Latest ArticlesChaihu(Bupleuri Radix),as a commonly used Chinese medicinal herb,has the effects of relieving fever,soothing liver and relieving depression,lifting Yangqi,clearing gallbladder and intercepting malaria. It mainly contains saponins,flavonoids,polysaccharides,coumarins and other components,which have many pharmacological activities such as anti-inflammatory,analgesic,antidepressant,anti-tumor,anti-fibrosis and hypolipidemic effects. In the process of sorting out the relevant ancient books and processing specifications,it is found that Chaihu(Bupleuri Radix)has formed many processed varieties in the long history of medicine. However,the modern research mostly focuses on the raw products and vinegar-processed varieties of Chaihu(Bupleuri Radix),and in recent years,the research focus is also mainly on gene expression and Chaihu(Bupleuri Radix)prescription. By analyzing the literature research carried out in recent years,this paper summarized the herbal research,chemical composition and pharmacological effects to provide a reference for further exploration of the pharmacological effects and mechanisms of Chaihu(Bupleuri Radix)and its processed products.
To explore the effect of Xiaofeng Powder(消风散),Ermiao Powder(二妙散)and Miconazole Nitrate on inflammatory factors and prognosis in patients with mycotic external otitis.
From August 2021 to August 2023,98 patients with mycotic external otitis were selected and divided into two groups with random number table method,49 cases in each. The control group was treated with Miconazole Nitrate,and the research group was treated with Xiaofeng Powder and Ermiao Powder combined with Miconazole Nitrate for 14 days. The clinical efficacy,incidence of adverse reactions,TCM syndrome scores and hearing level[bone conduction threshold(BC),air conduction threshold(AC),air conduction difference(ABG)],the levels of inflammatory factors[interleukin-2(IL-2),transforming growth factor-beta1(TGF-β1),interleukin-8(IL-8)]before and after 14 days of treatment were compared between the two groups. After followed up for 1 and 3 months after treatment,the recurrence rate of the two groups was counted.
The total effective rate of treatment in the study group(91.84%,45/49)was higher than that in the control group(71.43%,35/49)(P<0.05). The scores of ear itching,ear bloating and ear canal drainage in the study group were lower than those of the control group after 14 days of treatment(P<0.05). After 14 days of treatment,the levels of serum IL-8,IL-2 and TGF-β1 in the study group were lower than those in the control group(P<0.05). After 14 days of treatment,the values of BC,AC and ABG of the study group were lower than those of the control group(P<0.05). Compared with that of the control group(10.20%,5/49),the incidence of adverse reactions in the study group(8.16%,4/49)was not statistically significant(P>0.05). Compared with those of the control group[2.86%(1/35)、11.43%(4/35)],the recurrence rates[0.00%(0/44)、4.55%(2/44)]of the study group during the follow-up were not statistically significant(P>0.05).
Xiaofeng Powder combined with Ermiao Powder combined with Miconazole Nitrate has a significant effect on the treatment of patients with mycotic external otitis. It can effectively reduce the levels of inflammatory factors,improve the clinical symptoms and hearing level of patients,and has certain safety.
Atherosclerosis(AS)is a chronic vasculitis disease,which is the main pathological basis of cardiovascular and cerebrovascular diseases. The occurrence and development of AS involve various pathological mechanisms such as inflammatory response,oxidative stress,lipid infiltration,dysfunction of vascular endothelial cells,proliferation of vascular smooth muscle cells,macrophage polarization and imbalance of autophagy homeostasis. Sanqi(Notoginseng Radix et Rhizoma)is one of the traditional Chinese medicines for promoting blood circulation and removing blood stasis. The combination of Sanqi(Notoginseng Radix et Rhizoma)and multiple traditional Chinese medicines is commonly used in clinical practice for the treatment of AS,with definite therapeutic effects. Modern pharmacology shows that the active ingredients of Sanqi(Notoginseng Radix et Rhizoma)mainly include saponins,Panax notoginseng saponins,flavonoids,etc. As a saponin class,Panax notoginseng saponins(PNS)are important indicators for evaluating the quality of Sanqi(Notoginseng Radix et Rhizoma)and the main material basis for exerting pharmacological effects. It contains multiple monomers and has been proven to have various pharmacological effects such as anti-AS and improving cerebral ischemia-reperfusion injury. This article analyzed the pharmacological effects of the active ingredients of Sanqi(Notoginseng Radix et Rhizoma)and its anti-AS pharmacological mechanisms,summarized the mechanism of action of commonly used clinical anti-AS formulas of Sanqi(Notoginseng Radix et Rhizoma),and explored the impact of Sanqi(Notoginseng Radix et Rhizoma)processing methods on its anti-AS effects,in order to provide reference for better application of Sanqi(Notoginseng Radix et Rhizoma)in the treatment of AS and in-depth pharmacological research.
