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Exploration on the Phenomenon of Phenotypic Transition Following Biological Agent Treatment in Psoriasis, Eczema Based on the Theory of Xuanfu Qi Fluids
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Ruohan DIAO1, Xingwu DUAN1, *, Tiange QU1, Ye TIAN1, Min HUANG1, Yuexuan GAO2, Huanhuan DENG1, Xiaoting LI1
Acta Chinese Medicine and Pharmacology | 2026, 54(5) : 40 - 44
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Acta Chinese Medicine and Pharmacology | 2026, 54(5): 40-44
Exploration on the Phenomenon of Phenotypic Transition Following Biological Agent Treatment in Psoriasis, Eczema Based on the Theory of Xuanfu Qi Fluids
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Ruohan DIAO1, Xingwu DUAN1, *, Tiange QU1, Ye TIAN1, Min HUANG1, Yuexuan GAO2, Huanhuan DENG1, Xiaoting LI1
Affiliations
  • 1.Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
  • 2.Gulou Hospital of Traditional Chinese Medicine of Beijing, Beijing 100010, China
Published: 2026-05-20 doi: 10.19664/j.cnki.1002-2392.260094
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Treatment with biological agents may lead to eczema-like changes in patients with psoriasis and psoriasis-like changes in patients with eczema, and this phenotypic switching phenomenon is attracting more and more attention, whose molecular biological mechanism may be related to the dysregulation of the Th1/Th2 balance, and for which there is no clear therapeutic solution. Based on the Xuanfu qi fluids theory, this paper describes the evolution of the pathogenesis of psoriasis and eczema. In the course of treatment, the biological agents may improperly regulate qi and fluids transport, which ultimately leads to dampness on the outside and qi and blood dryness on the inside; dryness is present on the surface, while dampness is stagnant on the inside, which is manifested as the phenomenon of phenotypic transformation on the skin. For this complex dry-damp presentation, therapy must combine pungent-moistening agents to unblock the orifices with bland herbs to promote diuresis, thereby normalizing qi fluids dynamics without fostering pathogens or injuring upright qi. An illustrative case is presented to showcase this approach to managing pattern transition.

Psoriasis  /  Eczema  /  Biological agents  /  Theory of Xuanfu qi fluids
Ruohan DIAO, Xingwu DUAN, Tiange QU, Ye TIAN, Min HUANG, Yuexuan GAO, Huanhuan DENG, Xiaoting LI. Exploration on the Phenomenon of Phenotypic Transition Following Biological Agent Treatment in Psoriasis, Eczema Based on the Theory of Xuanfu Qi Fluids[J]. Acta Chinese Medicine and Pharmacology, 2026 , 54 (5) : 40 -44 . DOI: 10.19664/j.cnki.1002-2392.260094
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Article Info
doi: 10.19664/j.cnki.1002-2392.260094
  • Receive Date：2024-12-18
  • Online Date：2026-09-17
  • Published：2026-05-20
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  • Received：2024-12-18
  • Revised：2025-10-16
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    1.Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
    2.Gulou Hospital of Traditional Chinese Medicine of Beijing, Beijing 100010, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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