To explore the intervention mechanism of icaritin (ICT) on myocardial injury in sepsis.

Mice were divided into control group, model group, AMPK activator (MET) group, icaritin (ICT) group and icaritin+AMPK inhibitor compound C (ICT+CC) group, with 12 mice in each group. Except for the control group, the other mice were intraperitoneally injected with LPS. ICT group was intraperitoneally injected with ICT 30 minutes before modeling, and ICT+CC group was injected with AMPK inhibitor Compound C at the same time. After 24 hours of modeling, cardiac function, myocardial pathological changes, AMPK pathway and pyroptosis-related protein expression, serum inflammatory factors and myocardial injury markers were detected.

The intervention of ICT and AMPK activators significantly improved the survival rate of mice, increased cardiac LVEF and LVFS, and decreased LVIDD and LVIDS. Tissue damage was reduced and inflammatory cell infiltration was reduced. The levels of serum TNF-α, IL-1β, IL-18, CK-MB and LDH were decreased. The ratio of p-AMPK/AMPK was increased, and the expression of NLRP3, ASC, Cleaved Caspase-1, GSDMD-NT and Cleaved IL-1β was decreased (P < 0.05). Compound C could reverse the improvement effect of ICT on myocardial injury, increase inflammation index and pyroptosis protein expression (P <0.05).

ICT can improve myocardial injury and inflammatory response in sepsis mice, and its mechanism may be related to the activation of AMPK to inhibit pyroptosis mediated by NLRP3 signaling pathway.

To investigate the effect of Mulberry twig (Sangzhi) alkaloids (SZ-A), which is a new traditional Chinese medicinal, on myocardial fibrosis in diabetes mellitus (DM) and its underlying molecular mechanism.

The diabetic mouse model was established using high-fat diet combined with streptozotocin injections. Mice were randomly divided into non-diabetic (ND), diabetic (DM), and SZ-A low- (50 mg/kg/d) or high-dose (100 mg/kg/d) groups. Myocardial fibrosis-related proteins (Collagen Ⅰ, TGF-β1, Smad2/3, and their phosphorylated forms) were analyzed by Western blot, while mRNA levels of fibrosis markers (Collagen Ⅰ/Ⅲ, α-SMA, Fn1, Postn) were quantified via qRT-PCR. Molecular docking simulations (AlphaFold2/Autodock) were performed to validate interactions between SZ-A components (DNJ, FGM, DAB) and TGF-β1.

SZ-A treatment significantly reduced myocardial Collagen deposition in diabetic mice, downregulated mRNA expression of Collagen Ⅰ/Ⅲ, α-SMA, Fn1, and Postn (P < 0.05), and suppressed TGF-β1 expression and Smad2/3 phosphorylation. Molecular docking revealed stable binding affinities between DNJ/FGM/DAB and TGF-β1. Exogenous TGF-β1 administration reversed SZ-A's anti-fibrotic effects, restoring Collagen Ⅰ, TGF-β1, and p-Smad2/3 levels (P <0.05).

SZ-A ameliorates diabetic myocardial fibrosis by targeting the TGF-β1/Smad signaling pathway, highlighting its therapeutic potential for diabetic cardiomyopathy.

To investigate the effect of three different strains on the chemical composition of Polygonatum in the fermentation process of Polygonatum.

the crushed Rhizoma Polygonati was prepared into a suspension according to the 30 ∶ 70 ratio of care solution, and the three activated bacterial solutions of Lactobacillus casei, Lactobacillus rhamnosus and Bacillus subtilis were separately added according to the 5% inoculum. The sample morphology and the number of viable bacteria were observed. Ultra performance liquid chromatography quadrupole time-of-flight mass spectrometry (uplc-q-tof-ms) was used to analyze the differential chemical components of Polygonatum sibiricum before and after fermentation.

Rhizoma Polygonati was thickened after fermentation, with fluidity and sour taste. Milky white folds appeared after fermentation by Lactobacillus rhamnosus and Bacillus subtilis. On the 6th day of fermentation, Lactobacillus casei and Bacillus subtilis had the highest viable counts, which were 3.40 × 10⁸ CFU/g and 2.62 × 10⁹ CFU/g, respectively; The number of viable bacteria was the highest when Lactobacillus rhamnosus was fermented for 7 days, which was 2.59 × 10⁸ CFU/g; Three triterpenoid saponins, 2 flavonoids, 1 organic acid.

