Most ReadYanhusuo（Corydalis Rhizoma）is a commonly used medicine for promoting blood circulation and relieving pain，and is one of the“eight flavours of Zhejiang”，whose traditional local production areas are Dongyang and Pan’an in Zhejiang.Modern research shows that the main chemical components of Yanhusuo（Corydalis Rhizoma）include alkaloids，organic acids，nucleosides，steroids，etc.Alkaloids are the material basis for the pharmacological effects of Yanhusuo（Corydalis Rhizoma）.Yanhusuo（Corydalis Rhizoma）has analgesic，sedative and other effects on regulating the central nervous system，as well as vasodilatory and anti myocardial is chemia effects on regulating the cardiovascular system.It also has various pharmacological activities such as anti-tumor，anti-inflammatory，hypoglycemic and lipid-lowering effects.Based on the theory of quality marker（QMarker）in traditional Chinese medicine，through the Q-marker prediction analysis of different dimensions of Yanhusuo（Corydalis Rhizoma），it is suggested that the quality markers of tetrahydropalmatine，d-corydaline，dehydrocorydaline，protopine，palmatine，berberine，canadine，bulbocapnine，yuanhunine and d-glaucine are suggested as the quality markers of Yanhusuo（Corydalis Rhizoma），which can be used for the provide scientific basis for the rationalevaluation of the quality of Yanhusuo（Corydalis Rhizoma）.
Maidong（Ophiopogonis Radix），as a good Yin tonic in traditional Chinese medicine system，has the effect of nourishing Yin and moistening lung，invigorating stomach and promoting fluid，clearing heart and eliminating irritability.In modern pharmacological research，it plays an important role in improving cardiac function，regulating blood glucose and lipid levels，antitumor and anti-oxidation.In clinical practice，Maidong（Ophiopogonis Radix）is often used in combination with Renshen（Ginseng Radix et Rhizoma），Shashen（Glehniae Radix），Wuweizi（Schisandrae Chinensis Fructus），Huanglian（Coptidis Rhizoma），Banxia（Pinelliae Rhizoma）and other traditional Chinese medicines，so as to enhance the curative effect and expand the therapeutic range.The purpose of this paper is to systematically review the pharmacological action of Maidong（Ophiopogonis Radix）and the clinical application of its common drug pairs，and further explore the rules and theories of its compatible use，in order to provide reference and guidance for the further development and application of Maidong（Ophiopogonis Radix）and its drug pairs.
Multiplemyeloma（MM）is one of the most common malignant tumors of the hematologic system，with multiple myeloma bone disease（MBD）as a hematological complication.MBD is prominently characterized by pathological fractures，osteoporosis and osteolytic lesions，all of which severely impact patients'quality of life and survival rates.The primary mechanisms of MBD involve bone destruction and impaired osteogenesis，especially the abnormal activation of the receptor activator of nuclear factor kappa B（RANK）/ligand of RANK（RANK-L）/osteoprotegerin（OPG）system，along with an imbalance in the regulation of osteoclast and osteoblast function by pro-inflammatory cytokines in the bone marrow microenvironment.In recent years，substantial progress has been achieved in MBD treatment through integrated traditional Chinese and Western therapeutic strategies.This combined approach harnesses multiple therapeutic advantages to alleviate bone pain，enhance bone strength and reduce the risk of complications.To standardize this integrated diagnosis and treatment protocol，an expert team has developed a consensus based on evidence-based medicine and regional resources in traditional Chinese and Western medicine within the Lingnan area.This consensus aims to provide guidance for clinical practice and improve patients'quality of life and prognosis.
To observe the clinical efficacy of Qingre Jiedu Decoction（清热解毒汤）in the treatment of severe psoriasis vulgaris（blood-heat type）and its impacton serum inflammation and immune function in patients.
A prospective study was conducted on 100 patients with psoriasis vulgaris who received treatment at Shengli Oilfield Central Hospital in Dongying City.They were divided into a control group and an observation group in the order of admission，with 50 patients in each group.The control group received conventional Western medicine treatment，while the observation group received oral administration with Qingre Jiedu Decoction for 8 weeks.The total effective rate，traditional Chinese medicine syndrome scores，serum inflammation level，immune function and adverse reactions between two groups were compared.
