To observe the effects of Bushen Huoxue Formula（补肾活血方）combined with enema treatment on hormone, inflammation levels and pregnancy outcomes in patients with chronic endometritis complicated with infertility.

A prospective study was conducted on 102 patients with chronic endometritis who received treatment at Hengshui People＇s Hospital from July 2022 to March 2024.. The patients were divided into a control group and an observation group according to the random number table method, with 51 patients in each group. The control group received Western medicine anti infection treatment, while the observation group was treated with a combination of Bushen Huoxue Formula orally and traditional Chinese medicine enema for three consecutive menstrual cycles. The traditional Chinese medicine syndrome scores, traditional Chinese medicine syndrome efficacy, serum sex hormone and inflammation levels, pregnancy outcomes and adverse reactions were compared between two groups.

The total effective rate of the observation group（96.08%, 49/51）was significantly better than that of the control group（84.31%, 43/51）, and the difference was statistically significant（P<0.05）. Before intervention, there was no significant difference in the TCMsyndrome scores of the main or secondary symptoms between the two groups（P>0.05）. After intervention, compared with those of the control group, the TCMsyndrome scores of the main and secondary symptoms in the observation group were significantly down-regulated（P<0.01）. There was no significant difference in the levels of progesterone（P）, estradiol 2（E2）or follicle stimulating hormone（FSH）between the two groups before intervention（P>0.05）. After intervention, the levels of P and FSH were down-regulated and the E2 levels up-regulated in the two groups and the changes of the observation group was more obvious（P<0.01）. After intervention, the levels of interleukin-1 β（IL-1 β）, interleukin-6（IL-6）and tumor necrosis factor-α（TNF-α）in the observation group were significantly down-regulated（P<0.01）. The incidence of adverse reactions in the observation group（15.68%, 8/51）showed no significant difference compared to that in the control group（9.80%, 5/51）（P>0.05）. Compared with those of the control group, the clinical pregnancy rate and embryo implantation rate of the observation group were significantly up-regulated（P<0.05）, while there was no significant difference in ectopic pregnancy rate, miscarriage rate or preterm birth rate between the two groups（P>0.05）.

The combination of Bushen Huoxue Formula and enema can significantly enhance the therapeutic effect, alleviate the clinical symptoms such as abdominal pain and menstrual disorders, regulate the hormone levels, inhibit the inflammatory reactions and improve the pregnancy outcomes of infertile patients with chronic endometritis.