To investigate the clinical effect of Liujunzi Decoction（六君子汤）in the adjuvant treatment of children with bronchial asthma, and its effects on intestinal flora, corticotropin, corticosterone and microflora.

A total of 116 children with bronchial asthma admitted to the Department of Pediatrics of Jurong Hospital Affiliated to Jiangsu University from November 2022 to June 2024 were selected as the study objects. The patients were divided into two groups by random number table method, and 58 patients in the control group received conventional Western medicine treatment and those（58 patients）in the experimental group were treated with Liujunzi Decoction on the basis of conventional western medicine, all of whom were treated for 4 weeks. After treatment, the clinical effects, TCMsyndrome scores, intestinal flora, adrenocorticotropin and corticosterone before and after treatment were observed and compared between the two groups.

Compared with that（82.76%）of the control group, the overall curative effect was 96.55%（P<0.05）. Compared with those of the control group, the TCMsyndrome scores of the experimental group decreased more significantly（P<0.05）. Compared with those of the control group, the levels of corticotropin and corticosterone in the experimental group were lower（P<0.05）. Compared with those of the control group, bifidobacterium and lactobacillus in the experimental group were higher, and Escherichia coli was lower（P<0.05）. The detection rates of Staphylococcus aureus and Streptococcus virescens in the experimental group were lower than those in the control group（P<0.05）, and the detection rates of other bacteria groups were not statistically different between the two groups（P>0.05）.

After the adjuvant treatment of children with bronchial asthma with Liujunzi Decoction, the therapeutic effect is significantly improved, which can effectively improve the imbalance of intestinal flora and promote the recovery of children. It provides solid theoretical support for the clinical application of formulas and fosters the inheritance and innovation of traditional Chinese medicine.

To explore the effect of Guizhi Shaoyao Zhimu Decoction（桂枝芍药知母汤）combined with adalimumab on inflammatory response and blood viscosity in rheumatoid arthritis（RA）.

Seventy-two patients with RA of windcold-dampness type admitted to Shandong Wendeng Orthopedic Hospital from January 2021 to December 2023 were enrolled for the research and randomly divided into the control group（adalimumab treatment, 36 cases）and the experimental group（Modified Guizhi Shaoyao Zhimu Decoction combined with adalimumab treatment, 36 cases）. The blood levels of inflammatory indicators[tumor necrosis factor-α（TNF-α）, C-reactive protein（CRP）, interleukin-6（IL-6）, nod-like receptor protein3（NLRP3）], blood viscosity related indicators[whole blood viscosity-high shear, whole blood viscosity-low shear, plasma viscosity, fibrinogen（Fib）], traditional Chinese medicine syndrome scores, disease activity scale-28（DAS-28）, World Health Organization Quality of Life Test-Bref（WHOQOL-BREF）scores were compared between the experimental group and the control group before and 12 weeks after treatment.

There were no statistically significant differences in the general information and various indicators between the experimental group and the control group of RA patients before treatment（P>0.05）. Compared with those before treatment within the group, the blood levels of TNF-α, CRP, IL-6, NLRP3, whole blood viscosity-high shear, whole blood viscosity-low shear, plasma viscosity and Fib, traditional Chinese medicine syndrome score and DAS-28 score in two groups were significantly reduced, while the WHOQOL-BREF total score was significantly increased（P<0.05）. The blood levels of TNF-α, CRP, IL-6, NLRP3, whole blood viscosity-high shear, whole blood viscosity-low shear, plasma viscosity, Fib, Traditional Chinese Medicine syndrome score and DAS-28 score after treatment in experimental group were all significantly lower than those in the control group, while the total score of WHOQOL-BREF was significantly higher than that in the control group（P<0.05）.

Guizhi Shaoyao Zhimu Decoction combined with adalimumab treatment could significantly alleviate the inflammation and blood viscosity in RA patients with wind-cold-dampness type, improve traditional Chinese medicine syndromes, reduce the disease activity and improve the quality of life, which is worthy of promoting and applying.

To analyze the effects of Modified Buyang Huanwu Decoction（补阳还五汤加减）combined with consciousness-restoring and orifice-opening acupuncture on hemorheology and serum levels of interleukin-6（IL-6）and tumor necrosis factor-α（TNF-α） in patients with ischemic stroke in the convalescent period（Qi deficiency syndrome）.

