To analyze the clinical effect of Modified Banxia Xiexin Decoction（半夏泻心汤）in the treatment of chronic gastritis.

A total of 128 patientswith chronic gastritis admitted to our hospital from February 2021 to July 2024 were included as the research objects. They were divided into two groups by the random number tablemethod.64 patients in the control group were treated with the Western medicine quadruple therapy，and 64 patients in the observation group were treated with themodified Banxia Xiexin Decoction on the basis of the above-mentioned treatment. The differences in curative effects，TCM syndrome scores，gastric mucosal function，inflammatory factors，and Helicobacter pylori（Hp）negative conversion rate were compared between the two groups.

The total effective rate of treatment in the observation group was 96.88%（62/64），which wasmuch higher than 82.81%（53/64）in the control group，and the difference between the two groups was significant（P<0.05）. After treatment，the scores of four symptoms，including epigastric pain，fullness and discomfort，epigastric burning，belching and acid reflux，bitter taste and drymouth in the observation group were lower than those in the control group（P<0.05）. After treatment，the levels of pepsinogen I（PG I），pepsinogenⅡ（PGⅡ），pepsinogen ratio（PGR），gastrin-17（G-17），and the levels of inflammatory factors such as tumor necrosis factor-α（TNF-α），interleukin-1β（IL-1β），and interleukin-6（IL-6）in the observation group were all lower than those in the control group（P<0.05）. One month after treatment，the Hp negative conversion rate in the observation group was 90.63%（58/64），which was significantly higher than 75.00%（48/64）in the control group，and the difference between the two groupswas significant（P<0.05）.

The application ofmodified Banxia Xiexin Decoction in the treatment of patientswith chronic.

To observe the regulation effect of Sini Hewei Formula（四逆和胃方）combined with triple therapy on visceral hypersensitivity and gastrointestinal hormone secretion disorder in patients with Helicobacter pylori（Hp）-positive gastroesophageal reflux disease（GERD）.

Ninety cases of Hp-positive GERD patients admitted to the hospital from February 2021 to May 2023 were selected as the study subjects and the patients who met the criteria were divided into two groups by simple randomization method. Forty-five cases in the control group were treated with triple therapy，and the other 45 cases in the Sini Hewei Formula group were treated with Sini Hewei Formula on the basis of triple therapy. The efficacy，Hp conversion rate，Gastroesophageal Reflux Disease Questionnaire（GERDQ）score，esophageal dynamics，traditional Chinese medicine syndrome score，Gastroesophageal Reflux Disease Related Quality of Life Scale（GERDQ）score，visceral hypersensitivity related factors and gastrointestinal hormones were compared between the two groups.

The total effective rate of the Sini Hewei Formula group was higher than that of the control group，and the Hp conversion rate was was not statistically significant compared with that of the control group by theχ² test（P>0.05）. Comparison of esophageal dynamic function before treatment between the two groups showed no statistical difference（P>0.05）. The postreflux swallow-induced peristaltic wave（PSPW）index，esophageal mass clearance time and the number of acid reflux were lower than those before treatment in both groups，and they were lower in the Sini Hewei Formula group than that in the control group after treatment（P<0.05）. Comparison of TCM evidence score，GERDQ score and GERD-HROL score before treatment between the two groups did not show any statistical difference（P>0.05）. The above scores were lower than those before treatment in both groups after treatment，and were lower in the Sini Hewei Formula group than those in the control group（P<0.05）. Comparison of visceral hypersensitivity-related factors and gastrointestinal hormones between the two groups before treatment showed no statistical difference（P>0.05）. Substance P（SP），nerve growth factor（NGF），calcitonin gene-related peptide（CGRP）and vasoactive intestinal peptide（VIP）were all lower in both groups than those in the control group after treatment（P<0.05）. The levels of VIPwere lower than those before treatment，and they were lower in the Sini Hewei Formula group than those in the control group after treatment（P<0.05）. The levels of motilin（MTL）and gastrin（GAS）were higher than those in the control group after treatment in both groups，and they were higher in the Sini Hewei Formula group than those in the control group after treatment（P<0.05）.

The combination of Sini Hewei Formula and triple therapy can improve esophageal dynamic function，reduce visceral hypersensitivity，regulate gastrointestinal hormone secretion disorder and improve curative effect in Hp-positive GERD patients.

To compare and analyze the differences of the special odors of Jiucaizi（Semen Allii Tuberosi）under different processing methods，such as raw products，stir-fried products with wine，stir-fried products with salt，stir-fried products with vinegar，stir-fried products with nothing，stir-fried products with salt and wine，steamed products. And to establish a method for distinguishing different processed products of Jiucaizi（Semen Allii Tuberosi）from their odors to provide a reference for further study of chemical transformation of Jiucaizi（Semen Allii Tuberosi）.

GC-IMStechnology was used to detect volatile organic compounds in different processed products of Jiucaizi（Semen Allii Tuberosi）through the instrument combined with VOCal and plug-in Reporter，Gallery Plot and Dynamic PCA analysis from different angles including differential analysis，fingerprint analysis，dynamic principal component analysis，similarity analysis and qualitative analysis of differential substances.

