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Based on metabolomics methods, this study aims to explore the differential metabolites of different primitive Chinese medicinal herbs (such as Chinese medicinal herb, Chinese medicinal herb, and Chinese medicinal herb) and screen the main metabolites identified by primitive identification.
The chemical composition of different types of Platycodon grandiflorus was analyzed by ultra-high performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS). Principal component analysis, cluster heatmap, orthogonal partial least squares discriminant analysis, and other methods were used to compare the differences in metabolites among the three types of Platycodon grandiflorus. Differential metabolites were identified using a database.
A total of 691 compounds were identified in negative ion mode, with lipids, organic acids and their derivatives, and flavonoids being the main metabolites. Differential metabolites were significantly enriched in the flavonoid biosynthesis pathway. There are a total of 11 differential metabolites among the three groups, with flavonoids (3, 27.27%) and lipids (3, 27.27%) accounting for the largest proportion. Combined with the difference factor, rutin, anthocyanin B2, and isorhamnetin-3-O-rutinoside were identified as the three differential metabolites based on their respective origins.
UPLC-Q-TOF-MS metabolomics technology can elucidate the differences in chemical composition of different basal components of Eucommia ulmoides, providing new ideas for differential analysis of different basal components of Eucommia ulmoides, and also providing references for the quality control, evaluation, and clinical use of medicinal materials of Eucommia ulmoides.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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