From April 2022 to March 2024, 80 patients with ischemic stroke in the convalescent period who were admitted to rehabilitation medicine department of the hospital were selected and divided into the control group（4 weeks of conventional treatment with Modified Buyang Huanwu Decoction）and the observation group（4 weeks of combined treatment with Modified Buyang Huanwu Decoction and consciousness-restoring and orifice-opening acupuncture）using the random number table method, with 40 cases in each group. The TCMclinical effect, hemorheology[whole blood high-shear viscosity, whole blood low-shear viscosity, plasma viscosity and fibrinogen（FIB）], neurological function indicators[the National Institutes of Health Stroke Scale（NIHSS）, nerve growth factor（NGF）and brain-derived neurotrophic factor（BDNF）], serum levels of IL-6 and TNF-α, quality of life[Short Form 36（SF-36）]and the incidence of adverse reactions were compared between the groups.

The effective rate of treatment in the observation group（92.50%, 37/40）was higher than that in the control group（75.00%, 30/40）（P<0.05）. After treatment, the levels of whole blood high-shear viscosity, whole blood low-shear viscosity, plasma viscosity and FIB in the observation group were lower than those in the control group（P<0.05）. After treatment, NIHSS score of the observation group was lower than that of the control group, and the levels of NGF and BDNF were higher than those of the control group（P<0.05）. The serum levels of IL-6 and TNF-αin the observation group after 2 and 4 weeks of treatment were lower than those in the control group, while SF-36 scores were higher than those of the control group（P<0.05）. The incidence rates of adverse reactions in the two groups were 12.50%（5/40）and 10.00%（4/40）, without statistically significant difference between two groups（P>0.05）.

Applying Modified Buyang Huanwu Decoction combined with consciousness-restoring and orifice-opening acupuncture in the treatment of patients with Qi deficiency type of ischemic stroke in the convalescent period can significantly improve the clinical effect, hemorheology, serum levels of IL-6 and TNF-α, neurological function and quality of life. It is safe and reliable.

To investigate the effects of Shuangshen Decoction（双肾汤）on inflammatory factors, immune function and recurrence in children with purpura nephritis.

A hundred cases with purpura nephritis were randomly divided into the control group and the observation group, 50 cases in each group. Both groups were given glucocorticoid therapy, and the observation group was given Shuangshen Decoction simultaneously. The changes of syndrome scores, serum inflammatory factors and immune function were observed before and 12 weeks after treatment, and the recurrence of infection was followed up within 12 months.

There was no statistically significant difference in the scores of traditional Chinese medicine symptoms between the two groups before treatment（P>0.05）. The scores decreased at after treatment（P<0.05）and the decline degree in the observation group was greater than that in the control group（P<0.05）. There was no statistically significant difference in the serum tumor necrosis factor-α（TNF-α）, interleukin（IL）-6 or IL-10 between the two groups before treatment（P>0.05）. There were decreased after treatment（P<0.05）and the decline degree in the observation group was greater than that in the control group（P<0.05）. There was no statistically significant difference in the CD4⁺, CD8⁺, IgA, IgG or IgM between the two groups before treatment（P>0.05）. The levels of CD4⁺, IgA and IgG in the observation group were higher after treatment than those before treatment（P<0.05）, and it was higher than that of the control group after treatment（P<0.05）. The recurrence rate and infection rate of the observation group were 22.00%（11/50）and 34.00%（17/50）, which were lower than those of the control group[44.00%（22/50）and 62.00%（31/50）]（P<0.05）. The number of recurrence and infection in the observation group was lower than that in the control group（P<0.05）, and the therapeutic effect in the observation group was higher than that in the control group（P<0.05）.

Shuangshen Decoction in the treatment of children with purpura nephritis can help to alleviate symptoms, improve immune function and inflammatory response, and reduce infection and recurrence rate.

To observe the efficacy of Bailing Tablets（百令片）combined with conventional western medicine on connective tissue disease-related interstitial lung disease（CTD-ILD）.

Sixty-seven patients with CTD-ILD from 6 hospitals were included for analysis. All patients received conventional western medicine treatment. They were divided into observation group（36 cases）and control group（31 cases）according to their preference. The observation group was additionally administered with Bailing Tablets, 5 tablets for each time, 3 times per day. Two groups were treated for 6 months. The follow-up time was 3 and 6 months after enrollment. The outcomes were lung function, traditional Chinese medicine（TCM）syndrome scores, St. George＇s Respiratory Questionnaire（SGRQ）scores, 6-minute walk test distance（6MWT）and humoral immune indicators. Safety evaluation data was also recorded.

