To explore the effect of Xiaofeng Powder（消风散），Ermiao Powder（二妙散）and Miconazole Nitrate on inflammatory factors and prognosis in patients with mycotic external otitis.

From August 2021 to August 2023，98 patients with mycotic external otitis were selected and divided into two groups with random number table method，49 cases in each. The control group was treated with Miconazole Nitrate，and the research group was treated with Xiaofeng Powder and Ermiao Powder combined with Miconazole Nitrate for 14 days. The clinical efficacy，incidence of adverse reactions，TCM syndrome scores and hearing level［bone conduction threshold（BC），air conduction threshold（AC），air conduction difference（ABG）］，the levels of inflammatory factors［interleukin-2（IL-2），transforming growth factor-beta1（TGF-β1），interleukin-8（IL-8）］before and after 14 days of treatment were compared between the two groups. After followed up for 1 and 3 months after treatment，the recurrence rate of the two groups was counted.

The total effective rate of treatment in the study group（91.84%，45/49）was higher than that in the control group（71.43%，35/49）（P<0.05）. The scores of ear itching，ear bloating and ear canal drainage in the study group were lower than those of the control group after 14 days of treatment（P<0.05）. After 14 days of treatment，the levels of serum IL-8，IL-2 and TGF-β1 in the study group were lower than those in the control group（P<0.05）. After 14 days of treatment，the values of BC，AC and ABG of the study group were lower than those of the control group（P<0.05）. Compared with that of the control group（10.20%，5/49），the incidence of adverse reactions in the study group（8.16%，4/49）was not statistically significant（P>0.05）. Compared with those of the control group［2.86%（1/35）、11.43%（4/35）］，the recurrence rates［0.00%（0/44）、4.55%（2/44）］of the study group during the follow-up were not statistically significant（P>0.05）.

Xiaofeng Powder combined with Ermiao Powder combined with Miconazole Nitrate has a significant effect on the treatment of patients with mycotic external otitis. It can effectively reduce the levels of inflammatory factors，improve the clinical symptoms and hearing level of patients，and has certain safety.