The total effective rate of the observation group（96.00%）was significantly better than that（84.00%）of the control group，and the difference was statistically significant（P<0.05）.Before intervention，there was no significant difference in skin lesions and quality of life scores between the two groups（P>0.05）.After8 weeks of intervention，compared with those of the controlgroup，the psoriasis area and severity index（PASI）and dermatology life quality index（DLQI）of the observation group were significantly reduced（P<0.01）.The scores of symptoms such as rash color，burning sensation，itching and irritability in the observation group significantly decreased（P<0.01）.There was no significant difference in serum inflammation or T lymphocyte subsets levels between the two groups before intervention.After 8 weeks of intervention，the levels of serum tumor necrosis factor-α（TNF-α），transforming growth factor-β（TGF-β）and interleukin-6（IL-6）of the observation group were significantly down-regulated compared to those of the control group（P<0.01）.The levels of CD3+，CD4+and CD4+/CD8+in the observation group were significantly increased compared to those in the control group，while the levels of CD8+were significantly decreased，with statistical significance（P<0.01，P<0.05）.The incidence of adverse reactions in the observation group（16.00%）showed no significant difference compared to that（10.00%）in the control group（P>0.05）.
The combination of Qingre Jiedu Decoction（Psoriasis External Wash No.1 Formula）and Avia Capsules can improve the clinical efficacy in patients with severe psoriasis vulgaris，further improve the clinical symptoms，enhance the quality of life and significantly reduce PASI，and the mechanism of action is related to inhibiting the body's inflammatory response and regulating immune function.
As a traditional Chinese herbal medicine，Cangzhu（Atractylodis Rhizoma）has the functions of drying dampness and strengthening spleen，dispelling wind and cold，eliminating filth and turbidizing，improving eyesight，promoting gastrointestinal peristalsis，protecting gastric mucosa，anti-inflammatory，diuretic and other pharmacological effects，and Cangzhu（Atractylodis Rhizoma）is often used in clinical use in the form of medicine pair with Baizhu（Atractylodis Macrocephalae Rhizoma），Huangbai（Phellodendri Chinensis Cortex），Houpo（Magnoliae Officinalis Cortex）and other drugs.In this paper，the researches aboutCangzhu（Atractylodis Rhizoma）and its pharmacologic effects，clinicalapplications and related network pharmacology in CNKI，Wanfang，TCMSP and PubMed were summarized.In this paper，the research status and progress of Cangzhu（Atractylodis Rhizoma）and its drug pairs were reviewed，and the mechanism of action was discussed，which provided the basis and new ideas for revealing the application law and compatibility theory of Cangzhu（Atractylodis Rhizoma）and its drug pairs.
To observe the effect of Yinzhihuang Granules（茵栀黄颗粒）combined with ursodeoxycholic acid on the efficacy and liver function of patients with chronic jaundice hepatitis B.
A totalof132 patientswith chronic jaundice hepatitis B were enrolled in the hospital and random ly divided into observation group and control group according to the random number table method，with 66 cases in each group.The control group was treated with ursodeoxycholic acid，and the observation group was treated with Yinzhihuang Granules combined with ursodeoxycholic acid.The clinical efficacy，liver function，traditional Chinese medicine syndrome score，hepatitis B virus deoxyribonucleic acid（HBV DNA）negative conversion rate and occurrence of adverse reactions were observed in the two groups before and after treatment.
After treatment，the total effective rate of the observation group was 89.39%，which was significantly higher than that of the control group（74.24%）（P<0.05）.The liver functions of the two groups were alanine aminotransferase（ALT），aspartate aminotransferase（AST），total bilirubin（TBIL），total bile acids（TBA）andγ-glutamyl transferase（GGT）were all lower than those before treatment（P<0.05），while observing the liver function indicators of the observation group were significantly lower than those of the control group（P<0.05）.The TCM syndrome scores of the two groups were significantly lower than those before treatment（P<0.05）.At the same time，the TCM syndrome scores of the observation group were significantly lower than those of the controlgroup（P<0.05）.The HBV DNA negative conversion rate in the observation group was 56.06%，and that in the control group was 28.79%.The negative conversion rate in the observation group was significantly higher than that in the control group（P<0.05）.The incidence of liver injury in the observation group was 1.52%，which was significantly lower than that（13.64%）in the control group（P<0.05）.The incidence of adverse reactions in the observation group was 3.03%，which was not significant compared with that（10.61%）in the control group（P>0.05）.
Yinzhihuang Granules combined with ursodeoxycholic acid has a significant effect on patientswith chronic jaundice hepatitis B.It can effectively improve the clinical symptoms and liver function of patients，promote the HBV DNA negative conversion rate，and reduce the incidence of adverse reactions.