Lactobacillus rhamnosus and Lactobacillus casei can convert triterpenoid steroidal saponins into aglycones during the fermentation of Polygonatum sibiricum, and the utilization effect of saponins is better. Bacillus subtilis can convert flavonoid glycosides into aglycones, and the utilization effect of flavonoid glycosides is better.

To optimize the extraction process of total flavonoids from Mayaqi and study its antioxidant activity and stability.

Key factors were screened by Plackett-Burman experiment, and the optimal process was obtained by Box-Behnken Design surface design; The antioxidant activity of total flavonoids of Mayaqi was evaluated by measuring the scavenging effects on hydroxyl radicals, DPPH radicals, ABTS radicals and the ability to reduce ferric ions. The correlation between the concentration of total flavonoids extract and different antioxidant activities was by SPSS software, and the effects of temperature, light and pH on the stability of antioxidant activity were investigated.

The optimal extraction technology for total flavonoids from Mayaqi was as follows: extraction 140 W, ethanol concentration 65%, temperature 70 ℃, extraction time 30 min, and the extraction rate of total flavoids was 4.608 5 ±0.031 7 mg/g. The scavenging effects of the total flavonoids extract on Mayaqi DPPH radicals, and ABTS radicals, and the ability to reduce ferric ions were 64.16%、55.67%、95.97% and 50.49%, of the same concentration of Vc, respectively. Correlation showed that the concentration of the total flavonoids extract from Mayaqi was significantly correlated with the scavenging rate of xyl radicals. The antioxidant stability test showed that the total flavonoids extract from Mayaqi should be stored at low (below 25 ℃), away from light, and in neutral conditions.

This technology is stable and feasible, and the total flavonoids extract Mayaqi has high antioxidant activity.

To explore the clinical efficacy of Sancai acupuncture combined with Frontal-three-needles in treating insomnia of Heart-kidney disharmony Type.

According to the random number table method, 60 patients with heart kidney non overlapping insomnia treated at Bengbu TCM Hospital from January 2023 to February 2024 were divided into two groups. The control group of 30 cases received conventional acupuncture treatment, while the treatment group of 30 cases received a combination of Sancai acupuncture and frontal three acupuncture treatment. Both groups were treated for 4 weeks. The sleep quality, TCM syndrome scores, neurotransmitter levels, and clinical efficacy were analyzed.

After treatment, the scores of each dimension of PSQI and the total PSQI score in both groups decreased (P < 0.05), and the scores in treatment group were lower (P < 0.05). After treatment, the scores of traditional Chinese medicine syndrome in both groups decreased (P < 0.05), and the scores in treatment group were lower(P < 0.05). After treatment, the levels of serum5-HT, DA, and MT increased in both groups (P <0.05), and the indexes in treatment group were higher (P < 0.05). The effective rate in treatment group (93.33%) was higher compared with control group (73.33%) (P <0.05).

Sancai acupuncture combined with frontal-three-needles has a good therapeutic effect on insomnia of Heart-kidney disharmony type, which can improve sleep quality and neurotransmitter levels, and effectively reduce TCM syndrome scores.

To explore the clinical effect of combined therapy with Chifeng Yingyuan acupuncture method and traditional Chinese medicine Reyanbao therapy in the treatment of chronic lumbar muscle strain.

A total of 130 patients with chronic lumbar muscle strain in the hospital from From January 2022 to April 2025 were randomly grouped. Both groups received basic Western medicine treatment. On this basis, 65 cases in the control group were treated with the Chifeng Yingyuan acupuncture method, and 65 cases in the combined group were treated with the Chifeng Yingyuan acupuncture method combined with traditional Chinese medicine hot compress. The clinical efficacy, TCM syndrome scores, pain degree and lumbar function of the two groups were compared to evaluate the safety of the two groups.

Compared with the control group, the clinical efficacy in the combined group was enhanced after treatment while the TCM syndromes scores were reduced (P < 0.05). Compared with the control group, the Visual Analogue Scale (VAS) of the one-course and two-course combined groups after treatment decreased (P < 0.05); Compared with the control group, the Oswestry Disability Index (ODI) scores of the one-course and two-course combined groups after treatment decreased (P < 0.05); The adverse reactions revealed no significant differences between both groups (P > 0.05).

