF-αand OHIP-14 scale scores in the observation group were superior to those in the control group（P<0.05）. The total adverse reaction rate of the observation group was lower than that of the control group（P<0.05）.
In elderly patients with chronic periodontitis，Qingwei Guchi Prescription combined with tinidazole has good clinical effect，which can effectively reduce the inflammatory response of the body and improve the distribution of periodontal plaque in patients，so as to improve the condition and quality of life of patients. The treatment is safe and reliable and less adverse reaction.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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