To study the therapeutic effect of Yishen Tiaojing Decoction(益肾调经方)on kidney deficiency type of hypomenorrhea based on“consolidating basis and cultivating primordial Qi”theory of Xin’an physicians.
A total of 116 patients with hypomenorrhea were selected and divided into observation group(58 cases)and control group(58 cases)by the random number table method. The control group received conventional western medicine treatment,and the observation group was given conventional western medicine combined with Yishen Tiaojing Decoction,and both groups were treated for 3 courses with 1 menstrual cycle as 1 course of treatment. The clinical efficacy after treatment,TCM syndromes scores,pictorial blood loss assessment chart(PBAC)score,sex hormones[follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),progesterone(P)]and uterine spiral artery blood flow parameters[arterial pulsatility index(PI),resistance index(RI),peak systolic velocity(PSV)]before and after treatment were compared between the two groups,and the safety was analyzed in both groups.
The clinical efficacy in the observation group was 84.48%(49/58),which was higher than that(68.97%,40/58)in the control group(P<0.05). After treatment,the scores of TCM syndromes and total score,the levels of serum FSH and LH,the values of PI and RI were decreased in both groups,and the above indicators were lower in the observation group(all P<0.05). The menstrual period,PBAC score,the levels of serum E2 and P and the value of PSV in both groups after treatment were significantly increased(P<0.05),and the observation group had longer or higher indicators(all P<0.05). The incidence rate of adverse reactions revealed no statistical difference between observation group(10.34%,6/58)and control group(8.62%,5/58)(P>0.05).
Based on“consolidating basis and cultivating primordial Qi”theory of Xin’an physicians,the application of Yishen Tiaojing Decoction in the treatment of patients with kidney deficiency type of hypomenorrhea is beneficial to improving the sex hormone secretion,regulating the uterine spiral artery blood flow parameters and effectively relieving the symptoms such as few menstruations volume,and the therapy has certain safety.
Ischemic stroke,a prevalent type of cerebrovascular disease,is marked by high incidence and mortality rates,with an alarming trend towards younger demographics in China. In this context,tanshinone ⅡA and tetramethylpyrazine have garnered research attention for their multifaceted therapeutic effects and minimal side effects in treating ischemic stroke. These two traditional Chinese medicinal compounds exhibit similar biological effects,including antioxidant,anti-inflammatory,anti-apoptotic properties,protecting blood-brain barrier and promoting neovascularization effects. They also protect the nervous system by modulating key signaling pathways such as Nrf2/HO-1,NF-κB and PI3K/Akt. Clinical studies have demonstrated significant efficacy and good safety profiles for tanshinone ⅡA and tetramethylpyrazine injections in the treatment of stroke. This article aimed to synthesize the research advancements of tanshinone ⅡA and tetramethylpyrazine in ischemic stroke therapy,offering new perspectives for drug development,mechanistic research and treatment strategies for ischemic stroke.
To investigate the effects of Modified Wuling Powder(五苓散加味)combined with transurethral resection of prostate(TURP)on factors related to urodynamics and tissue pathological reconstitution in patients with benign prostatic hyperplasia(BPH).
A total of 110 patients with BPH were treated in the hospital from June 2022 to August 2023,and were divided into the control group and the experimental group,with 55 cases in each group,using random number table method. The control group was treated with TURP,and the experimental group was treated with Modified Wuling Powder on the basis of TURP for a total of 4 weeks. The urodynamics,the factors related to tissue pathological reconstruction and traditional Chinese medicine syndrome scores of two groups before treatment and 4 weeks after treatment were compared,and the efficacy was evaluated 4 weeks after treatment and the occurrence of adverse reactions 4 weeks after surgery were compared.
Compared with those before treatment,after 4 weeks of treatment,the levels of slender urine dribbling,urethral astringency pain,frequent urinate,lower abdominal distension pain,dry stool,bitter mouth yellow score,maximumurination pressure(Pves),serum vascular endothelial growth factor(VEGF),transforming growth factor-β1(TGF-β1),connective tissue growth factor(CTGF)and fibronectin 1(FN1)in two groups decreased,and those in the experimental group were lower(P<0.05). Compared with those before treatment,after 4 weeks of treatment,the bladder volume and maximum urinaryflow rate(Qmax)of the two groups increased,and they were higher in the experimental group(P<0.05). The total effective rate of the experimental group was 74.07%(40/54),higher than that of the control group(90.38%,47/52)after 4 weeks of treatment(P<0.05). Four weeks after surgery,there was no significant difference in the incidence of adverse reactions between the two groups[13.46%(7/52)vs 7.41%(4/54)](P<0.05).