Chifeng Yingyuan acupuncture method combined with traditional Chinese medicine Reyanbao therapy has significant efficacy in the treatment of chronic lumbar muscle strain. Additionally, it can effectively relieve the pain, and promote the recovery of lumbar function, with high safety.

To investigate the efficacy and safety of Xiegan Zhitong Decoction combined with famciclovir tablets and mecobalamin tablets in treating herpes zoster with liver channel stagnation-heat syndrome.

92 patients diagnosed with herpes zoster with liver channel stagnation-heat syndrome in the Department of Dermatology of Third Affiliated Hospital of Beijing University of Chinese Medicine from June 2022 to June 2024 were included. All patients received oral Xiegan Zhitong Decoction (1 dose/day, decocted in water) for one week as one treatment course, combined with famciclovir tablets for antiviral treatment and mecobalamin tablets for nerve nutrition. Clinical efficacy at different treatment courses, time-effect scores (time to stop blistering, crust formation time, crust shedding time, and pain relief time), pain and sleep scores, incidence of postherpetic neuralgia, and TCM syndrome scores were evaluated.

After treatment at each course, significant improvements were observed in time-effect scores, sleep and pain scores, and TCM syndrome scores (P <0.01, P < 0.001). The cumulative effective rates at 1, 2, 3, and 4 weeks were 27.17% (25/92), 88.04% (81/92), 94.57% (87/92), and 98.91% (91/92) respectively. The incidence of postherpetic neuralgia was 1.09% (1/92).

Xiegan Zhitong Decoction combined with famciclovir and mecobalamin tablets shows significant efficacy in treating herpes zoster with liver channel stagnation-heat syndrome, shortening recovery time, improving sleep, reducing pain, ameliorating TCM syndromes, with low incidence of postherpetic neuralgia and few adverse reactions.

To explore the clinical efficacy and safety research on children with anorexia-spleen deficiency and dyspepsia based on Ganji Powder combined with Zengshi Oral Paste.

Children with anorexia attending the outpatient clinic of Tongling Traditional Chinese Medicine Hospital from July 2022 to December 2023 were selected for the study, and were divided into four groups using the random number table method; the Saccharomyces boulardii group (36 cases) was treated with a single Saccharomyces boulardii orally, the Ganji Powder group (41 cases) was treated with Ganji Powder externally applied to the acupoints alone, the Zengshi Oral Paste group (49 cases) was treated with Zengshi Oral Paste orally alone, and the combined group used the The combined group was treated with Ganji Powder applied externally to two acupoints, Shenque and Mingmen, and combined with Zengshi Oral Paste (an in-hospital preparation). All four groups were treated for one treating course. The clinical efficacy of the children in the four groups, the time for the children's food intake to return to normal and the amount of increase in body mass, the points of Chinese medicine symptoms, the level of nutritional indexes, the adverse reactions and the six-month follow-up were observed.

The total effective rate was 89.47% (68/76) in the combined group, 58.33% (21/36) in the Saccharomyces boulardii group, 70.73% (29/41) in the Ganji Powder group, and 75.51% (37/49) in the Zengshi Oral Paste group. The total effective rate of the combined group and the time for the return of the normal food intake and the increase of the body mass of the children, the Chinese medicine symptom scores of the main evidence and the secondary evidence, the tongue and pulse, and the levels of the proteins, the body fats, the muscle mass, the basal metabolic rate, the transferrin, the retinol-binding protein, the pre-albumin Nutritional indicators such as protein, body fat, muscle mass, basal metabolic rate, transferrin, retinol-binding protein, prealbumin, haemoglobin, average haemoglobin content and dihydroxyvitamin D were all better than those of the Saccharomyces boulardii group, the noma group and the Zengshi Oral Paste group (P <0.05, P < 0.01); All indicators of the Ganji Powder and Zengshi Oral Paste were superior to those of Saccharomyces boulardii group. (P <0.05). There were no serious adverse reaction situations during the treatment period of each group, and the relapse rate of the combined group was the lowest after six months of follow-up.

The treatment of children's anorexia with spleen deficiency and dyspepsia based on Ganji Powder and Zengshi Oral Paste can significantly reduce children's clinical symptoms, and the children's gastrointestinal function recovered well, with a significant clinical effect and high safety.

