Latest ArticlesTo investigate the distribution of clinical characteristics and traditional Chinese medicine (TCM) syndrome patterns in patients with diabetes mellitus complicated with osteoporosis (DM-OP), and to explore the associations between TCM syndromes and laboratory indicators, so as to elucidate the intrinsic patterns of the "disease-syndrome-symptom-laboratory indicator" relationship.
Retrospectively collected medical records of patients with diabetes complicated by osteoporosis who were hospitalized in the Department of Endocrinology at Guang'anmen Hospital, China Academy of Chinese Medical Sciences, from January 1, 2015 to December 31, 2024. The distribution of TCM syndrome patterns was analyzed, and the associations between different syndromes and general characteristics, comorbidities, symptom profiles, tongue and pulse features, bone mineral density, and laboratory indicators were explored.
Among patients with DM-OP, spleen-kidney deficiency syndrome was the most common pattern, followed by liver-kidney yin deficiency syndrome, damp-heat accumulation syndrome, and spleen-stomach qi deficiency syndrome. Significant differences were observed among different TCM syndromes in terms of age, body mass index (BMI), blood pressure, comorbidities, certain symptoms and tongue-pulse features, femoral neck bone mineral density, and selected laboratory indicators. Patients with spleen-stomach qi deficiency syndrome were relatively younger and had higher BMI, whereas those with liver-kidney yin deficiency syndrome and spleen-kidney deficiency syndrome were older, had lower femoral neck bone mineral density, and showed higher incidences of fractures and chronic kidney disease.
The distribution of TCM syndromes in DM-OP reflects a progressive pathomechanism involving the spleen and kidney. Different TCM syndromes exhibit distinct characteristics in clinical manifestations, comorbidities, bone mineral density, and laboratory indicators.
Based on metabolomics methods, this study aims to explore the differential metabolites of different primitive Chinese medicinal herbs (such as Chinese medicinal herb, Chinese medicinal herb, and Chinese medicinal herb) and screen the main metabolites identified by primitive identification.
The chemical composition of different types of Platycodon grandiflorus was analyzed by ultra-high performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS). Principal component analysis, cluster heatmap, orthogonal partial least squares discriminant analysis, and other methods were used to compare the differences in metabolites among the three types of Platycodon grandiflorus. Differential metabolites were identified using a database.
A total of 691 compounds were identified in negative ion mode, with lipids, organic acids and their derivatives, and flavonoids being the main metabolites. Differential metabolites were significantly enriched in the flavonoid biosynthesis pathway. There are a total of 11 differential metabolites among the three groups, with flavonoids (3, 27.27%) and lipids (3, 27.27%) accounting for the largest proportion. Combined with the difference factor, rutin, anthocyanin B2, and isorhamnetin-3-O-rutinoside were identified as the three differential metabolites based on their respective origins.
UPLC-Q-TOF-MS metabolomics technology can elucidate the differences in chemical composition of different basal components of Eucommia ulmoides, providing new ideas for differential analysis of different basal components of Eucommia ulmoides, and also providing references for the quality control, evaluation, and clinical use of medicinal materials of Eucommia ulmoides.
Parkinson's disease (PD) is a chronic neurodegenerative disease closely associated with multiple factors such as age, genetics and environment, characterized by progressive motor function impairment and a wide range of non-motor symptoms. This disease has a long course and diverse clinical symptoms, and the existing treatment regimens in modern medicine have many side effects and certain limitations. Traditional Chinese Medicine (TCM) has unique advantages in treating this disease and can serve as a powerful supplement and alternative for PD treatment. The etiology and pathogenesis of PD are complex. Professor Wang Shun innovatively applies the method of "Regulating spirit and easing the mind" to regulate the heart, brain and five viscera, relax tendons and stop tremors, and has achieved satisfactory curative effects, which provides a new idea for the treatment of this disease.
