Latest ArticlesQizhi Weitong Granule（气滞胃痛颗粒）is the exclusive Chinese patent medicine of Liaoning Huarun Benxi Third Pharmaceutical Co.，Ltd.It is modified from the classic prescription Sini Powder（四逆散），which has the effect of soothing liver，regulating Qi and relieving stomach pain.Years of clinical use have proven its good therapeutic efficacy and high safety.To further deepen the clinical application of Qizhi Weitong Granule and clarify its advantages and safety，this consensus follows the compilation process of expert consensus on the clinical application of Chinese patent medicines by the China Association of Chinese Medicine.Finally，11 consensus recommendations are formulated，clarifying the pharmacological effects，core indications for clinical application，indications，dosage and administration，treatment duration，adverse reactions，precautions and other aspects of Qizhi Weitong Granules.This consensus has been reviewed and approved by the China Association of Chinese Medicine and published in August 2024（document number：GS/CACM361-2024）.
To optimize the fermentation conditions of Fupenzi（Rubi Fructus）by Lactobacillus plantarum using Fupenzi（Rubi Fructus）as the raw material.
Taking the ratio of material to liquid，inoculation amount，sugar addition amount and fermentation time as the investigation factors，and the contents of total flavonoids and total phenols as the evaluation indexes，the single factor and orthogonal experiments were designed to screen the optimum process conditions for the fermentation of Fupenzi（Rubi Fructus）by Lactobacillus plantarum，and the characteristic volatile flavor substances before and after fermentation were analyzed.
The optimum conditions for the fermentation of Fupenzi（Rubi Fructus）by Lactobacillus plantarum were as follows：solid-liquid ratio 1：25 g/mL，inoculation amount8%，sugar addition amount2%，fermentation time 24 h. A total of 52 volatile flavor substances were detected in the samples before and after fermentation，including 8 type of alcohols，4 type of ketones，12 type of aldehydes，7 type of acids，7 type of esters，6 type of alkanes，3 type of phenols and 6 type of other substances.
Fermentation can effectively improve the flavor and nutritional value of Fupenzi（Rubi Fructus）.
Non alcoholic fatty liver disease（NAFLD）has become the most common chronic liver disease in the world. The incidence rate is increasing year by year. In addition to causing serious damage to the liver itself，it is also an independent risk factor for systemic metabolic diseases and cardiovascular and cerebrovascular diseases. Autophagy is an important self-protection mechanism in the pathogenesis of NAFLD. According to the concept of“analogical analogy”in traditional Chinese medicine，it is believed that the pathogenesis of NAFLD caused by“Yang deficiency and Yin excess”is similar to that caused by autophagy. Therefore，this article analyzed the relationship between Yin-Yang and autophagy in NAFLD from the aspects of physiology，pathology，diagnosis and treatment. Exploring the micro level application of autophagy and the connection between Yin and Yang in traditional Chinese medicine to induce the restoration of“Yin-Yang balance”of the body and guide the treatment of NAFLD，that is，restoring autophagy function（Yang）and reducing lipid droplet deposition（phlegm dampness，blood stasis and other Yin pathogens），providing reference for theoretical research，clinical prevention and treatment of this disease.
To analyze the effect of ursolic acid on the expressions of long chain non coding RNA（lncRNA）-LINC01089 and its targetgenes in papillary thyroid carcinoma（PTC）.
LINC01089 was a differentially expressed lncRNA that was previously screened and verified by transcriptome sequencing in the early stage. TPC-1 cells and normal human thyroid cells（Nthy-ori3-1）were routinely cultured in vitro and were divided into normal human thyroid cell group，control group and UA groups（10，20，40 μmol·L-1）. The survival rate of TPC-1 cells in each group was detected by CCK-8 assays. Scratch and Transwell experiments were conducted to investigate the effects of different concentrations of ursolic acid on the horizontal，vertical migration and invasion of TPC-1 cells. RT qPCRmethod was used to detect the relative expression level of LINC01089 in TPC-1 cells and the intervention effect of ursolic acid. RT-qPCR and Western blot were used to detect the mRNA and protein expression levels of target genes Ras Homolog Family Member F（RHOF）and 4-Hydroxyphenylpyruvate Dioxygenase（HPD）as well as the intervention effectof ursolic acid.