To explore the clinical effect of modified Shaoyao Decoction combined with acupoint embedding in the treatment of patients with ulcerative colitis (UC).

A total of 120 patients with internal damp-heat type UC who visited the Department of Anorectal Diseases of the Second Affiliated Hospital of Hunan University of Chinese Medicine from April 2023 to April 2025 were prospectively selected. They were grouped using the random number table method and assigned by independent researchers. Although the intervention measures limited the blinding of patients, the assessment of endoscopic outcomes strictly followed the blinding principle. The treatment was carried out by endoscopists who were unaware of the grouping situation. The control group (with 0 cases dropped out and 60 cases ultimately included) was given Western medicine and acupoint embedding treatment, while the combined group (with 0 cases dropped out and 60 cases ultimately included) was treated with modified Shaoyao Decoction on this basis. The treatment courses are all 6 weeks. The changes of TCM symptoms scores and ulcerative colitis endoscopic index of severity (UCEIS) before and after treatment were compared between groups. The expression levels of Th17/Treg cell balance-related indicators [IL-22, IL-21, IL-10, transforming growth factor-β (TGF-β)] were detected, and the clinical efficacy and safety of the two groups before and after treatment were evaluated.

After 6 weeks of treatment, the total clinical effective rate in the combined group was 95.00% (57/60), which was much higher than 83.33% (50/60) in the control group (χ² = 4.227, P < 0.05). The UCEIS scores, TCM symptoms scores and levels of IL-22 and IL-21 in the two groups after treatment were significantly reduced compared with those before treatment (P < 0.05), and the above scores and levels were lower in the combined group than those in the control group (P <0.05). The levels of IL-10 and TGF-β were significantly enhanced in the two groups compared to before treatment (P < 0.05), and the combined group had higher levels (P <0.05). There were no obvious adverse reactions in the two groups after treatment.

The modified Shaoyao Decoction combined with acupoint embedding thread can effectively improve the symptoms and therapeutic effect of UC patients, and can reduce the UCEIS scores. Additionally, it can also reduce the inflammatory response by regulating the expression levels of Th17/Treg cell balance-related indicators, with good safety.

To analyze the effect of Modified Tongbi Formula combined with traditional Chinese medicine fumigation on rheumatoid arthritis (RA) syndrome of cold-dampness obstruction.

168 patients with RA cold-dampness obstruction syndrome admitted to the Eastern Theater General Hospital from April 2021 to June 2024 were divided into 2 groups according to different treatment methods. 83 patients in the control group were treated with traditional Chinese medicine fumigation, and 85 patients in the observation group were treated with Modified Tongbi Formula. The therapeutic effect of the two groups was compared.

The treatment effect of observation group was compared with control group (P <0.05). After treatment, TCM syndrome score, 28 joint activity score (DAS28) and clinical disease activity index (CDAI) in observation group were lower than those in control group (P < 0.05). After treatment, the levels of rheumatoid factor (RF), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), D-dimer (D-D) and immunoglobulin (IgG, IgA, IgM) in observation group were lower than those in control group (P < 0.05). The incidence of adverse reactions was compared between observation group and control group (P >0.05).

Modified Tongbi Formula combined with traditional Chinese medicine fumigation has a remarkable effect, which can significantly reduce the score of traditional Chinese medicine symptoms, significantly reduce the level of inflammation, enhance immune function, reduce disease activity, and do not increase adverse drug reactions.

To observe the effect of Jianpi Anshen Decoction combined with warm acupuncture at Periumbilical Four-Sided Points on the treatment of patients with chronic insomnia heart-spleen deficiency syndrome.

A total of 92 patients with chronic insomnia heart-spleen deficiency syndrome treated in Ma'anshan Shiqiye Hospital from January 2020 to September 2024 were selected and divided into experimental group (n=46) and control group (n = 46) by random number table method. The control group was treated with warm acupuncture at Periumbilical Four-Sided Points, the experimental group received Jianpi Anshen decoction on the basis of the control group. Both groups were treated for 3 months. The TCM symptom score, sleep structure, insomnia degree, sleep quality, clinical efficacy, neurotransmitter and adverse reactions were compared between the two groups.