After treatment, the forced vital capacity（FVC）showed an improving trend in the observation group[（0.38±0.75）L], which was statistically significant compared with that in the control group[（-0.22±0.76）L]（P<0.05）. Compared with the control group, the observation group had significantly higher levels of improvement difference in percentage of forced vital capacity to predicted value（FVC% pre）, percentage of forced expiratory volume in the first second to predicted value（FEV1% pre）and forced expiratory volume in the first second（FEV1）（P<0.05）. The observation group showed better improvement in TCMsyndrome scores, SGRQ scores and 6MWT compared to the control group, and had lower levels of IgG and IgM, with statistically significant differences（P<0.05）. No obvious adverse reactions were observed in either group.

Based on the combination of conventional western medicine treatment, Bailing Tablets can improve the clinical symptoms and lung function of CTD-ILD, regulate the immune function, and have high safety.

To observe the curative effect of Shunao Jieyu Decoction（疏脑解郁汤）combined with moxibustion of regulating governor and relieving depression-transcranial magnetic stimulation（rTMS）on the rehabilitation of the patients with post-stroke depression（PSD）.

A total of PSD patients admitted to Hebei Provincial Hospital of Traditional Chinese Medicine from June 2021 to January 2023 were randomly divided into the combined group（60 cases）and the control group（60 cases）. Both groups were treated with Escitalopram Oxalate Tablets and the moxibustion method of regulating Du meridian and relieving depression-rTMS, and the combined group was intervened with Shunao Jieyu Decoction for 4 weeks. The changes of Hamilton Depression Scale（HAMD）, TCMsyndrome scores and modified Edinburgh-Scandinavian stroke scale（MESSS）before and after treatment were compared between the two groups. The side effects of the two groups were evaluated by Asperger＇s anti-depressant side effects scale, and the therapeutic effects of the two groups were evaluated after treatment.

After 2 and 4 weeks of treatment, the HAMD scores, TCMsyndrome scores and MESSS scale scores of the two groups decreased compared with those before treatment, while the scores of the combined group were lower than those of the control group after 2 and 4 weeks of treatment（P<0.05）. The incidence of side effects in the combined group and the control group were 15.00%（9/60）and 18.33%（11/60）, respectively, and there was no statistical difference between the two groups（P>0.05）. The total effective rate of the combined group was 91.67%（55/60）, which was significantly higher than that of the control group（76.67%, 46/60）（P<0.05）.

On the basis of regulating Du and relieving depression moxibustion-rTMS therapy, the combined application of Shunao Jieyu Decoction can effectively regulate the depression, relieve the clinical symptoms and improve the neurological function without affecting the safety of treatment, so as to achieve a more ideal therapeutic effect.

To explore the effects of a multimodal analgesia regimen combining pre-treatment with acetaminophen mannitol injection, acupuncture and transversus abdominis plane block（TAPB）on postoperative recovery in elderly patients after laparoscopic radical gastrectomy.

This study utilized a randomized controlled trial design, enrolling the elderly patients undergoing radical gastrectomy who were randomly assigned into three groups: the control group（TAPB group）, the acetaminophen +TAPB group, and the acupuncture +acetaminophen + TAPB group. Pretreatment with paracetamol mannitol injection was given before operation, and TAPB, acupuncture and moxibustion and combined treatment were performed after operation. The vital signs, pain scores, analgesic drug usage, postoperative recovery and incidence of adverse events within 48 hours after surgery were compared among the three groups.

Compared to the TAPB group, the acupuncture +acetaminophen + TAPB group demonstrated significant differences in postoperative heart rate recovery, blood pressure stability, control of visual analogue scale（VAS）scores, reduced postoperative analgesic consumption, earlier time to first ambulation, shortened time to first flatus and decreased incidence of postoperative delirium and shoulder pain（P<0.05）. The acetaminophen + TAPB group also showed advantages over the TAPB group in some indicators, but not as significantly as the acupuncture + acetaminophen + TAPB group.

The multimodal analgesia regimen of pretreatment with acetaminophen mannitol injection combined with acupuncture and TAPB significantly improves postoperative recovery in the elderly patients after laparoscopic radical gastrectomy. It effectively controls the postoperative pain, reduces the analgesic use, promotes the gastrointestinal function recovery and decreases the incidence of postoperative adverse events.