Modified Wuling Powder combined TURP can regulate the expressions of VEGF,TGF-β1,CTGF,FN1 and other factors related to tissue pathological reconstitution in BPH patients,improve the urodynamics,reduce the traditional Chinese medicine syndrome scores,and has accurate efficacy without increasing safety risk.
To explore the influence of Modified Shaoyao Gancao Decoction(加味芍药甘草汤)combined with estradiol valerate tablets in the treatment of mild intrauterine adhesion(IUA)on microinflammatory state and sex hormones levels.
A total of 92 patients with mild IUA as the research subjects. According to the random number method,they were divided into control group and observation group,with 46 cases in each group. The control group was treated with estradiol valerate tablets,while the observation group was given Modified Shaoyao Gancao Decoction on the basis of the control group. The clinical efficacy,TCM syndrome scores,uterine examination indexes(endometrial thickness,endometrial volume),hemodynamic indexes[endometrial spiral artery resistance index(RI),pulsatility index(PI)],matrix metalloproteinase(MMP)-2,MMP-3,MMP-9,inflammatory factors[transforming growth factor(TGF)-β1,tumor necrosis factor(TNF)-α,interleukin(IL)-6]and sex hormones[estradiol(E2),luteinizing hormone(LH)]before and after treatment were compared between both groups.
After treatment,the total effective rate in the observation group was higher than that in the control group(P<0.05). The TCM syndrome scores and levels of TGF-β1,TNF-α,IL-6 and LH in both groups were decreased,and the decreases in the observation group were higher than those in the control group(all P<0.05). The endometrial thickness,endometrial volume,PI,RI and levels of MMP-2,MMP-3,MMP-9,E2 and LH were increased in the two groups,and the increases were higher in the observation group than those in the control group(all P<0.05).
Modified Shaoyao Gancao Decoction combined with estradiol valerate tablets can effectively improve the clinical symptoms,uterine morphology and hemodynamic indexes in the treatment of mild IUA,and it has exact efficacy,and the role mechanism is related to the regulations of expressions of matrix metalloproteinases,inflammatory factors and sex hormones.
To analyze the effects of folic acid and vitamin B12 combined with Huangqi Shengmai Decoction(黄芪生脉饮)on homocysteine(Hcy),C-reactive protein(CRP),nerve function and vascular endothelial function in patients with acute cerebral infarction(ACI).
A total of 113 ACI patients admitted to the hospital from January 2018 to January 2022 were selected and divided into two groups using a random number table method. The control group(48 cases)were treated with conventional therapy plus folic acid combined with vitamin B12,and the observation group(65 cases)were treated with Huangqi Shengmai Decoction on the basis of the control group. The levels of Hcy and CRP,National Institutes of Health Stroke Scale(NIHSS)score,the activity of daily living Barthel index score,the levels of vascular endothelial function indicators[nitric oxide(NO),endothelin-1(ET-1),vascular endothelial growth factor(VEGF)],the cerebral blood perfusion level and the vascular endothelium before and after treatment were statistically analyzed in the two groups.
After treatment,the serum levels of Hcy and CRP in the two groups were significantly decreased(P<0.001). The serum Hcy and CRP levels in the observation group after treatment were significantly lower than those in the control group,and the difference was statistically significant(P<0.01). After treatment,NIHSS score decreased significantly(P<0.001)and Barthel index score increased significantly(P<0.001). There was a statistically significant difference between the observation group and the control group in NIHSS score and Barthel index score after treatment(P<0.01). After treatment,the levels of NO in the two groups were significantly increased(P<0.001)while the levels of ET-1 and VEGF were significantly decreased(P<0.001). There were statistically significant differences in the levels of NO,ET-1 and VEGF between the observation group and the control group after treatment(P<0.01). After treatment,the levels of CRP,interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in the observation group were significantly lower than those in the control group(P<0.05). The activated partial thromboplastin time(aPTT),prothrombin time(PT)and D-dimer(D-D)in the observation group after treatment were higher than those before treatment and the control group at the same period(P<0.05),and the FIB was lower than that in the control group before treatment and the control group at the same period(P<0.05). The values of cerebral blood volume(CBV)and cerebral blood flow(CBF)in the observation group were significantly higher than those in the control group after treatment,and the difference was statistically significant(P<0.05). After treatment,the levels of NO,ET-1 and VEGF in the observation group were significantly better than those in the control group,and the differences were statistically significant(P<0.05).