After treatment, the scores of TCM syndrome, wake after sleep on set (WASO), sleep latency (SOL), insomnia Severity Index Scale (ISI) and Pittsburgh Sleep Quality Index (PSQI) were all decreased in two groups, and the experimental group was lower (P < 0.05). After treatment, total sleep time (TST) and sleep efficiency (SE) were increased in both groups, and higher in the experimental group (P < 0.05). The experimental group with total effective rate (93.65%) was higher than the control group (82.61%) (P <0.05). After treatment, serum 5-hydroxytryptamine (5-HT) and glycated serum albumin (GA) levels were increased in both groups, and higher in experimental group (P < 0.05). After treatment, serum dopamine (DA) level was decreased in both groups, and lower in experimental group (P < 0.05). During the treatment period, there were no obvious adverse reactions in both groups. Within 3 months of treatment, there was no significant difference in recurrence rate between the two groups (P > 0.05).

Jianpi Anshen Decoction combined with warm acupuncture at Periumbilical Four-Sided Points in the treatment of chronic insomnia patients with heart-spleen deficiency syndrome is effective, can improve the sleep structure and sleep quality of patients, reduce insomnia symptoms, regulate neurotransmitters, good safety, and good short-term prognosis.

To investigate epidemiological trends in pulmonary nodule detection, characterize the distribution patterns of nodule size, morphology, anatomical location, and multiplicity, analyze gender- and age-related correlations, and propose Traditional Chinese Medicine (TCM)-based intervention strategies.

A retrospective cohort analysis was conducted using low-dose computed tomography (LDCT) data from 5 426 individuals undergoing routine health screenings at Liaocheng Hospital of Traditional Chinese Medicine from January to December 2024, identifying 4 076 patients with pulmonary nodules. Statistical analyses, including chi-square tests and Fisher's exact tests, were performed using SPSS 23.0.

Pulmonary nodule detection rates demonstrated a progressive increase in recent years, peaking in 2022, followed by stabilization in 2024. Nodule characteristics revealed a predominance of solid nodules (70.6%), micro-nodules (< 10 mm, 73.3%), and multiple nodules (84.3%). Anatomically, the right upper lobe exhibited the highest nodule prevalence (20.8%). Gender-specific analysis identified significant disparities: females displayed a higher proportion of multiple nodules (P < 0.05) and ground-glass opacity (GGO) nodules (33.7% vs. 23.0% in males), whereas males exhibited a greater prevalence of solid nodules (75.5% vs. 64.7%). Age-stratified comparisons indicated markedly higher detection rates in middle-aged and elderly cohorts (≥40 years) versus younger groups (P <0.05), with larger nodules (≥10 mm) more frequent in older populations (3.0% vs. 0.8%). Notably, part-solid nodules constituted the predominant subtype among larger lesions (27.3%). TCM Constitution distribution showed that the top four biased constitutions were phlegm dampness constitution (19.9%), qi stagnation constitution (15.0%), Qi deficiency constitution (12.0%), and blood stasis constitution (10.0%).

Gender and age significantly influence pulmonary nodule characteristics, with part-solid morphology being disproportionately associated with larger nodules, underscoring the necessity for enhanced malignancy risk stratification in such cases. The centralized distribution of TCM Constitution further confirms the core pathogenesis of qi stagnation and phlegm coagulation. This study establishes foundational epidemiological data for pulmonary nodule management in asymptomatic populations and integrates TCM theoretical frameworks into clinical strategies. However, longitudinal follow-up and comprehensive adjustment for confounders are required to validate these findings and optimize therapeutic approaches.

To observe the effects of Rhubarb Decoction combined with intradermal granule on bone marrow edema, finger microcirculation and Th17/Treg in peripheral blood of rheumatoid arthritis.

A total of 100 patients with rheumatoid arthritis treated in the hospital from April 2022 to February 2024 were selected and divided into control group and observation group with 50 cases in each group by random number table method. Both groups were given basic symptomatic treatment, the control group was given granular intradermal acupuncture treatment on the basis of this treatment, and the observation group was given ultrasonic introduction therapy with rhubarb decoction on the basis of the control group. After 4 weeks of continuous treatment, the clinical efficacy of the control group and the observation group were compared. TCM syndrome score and wrist bone marrow edema score were observed before and after treatment, 6-point behavior score (BRS-6) and 28-point joint disease activity score (DAS-28) were performed. The vascular resistance index, vascular index, blood flow index and blood flow index of the middle nail bed artery of the patient were detected and calculated, and the levels of Th17/Treg, tumor necrosis factor-α (TNF-α), rheumatoid factor (RF) and reactive oxygen species (ROS) were detected.

