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Pharmacological Effects and Clinical Application of Main Active Ingredients of Danshen（Salviae Miltiorrhizae Radix et Rhizoma）and Chuanxiong（Chuanxiong Rhizoma）in Treatment of Ischemic Stroke
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Qixiu WANG1, Wei ZHANG2, Hongfei ZHOU1, 2, Jun LIU2
Chinese Archives of Traditional Chinese Medicine | 2026, 44(1) : 208 - 214
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Chinese Archives of Traditional Chinese Medicine | 2026, 44(1): 208-214
• Platform of Provincial Project •
Pharmacological Effects and Clinical Application of Main Active Ingredients of Danshen（Salviae Miltiorrhizae Radix et Rhizoma）and Chuanxiong（Chuanxiong Rhizoma）in Treatment of Ischemic Stroke
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Qixiu WANG1, Wei ZHANG2, Hongfei ZHOU1, 2, Jun LIU2
Affiliations
  • 1.Liaoning University of Traditional Chinese Medicine, Shenyang 110847, Liaoning, China
  • 2.Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110032, Liaoning, China
Published: 2026-01-10 doi: 10.13193/j.issn.1673-7717.2026.01.040
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Ischemic stroke，a prevalent type of cerebrovascular disease，is marked by high incidence and mortality rates，with an alarming trend towards younger demographics in China. In this context，tanshinone ⅡA and tetramethylpyrazine have garnered research attention for their multifaceted therapeutic effects and minimal side effects in treating ischemic stroke. These two traditional Chinese medicinal compounds exhibit similar biological effects，including antioxidant，anti-inflammatory，anti-apoptotic properties，protecting blood-brain barrier and promoting neovascularization effects. They also protect the nervous system by modulating key signaling pathways such as Nrf2/HO-1，NF-κB and PI3K/Akt. Clinical studies have demonstrated significant efficacy and good safety profiles for tanshinone ⅡA and tetramethylpyrazine injections in the treatment of stroke. This article aimed to synthesize the research advancements of tanshinone ⅡA and tetramethylpyrazine in ischemic stroke therapy，offering new perspectives for drug development，mechanistic research and treatment strategies for ischemic stroke.

ischemic stroke  /  tanshinone ⅡA  /  tetramethylpyrazine  /  traditional Chinese medicine monomer
王启秀, 张威, 周鸿飞, 刘峻. 丹参川芎两药主要活性成分治疗缺血性脑卒中药理作用及临床应用研究. 中华中医药学刊, 2026 , 44 (1) : 208 -214 . DOI: 10.13193/j.issn.1673-7717.2026.01.040
Qixiu WANG, Wei ZHANG, Hongfei ZHOU, Jun LIU. Pharmacological Effects and Clinical Application of Main Active Ingredients of Danshen（Salviae Miltiorrhizae Radix et Rhizoma）and Chuanxiong（Chuanxiong Rhizoma）in Treatment of Ischemic Stroke[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (1) : 208 -214 . DOI: 10.13193/j.issn.1673-7717.2026.01.040
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Year 2026 volume 44 Issue 1
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doi: 10.13193/j.issn.1673-7717.2026.01.040
  • Online Date：2026-10-14
  • Published：2026-01-10
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Affiliations
    1.Liaoning University of Traditional Chinese Medicine, Shenyang 110847, Liaoning, China
    2.Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110032, Liaoning, China
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表12种不同金属材料的力学参数
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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