Most ReadMaidong（Ophiopogonis Radix），as a good Yin tonic in traditional Chinese medicine system，has the effect of nourishing Yin and moistening lung，invigorating stomach and promoting fluid，clearing heart and eliminating irritability.In modern pharmacological research，it plays an important role in improving cardiac function，regulating blood glucose and lipid levels，antitumor and anti-oxidation.In clinical practice，Maidong（Ophiopogonis Radix）is often used in combination with Renshen（Ginseng Radix et Rhizoma），Shashen（Glehniae Radix），Wuweizi（Schisandrae Chinensis Fructus），Huanglian（Coptidis Rhizoma），Banxia（Pinelliae Rhizoma）and other traditional Chinese medicines，so as to enhance the curative effect and expand the therapeutic range.The purpose of this paper is to systematically review the pharmacological action of Maidong（Ophiopogonis Radix）and the clinical application of its common drug pairs，and further explore the rules and theories of its compatible use，in order to provide reference and guidance for the further development and application of Maidong（Ophiopogonis Radix）and its drug pairs.
Gastric ulcer is a common clinical gastrointestinal disease，which is characterized by its susceptibility，recurrence and high medical cost.Nowadays，due to the extensive use of proton pump inhibitors，H2 receptor antagonists and antimicrobial drugs，the incidence of gastric ulcers has decreased，but the recurrence rate of gastric ulcers and the incidence of complications are still not effectively controlled.The Chinese herb Huanglian（Coptidis Rhizoma）has the effects of clearing heat and drying dampness，purging fire and removing toxin，which plays a significant role in the treatment of sores，carbuncles and ulcers，and it can enter the stomach meridian，which iswidely used in the treatment of gastric ulcers，and it can effectively reduce the index of ulcers and accelerate the healing of ulcers.Through searching CNKI，Pubmed and other databases，the article comprehensively discussed the mechanism of Huanglian（Coptidis Rhizoma）and its active ingredients in the treatment of gastric ulcers，in order to provide a basis for the clinical application of Huanglian（Coptidis Rhizoma）in ulcer diseases as well as further scientific research.
Yanhusuo（Corydalis Rhizoma）is a commonly used medicine for promoting blood circulation and relieving pain，and is one of the“eight flavours of Zhejiang”，whose traditional local production areas are Dongyang and Pan’an in Zhejiang.Modern research shows that the main chemical components of Yanhusuo（Corydalis Rhizoma）include alkaloids，organic acids，nucleosides，steroids，etc.Alkaloids are the material basis for the pharmacological effects of Yanhusuo（Corydalis Rhizoma）.Yanhusuo（Corydalis Rhizoma）has analgesic，sedative and other effects on regulating the central nervous system，as well as vasodilatory and anti myocardial is chemia effects on regulating the cardiovascular system.It also has various pharmacological activities such as anti-tumor，anti-inflammatory，hypoglycemic and lipid-lowering effects.Based on the theory of quality marker（QMarker）in traditional Chinese medicine，through the Q-marker prediction analysis of different dimensions of Yanhusuo（Corydalis Rhizoma），it is suggested that the quality markers of tetrahydropalmatine，d-corydaline，dehydrocorydaline，protopine，palmatine，berberine，canadine，bulbocapnine，yuanhunine and d-glaucine are suggested as the quality markers of Yanhusuo（Corydalis Rhizoma），which can be used for the provide scientific basis for the rationalevaluation of the quality of Yanhusuo（Corydalis Rhizoma）.
To study the clinical study of Jingu Tongxiao Pill（筋骨痛消丸）combined with arthroscopy in the treatment of knee osteoarthritis（cold coagulation blood stasis syndrome）.
A total of 120 patients diagnosed as knee osteoarthritis（cold coagulation and blood stasis syndrome）were selected and divided into two groups according to random number table.The reference group（60 cases）received arthroscopic treatment，and the study group（60 cases）received Jingu Tongxiao Pill and arthroscopic treatment.The clinical efficacy，TCM syndrome score，osteoarthritis index，inflammatory factor level and oxidative stress reaction of the two groupswere observed and compared.
Compared with that（75.00%）of the reference group，the total effective rate of the study group was98.33%，and the difference was statistically significant（P<0.05）.After treatment，the TCM syndrome score of the study group was lower than that of the reference group，and the difference was statistically significant（P<0.05）.After treatment，compared with those of the reference group，the pain，stiffness and difficulty scores of daily activities in the study group were lower，and the difference was statistically significant（P<0.05）.After treatment，compared with those of the reference group，the levels of tumor necrosis factor-alpha（TNF-α），interleukin-1 beta（IL-1β）and matrixmetalloproteinase-3（MMP-3）in the study group were lower，and the difference was statistically significant（P<0.05）.
The patients with knee osteoarthritis（cold coagulation blood stasis syndrome）were treated with arthroscopy and Jingu Tongxiao Pill，and the therapeutic effect was good，which could effectively improve the clinical symptoms and promote the recovery of patients，and the clinical application value was high.