Treatment with biological agents may lead to eczema-like changes in patients with psoriasis and psoriasis-like changes in patients with eczema, and this phenotypic switching phenomenon is attracting more and more attention, whose molecular biological mechanism may be related to the dysregulation of the Th1/Th2 balance, and for which there is no clear therapeutic solution. Based on the Xuanfu qi fluids theory, this paper describes the evolution of the pathogenesis of psoriasis and eczema. In the course of treatment, the biological agents may improperly regulate qi and fluids transport, which ultimately leads to dampness on the outside and qi and blood dryness on the inside; dryness is present on the surface, while dampness is stagnant on the inside, which is manifested as the phenomenon of phenotypic transformation on the skin. For this complex dry-damp presentation, therapy must combine pungent-moistening agents to unblock the orifices with bland herbs to promote diuresis, thereby normalizing qi fluids dynamics without fostering pathogens or injuring upright qi. An illustrative case is presented to showcase this approach to managing pattern transition.
Based on the theory of "Head qijie", this paper explores the etiology, pathogenesis and treatment of post-stroke sequelae. The theory of Head qijie is an important part of acupuncture theory. Zang-fu organs, acupoints, and meridians are connected through the pathway of Qijie, expanding the treatment scope of acupuncture from points to surfaces. The pathological location of post-stroke sequelae is in the head, which is closely related to the theory of Head qijie. Based on the correlation between brain functions, the meridian system, and the etiology and pathogenesis of post-stroke sequelae, this paper integrates traditional medicine theories and modern medical research results, focuses on discussing the action mechanisms of main acupoints of Head qijie, Bladder-associated acupoints, and syndrome-specific acupoints in the treatment of post-stroke sequelae. Guided by this theory, it proposes the principles for selecting acupoints and formulating traditional Chinese medicine prescriptions, aiming to guide clinical acupuncture and Chinese materia medica treatment for post-stroke sequelae.
Through the records of Sophorae Tonkinensis Radix et Rhizoma(S. Tonkinensis) in ancient Chinese herbal medicines, medical books and modern literature, this paper examines the name, origin, producing areas, nature and flavor, efficacy and indications, collection and processing, usage, dosage, toxicityand compatibility taboos of S. Tonkinensis. The results showed that most of the ancient Chinese herbs were named after S. Tonkinensis, and their aliases were mostly derived from it's efficacy, morphology, nature and flavor and producing areas. The basic source of S. Tonkinensis recorded in ancient books was relatively confusing, and some of them were contrary to the basic source of S. Tonkinensis included in the modern Chinese Pharmacopoeia, and the source of S. Tonkinensis plants used in modern places was also different, showing certain regional differences. The geoherbalism, harvesting and efficacy of plants were basically as same as those of modern times, but the processing method and toxicity were different from modern research, and we think that it's processing method may affect it's toxicity, which needs further research.
To analyze the application value of mind-regulating acupuncture combined with sensory integration training in the language rehabilitation of children with autism.
A prospective study was conducted. A total of 93 children with autism admitted to the Department of Rehabilitation of Pingdingshan First People's Hospital from January 2024 to January 2025 were selected as the study subjects. They were randomly divided into a control group and an observation group using a random number table method, with 45 cases in each group. The control group received sensory integration training intervention, while the observation group received mind-regulating acupuncture combined with sensory integration training intervention. Both groups were continuously intervened for 6 months. The scores of the Autism Behavior Checklist (ABC), Children's Sensory Integration Development Rating Scale, Autism Treatment Evaluation Checklist (ATEC), and Childhood Autism Rating Scale (CARS) were compared between the two groups before treatment, at 3 months of treatment, and at 6 months of treatment.
Repeated measures ANOVA showed that the main effect of the group was statistically significant in the following scale scores (P <0.05) : Children's Sensory Integration Development Rating Scale, ATEC score, CARS score, and the sensory, social interaction, motor, language, and self-care dimensions of the ABC score. Further trend analysis indicated that the total ATEC score, total CARS score, and all dimension scores of the ABC showed a significant downward trend over time (P <0.05) ; the score of the Children's Sensory Integration Development Rating Scale showed a significant upward trend over time (P < 0.05).
Mind-regulating acupuncture combined with sensory integration training can improve the core symptoms of children with autism, enhance sensory integration ability, and has a good effect on language rehabilitation in these children.
To explore the mechanism of promoting awakening effect and prognosis of coma patients with severe craniocerebral injury based on meridian flow theory combined with acupuncture.