The total effective rate of Rhubarb Decoction combined with intradermal acupuncture group was 98.00%, and that of Western medicine group was 82.00%. The total effective rate of Rhubarb Decoction combined with intradermal acupuncture group was higher than that of Western medicine group (P < 0.05). Joint pain, fever, joint swelling, morning stiffness, joint fever, sweating, poor joint flexion and extension, and thirst score of Rhubarb Decoction combined with intradermal acupuncture group were lower than those of Western medicine group (P < 0.05). DAS28, bone marrow edema and BRS-6 scores of Rhubarb Decoction combined with intradermal acupuncture group were lower than those of western medicine group (P < 0.05). The fingernail bed artery resistance index of Rhubarb Decoction combined with intradermal acupuncture group was lower than that of Western medicine group (P < 0.05), and the vascular index, blood flow index and blood flow index of Rhubarb Decoction combined with intradermal acupuncture group were higher than that of Western medicine group (P <0.05). The contents of Th17/Treg, TNF-α, RF and ROS in Rhubarb Decoction combined with intradermal acupuncture group were lower than those in western medicine group (P < 0.05).

Rhubarb Decoction combined with granular intradermal acupuncture can regulate Th17/Treg balance, inhibit inflammation and oxidative stress, reduce bone marrow edema, improve finger microcirculation, relieve pain and improve clinical efficacy in the treatment of patients with rheumatoid arthritis.

To explore the efficacy of Fuzheng Qufeng Decoction in patients with chronic urticaria, its effects on the Weekly Urticaria Activity Score (UAS7), Dermatology Life Quality Index (DLQI), and serum C-reactive protein (CRP) and immunoglobulin levels. Additionally, it evaluated the decoction's regulatory effects on serum inflammatory factors, chemokines, and immune function.

This prospective study enrolled 211 patients with chronic urticaria treated at our hospital from March 2020 to March 2024. Patients were randomly assigned into a control group (n=106), receiving levocetirizine hydrochloride tablets, and an observation group (n=105), receiving Fuzheng Qufeng Decoction in combination with levocetirizine hydrochloride. Both groups were treated for 4 weeks. UAS7 and DLQI scores were evaluated before and after treatment in both groups. Traditional Chinese Medicine (TCM) symptom scores, serum levels of inflammatory cytokines, chemokines, and immune function-related indicators were measured and compared between the two groups. The efficacy and incidence of adverse reactions were statistically analyzed.

After treatment, both the UAS7 and DLQI scores decreased in the observation group and the control group, with median UAS7 and DLQI scores in the observation group being 7.00 and 2.00, respectively, both lower than the control group's 7.50 and 3.00 (P < 0.05). The primary and secondary symptom scores of Traditional Chinese Medicine (TCM) syndromes also decreased in both groups, with the observation group showing significantly lower scores than the control group (P <0.05). Post-treatment, serum levels of IL-17, IL-23, IL-31, IL-33, IFN-γ, TGF-β, CRP, SAA, D-dimer, MCP-1, RANTES, Eotaxin, C5a, and IgE were all lower in the observation group compared to the control group (P <0.05), while serum C3 and C4 levels were higher in the observation group (P <0.05). The total treatment efficacy rate in the observation group was higher than that in the control group. The total incidence of adverse reactions in the observation group was lower than that in the control group (P < 0.05).

Fuzheng Qufeng Decoction significantly improved clinical symptoms, reduced UAS7 and DLQI scores, lowered serum levels of inflammatory cytokines and chemokines, enhanced immune function, and demonstrated high safety with fewer adverse reactions. It holds substantial clinical value for treating chronic urticaria.

To evaluate the efficacy of celecoxib combined with Danggui Niantong Decoction in the treatment of cervical spondylotic radiculopathy Wind-Damp-Heat Obstruction syndrome).

