To investigate the effects of Modified Wuling Powder（五苓散加味）combined with transurethral resection of prostate（TURP）on factors related to urodynamics and tissue pathological reconstitution in patients with benign prostatic hyperplasia（BPH）.

A total of 110 patients with BPH were treated in the hospital from June 2022 to August 2023，and were divided into the control group and the experimental group，with 55 cases in each group，using random number table method. The control group was treated with TURP，and the experimental group was treated with Modified Wuling Powder on the basis of TURP for a total of 4 weeks. The urodynamics，the factors related to tissue pathological reconstruction and traditional Chinese medicine syndrome scores of two groups before treatment and 4 weeks after treatment were compared，and the efficacy was evaluated 4 weeks after treatment and the occurrence of adverse reactions 4 weeks after surgery were compared.

Compared with those before treatment，after 4 weeks of treatment，the levels of slender urine dribbling，urethral astringency pain，frequent urinate，lower abdominal distension pain，dry stool，bitter mouth yellow score，maximumurination pressure（Pves），serum vascular endothelial growth factor（VEGF），transforming growth factor-β1（TGF-β1），connective tissue growth factor（CTGF）and fibronectin 1（FN1）in two groups decreased，and those in the experimental group were lower（P<0.05）. Compared with those before treatment，after 4 weeks of treatment，the bladder volume and maximum urinaryflow rate（Qmax）of the two groups increased，and they were higher in the experimental group（P<0.05）. The total effective rate of the experimental group was 74.07%（40/54），higher than that of the control group（90.38%，47/52）after 4 weeks of treatment（P<0.05）. Four weeks after surgery，there was no significant difference in the incidence of adverse reactions between the two groups［13.46%（7/52）vs 7.41%（4/54）］（P<0.05）.

Modified Wuling Powder combined TURP can regulate the expressions of VEGF，TGF-β1，CTGF，FN1 and other factors related to tissue pathological reconstitution in BPH patients，improve the urodynamics，reduce the traditional Chinese medicine syndrome scores，and has accurate efficacy without increasing safety risk.