A total of 102 coma patients with severe craniocerebral injury admitted to Xinxiang Central Hospital from October 2021 to October 2024 were divided into observation group and control group. The control group was given routine intervention. On the basis of the control group, the observation group was given meridian flow theory combined with acupuncture treatment. The waking time, waking rate, GCS and FOUR scores and prognosis were compared between the two groups. The levels of neuron-specific enolase (NSE), S100B protein (S-100B) and myelin basic protein (MBP) were compared between the two groups before and after treatment. The improvement of cerebral blood flow (CBF) and cerebral blood volume (CBV) before and after treatment was compared between the two groups.
The awakening rate of observation group was 82.35% higher than that of control group 64.71%, and the awakening time was significantly lower than that of control group (P <0.05). After 10 and 30 days of treatment, GCS and FOUR scores of both groups significantly increased, and the observation group was significantly higher than the control group (P <0.05) ; After treatment, NSE, S-100B and MBP significantly decreased in both groups, and the observation group was significantly lower than the control group (P < 0.05). After treatment, CBF and CBV significantly increased in both groups, and the observation group was significantly higher than the control group (P <0.05). Compared with 68.63% of the control group, the total effective rate of the observation group was 86.27% (P < 0.05).
Acupuncture combined with meridian injection theory can significantly improve the awakening rate of coma patients with severe craniocerebral injury, improve nerve function and cerebral blood flow indexes, and the prognostic effect is better than conventional treatment.
To explore the effects of Qingyan Runhou (throat-clearing and moistening) tea on the clinical symptoms and recurrence of children with chronic pharyngitis (lung-kidney yin deficiency syndrome).
A total of 112 children with chronic pharyngitis from January 2023 to October 2024 were selected as the subjects of this trial. Randomly divide it into 2 groups, 56 children in the control group were given Xuanmai Ganju granules, and 56 children in the treatment group were given clear throat and throat tea. After treatment, the efficacy, clinical symptoms, pharyngeal sign scores, immunological function, adverse reactions and recurrence rates of the two groups were compared.
Treatment group demonstrated a higher clinical efficacy rate than control group (P < 0.05). After treatment, the clinical symptom scores and pharyngeal sign scores of the two groups were lower than before, and treatment group was lower than control group (P < 0.05). After treatment, the levels of immunoglobulin A and immunoglobulin M of the two groups were lower than before, and treatment group was higher than control group (P <0.05). No statistical difference was found in thyroid function and adverse reactions between two groups (P > 0.05). Recurrence rate of the treatment group was lower than the control group (P <0.05).
Throat-clearing and throat-moistening tea has obvious effects on children with chronic pharyngitis syndrome of lung and kidney yin deficiency. It can improve clinical symptoms, enhance immunological function, and reduce the recurrence rate while ensuring safety.
To investigate the efficacy of modified Sangbaipi Decoction on patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) and its effect on pulmonary function.
A total of 120 patients with acute exacerbation of COPD admitted to Shunyi Hospital, Beijing Traditional Chinese Medicine Hospital, from June 2023 to June 2025 were selected and randomly divided into a control group (conventional Western medicine treatment) and an observation group (conventional Western medicine + modified Sangbaipi Decoction treatment) with 60 cases each. Observed and compared the TCM Syndrome Score, clinical efficacy, pulmonary function indices, inflammatory factors and the incidence of adverse reactions in both groups.
The total effectiveness rate of the observation group after treatment were higher than that of the control group (P < 0.05) ; The TCM syndrome score subjects group was lower than that of the control group (P <0.05). After treatment, the levels of FEV1, FVC and FEV1/FVC in both groups were increased and the levels of IL-6, CRP and PCT were decreased (P < 0.05), and the observation group was lower than that of the control group (P < 0.05). There was no apparent difference in the incidence of adverse reactions between both groups (P > 0.05).
Modified Sangbaipi Decoction has significant efficacy in patients with acute exacerbation of COPD (Phlegm-heat obstructing lung syndrome), can effectively improve the clinical symptoms and pulmonary function indices, reduce the level of inflammatory factors, and it has a high degree of safety.
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