To observe the clinical efficacy of Wangbi Capsule（尪痹胶囊）in the treatment of dampness-heat blocking collateral type of rheumatoid arthritis and its effects on serum granulocyte-macrophage colony-stimulating factor（GM-CSF），tumor necrosis factor-α（TNF-α）and CD4+T cell subsets.
Ninety-eighty patients with rheumatoid arthritis treated in the Rheumatology and Immunology Department of the hospital from June 2020 to June 2023 were selected as the study objects，and the above patients were divided into control group and observation group with 49 cases in each group by random number table method.The control group was given leflunomide orally，and the observation group was given Wangbi Capsule on the basis of the control group.The clinical efficacy，TCM syndrome score and adverse reactions，the degree of joint pain and the levels of serum inflammatory factors before and after treatment were compared between two groups.
The effective rate of the control group was 79.59%，and that of the observation group was 93.88%.Compared with that of the control group，the effective rate of the observation group was significantly increased（P<0.05）.There was no significant difference in TCM syndrome scores between the two groups before treatment（P>0.05）.After treatment，the levels of morning stiffness，joint flexion and extension，fever，joint swelling pain and heat in the observation group were significantly decreased compared with those in the control group（P<0.01）.Before intervention，there was no significant difference in ultrasound scores between the two groups（P>0.05）.After the intervention，the ultrasound scores in the observation group were significantly higher than those in the control group（P<0.05）.Before intervention，there was no significant difference in the degree of joint pain between the two groups（P>0.05）.Compared with those of the control group，visual analog scale（VAS）score and disease activity score 28（DAS28）score of the observation group were significantly decreased after treatment（P<0.01）.There was no significant difference in serum inflammatory factors between the two groups before intervention（P>0.05）.After the intervention，the levels of erythrocyte sedimentation rate（ESR），C-reactive protein（CRP），rheumatoid factor（RF），GM-CSF and TNF-αin the observation group were significantly decreased compared with those in the control group（P<0.01）.During the intervention，the main adverse reactions of all patients were gastrointestinal discomfort，hemocytopenia，elevated aminotransferase and skin allergy，and there was no significant difference in the incidence of adverse reactions between the two groups（P>0.05）.
Wangbi Capsule combined with leflunomide has a good clinical effect in the treatment of moisture-heat blocking collateral type of rheumatoid arthritis，which can alleviate the joint pain and dysfunction，improve the jointultrasound status and inhibit the inflammation，without increasing the adverse reactions.
To investigate the efficacy and safety of Sanhuangtangshenkang（三黄糖肾康）combined with Dapagliflozin in the treatment of Qi deficiency and blood stasis type of early diabetic nephropathy（DN）.
A randomized，double-blind and placebo-controlled clinical trial was conducted involving 120 patients from the Endocrinology and Nephrology Departments at Taizhou Hospital of Traditional Chinese Medicine from June 2021 to June 2023.The participants were allocated into two groups.The experimental group（60 patients）received standard care augmented with Sanhuangtangshenkang and Dapagliflozin，while the control group（60 patients）was treated with standard care plus placebo granules and Dapagliflozin.The duration of treatmentwas 12 weeks.The primary endpoints included the efficacy of treatment，the renal function，the inflammatory markers，the enhancement of traditional Chinese medicine（TCM）syndromes，and the frequency of adverse events.
A total of 117 patients were successfully enrolled，59 in the experimental group and 58 in the control group.The experimental group showed a significantly higher overall effective rate compared to the control group（98.30% versus70.68%，P<0.05）.Biochemical indicators such as the urine albumin-to-creatinine ratio（UACR），24-hour urinary microalbumin（UMA）and 24-hour urinary protein were significantly improved in the experimental group compared to those in the control group after 12 weeks of treatment（P<0.05）.Inflammatory markers including serum amyloid A（SAA），interleukin-6（IL-6），C-reactive protein（CRP）and homocysteine（Hcy）also showed more significant reductions in the experimental group，especially after 12 weeks of treatment（P<0.05）.The improvements in renal function and other biochemical indicators，such as glycated hemoglobin（HbA1c），estimated glomerular filtration rate（eGFR）and total cholesterol（TC），were also notably better in the experimental group（P<0.05）.TCM symptom scores further confirmed the improvement in various indicators in the experimental group after treatment（P<0.05）.Although there was no statistically significant difference in the incidence of adverse reactions between the two groups（P>0.05）.The experimental group exhibited a lower rate of adverse reactions（3.38%）compared to the control group（8.62%）.
The combination of Sanhuangtangshenkang with Dapagliflozin is highly effective and safe for improving renal function，glycemic control and TCM syndromes in patients with early-stage DN characterized by Qi deficiency and blood stasis，demonstrating both enhanced safety and superior efficacy.