Different concentrations of UA（10，20，40 and 80 μmol·L-1）could inhibit the proliferation of TPC-1 cells for different periods of time（12～48 hours）. When the concentration of ursolic acid was 10～40 μmol·L-1，the inhibitory effect of the cells gradually increased with increasing of concentration and prolongation of action time within 12 and 24 hours（P<0.05）. After treating TPC-1 cells with ursolic acid for 24 hours，the cell proliferation was slow，and as the concentration of ursolic acid（10，20 and 40 μmol·L-1）increased，morphological changed in cell apoptosis. Compared with the control group，the ursolic acid（10，20，40 μmol·L-1）groups inhibited the migration and invasion of TPC-1 cells in a significant concentration dependent manner（P<0.01）. Ursolic acid can up-regulate the expression of LINC01089，and down-regulate themRNA and protein expression levels of RHOF and HPD.
Ursolic acid has a certain inhibitory effect on thyroid papillary carcinoma cells，and its mechanism may be related with the LINC01089 and its target gene RHOF.
Millimeter wave radar and traditional Chinese medicine observation have the same non-inductive observation in common. Existing studies have confirmed that the application of millimeter wave radar in medicine can detect the two vital signs of breathing and heart rate. In addition to breathing and heart rate，it also can identify human movements and other signals through ranging and speed measurement. Based on the principles of millimeter wave radar such as angle measurement，distance measurement and recognition of human vital signs，this paper discussed the relationship between the detected signals and the eight aspects of observation such as spirit，color，body，state，complexion，eyes，emotions and breath，and made theoretical innovations based on millimeter wave radar and various technologies to detect and sense human physical signs displayed outside，in the hope of contributing to the accurate judgment and rapid diagnosis of diseases in clinic.
This study explored the application of the Segment Anything Model（SAM）series in digitalizing traditional Chinese medicine（TCM）inspection diagnosis research，aiming to reduce extensive manual annotation required for specific part segmentation models of tongue，face，eye，and hand under TCM theoretical guidance.
First，the Fast Segment Anything Model（Fast SAM）was used to perform unsupervised segmentation on images of the tongue，face and eyes. The evaluation of its ability to fully segment these areas indicated that FastSAM is highly effective in isolating the specific regions needed for TCM diagnostics. Secondly，SAM used with bounding box prompts，can compensate for Fast SAM＇s suboptimal performance in segmenting finer details such as cracks in the tongue，the forehead on the face，blood vessels in the eyes，and fingernails on the hands.
FastSAM achieved Intersection over Union（IOU）values exceeding 0.9 for both the tongue and facial areas，and over 0.8 for the ocular area，indicating its good performance in overall or partial image segmentation. Additionally，SAM demonstrated the excellent segmentation results for detailed areas that Fast SAM cannot handle.
The SAM series of models offers a novel segmentation approach for the subsequent analysis of image features in TCM inspection guided by TCM theory. It enables zeroshot segmentation of various TCM inspection images across different dimensions，potentially significantly reducing the manual annotation workload for TCM inspection image features. At the same time，it effectively enhances the accuracy and reliability of TCM inspection.
Spleen is the acquired foundation and the source of Qi-blood biochemistry. Qi deficiency of spleen will lead to the dysregulation of body transportation and metabolic disorders，resulting in type 2 diabetes（T2DM）. Previous studies of the research group believes that spleen is related to sweet taste，that is，spleen can“store essence in spleen”through the intervention of sweet drugs，so as to improve the symptoms of T2DM. It is known that sweet compounds activate sweet taste receptors in taste buds in the oral cavity. In order to further explore the correlation between sweet taste receptors and the application of spleen in the treatment of T2DM，the role of sweet taste receptors in T2DM was systematically reviewed by combining the bibliometrics method，and the scientific connotation of spleen in taste was explained from the perspective of sweet taste receptors. It fully embodies the application basis of treating T2DM from spleen from the perspective of the theories that sweet taste drugs can treat spleen diseases，spleen is related to sweet taste，sweet taste drugs can nourish spleen，sweet taste drugs can treat T2DM and so on.