A total of 98 patients with cervical radiculopathy (Wind-Damp-Heat Obstruction syndrome) admitted to the orthopedics and inpatient department of Huanggang Central Hospital from January 2023 to December 2023 were selected as the study objects, and were divided into 2 groups according to random number table method, with 49 cases each. The control group was treated with celecxib on the basis of cervical traction therapy, and the experimental group was treated with Danggui Niantong Decoction on the basis of control group for 4 weeks. The clinical efficacy, TCM symptom score, VAS scale score, NDI questionnaire, CASCS scale score, serum inflammatory indicators IL-1β, IL-6β, TNF-αlevel and incidence of adverse reactions were compared between the two groups.

The total effective rate of experimental group after treatment was significantly higher than that of control group (P < 0.05). After treatment, TCM symptom score of two groups was significantly decreased, and the test group was lower than the control group(P < 0.05). VAS and NDI scores after treatment were lower than before treatment, CASCS scores were higher than before treatment, and the change range of experimental group was higher than that of control group (P <0.05). The serum levels of IL-1β, IL-6β and TNF-αin 2 groups after treatment were lower than before treatment, and the experimental group was lower than the control group(P < 0.05).

Danggui Niantong Decoction combined with celecxib has a good effect in the treatment of cervical spondylopathy patients with rheumatic heat arthralgia nerve root type, which can significantly improve cervical spine function and clinical symptoms, reduce the level of pain and inflammatory factors, and is safe, worthy of clinical promotion.

To observe the effects of self-formulated modified Tiaoying Decoction with modifications combined with herb-partitioned moxibustion on immune regulation, platelet parameters and the number and function of endothelial progenitor cells in peripheral blood of patients with myeloid suppression anemia after chemotherapy for advanced gastric cancer.

We selected 104 patients with myelosuppressive anemia after chemotherapy for advanced gastric cancer who were treated in Hengshui Hospital of Traditional Chinese Medicine from April 2022 to April 2024. They were divided into a control group of 52 cases (3 cases dropped out, and finally 49 cases were included) and a treatment group of 52 cases (4 cases dropped out, and finally 48 cases were included) by the random number table method. Both groups were given routine Western medicine treatment simultaneously. The treatment group was given herb-partitioned moxibustion combined with self-formulated modified Tiaoying Decoction with modifications on the basis of routine Western medicine treatment. After the treatment course, the clinical efficacy of the two groups was compared. Before and after treatment, the scores of various traditional Chinese medicine syndromes were observed. The quality of life was evaluated by the Functional Assessment of Cancer Therapy-General (FACT-G). The levels of neutrophils, hemoglobin, white blood cell count and platelet count of patients were detected. The number and migration ability of circulating endothelial progenitor cells in peripheral blood were detected. The levels of reactive oxygen species (ROS), granulocyte-macrophage colony-stimulating factor (GM-CSF), Notch2, Numb1, CD4⁺ cells, CD8⁺cells and CD16⁺ CD56⁺ cells in patients were detected. The 1-year recurrence rate and 1-year survival rate of the two groups of patients were compared.

The treatment group's total effective rate was 95.83%. The control group's total effective rate was 79.59%. The treatment group's total effective rate was higher than the control group (P < 0.05). The treatment group's scores of TCM syndrome was lower than control group (P < 0.05). The treatment group's FACT-G scores was higher than the control group (P <0.05). The treatment group's neutrophil, hemoglobin, white blood cell count and platelet count in treatment group levels were higher than control group (P < 0.05). The treatment group's number and migration ability of peripheral blood circulating endothelial progenitor cells were lower than control group (P <0.05). The treatment group's CD4⁺ cells and CD16⁺ CD56⁺ cells levels were higher than control group (P < 0.05). The treatment group's expression of CD8⁺ cells was lower than control group (P < 0.05). The treatment group's ROS, GM-CSF and Notch2 expression levels were lower than control group (P < 0.05). The treatment group's expression level of Numb1 was higher than that in the control group (P < 0.05). The 1-year recurrence rate of the treatment group was 31.25%, which was lower than 53.06% of the control group (P < 0.05), and the 1-year survival rate of the treatment group was 97.92%, which was higher than 81.63% of the control group (P < 0.05).

Self-formulated modified Tiaoying Decoction with modifications combined with herb-partitioned moxibustion can reduce the oxidative stress response, regulate the immune function and platelet parameters of patients, improve the number and function of peripheral blood endothelial progenitor cells, alleviate the disease, and improve the clinical efficacy and quality of life in the treatment of patients with advanced gastric cancer after chemotherapy.