Neurodegenerative diseases（NDDs）are a complex group of conditions caused by progressive degeneration and dysfunction of cells and tissues in the central nervous system.The pathogenesis is intricate，and they are often chronic and difficult to cure，with no effective treatments currently available.Recent studies have shown that Chuanxiong（Chuanxiong Rhizoma），a traditional Chinese medicinal herb，exhibits a wide array of pharmacological effects.The main components of Chuanxiong（Chuanxiong Rhizoma）possess advantages in treating NDDs throughmulti-targetandmulti-pathwaymechanisms.This article reviewed the latest research advancements in the field of Chuanxiong（Chuanxiong Rhizoma）application to NDDs，primarily Parkinson's disease（PD），Alzheimer's disease（AD）and epilepsy.It summarized the use of Chuanxiong（Chuanxiong Rhizoma）and its compound formulations in the treatment of NDDs over recent years.The article particularly delved into the pharmacological effects of its active ingredients，including ferulic acid，tetramethylpyrazine（TMP），vanillic acid and ligustilide，in terms of their anti-inflammatory，antioxidant，anti-apoptotic，neurotoxicity-reducing，immunomodulatory and mitochondrial function-improving properties.This review served as a theoretical foundation for the future development of natural drugs derived from Chuanxiong（Chuanxiong Rhizoma）for the prevention and treatment of NDDs.
Syndromes are the cornerstone of the theoretical system of Traditional Chinese Medicine（TCM）and the core of syndrome differentiation and treatment and clinical diagnosis and treatment in TCM.Scientific identification of syndromes is an eternal theme in industry research.Traditional research on TCM syndromes mainly focuses on the macro-phenotype and microphenotype levels of syndromes，forming a complete theoretical system and methodology.With the rapid development ofmedical imaging in the last century，it is comprehensively expanding and enriching the research field and methodology of TCM syndromes.TCM syndrome science and medical imaging are colliding and integrating with each other，and syndrome imaging，a new interdisciplinary research field，has emerged.This article focused on explaining the background significance，research content，research characteristics and future development directions of syndrome imaging.
To observe the clinical efficacy of Qingre Jiedu Decoction（清热解毒汤）in the treatment of severe psoriasis vulgaris（blood-heat type）and its impacton serum inflammation and immune function in patients.
A prospective study was conducted on 100 patients with psoriasis vulgaris who received treatment at Shengli Oilfield Central Hospital in Dongying City.They were divided into a control group and an observation group in the order of admission，with 50 patients in each group.The control group received conventional Western medicine treatment，while the observation group received oral administration with Qingre Jiedu Decoction for 8 weeks.The total effective rate，traditional Chinese medicine syndrome scores，serum inflammation level，immune function and adverse reactions between two groups were compared.
The total effective rate of the observation group（96.00%）was significantly better than that（84.00%）of the control group，and the difference was statistically significant（P<0.05）.Before intervention，there was no significant difference in skin lesions and quality of life scores between the two groups（P>0.05）.After8 weeks of intervention，compared with those of the controlgroup，the psoriasis area and severity index（PASI）and dermatology life quality index（DLQI）of the observation group were significantly reduced（P<0.01）.The scores of symptoms such as rash color，burning sensation，itching and irritability in the observation group significantly decreased（P<0.01）.There was no significant difference in serum inflammation or T lymphocyte subsets levels between the two groups before intervention.After 8 weeks of intervention，the levels of serum tumor necrosis factor-α（TNF-α），transforming growth factor-β（TGF-β）and interleukin-6（IL-6）of the observation group were significantly down-regulated compared to those of the control group（P<0.01）.The levels of CD3+，CD4+and CD4+/CD8+in the observation group were significantly increased compared to those in the control group，while the levels of CD8+were significantly decreased，with statistical significance（P<0.01，P<0.05）.The incidence of adverse reactions in the observation group（16.00%）showed no significant difference compared to that（10.00%）in the control group（P>0.05）.
The combination of Qingre Jiedu Decoction（Psoriasis External Wash No.1 Formula）and Avia Capsules can improve the clinical efficacy in patients with severe psoriasis vulgaris，further improve the clinical symptoms，enhance the quality of life and significantly reduce PASI，and the mechanism of action is related to inhibiting the body's inflammatory response and regulating immune function.
Multiplemyeloma（MM）is one of the most common malignant tumors of the hematologic system，with multiple myeloma bone disease（MBD）as a hematological complication.MBD is prominently characterized by pathological fractures，osteoporosis and osteolytic lesions，all of which severely impact patients'quality of life and survival rates.The primary mechanisms of MBD involve bone destruction and impaired osteogenesis，especially the abnormal activation of the receptor activator of nuclear factor kappa B（RANK）/ligand of RANK（RANK-L）/osteoprotegerin（OPG）system，along with an imbalance in the regulation of osteoclast and osteoblast function by pro-inflammatory cytokines in the bone marrow microenvironment.In recent years，substantial progress has been achieved in MBD treatment through integrated traditional Chinese and Western therapeutic strategies.This combined approach harnesses multiple therapeutic advantages to alleviate bone pain，enhance bone strength and reduce the risk of complications.To standardize this integrated diagnosis and treatment protocol，an expert team has developed a consensus based on evidence-based medicine and regional resources in traditional Chinese and Western medicine within the Lingnan area.This consensus aims to provide guidance for clinical practice and improve patients'quality of life and prognosis.
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