To observe the effect of Zuojin Jiawei Prescription（左金加味方）combined with dexzopiclone in the treatment of gastroesophageal reflux disease（liver-stomach stagnation heat type）with insomnia.

A total of 68 patients with gastroesophageal reflux disease（liver-stomach stagnation heat type）with insomnia admitted from June 2021 to January 2024 were included in the study. The patients were divided into two groups by random number table method, namely control group and observation group, with 34 cases in each group. All patients in the group received conventional Western medicine treatment, while the control group received dexzopiclone treatment. The observation group was treated with Zuojin Jiawei Prescription on the basis of control group, and the data of patients in each group was observed and compared, including clinical efficacy, changes of TCMsyndrome scores（acid reflux, heartburn, belching or regurgitation, epigastric burning pain, etc.）before and after treatment, endoscopic esophageal mucosa score and reflux diagnostic questionnaire changes in RDQ scores, the changes in Pittsburgh sleep quality index（PSQI）and short form 36 questionnaire（SF-36）scores and adverse reactions.

The total effective rate of the observation group was higher than that of thee control group（P<0.05）. The adverse reaction rate was lower in both groups（P>0.05）. Comparison of TCMsyndrome scores（acid reflux, heartburn, belching or regurgitation, epigastric burning pain, etc）, endoscopic esophageal mucosa score, RDQ score, PSQI score and SF-36 score in both groups before treatment was not significant（P>0.05）. After treatment, TCM syndrome scores（acid reflux, heartburn, belching or regurgitation, epigastric burning pain, etc.）, endoscopic esophageal mucosa scores, RDQ scores, PSQI scores and SF-36 scores were all improved in both groups. And these indexes in the observation group were all better than those in the control group（P<0.05）.

Zuojin Jiawei Prescription combined with dexzopiclone has a good effect in the treatment of gastroesophageal reflux disease（liver-stomach stagnation heat type）with insomnia, and can improve the clinical symptoms, sleep quality and quality of life of patients, which is worthy of application.