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A Real-World Study on Efficacy of Bailing Tablets（百令片）in Treatment of Connective Tissue Disease-Related Interstitial Lung Disease
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Jian LIU1, Xuechao LU2, Zhen WANG3, Xiaoming XUE4, Yixing CHENG5, Facai FAN6, Hongchun ZHANG1
Chinese Archives of Traditional Chinese Medicine | 2026, 44(4) : 61 - 65
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Chinese Archives of Traditional Chinese Medicine | 2026, 44(4): 61-65
• Target on National Project •
A Real-World Study on Efficacy of Bailing Tablets（百令片）in Treatment of Connective Tissue Disease-Related Interstitial Lung Disease
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Jian LIU1, Xuechao LU2, Zhen WANG3, Xiaoming XUE4, Yixing CHENG5, Facai FAN6, Hongchun ZHANG1
Affiliations
  • 1.China-Japan Friendship Hospital, Beijing 100029, China
  • 2.Qingdao Haici Hospital Affiliated to Qingdao University, Qingdao 266033, Shandong, China
  • 3.Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou 310006, Zhejiang, China
  • 4.Shanxi Provincial Hospital of Traditional Chinese Medicine, Taiyuan 030012, Shanxi, China
  • 5.Huzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Huzhou 313000, Zhejiang, China
  • 6.Wuyi Hospital of Traditional Chinese Medicine in Jiangmen, Jiangmen 529000, Guangdong, China
Published: 2026-04-10 doi: 10.13193/j.issn.1673-7717.2026.04.014
Outline
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Objective

To observe the efficacy of Bailing Tablets（百令片）combined with conventional western medicine on connective tissue disease-related interstitial lung disease（CTD-ILD）.

Methods

Sixty-seven patients with CTD-ILD from 6 hospitals were included for analysis. All patients received conventional western medicine treatment. They were divided into observation group（36 cases）and control group（31 cases）according to their preference. The observation group was additionally administered with Bailing Tablets, 5 tablets for each time, 3 times per day. Two groups were treated for 6 months. The follow-up time was 3 and 6 months after enrollment. The outcomes were lung function, traditional Chinese medicine（TCM）syndrome scores, St. George＇s Respiratory Questionnaire（SGRQ）scores, 6-minute walk test distance（6MWT）and humoral immune indicators. Safety evaluation data was also recorded.

Results

After treatment, the forced vital capacity（FVC）showed an improving trend in the observation group[（0.38±0.75）L], which was statistically significant compared with that in the control group[（-0.22±0.76）L]（P<0.05）. Compared with the control group, the observation group had significantly higher levels of improvement difference in percentage of forced vital capacity to predicted value（FVC% pre）, percentage of forced expiratory volume in the first second to predicted value（FEV1% pre）and forced expiratory volume in the first second（FEV1）（P<0.05）. The observation group showed better improvement in TCMsyndrome scores, SGRQ scores and 6MWT compared to the control group, and had lower levels of IgG and IgM, with statistically significant differences（P<0.05）. No obvious adverse reactions were observed in either group.

Conclusion

Based on the combination of conventional western medicine treatment, Bailing Tablets can improve the clinical symptoms and lung function of CTD-ILD, regulate the immune function, and have high safety.

connective tissue disease-related interstitial lung disease  /  Bailing Tablets（百令片）  /  lung function  /  traditional Chinese medicine syndrome scores
刘剑, 陆学超, 王真, 薛晓明, 成一星, 范发才, 张洪春. 百令片在治疗结缔组织病相关间质性肺疾病中疗效的真实世界研究. 中华中医药学刊, 2026 , 44 (4) : 61 -65 . DOI: 10.13193/j.issn.1673-7717.2026.04.014
Jian LIU, Xuechao LU, Zhen WANG, Xiaoming XUE, Yixing CHENG, Facai FAN, Hongchun ZHANG. A Real-World Study on Efficacy of Bailing Tablets（百令片）in Treatment of Connective Tissue Disease-Related Interstitial Lung Disease[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (4) : 61 -65 . DOI: 10.13193/j.issn.1673-7717.2026.04.014
Appendix
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Year 2026 volume 44 Issue 4
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Article Info
doi: 10.13193/j.issn.1673-7717.2026.04.014
  • Online Date：2026-10-14
  • Published：2026-04-10
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Affiliations
    1.China-Japan Friendship Hospital, Beijing 100029, China
    2.Qingdao Haici Hospital Affiliated to Qingdao University, Qingdao 266033, Shandong, China
    3.Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou 310006, Zhejiang, China
    4.Shanxi Provincial Hospital of Traditional Chinese Medicine, Taiyuan 030012, Shanxi, China
    5.Huzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Huzhou 313000, Zhejiang, China
    6.Wuyi Hospital of Traditional Chinese Medicine in Jiangmen, Jiangmen 529000, Guangdong, China
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表12种不同金属材料的力学参数
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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