As a rare animal traditional Chinese medicine，Tubiechong（Eupolyphaga Steleophaga）has been commonly used in clinical practice，which is the essentialmedicine of ancient doctors to promote blood circulation and treat injury. It has the effect of breaking blood and removing blood stasis，and reinforcing tendons and setting bones. The processing of Tubiechong（Eupolyphaga Steleophaga）has a long history，and it was recorded as early as in the Han Dynasty. There were more than 10 processing methods，such as stir-frying，baking，lime and so on after Han Dynasty. Tubiechong（Eupolyphaga Steleophaga）hasmild toxicity. After processing，it can reduce toxicity，correctodor and flavor，facilitate pulverization and clinicalapplication. Modern studies have shown that the main chemical components of Tubiechong（Eupolyphaga Steleophaga）include protein polypeptides，nucleosides，fatty acids，phenylpropanoids，alkaloids and other compounds，which have anti-coagulant，anti-thrombotic，anti-tumor and analgesia effects and so on. This paper reviewed the processing history evolution，chemical constituents and pharmacological effects of Tubiechong（Eupolyphaga Steleophaga）by referring to herbs，medical books and related literature in the past dynasties，in order to lay a foundation for the clinical rational drug use of Tubiechong（Eupolyphaga Steleophaga）of different processing specifications，the improvement of the standards of decoction pieces and the functional core substances and other related research.
To optimize the extraction and inclusion technology of the mixed volatile oil of Foshou（Citri Sarcodactylis Fructus），Xiangyuan（Citri Fructus），Chenpi（Citri Reticulatae Pericarpium）and Bohe（Menthae Haplocalycis Herba）.
Under the guidance of the quality by design concept，the key process parameters of volatile oil extraction were qualitatively and quantitatively screened using fishbone diagram，failuremodel and effect analysis respectively，and the extraction process of mixed volatile oilwas optimized using single factor test combined with Box-Behnken response surface test. The extraction rate，contents of D-limonene，γ-terpinene and L-menthol of volatile oilwere scored by Analytic Hierarchy Process（AHP）-entropy weight method，and the space of extraction process design was established. Single factor testand orthogonal testwere used to optimize the inclusion process of volatile oil and characterize its inclusion compounds.
The extraction time，water adding ratio and soaking time were the key parameters，and the extraction time was4.5-5 h，water adding ratio was 8.8-10 times and soaking time was 44-60 min. The optimal process of inclusion of volatile oil included the inclusion time of2.5 h，the ratio ofβ-cyclodextrin to volatile oil of12∶1 g/mL and the inclusion temperature of30℃.
The extraction and inclusion process of the volatile oil from the mixture of Foshou（Citri Sarcodactylis Fructus），Xiangyuan（Citri Fructus），Chenpi（Citri Reticulatae Pericarpium）and Bohe（Menthae Haplocalycis Herba）is stable and reliable based on the quality by design concept and AHP-entropy weightmethod，which provides an experimental basis for the subsequent development and industrial production of related preparations.
Honghua（Carthamus tinctorius L.）is amedicinal and edible herb of Composite family. It has the effects of promoting blood circulation andmenstruation，removing blood stasis and relieving pain. So far，a variety of chemical components have been isolated from Honghua（Carthamus tinctorius L.），involving flavonoids，alkaloids，polyacetylene，spermidine，polysaccharides and inorganic elements，among which flavonoids are themost. It has various pharmacological activities such as anti cardiovascular，immune regulation，anti-inflammatory and analgesic，anti-tumor and antioxidant effect，etc. Honghua（Carthamus tinctorius L.）polysaccharide is one of themain pharmacological components of Honghua（Carthamus tinctorius L.）. Ithas pharmacological activities such as immune regulation，anti-tumor，antioxidant，etc.，with themost prominentanti-tumor effect，and has potential research and developmentvalue. Therefore，the present study elucidated the extraction process，isolation and purification，structural characterization，pharmacological activity and molecular mechanism，in which，the structural characterization of Honghua（Carthamus tinctorius L.）polysaccharides was described in detail. Meanwhile，the in vivo，in vitro and clinical bioactivities of saffron polysaccharides were reviewed，and the possiblemechanisms of their bioactivities were discussed. Finally，a new outlook for future research is presented. In conclusion，this paper reviewed the research progress on the extraction，purification，structural characterization，bioactivity and pharmacological application of Honghua（Carthamus tinctorius L.）polysaccharides，and provided new valuable insights for future research on Honghua（Carthamus tinctorius L.）polysaccharides，aswell as a reference for the utilization of the chemical components of Honghua（Carthamus tinctorius L.）polysaccharide resources.
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