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Optimized Extraction and Inclusion Process of Volatile Oil from Foshou（Citri Sarcodactylis Fructus），Xiangyuan（Citri Fructus），Chenpi（Citri Reticulatae Pericarpium）and Bohe（Menthae Haplocalycis Herba）Based on Quality by Design Concept and AHP-entropy Weight Method
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Chang SU1, 2, Yangli GENG1, 2, Xiaojing NIU2, 3, Yanrao WU2, 3, Liran XU2, 3, Xiaoying DUAN2, 3
Chinese Archives of Traditional Chinese Medicine | 2025, 43(9) : 42 - 49
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Chinese Archives of Traditional Chinese Medicine | 2025, 43(9): 42-49
• Target on National Project •
Optimized Extraction and Inclusion Process of Volatile Oil from Foshou（Citri Sarcodactylis Fructus），Xiangyuan（Citri Fructus），Chenpi（Citri Reticulatae Pericarpium）and Bohe（Menthae Haplocalycis Herba）Based on Quality by Design Concept and AHP-entropy Weight Method
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Chang SU1, 2, Yangli GENG1, 2, Xiaojing NIU2, 3, Yanrao WU2, 3, Liran XU2, 3, Xiaoying DUAN2, 3
Affiliations
  • 1.Henan University of Chinese Medicine，Zhengzhou 450046，Henan，China
  • 2.Department of Pharmacy，The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450003，Henan，China
  • 3.Henan Provincial Research Center for Clinical Application，Evaluation and Transformation of Traditional Chinese Medicine，Henan Provincial Key Laboratory of Traditional Chinese Medicine Clinical Pharmacy，Zhengzhou 450003，Henan，China
Published: 2025-09-10 doi: 10.13193/j.issn.1673-7717.2025.09.008
Outline
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Objective

To optimize the extraction and inclusion technology of the mixed volatile oil of Foshou（Citri Sarcodactylis Fructus），Xiangyuan（Citri Fructus），Chenpi（Citri Reticulatae Pericarpium）and Bohe（Menthae Haplocalycis Herba）.

Method

Under the guidance of the quality by design concept，the key process parameters of volatile oil extraction were qualitatively and quantitatively screened using fishbone diagram，failuremodel and effect analysis respectively，and the extraction process of mixed volatile oilwas optimized using single factor test combined with Box-Behnken response surface test. The extraction rate，contents of D-limonene，γ-terpinene and L-menthol of volatile oilwere scored by Analytic Hierarchy Process（AHP）-entropy weight method，and the space of extraction process design was established. Single factor testand orthogonal testwere used to optimize the inclusion process of volatile oil and characterize its inclusion compounds.

Results

The extraction time，water adding ratio and soaking time were the key parameters，and the extraction time was4.5-5 h，water adding ratio was 8.8-10 times and soaking time was 44-60 min. The optimal process of inclusion of volatile oil included the inclusion time of2.5 h，the ratio ofβ-cyclodextrin to volatile oil of12∶1 g/mL and the inclusion temperature of30℃.

Conclusion

The extraction and inclusion process of the volatile oil from the mixture of Foshou（Citri Sarcodactylis Fructus），Xiangyuan（Citri Fructus），Chenpi（Citri Reticulatae Pericarpium）and Bohe（Menthae Haplocalycis Herba）is stable and reliable based on the quality by design concept and AHP-entropy weightmethod，which provides an experimental basis for the subsequent development and industrial production of related preparations.

quality by design  /  AHP-entropy weightmethod  /  volatile oil  /  extraction process  /  inclusion process
苏畅, 耿阳丽, 牛晓静, 吴延娆, 徐立然, 段晓颖. 基于质量源于设计理念与AHP-熵权法优化佛手、香橼、陈皮、薄荷挥发油提取与包合工艺. 中华中医药学刊, 2025 , 43 (9) : 42 -49 . DOI: 10.13193/j.issn.1673-7717.2025.09.008
Chang SU, Yangli GENG, Xiaojing NIU, Yanrao WU, Liran XU, Xiaoying DUAN. Optimized Extraction and Inclusion Process of Volatile Oil from Foshou（Citri Sarcodactylis Fructus），Xiangyuan（Citri Fructus），Chenpi（Citri Reticulatae Pericarpium）and Bohe（Menthae Haplocalycis Herba）Based on Quality by Design Concept and AHP-entropy Weight Method[J]. Chinese Archives of Traditional Chinese Medicine, 2025 , 43 (9) : 42 -49 . DOI: 10.13193/j.issn.1673-7717.2025.09.008
Appendix
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Year 2025 volume 43 Issue 9
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Article Info
doi: 10.13193/j.issn.1673-7717.2025.09.008
  • Online Date：2026-10-30
  • Published：2025-09-10
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Affiliations
    1.Henan University of Chinese Medicine，Zhengzhou 450046，Henan，China
    2.Department of Pharmacy，The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450003，Henan，China
    3.Henan Provincial Research Center for Clinical Application，Evaluation and Transformation of Traditional Chinese Medicine，Henan Provincial Key Laboratory of Traditional Chinese Medicine Clinical Pharmacy，Zhengzhou 450003，Henan，China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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