The difference analysis of GC-IMSshowed that there were significant differences in the specific odor components of Jiucaizi（Semen Allii Tuberosi）under different processing methods. About 54 compounds had been identified. Among them，geraniol，1-hydroxy-2-propanone，1-pentanol，2-methylpropanol，diallyl sulfide，Methyl-3-but-3-en-1-ol，ehanol，propanoic acid，2-acetylfuran，5-dimethylfuran，ethyl acetate，diallyl disulfide M，2-pentylfuran，hexanoic acid M and ethyl hexanoate can be used as the characteristic volatiles of the special odors of raw products. Ethyl 2-hydroxypropanoate and beta-Ocimene can be used as the characteristic volatiles of the special odors of Jiucaizi（Semen Allii Tuberosi）processed with wine or salt and wine；pentanal can be used as the characteristic volatiles of the special odors of stir-fried products with vinegar；3-hydroxy-2-butanone，butyrolactone and linalool could be used as the characteristic volatiles of steamed Jiucaizi（Semen Allii Tuberosi），and octanol could be used as the characteristic volatiles of stir-fried products with nothing. The PCA results showed that the separation of the samples was good，and the similarity of the samples with the same excipients was greater.

There are obvious differences in the specific odor components of Jiucaizi（Semen Allii Tuberosi）processed by different methods. GC-IMStechnology can be used as a method to distinguish the specific odor of different processed products of Jiucaizi（Semen Allii Tuberosi）. It also provides reference for further study on the processing and transformation of Jiucaizi（Semen Allii Tuberosi）.

To investigate the effects of Shengyu Decoction（圣愈汤）and Zengye Decoction（增液汤）combined with recombinant human granulocyte colony-stimulating factor on myelosuppression and peripheral blood image after chemotherapy for epithelial ovarian cancer.

All 75 patients were randomly divided into treatment group and control group according to the order of enrollment for epithelial ovarian cancer，35 cases in each group. The control group was prophylactically treated with pegylated recombinant human granulocyte colony stimulating factor（PEG-rhG-CSF）or recombinant human granulocyte colony stimulating factor（rhG-CSF）after chemotherapy. The treatment group was treated with Shengyu Decoction and Zengye decoction orally in addition to the treatment of the control group. The degree of myelosuppression after chemotherapy and peripheral blood images were observed at 1 day before chemotherapy，1，2 and 3 courses after chemotherapy.

The incidence of myelosuppression in the treatment group after 1，2 and 3 courses was significantly lower than that in the control group，and the difference was statistically significant（P<0.05）. There was no statistically significant difference in the levels of white blood cells，neutrophils，platelets or hemoglobin between the two groups before treatment（P>0.05）. The above indexes were both decreased after treatment and the decrease degree in the control group was significantly greater than that in the treatment group，and the difference was statistically significant（P<0.05）.

Shengyu Decoction and Zengye Decoction combined with recombinant human granulocyte colony-stimulating factor can reduce myelosuppression in patients with epithelial ovarian cancer，improve the decline of peripheral blood cells and promote the recovery of blood cell levels after chemotherapy.

To investigate clinical efficacy of Modified Shenghua Decoction（加味生化汤）combined with medroxyprogesterone in treatment of patients with perimenopausal abnormal uterine bleeding-ovulatory dysfunction（AUB-O）.

Sixty cases patients with perimenopausal AUB-Owere selected and randomly divided into the observation group（30 cases）and control group（30 cases）. The control group received oral treatment with medroxyprogesterone. On the basis of the control group，the observation group was treated with a combination of Modified Shenghua Decoction orally. The treatment course was 3 menstrual cycles. The changes of sex hormone level，endometrial thickness，uterine volume，menstrual volume，menstrual duration，prothrombin time，activated partial thromboplastin time，hemoglobin level and traditional Chinese medicine syndrome score（TCM）symptom score before and after treatment were observed.

The levels of estradiol（E2），follicle stimulating hormone（FSH），luteinizing hormone（LH）and prolactin（PRL）decreased before and after treatment in both groups（P<0.05）and the levels of the observation group were lower than those of the control group（P<0.05）. The endometrial thickness，menstrual volume and menstrual duration of two groups decreased after treatment compared to those before treatment（P<0.05）. The degree of decrease in the observation group was greater than that in the control group（P<0.05）. There was no statistically significant difference in uterine volume between the two groups before and after treatment（P>0.05）. The prothrombin time and activated partial thromboplastin time of two groups decreased after treatment compared to those before treatment（P<0.05）. The degree of decrease in the observation group was greater than that in the control group（P<0.05）. The hemoglobin level increased compared to that before treatment（P<0.05）and the increase in the observation group was greater than that in the control group（P<0.05）. The incidence of adverse reactions was 36.67%in the control group and 43.33%in the observation group. There was no statistically significant difference in comparison（P>0.05）. The scores of TCM symptoms in both groups decreased after treatment（P<0.05），and scores of the observation group were lower than those of the control group（P<0.05）. The therapeutic effect of the observation group was significantly better than that of the control group（P<0.05）.