To observe the effects of Bushen Huoxue Formula（补肾活血方）combined with enema treatment on hormone, inflammation levels and pregnancy outcomes in patients with chronic endometritis complicated with infertility.

A prospective study was conducted on 102 patients with chronic endometritis who received treatment at Hengshui People＇s Hospital from July 2022 to March 2024.. The patients were divided into a control group and an observation group according to the random number table method, with 51 patients in each group. The control group received Western medicine anti infection treatment, while the observation group was treated with a combination of Bushen Huoxue Formula orally and traditional Chinese medicine enema for three consecutive menstrual cycles. The traditional Chinese medicine syndrome scores, traditional Chinese medicine syndrome efficacy, serum sex hormone and inflammation levels, pregnancy outcomes and adverse reactions were compared between two groups.

The total effective rate of the observation group（96.08%, 49/51）was significantly better than that of the control group（84.31%, 43/51）, and the difference was statistically significant（P<0.05）. Before intervention, there was no significant difference in the TCMsyndrome scores of the main or secondary symptoms between the two groups（P>0.05）. After intervention, compared with those of the control group, the TCMsyndrome scores of the main and secondary symptoms in the observation group were significantly down-regulated（P<0.01）. There was no significant difference in the levels of progesterone（P）, estradiol 2（E2）or follicle stimulating hormone（FSH）between the two groups before intervention（P>0.05）. After intervention, the levels of P and FSH were down-regulated and the E2 levels up-regulated in the two groups and the changes of the observation group was more obvious（P<0.01）. After intervention, the levels of interleukin-1 β（IL-1 β）, interleukin-6（IL-6）and tumor necrosis factor-α（TNF-α）in the observation group were significantly down-regulated（P<0.01）. The incidence of adverse reactions in the observation group（15.68%, 8/51）showed no significant difference compared to that in the control group（9.80%, 5/51）（P>0.05）. Compared with those of the control group, the clinical pregnancy rate and embryo implantation rate of the observation group were significantly up-regulated（P<0.05）, while there was no significant difference in ectopic pregnancy rate, miscarriage rate or preterm birth rate between the two groups（P>0.05）.

The combination of Bushen Huoxue Formula and enema can significantly enhance the therapeutic effect, alleviate the clinical symptoms such as abdominal pain and menstrual disorders, regulate the hormone levels, inhibit the inflammatory reactions and improve the pregnancy outcomes of infertile patients with chronic endometritis.

To observe the effect of Zuojin Jiawei Prescription（左金加味方）combined with dexzopiclone in the treatment of gastroesophageal reflux disease（liver-stomach stagnation heat type）with insomnia.

A total of 68 patients with gastroesophageal reflux disease（liver-stomach stagnation heat type）with insomnia admitted from June 2021 to January 2024 were included in the study. The patients were divided into two groups by random number table method, namely control group and observation group, with 34 cases in each group. All patients in the group received conventional Western medicine treatment, while the control group received dexzopiclone treatment. The observation group was treated with Zuojin Jiawei Prescription on the basis of control group, and the data of patients in each group was observed and compared, including clinical efficacy, changes of TCMsyndrome scores（acid reflux, heartburn, belching or regurgitation, epigastric burning pain, etc.）before and after treatment, endoscopic esophageal mucosa score and reflux diagnostic questionnaire changes in RDQ scores, the changes in Pittsburgh sleep quality index（PSQI）and short form 36 questionnaire（SF-36）scores and adverse reactions.

The total effective rate of the observation group was higher than that of thee control group（P<0.05）. The adverse reaction rate was lower in both groups（P>0.05）. Comparison of TCMsyndrome scores（acid reflux, heartburn, belching or regurgitation, epigastric burning pain, etc）, endoscopic esophageal mucosa score, RDQ score, PSQI score and SF-36 score in both groups before treatment was not significant（P>0.05）. After treatment, TCM syndrome scores（acid reflux, heartburn, belching or regurgitation, epigastric burning pain, etc.）, endoscopic esophageal mucosa scores, RDQ scores, PSQI scores and SF-36 scores were all improved in both groups. And these indexes in the observation group were all better than those in the control group（P<0.05）.

Zuojin Jiawei Prescription combined with dexzopiclone has a good effect in the treatment of gastroesophageal reflux disease（liver-stomach stagnation heat type）with insomnia, and can improve the clinical symptoms, sleep quality and quality of life of patients, which is worthy of application.