Folic acid and vitamin B12 combined with Huangqi Shengmai Decoction can effectively improve the nerve function,vascular endothelial function,immune function and coagulation function of ACI patients,reduce the risk of cerebral infarction recurrence,and improve the quality of life of patients,which is worthy of clinical application.
To study the clinical effect of Lianqin Huashi Formula(连芩化湿方)combined with acupuncture on Helicobacter pylori(Hp)-positive chronic non-atrophic gastritis.
A total of 64 patients with Hp-positive chronic non-atrophic gastritis admitted to the Department of Acupuncture and Physiotherapy of the hospital from January 2022 to January 2024 were included in the study group. The patients were divided into study group and reference group by random number table method,32 patients in each group. The reference group was given the quadruple therapy with standard bismuth agent. The study group was given the standard bismuth quadruple therapy combined with Lianqin Huashi Formula and acupuncture treatment. The clinical effects,Hp conversion rate,TCM symptom scores(epigastric pain and burning,cacoic acid reflux,halitosis and mouth stickiness,nausea and thirst)of each group were compared,and motilin(MOT)and gastrointestinal hormone indexes such as MOT and gastrin(GAS)were changed to understand the changes in gastrointestinal function of patients,the changes in interleukin-8(IL-8)levels were assessed to understand the inflammatory status of patients,and the adverse reactions of treatment in each group were observed.
The total effective rate of the study group was 96.88%(31/32),which was significantly higher than that of the reference group(78.13%,25/32)(P<0.05). Compared with that of the reference group(78.13%,25/32),the Hp negative conversion rate of the study group(96.88%,31/32)was higher(P<0.05). The adverse reaction rate of the study group was 6.25%(2/32),which was significantly lower than that of the reference group(28.13%,9/32)(P<0.05). The comparison of epigastric pain,burning,cacogenic acid reflux,halitosis and sticky mouth,nausea and thirst,and the TCM syndrome scores,the levels of MOT,GAS and IL-8 in both groups before treatment was not significant(P>0.05). After treatment,TCM syndrome scores and the level of IL-8 significantly decreased,while the levels of MOT and GAS increased significantly. The improvement of various indexes in the study group after treatment was significantly better than that in the reference group(P<0.05).
The patients with Hp-positive chronic non-atrophic gastritis treated with Lianqin Huashi Formula combined with acupuncture obtain good effect. This treatment plan can better clear Hp infection,improve the clinical symptoms,promote the gastrointestinal function recovery,reduce the adverse reaction rate and improve the treatment safety,which is worthy of application.
To observe the effect of Modified Yinchen Zhizi Decoction(茵陈栀子加减方)combined with acupoint Tuina on the duration of jaundice,the serum bilirubin index and the levels of glutamic oxalic aminotransferase(AST)and alanine aminotransferase(AIT)in neonatal children with jaundice.
A total of 142 cases of neonatal jaundice admitted to the hospital from January 2020 to January 2022 were selected,and the patients were divided into control group(70 cases)and study group(72 cases)according to numerical random table method. The control group was given the routine treatment and Modified Yinchen Zhizi Decoction. The observation group was given Modified Yinchen Zhizi Decoction combined with acupoint Tuina treatment on the basis of control group. The first defecation time,jaundice duration,hospital stay and other clinical indexes were compared between the two groups after treatment. Serum bilirubin index,jaundice index and transcutaneous bilirubin index of the two groups were compared before and after treatment. The levels of AST and AIT before and after treatment were compared between the two groups. The adverse reactions such as drowsiness,nausea and vomiting,skin allergy and diarrhea were compared between the two groups during the treatment. The treatment satisfaction of the two groups was compared and observed.
The first defecation time,duration of jaundice,the length of hospital stay and the other clinical indexes in the study group were significantly better than those in the control group(P<0.05). After treatment,the serum bilirubin index,the jaundice index and transcutaneous bilirubin index in the study group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05). After treatment,the levels of AST and ALT in the study group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05). The incidence of adverse reactions such as drowsiness,nausea and vomiting,skin allergy and diarrhea in the study group was significantly lower than that in the control group,and the differences were statistically significant(P<0.05). The treatment satisfaction(94.44%,68/72)in the study group was significantly higher than that(81.43%,57/70)in the control group(P<0.05).
Modified Yinchen Zhizi Decoction combined with acupoint Tuina can obviously improve the duration of jaundice in neonatal children,effectively regulate the serum bilirubin and liver function indexes,and restore AST and AIT to normal levels,and the occurrence of adverse reactions is also low. It is worthy of clinical promotion and application.