Syndromes are the cornerstone of the theoretical system of Traditional Chinese Medicine（TCM）and the core of syndrome differentiation and treatment and clinical diagnosis and treatment in TCM.Scientific identification of syndromes is an eternal theme in industry research.Traditional research on TCM syndromes mainly focuses on the macro-phenotype and microphenotype levels of syndromes，forming a complete theoretical system and methodology.With the rapid development ofmedical imaging in the last century，it is comprehensively expanding and enriching the research field and methodology of TCM syndromes.TCM syndrome science and medical imaging are colliding and integrating with each other，and syndrome imaging，a new interdisciplinary research field，has emerged.This article focused on explaining the background significance，research content，research characteristics and future development directions of syndrome imaging.
The differential metabolites of Sangshen（Mori Fructus）with different maturities were studied to provide reference for the determination of Sangshen（Mori Fructus）harvest time.
Based on the metabolo micsmethod，the changes of chemical components in Sangshen（Mori Fructus）with different maturities were explored.The data of secondary metabolites in mulberry fruits was collected by ultra-high performance liquid chromatography-quadrupole/exactive Orbitrap mass spectrometry（UPLC-Q-Exactive Orbitrap MS）.Multivariate statistical analysis methods such as principal component analysis（PCA）and partial least squares discriminant analysis（PLS-DA）were used to explore the differences in metabolic components of Sangshen（Mori Fructus）with different maturities.
There were significant differences in the metabolites of Sangshen（Mori Fructus）with different maturities.A total of176 compounds in 11 categories were screened.Flavonoids and organic acids accounted for 23.30% and 21.02%，respectively.The contents of most screened flavonoids and organic acid differential metabolites increased with the increase of maturity，and the flavonoids and organic acid metabolites of Sangshen（Mori Fructus）of different germplasms were different.The contents of extract，total flavonoids，total polyphenols and rutin in the mature stage were higher than those in the immature stage.The antioxidant activity in the mature stage was stronger than that in the immature stage.The content of chlorogenic acid in the immature stage was higher than that in the mature stage，and the inhibitory effectonα-glucosidase was also stronger than that in the mature stage.
There are obvious differences in the metabolites of Sangshen（Mori Fructus）with different maturities.The contents of chemical components in Sangshen（Mori Fructus）are related to different maturities.Based on the antioxidant effect，it is better to harvest when Sangshen（Mori Fructus）is dark purple（mature）.Based on the hypoglycemic effect，it is better to harvest when the Sangshen（Mori Fructus）becomes red（immature），which provides a basis for the quality control of Sangshen（Mori Fructus）and the determination of harvesting time.
Baizhu Powder（白术散）is a classic prescription for invigorating spleen and nourishing stomach from Xiaoer Yaozheng Zhijue.Modern studies show that ithas the functions of regulating intestinal microecology，reducing inflammation，antiviral effect，regulating blood sugar，improving insulin resistance，protecting liver，etc.It is commonly used clinically to treat diarrhea of children，anorexia，auxiliary treatment of diabetes，hyperlipidemia，etc.On the basis of summarizing the research progress of chemical composition，pharmacological action and clinical application of Baizhu Powder，the prediction analysis was carried out according to the“five principles”of quality marker（Q-Marker）.The results showed that ginsenosides Rg1，Rb1，Re，atractylenolideⅠ，Ⅱ，Ⅲ，puerarin，daidzin，daidzein，patchouli alcohol，dehydrocostus lactone，costunolide，liquiritin（SH），glycyrrhizic acid，dehydrotumulosic acid and polyporenic acid C，can be considered as Q-Markers for Baizhu Powder，and this study can provide reference for the quality control of Baizhu Powder.
Atherosclerosis（AS）is a chronic and complex disease that occurs in the arterial wall and underlies a variety of cardiovascular pathologies.Nuclear factor erythroid 2-related factor 2（Nrf2）is an anti-oxidative stress high-sensitivity transcription factor that interacts with antioxidant response element（ARE）to activate downstream gene transcription and exerts various protective effects such as anti-inflammation，antioxidant and detoxification，thus protecting cellular components such as endothelial cells，macrophages，vascular smooth muscle cells，endothelial progenitor cells and so on in arterial vascular tissue，and plays an important role in the development of AS.Traditional Chinese medicine（TCM）has significant advantages in the treatment of AS due to its multi-targets and multi-pathways，stable efficacy，individualisation and safety.This article summarized the mechanism of Nrf2 regulation by TCM monomers，TCM extracts，TCM combinations and proprietary Chinese medicines in the prevention and treatment of AS，with a view to providing a theoretical basis for clinical research and drug development in the prevention and treatment of AS.
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