Modified Shenghua Decoction combined with medroxyprogesterone in treatment of patients with perimenopausal AUB-Ocan help to improve the levels of sex hormones，reduce endometrial thickness，menstrual volume and duration，improve coagulation function andclinical efficacy，and dose not significantly increase adverse reactions.

To investigate the mechanism of action of curculigoside（CUR）antioxidation in alleviating apoptosis of ovarian granulosa cells（GCs）in mice with premature ovarian failure（POF）.

Mice after acclimatization feeding were divided into blank，model，CUR low-dose，CUR mid-dose and CUR high-dose groups，and estradiol valerate group. The mouse model was replicated by intraperitoneal injection of cyclophosphamide（CTX）. After modeling，the mice were treated by gavage for 14 consecutive days and vaginal smears were performed daily，the body mass of the mice was weighed and the mice were killed 24 h after the last administration and the blood and ovary tissues were extracted，and the ovary tissues were weighed bilaterally to calculate the ovarian index. The levels of serum follicle stimulating hormone（FSH），anti-Müllerian hormone（AMH）and estradiol（E2）were measured. The ovaries were stained with hematoxylin-eosin（HE）staining to observe follicular development and corpus luteum morphology，and the apoptosis level of GCs was determined using terminal deoxynucleotidyl transferase-mediated dUTPNick-End Labeling（TUNEL），and the superoxide dismutase（SOD）activity and malondialdehyde（MDA）level were measured using protein peroxidase，glutathione peroxidase（GSH-Px）content and malondialdehyde（MDA）level in the ovary tissue. The protein expressions of ovarian protein kinase B（AKT），p-AKT，mammalian target of rapamycin（mTOR）and p-mTOR were detected using protein blotting（WB）.

Compared with the blank group，the mice in the model group showed disorganized estrous cycle，decreased ovarian index，large number of atretic follicles，high level of apoptosis of GCs and significantly upregulated levels of FSH，whereas AMH and E2 showed a significant decrease，suggesting a successful replication of the POF mouse model. Compared with the model group，the administration of CUR intervention was able to increase the antioxidant level，activate the AKT/mTOR signaling pathway，improve the estrous cycle and serum hormone levels，reduce apoptosis of GCs，and promote follicular development in POF mice，thus restoring the ovarian reserve function.

CUR ameliorated mouse POF caused by CTX，and the mechanism may be related to the activation of Akt/mTOR signaling pathway to exert antioxidant effects to alleviate the apoptosis of GCs in POF model mice.

To explore the effect of Wenyang Zhenshuai Granule（温阳振衰颗粒）medicated serum on adriamycin induced H9C2 myocardial cell injury based on long non-coding RNAs（LncRNA）metastasis associated lung adenocarcinoma transcript 1（malat-1）/microRNA-133（miR-133）pathway regulating p-ERK1/2.

H9C2 myocardial cell injury model was established by coculture with 2.67μmol/L adriamycin（ADR）for 45 h and set up a normal control group，a normal＋W group（W：Wenyang Zhenshuai Granule medicated serum），an miR-133 overexpression group，an miR-133 overexpression＋W group，an ADR group，an ADR ＋W group，an ADR ＋miR-133 overexpression group，and an ADR ＋miR-133 overexpression＋W group. The cell proliferative activity was detected by MTT method，while the change of N-terminal B-type brain natriuretic peptide precursor（NT-proBNP）was detected by ELISA. The contents of lncRNA malat-1，miR-133 and ERK1/2 mRNA in H9C2 cardiomyocytes of each group were detected by RT-PCR. The protein expressions of ERK1/2 and p-ERK1/2 were detected by Western-blot.

The myocardial cell activities in the ADR group，the ADR＋miR-133 overexpression group，the ADR＋W group，the ADR＋miR-133 overexpression＋W group，the normal control group，the miR-133 overexpression group，the normal＋W group and the miR-133 overexpression＋W group were increased in sequence（P<0.05）. The content of NT-proBNP was decreased in sequence（P<0.05）. After the experiment，there was no significant difference in ERK1/2 mRNA expression in myocardial cells among different groups（P>0.05）. The expression of the miR-133 in ADR group，the ADR＋miR-133 overexpression group，the ADR＋W group，the ADR＋miR-133 overexpression＋W group，the normal control group，the miR-133 overexpression group，the normal＋W group and the miR-133 overexpression＋W group increased in sequence（P<0.05）. The expression of LncRNA malat-1 was decreased in sequence（P<0.05）. There was no significant difference in ERK1/2 protein expression in myocardial cells among different groups after the experiment（P>0.05）. The p-ERK1/2 protein expression levels in the ADR group，the ADR＋W group，the ADR＋miR-133 overexpression group，the ADR＋miR-133 overexpression＋W group，the normal control group，the miR-133 overexpression group，the normal＋W group and the miR-133 overexpression＋W group were decreased in sequence（P<0.05）.

Wenyang Zhenshuai Granule medicated serum can reduce the expression of p-ERK1/2 protein in myocardial cells and exert the curative effect on chronic heart failure，which may be achieved by regulating the lncRNA malat-1/miR-133 pathway in myocardial cells.